Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

COVID-19 severity by vaccination status in the NCI COVID-19 and Cancer Patients Study (NCCAPS)

Best, Ana F ; Bowman, Melissa ; Li, Jessica ; Mishkin, Grace E ; Denicoff, Andrea ; Shekfeh, Marwa ; Rubinstein, Larry ; Warner, Jeremy L ; Rini, Brian ; Korde, Larissa A

We investigated the association of SARS CoV-2 vaccination with COVID-19 severity in a longitudinal study of adult cancer patients with COVID-19. 1610 patients who were within 14 days of initial positive SARS CoV-2 test and had received recent anticancer treatment or had a history of stem cell transplant or CAR-T cell therapy were enrolled between 5/21/2020 and 2/1/2022. Patients were considered fully vaccinated if they were 2 weeks past their second dose of mRNA vaccine (BNT162b2 or mRNA-1273) [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

Outcomes of Breakthrough COVID-19 Infections in Patients with Hematologic Malignancies

Chien, Kelly Sharon ; Peterson, Christine ; Young, Elliana ; Chihara, Dai ; Manasanch, Elizabet E ; Ramdial, Jeremy ; Thompson, Philip A

Patients with hematologic malignancies have both an increased risk for SARS-CoV2 infections and higher morbidity/mortality. They have lower seroconversion rates post-vaccination, potentially leading to inferior COVID-19 outcomes, despite vaccination. We consequently evaluated the clinical outcomes of COVID-19 infections in 243 vaccinated and 175 unvaccinated patients with hematologic malignancies. Hospitalization rates were lower in the vaccinated group when compared to the unvaccinated group [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

Consequences of coronavirus disease in women with breast cancer

Cvetkovic, Jovana Lj

The ongoing coronavirus (COVID-19) pandemic produces widespread concerns, fear and stress throughout the world, and our country is no exception in that regard, which is a natural and normal human reaction to this inconsistent and uncertain situation for us all.For the purpose of this study a sociodemographic questionnaire was devised as well as a Serbian version of the self-reported Depression, anxiety and stress scale-21.The average age ± [standard deviation (SD)] of the participants in the [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

“Predictors of in-hospital mortality in adult cancer patients with COVID-19 infection presenting to the emergency department: A retrospective study”

El Majzoub, Imad ; Kalot, Nour ; Khalifeh, Malak ; Estelly, Natalie ; El Zahran, Tharwat

Background : Adult cancer patients are at higher risk of morbidity and mortality following COVID-19 infection. Being on the front lines, it is crucial for emergency physicians to identify those who are at higher risk of mortality. The aim of our study was to determine the predictors of in-hospital mortality in COVID-19 positive cancer patients who present to the emergency department. Methods : This is a retrospective cohort study conducted on adult cancer patients who presented to the ED of the [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

Real-world Data on the Incidence of Coronavirus Disease (COVID-19) in Patients With Advanced Thoracic Cancer During the Early Phase of the Pandemic in Japan

FUKUDA, AKITO ; Yoshida, Tatsuya ; Yagishita, Shigehiro ; Shiotsuka, Mika ; Kobayashi, Osamu ; Iwata, Satoshi ; UMEGUCHI, HITOMI ; YANAGIDA, MASATOSHI ; Irino, Yasuhiro ; Masuda, Ken ; Shinno, Yuki ; Okuma, Yusuke ; Goto, Yasushi ; Horinouchi, Hidehito ; Hamada, Akinobu ; Yamamoto, Noboru ; Ohe, Yuichiro

Background/Aim: The severity and associated mortality of coronavirus disease 2019 (COVID-19) are higher in patients with thoracic cancer than in healthy populations and those with other cancer types. Here, we investigated real-world data on the incidence of COVID-19 and false-negative cases using severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) real-time reverse-transcription polymerase chain reaction (rRT-PCR) testing in patients with thoracic cancer. Patients and Methods: We [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

Early administration of SARS-CoV-2 monoclonal antibody reduces the risk of mortality in hematologic malignancy and hematopoietic cell transplant patients with COVID-19

Jabr, Ra'ed ; Khatri, Akshay ; Anderson, Anthony D. ; Garcia, Leopoldo Cordova ; Viotti, Julia Bini ; Natori, Yoichiro ; Raja, Mohammed ; Camargo, Jose F. ; Morris, Michele I.

Background : Data on severe acute respiratory distress syndrome coronavirus 2 monoclonal antibody (SARS-CoV-2-specific mAb) use in hematologic malignancy and hematopoietic cell transplantation (HM/HCT) patients are limited. Here, we describe our experience with the use of casirivimab–imdevimab or bamlanivimab for the treatment of coronavirus disease 2019 (COVID-19) in HM/HCT patients. Methods : This was a retrospective chart review at the University of Miami Hospital and Sylvester Comprehensive [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

Estimation of Oncologic Surgery Case Volume Before and After the COVID-19 Pandemic in France

Le Bihan-Benjamin, Christine ; Rocchi, Mathieu ; Putton, Maxime ; Méric, Jean-Baptiste ; Bousquet, Philippe Jean

Importance : COVID-19 has had a major effect on health care activities, especially surgery. At first, comparisons were proposed using 2019 activities as the highest standard. However, while such an approach might have been suitable during the first months of the pandemic, this might no longer be the case for a longer period. Objective : To examine approaches that may better assess the use of cancer surgeries. Design, Setting, and Participants : In a cross-sectional design, the nationwide French [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

Nation-wide participation in FIT-based colorectal cancer screening in Denmark during the COVID-19 pandemic: An observational study

Olesen, Tina Bech ; Jensen, Henry ; Møller, Henrik ; Jensen, Jens Winther ; Andersen, Berit ; Rasmussen, Morten

Background: Worldwide, most colorectal cancer screening programmes were paused at the start of the COVID-19 pandemic, whilst the Danish faecal immunochemical test (FIT)-based programme continued without pausing. We examined colorectal cancer screening participation and compliance with subsequent colonoscopy in Denmark throughout the pandemic. Methods: We used data from the Danish Colorectal Cancer Screening Database among individuals aged 50-74 years old invited to participate in colorectal [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

Distinct systemic immune networks define severe vs. mild COVID-19 in hematologic and solid cancer patients

Pignataro-Oshiro,Flávio ; Figueiredo,Amanda B. ; Galdino,Nayane A. L. ; Morais,Katia L. P. ; Dutra,Walderez O. ; Silva,Bianca Grassi de Miranda ; Feriani,Diego ; Abrantes,Flávia de Azevedo ; Silva,Ivan Leonardo Avelino França e ; Filho,Jayr Schmidt ; Framil,Juliana Valéria de Souza ; Cesca,Marcelle Goldner ; Riechelmann,Rachel Simões Pimenta ; Batista,Marjorie V. ; Gollob,Kenneth J.

Introduction: The COVID-19 pandemic, caused by the coronavirus SARS-CoV-2, has impacted health across all sectors of society. A cytokine-release syndrome, combined with an inefficient response of innate immune cells to directly combat the virus, characterizes the severe form of COVID-19. While immune factors involved in the development of severe COVID-19 in the general population are becoming clearer, identification of the immune mechanisms behind severe disease in oncologic patients remains [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

The Scottish COVID Cancer Immunity Prevalence Study: A Longitudinal Study of SARS-CoV-2 Immune Response in Patients Receiving Anti–Cancer Treatment

Purshouse, Karin ; Thomson, John P ; Vallet, Mahéva ; Alexander, Lorna ; Bonisteel, Isaac ; Brennan, Maree ; Cameron, David A ; Figueroa, Jonine D ; Furrie, Elizabeth ; Haig, Pamela ; Heck, Mattea ; McCaughan, Hugh ; Mitchell, Paul ; McVicars, Heather ; Primrose, Lorraine ; Silva, Ines ; Templeton, Kate ; Wilson, Natalie ; Hall, Peter S

Background: Cancer and anti-cancer treatment (ACT) may be risk factors for severe SARS-CoV-2 infection and limited vaccine efficacy. Long–term longitudinal studies are needed to evaluate these risks. The Scottish COVID cancer immunity prevalence (SCCAMP) study characterizes the incidence and outcomes of SARS-CoV-2 infection and vaccination in patients with solid tumors undergoing ACT. This preliminary analysis includes 766 patients recruited since May 2020. Methods: Patients with solid-organ [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

COVID-19 Outcomes by Cancer Status, Site, Treatment, and Vaccination

Salvatore, Maxwell ; Hu, Miriam M. ; Beesley, Lauren J. ; Mondul, Alison M. ; Pearce, Celeste Leigh ; Friese, Christopher R. ; Fritsche, Lars G. ; Mukherjee, Bhramar

Studies have shown an increased risk of severe SARS-CoV-2–related (COVID-19) disease outcome and mortality for patients with cancer, but it is not well understood whether associations vary by cancer site, cancer treatment, and vaccination status.Using electronic health record data from an academic medical center, we identified a retrospective cohort of 260,757 individuals tested for or diagnosed with COVID-19 from March 10, 2020, to August 1, 2022. Of these, 52,019 tested positive for COVID-19 [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

Pandemic Phase-Adjusted Analysis of COVID-19 Outcomes Reveals Reduced Intrinsic Vulnerability and Substantial Vaccine Protection From Severe Acute Respiratory Syndrome Coronavirus 2 in Patients With Breast Cancer

Marco Tagliamento ; Alessandra Gennari ; Matteo Lambertini ; Ramon Salazar ; Nadia Harbeck ; Lucia Del Mastro ; Juan Aguilar-Company ; Mark Bower ; Rachel Sharkey ; Alessia Dalla Pria ; Andrea Plaja ; Amanda Jackson ; Jasmine Handford ; Ailsa Sita-Lumsden ; Clara Martinez-Vila ; Marta Matas ; Ana Miguel Rodriguez ; Bruno Vincenzi ; Giuseppe Tonini ; Alexia Bertuzzi ; Joan Brunet ; Paolo Pedrazzoli ; Francesca D'Avanzo ; Federica Biello ; Alasdair Sinclair ; Alvin J.X. Lee ; Sabrina Rossi ; Gianpiero Rizzo ; Oriol Mirallas ; Isabel Pimentel ; Maria Iglesias ; Ana Sanchez de Torre ; Annalisa Guida ; Rossana Berardi ; Alberto Zambelli ; Carlo Tondini ; Marco Filetti ; Francesca Mazzoni ; Uma Mukherjee ; Nikolaos Diamantis ; Alessandro Parisi ; Avinash Aujayeb ; Aleix Prat ; Michela Libertini ; Salvatore Grisanti ; Maura Rossi ; Federica Zoratto ; Daniele Generali ; Cristina Saura ; Gary H. Lyman ; Nicole M. Kuderer ; David J. Pinato ; Alessio Cortellini ; On behalf of the OnCovid Study Group

PURPOSE: Although representing the majority of newly diagnosed cancers, patients with breast cancer appear less vulnerable to COVID-19 mortality compared with other malignancies. In the absence of patients on active cancer therapy included in vaccination trials, a contemporary real-world evaluation of outcomes during the various pandemic phases, as well as of the impact of vaccination, is needed to better inform clinical practice. METHODS: We compared COVID-19 morbidity and mortality among [...]

Menée aux Etats-Unis à partir de données portant sur 131 enfants atteints d'un lymphome ou d'une leucémie et traités en ambulatoire, cette étude analyse le taux et les types d'erreurs médicamenteuses ainsi que les complications associées

Preventable harm because of outpatient medication errors among children with leukemia and lymphoma: A multisite longitudinal assessment

Wong, Chris I. ; Vannatta, Kathryn ; Gilleland Marchak, Jordan ; Quade, Emeric V. ; Rodgers, Isabelle M. ; Reid, Christine M. ; Dandoy, Christopher E. ; Billett, Amy L. ; Miller, Tamara P. ; Vaughn, Shelley ; Daraiseh, Nancy M. ; Liu, Shanshan ; Carle, Adam C. ; Walsh, Kathleen E.

Background: There is little longitudinal information about the type and frequency of harm resulting from medication errors among outpatient children with cancer. We aimed to characterize rates and types of medication errors and harm to outpatient children with leukemia and lymphoma over 7 months of treatment. Methods: We recruited children taking medications at home for leukemia or lymphoma from three pediatric cancer centers. Errors were identified by chart review, in-home medication review, [...]

Menée aux Etats-Unis à partir de données portant sur 131 enfants atteints d'un lymphome ou d'une leucémie et traités en ambulatoire, cette étude analyse le taux et les types d'erreurs médicamenteuses ainsi que les complications associées

Building new standards to prevent harm from medication errors in children with cancer

Helmig, Sara E. ; Hoffman, James M.

Children with cancer receive many medications outside the hospital administered by their caregivers. The study by Walsh et al. shows the number and types of medication errors in these patients. The study includes data from three different centers. Importantly, the study shows the types of errors that cause harm. The authors describe how the harmful errors can be prevented. We suggest ways these results can be used to identify which patients and families will benefit from additional attention. [...]