Menée aux Etats-Unis auprès de 70 802 personnes (durée de suivi : jusqu'à 16 ans), cette étude analyse l'association entre la qualité de l'alimentation et le risque de cancer du poumon (1 454 cas)

Diet quality and lung cancer incidence in a low-income population in the United States

Munro, Heather M. ; Yu, Danxia ; Zheng, Wei ; Blot, William J. ; Cai, Qiuyin ; Shrubsole, Martha J.

Background: Although tobacco smoking is the leading cause of lung cancer, interest in the relationship of diet quality on risk has been growing. Methods: We examined the association between Healthy Eating Index-2010 (HEI-10) at enrollment and lung cancer incidence among 70,802 participants in a predominantly African American and low-income prospective cohort in the southern United States. Outcomes were ascertained through linkages with state cancer registries and the National Death Index (NDI). [...]

Menée en Chine urbaine à l'aide de données portant sur 224 189 personnes, cette étude analyse l'association entre 4 polluants de l'air domestique et le risque de cancer du poumon (3 288 cas)

Household air pollution and risk of incident lung cancer in urban China: A prospective cohort study

Ji, Chen ; Lv, Jun ; Zhang, Jing ; Zhu, Meng ; Yu, Canqing ; Ma, Hongxia ; Jin, Guangfu ; Guo, Yu ; Pei, Pei ; Yang, Ling ; Chen, Yiping ; Du, Huaidong ; Chen, Zhengming ; Hu, Zhibin ; Li, Liming ; Shen, Hongbing ; the China Kadoorie Biobank Collaborative Group

Household air pollution (HAP) is associated with the development of lung cancer, yet few studies investigated the exposure patterns and joint associations with tobacco smoking. In our study, we included 224 189 urban participants from China Kadoorie Biobank (CKB), 3288 of which diagnosed with lung cancer during the follow-up. Exposure to four HAP sources (solid fuels for cooking/heating/stove and environmental tobacco smoke exposure) was assessed at baseline. Distinct HAP patterns and their [...]

Menée en Italie à partir de données multicentriques portant sur 545 patientes infectées par le papillomavirus humain (HPV) depuis au moins 6 mois, cette étude analyse l'association entre la durée de la persistance du HPV et le risque de récidive à 5 ans d'une dysplasie de haut grade (CIN2+)

Duration of human papillomavirus persistence and its relationship with recurrent cervical dysplasia

Bogani, Giorgio ; Sopracordevole, Francesco ; Ciavattini, Andrea ; Vizza, Enrico ; Vercellini, Paolo ; Giannini, Andrea ; Ghezzi, Fabio ; Scambia, Giovanni ; Raspagliesi, Francesco ; Di Donato, Violante ; Italian Society of Colposcopy ; Cervico-Vaginal Pathology ; The Investigators of the Italian HPV study group

Objective: To evaluate how the duration of human papillomavirus (HPV) persistence influences the risk of developing recurrent high-grade cervical dysplasia (CIN2+). Methods: Data of patients with persistent HPV infection (at least at 6 months) after primary conization were extracted from a multi-institutional Italian database, retrospectively. Kaplan–Meier and Cox proportional hazards models were used to evaluate associations between duration of HPV persistence with the 5-year risk of [...]

Menée à partir de données 2006-2010 de la "UK Biobank" portant sur 250 312 femmes (âge : 40-69 ans ; durée médiane de suivi : 11,1 ans), cette étude analyse l'association entre un diabète et le risque de cancer du sein (8 182 cas)

Diabetes mellitus and risk of breast cancer: a large-scale, prospective, population-based study

Xiong, Fanxiu ; Wang, Jingxuan ; Nierenberg, Jovia L. ; Van Blarigan, Erin L. ; Kenfield, Stacey A. ; Chan, June M. ; Schmajuk, Gabriela ; Huang, Chiung-Yu ; Graff, Rebecca E.

Background: The objective of this study was to evaluate associations of diabetes overall, type 1 diabetes (T1D), and type 2 diabetes (T2D) with breast cancer (BCa) risk. Methods: We included 250,312 women aged 40–69 years between 2006 and 2010 from the UK Biobank cohort. Adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) were calculated for associations of diabetes and its two major types with the time from enrollment to incident BCa. Results: We identified 8182 BCa cases during a [...]

Menée à l'aide de données des registres allemands des cancers portant sur 217 202 patients ayant survécu à un cancer colorectal diagnostiqué entre 1990 et 2011, cette étude identifie les facteurs de risque de second cancer primitif (18 751 cas)

Second primary cancer among 217702 colorectal cancer survivors: An analysis of national German cancer registry data

Liang, Linda A. ; Tseng, Ying-Ju ; Tanaka, Luana F. ; Klug, Stefanie J.

With improvements in survival after colorectal cancer (CRC), more survivors are at risk of developing a second cancer, particularly in younger populations where CRC incidence is increasing. We estimated the incidence of second primary cancer (SPC) in CRC survivors and its potential risk factors. We identified CRC cases diagnosed between 1990 and 2011 and SPCs until 2013 from nine German cancer registries. Standardized incidence ratios (SIR) and absolute excess risk (AER) per 10 000 person-years [...]

Menée aux Etats-Unis auprès de 10 413 patients infectés par le VIH, cette étude analyse l'association entre la charge virale, le taux de lymphocytes CD4+ et le risque de développer un cancer non lié au SIDA

Association of CD4 count and HIV viral load with risk of Non-AIDS-defining cancers

MA, Yunqing ; Zhang, Jiajia ; Yang, Xueying ; Chen, Shujie ; Weissman, Sharon ; Olatosi, Bankole ; Alberg, Anthony ; Li, Xiaoming

Objectives: HIV-induced immunodeficiency contributes to an increased risk of non-AIDS-defining cancers (NADC). This study aims to identify the most predictive viral load (VL) or CD4 measures of NADC risk among people living with HIV (PLWH). Design: Extracted from South Carolina electronic HIV reporting system, we studied adult PLWH who were cancer-free at baseline and had at least 6 months of follow-up since HIV diagnosis between January 2005 and December 2020. Methods: Using multiple [...]

Menée aux Etats-Unis à l'aide de données portant sur 70 397 femmes ménopausées, cette étude analyse l'effet de la corpulence à l'âge adulte sur l'association entre le poids à la naissance et le risque de cancer colorectal

Birth weight, adult body size, and risk of colorectal cancer

Su, Le ; Hendryx, Michael ; Li, Ming ; Pichardo, Margaret S. ; Jung, Su Yon ; Lane, Dorothy S. ; Chlebowski, Rowan ; Sun, Yangbo ; Li, Chao ; Luo, Juhua

Background: Evidence suggests that birth weight may be associated with colorectal cancer (CRC) risk later in life. Whether the association is mediated by adult body size remains unexamined. Method: Cox proportional hazards models (Hazard Ratio (HR) and 95 % Confidence Intervals (CI)) were used to evaluate the association between self-reported birth weight (<6 lbs, 6-<8 lbs, ≥8 lbs) and CRC risk among 70,397 postmenopausal women from the Women’s Health Initiative. Further, we assessed whether [...]

Menée à partir de données 2013-2021 portant sur 290 témoins et 290 patients atteints d'un cancer de la cavité buccale, cette étude analyse l'association entre des polymorphismes à simple nucléotide du gène FAM13A et le risque de développer la maladie

FAM13A polymorphisms are associated with a specific susceptibility to clinical progression of oral cancer in alcohol drinkers

Hsieh, Ming-Ju ; Lo, Yu-Sheng ; Tsai, Yun-Jung ; Ho, Hsin-Yu ; Lin, Chia-Chieh ; Chuang, Yi-Ching ; Lin, Shu-Hui ; Chen, Mu-Kuan

Background: Single nucleotide polymorphism (SNP) is a genetic variation that occurs when a single nucleotide base in the DNA sequence varies between individuals and is present in at least 1% of the population. Genetic variants in FAM13A are associated with different types of chronic respiratory diseases, including chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), and lung cancer. However, there is little literature on the association of FAM13A genotypes with oral cancer. [...]