Menée à partir de données 2009-2012 de la "UK Biobank" portant sur 197 426 personnes (durée médiane de suivi : 9,8 ans ; âge : 40- 69 ans ; 54,6 % de femmes), cette étude analyse l'association entre la proportion d'aliments ultra-transformés consommés et le risque de cancer (15 921 cas), ainsi que la mortalité spécifique (4 009 décès)

Ultra-processed food consumption, cancer risk and cancer mortality: a large-scale prospective analysis within the UK Biobank

Chang, Kiara ; Gunter, Marc J. ; Rauber, Fernanda ; Levy, Renata B. ; Huybrechts, Inge ; Kliemann, Nathalie ; Millett, Christopher ; Vamos, Eszter P.

Background: Global dietary patterns are increasingly dominated by relatively cheap, highly palatable, and ready-to-eat ultra-processed foods (UPFs). However, prospective evidence is limited on cancer development and mortality in relation to UPF consumption. This study examines associations between UPF consumption and risk of cancer and associated mortality for 34 site-specific cancers in a large cohort of British adults. Methods: This study included a prospective cohort of UK Biobank [...]

Menée en Australie à l'aide de données nationales 1983-2016 et menée auprès de 4 507 hommes ayant travaillé au moins 3 mois dans une fonderie d'aluminium, cette étude analyse leur risque de cancer et de décès par rapport à la population générale

Workers in Australian prebake aluminium smelters: update on risk of mortality and cancer incidence in the Healthwise cohort

Del Monaco, Anthony ; Dimitriadis, Christina ; Xie, Sophia ; Benke, Geza ; Sim, Malcolm Ross ; Walker-Bone, Karen

Objectives: To investigate mortality and the rates of incident cancer among a cohort of aluminium industry workers. Methods: Among 4507 male employees who worked in either of two Australian prebake smelters for at least 3 months, data linkage was undertaken with the Australian National Death Index and Australian Cancer Database. Standardised Mortality Ratios (SMRs) and Standardised Incidence Rates (SIRs) were estimated for the whole cohort and for: production; maintenance and office workers. [...]

Menée en Suède à l'aide de données 1987-2018 d'un registre des hospitalisations et à partir du registre national des cancers, cette étude analyse l'association entre 43 maladies autoimmunes et le risque de cancer hépatobiliaire (3 191 cas)

Autoimmune diseases as comorbidities for liver, gallbladder, and biliary duct cancers in Sweden

Hemminki, Kari ; Sundquist, Kristina ; Sundquist, Jan ; Försti, Asta ; Liska, Vaclav ; Hemminki, Akseli ; Li, Xinjun

Background: Autoimmune diseases are associated with many cancers but there is a lack of population-based studies with different autoimmune diseases that have a long follow-up. This is also true of hepatobiliary cancers, which include hepatocellular cancer (HCC) and rarer entities of gallbladder cancer (GBC), intra- and extrahepatic cholangiocarcinoma (iCCA and eCCA), and ampullary cancer. Methods: Diagnostic data on 43 autoimmune diseases were collected from the Swedish Inpatient Register from [...]

Menée à partir de données 2006-2021 de la "UK Biobank" portant sur 450 207 personnes (durée médiane de suivi : 12,5 ans ; âge moyen : 56 ans ; 53,3 % de femmes), cette étude analyse l'association entre une supplémentation en glucosamine et le risque de cancer par localisation

Regular glucosamine use may have different roles in the risk of site-specific cancers: findings from a large prospective cohort

Li, Fu-Xiao ; Zhao, Hou-Yu ; Lin, Teng-Fei ; Jiang, Yi-Wen ; Liu, Di ; Wei, Chang ; Zhao, Zi-Yi ; Yang, Zu-Yao ; Sha, Feng ; Yang, Zhi-Rong ; Tang, Jin-Ling

Background: Previous studies indicated that glucosamine supplements may have a general anti-cancer effect. This study aimed to assess whether the potential effect differs across different types of cancers in a large prospective cohort study. Methods: All participants from the UK Biobank who were free of cancers and had complete information on glucosamine use at baseline were included and followed up from 2006 until 2021. Cox proportional hazards models were used to assess the associations [...]

Cette étude met en évidence l'importance des études d'association sur le génome entier pour comprendre le risque héréditaire de cancer colorectal

The complementary roles of genome-wide approaches in identifying genes linked to an inherited risk of colorectal cancer

Ahmad, Olfat ; Försti, Asta

The current understanding of the inherited risk of colorectal cancer (CRC) started with an observational clinical era in the late 19th century, which was followed by a genetic era starting in the late 20th century. Genome-wide linkage analysis allowed mapping several high-risk genes, which marked the beginning of the genetic era. The current high-throughput genomic phase includes genome-wide association study (GWAS) and genome-wide sequencing approaches which have revolutionized the conception [...]