Menée aux Etats-Unis à partir de données portant sur 714 patients âgés atteints d'une tumeur gastrointestinale (âge moyen : 70 ans), cette étude transversale prospective analyse la prévalence de douleurs au moment du diagnostic de la maladie puis évalue l'association entre la douleur et des déficiences fonctionnelles, des troubles cognitifs et psychiques (dépression, anxiété)

Pain among older adults with gastrointestinal malignancies- results from the cancer and aging resilience evaluation (CARE) Registry

Al-Obaidi, Mustafa ; Kosmicki, Sarah ; Harmon, Christian ; Lobbous, Mina ; Outlaw, Darryl ; Khushman, Moh’d ; McGwin, Gerald ; Bhatia, Smita ; Giri, Smith ; Williams, Grant R.

Purpose : The impact of pain on functional status and mental health among older adults with cancer is a relevant, yet understudied. We sought to identify the prevalence of pain at diagnosis in older adults with gastrointestinal (GI) malignancies and evaluate the association of pain with functional status limitations, cognition, and mental health. Methods : This prospective cross-sectional study included older adults (age ≥ 60) with GI cancers enrolled in the CARE Registry. Pain measured in [...]

A partir d'une revue systématique de la littérature publiée jusqu'en janvier 2022, cette méta-analyse évalue l'effet, sur les toxicités cardiaques, la santé cardiorespiratoire et des marqueurs cardiaques, d'exercices aérobiques chez des patientes atteintes d'un cancer du sein recevant des anthracyclines ou du trastuzumab

Effect of aerobic exercise on cardiotoxic outcomes in women with breast cancer undergoing anthracycline or trastuzumab treatment: a systematic review and meta-analysis

Ma, Zhu-yue ; Yao, Shan-shan ; Shi, Yan-yan ; Lu, Ning-Ning ; Cheng, Fang

Purpose : We aimed to assess the impact of aerobic exercise (AE) on parameters related to cardiotoxicity in breast cancer (BC) patients receiving anthracycline or trastuzumab. Methods : We performed a systematic review and meta-analysis of comparative studies on AE via the screening of standard databases from their inception to January 18, 2022. The risk of bias was assessed qualitatively using the domains outlined in the Cochrane Handbook for Systematic Reviews of Interventions. Data were [...]

A partir de données de revues systématiques et de méta-analyses (29 revues), cette étude évalue l'intérêt d'interventions comportant des exercices physiques pour soulager la fatigue liée à un cancer du sein

Effects of exercise interventions on cancer-related fatigue in breast cancer patients: an overview of systematic reviews

Zhou, Hong-Juan ; Wang, Tao ; Xu, Yong-Zhi ; Chen, Yan-Nan ; Deng, Li-Jing ; Wang, Chang ; Chen, Jin-Xiu ; Tan, Jing-Yu

Objective : This overview of systematic reviews aims to critically appraise and consolidate evidence from current systematic reviews (SRs)/meta-analyses on the effects of exercise interventions on cancer-related fatigue (CRF) in breast cancer patients. Methods : SRs/meta-analyses that explored the effects of exercise interventions on CRF in breast cancer patients compared with the routine methods of treatment and care were retrieved from nine databases. The methodological quality of the [...]

Menée aux Etats-Unis à partir de données portant sur 92 431 participants âgés (âge moyen : 69,4 ans), cette étude de cohorte analyse le risque de fracture osseuse en fonction des antécédents de cancer

Fracture Risk Among Older Cancer Survivors Compared With Older Adults Without a History of Cancer

Rees-Punia, Erika ; Newton, Christina C. ; Parsons, Helen M. ; Leach, Corinne R. ; Diver, W. Ryan ; Grant, Amber C. ; Masters, Matthew ; Patel, Alpa V. ; Teras, Lauren R.

Importance : The number of cancer survivors living in the US is projected to be 26.1 million by 2040. Cancer survivors may be at increased risk of bone fractures, but research is limited in several important ways. Objective :To investigate the associations of cancer diagnoses, including time since diagnosis and stage at diagnosis, with risks of pelvic, radial, and vertebral fractures (separately and combined) among older cancer survivors and compared with fracture risk among older adults [...]

Menée aux Etats-Unis à partir de données portant sur 685 patients dont le résultat de l'examen de dépistage du cancer du poumon s'est avéré positif, cette étude de cohorte prospective analyse les facteurs associés à leur adhésion aux recommandations concernant le parcours de soins à suivre

Receipt of Recommended Follow-up Care After a Positive Lung Cancer Screening Examination

Rivera, M. Patricia ; Durham, Danielle D. ; Long, Jason M. ; Perera, Pasangi ; Lane, Lindsay ; Lamb, Derek ; Metwally, Eman ; Henderson, Louise M.

Importance : Maximizing benefits of lung cancer screening requires timely follow-up after a positive screening test. The American College of Radiology (ACR) Lung CT Screening Reporting and Data System (Lung-RADS) recommends testing and follow-up timing based on the screening result. Objective : To determine rates of and factors associated with recommended follow-up after a positive lung cancer screening examination by Lung-RADS category. Design, Setting, and Participants :This prospective [...]

Menée en France à partir des données du registre de Loire Atlantique Vendée portant sur 12 738 patientes atteintes d'un carcinome invasif du sein diagnostiqué entre 2008 et 2015, cette étude analyse l'association entre le statut socioéconomique, le stade au diagnotic et la survie nette

Is survival rate lower after breast cancer in deprived women according to disease stage?

Delacôte, Claire ; Delacour-Billon, Solenne ; Ayrault-Piault, Stéphanie ; Tagri, Anne-Delphine ; Rousseau, Gwenaëlle ; Vincent, Mélissa ; Amossé, Sophie ; Delpierre, Cyrille ; Cowppli-Bony, Anne ; Molinié, Florence

Background : Socioeconomic deprivation has been associated with lower breast cancer (BC) survival, but the influence of stage at diagnosis on this association merits further study. Our aim was to investigate this association using the Loire-Atlantique/Vendee Cancer Registry (France). Methods : Twelve-thousand seven-hundred thirty-eight women living in the area covered by the registry and diagnosed with invasive breast carcinoma between 2008 and 2015 were included in the study. They were [...]

Menée aux Etats-Unis à partir de données 1999-2020, cette étude analyse les disparités ethniques dans l'évolution de la mortalité chez des patientes atteintes d'un cancer du sein

Trends in breast cancer mortality by race/ethnicity, age, and US census region, United States

Ellington, Taylor D. ; Henley, S. Jane ; Wilson, Reda J. ; Miller, Jacqueline W. ; Wu, Manxia ; Richardson, Lisa C.

Background : Breast cancer remains a leading cause of morbidity and mortality among women in the United States. Previous analyses show that breast cancer incidence increased from 1999 to 2018. The purpose of this article is to examine trends in breast cancer mortality. Methods : Analysis of 1999 to 2020 mortality data from the Centers for Disease Control and Prevention, National Center for Health Statistics, among women by race/ethnicity, age, and US Census region. Results : It was found that [...]

A partir d'une revue systématique de la littérature (13 études), cette étude analyse l'intérêt des psychothérapies pour prendre en charge la peur de la récidive chez des patients atteints d'un cancer

Therapeutic intervention in fear of cancer recurrence in adult oncology patients: a systematic review

Paperák, Patrik ; Javůrková, Alena ; Raudenská, Jaroslava

Purpose : The study aims to provide an updated overview of studies that show the impact of psychotherapeutic interventions on fear of cancer recurrence (FCR), to explore the relationship between FCR and related factors (psychological distress, well-being, anxiety, depression, fear, coping strategies, quality of life), and to identify the most effective therapeutic approaches in managing FCR. Methods : Three databases were searched between January 2021 and April 2021 using the key words “fear of [...]

Mené en Suède à partir de données portant sur 174 enfants atteints d'un lymphome diagnostiqué avant l'âge de 15 ans (âge moyen au diagnostic : 7,8 ans), cette étude analyse leurs difficultés dans leur parcours scolaire

Childhood lymphoma treatment impacts educational outcomes: a registry study from Sweden

Lönnerblad, Malin ; Suominen, Reina ; Harila-Saari, Arja

Purpose : This study aimed to explore educational outcomes in individuals diagnosed with lymphoma in childhood concerning school grade year 9 and attendance in high school and post-compulsory education. Whether sex or age at diagnosis affected the assessed variables was also explored. Methods : Data from 174 children born 1988–1996 and diagnosed with lymphoma before age 15 were matched with approximately five controls per patient. The mean time since diagnosis to receiving school year 9 grades [...]

Mené sur 447 patientes ayant survécu à un cancer du sein (âge : 20-49 ans), cet essai randomisé évalue l'effet, sur la réduction de la peur de la récidive de la maladie, d'une psychothérapie dispensée sur smartphone

Smartphone Psychotherapy Reduces Fear of Cancer Recurrence Among Breast Cancer Survivors: A Fully Decentralized Randomized Controlled Clinical Trial (J-SUPPORT 1703 Study)

Tatsuo Akechi ; Takuhiro Yamaguchi ; Megumi Uchida ; Fuminobu Imai ; Kanae Momino ; Fujika Katsuki ; Naomi Sakurai ; Tempei Miyaji ; Tomoe Mashiko ; Masaru Horikoshi ; Toshi A. Furukawa ; Akiyo Yoshimura ; Shinji Ohno ; Natsue Uehiro ; Kenji Higaki ; Yoshie Hasegawa ; Kazuhisa Akahane ; Yosuke Uchitomi ; Hiroji Iwata

PURPOSE : Fear of cancer recurrence (FCR) is a common distressing condition. We investigated the efficacy of smartphone problem-solving therapy and behavioral activation applications in breast cancer survivors. METHODS : This was a decentralized randomized trial. Participants were disease-free breast cancer survivors age 20-49 years who were randomly assigned to the smartphone-based intervention or waitlist control. Both groups received treatment as usual. The control group could access the [...]

Menée dans un contexte canadien et américain, cette étude compare le rapport coût-efficacité de 4 stratégies de première et de seconde ligne à base de polatuzumab et de lymphocytes CAR-T anti-CD19 chez des patients atteints d'un lymphome diffus à grandes cellules B à risque élevé ou intermédiaire de récidive

Cost-Effectiveness Analysis of Frontline Polatuzumab-Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone and/or Second-Line Chimeric Antigen Receptor T-Cell Therapy Versus Standard of Care for Treatment of Patients With Intermediate- to High-Risk Diffuse Large B-Cell Lymphoma

Abi Vijenthira ; John Kuruvilla ; Michael Crump ; Michael Jain ; Anca Prica

PURPOSE : Recent studies of polatuzumab vedotin and CD19 chimeric antigen receptor T-cell therapy (CAR-T) have shown significant improvements in progression-free survival over standard of care (SOC) for patients with diffuse large B-cell lymphoma. However, they are costly, and it is unclear whether these strategies, alone or combined, are cost-effective over SOC. METHODS : A Markov model was constructed to compare four strategies for patients with newly diagnosed intermediate- to high-risk [...]

Menée aux Pays-Bas à partir de données portant sur 78 patients atteints d'un mésothéliome péritonéal malin et pris en charge dans des centres experts pour le mésothéliome, cette étude de cohorte analyse l'impact de la centralisation des soins sur le nombre de patients ayant bénéficié de traitements anti-cancéreux

Impact of centralization of care for malignant peritoneal mesothelioma: A historical cohort study from the Dutch mesothelioma expert centers

van Kooten, Job P. ; de Gooijer, Cornedine J. ; von der Thüsen, Jan H. ; Brandt-Kerkhof, Alexandra R. M. ; Albers, Arend G. J. ; Lahaye, Max J. ; Monkhorst, Kim ; Burgers, Jacobus A. ; Aerts, Joachim G. J. V. ; Verhoef, Cornelis ; Madsen, Eva V. E.

Background : Malignant peritoneal mesothelioma (MPM) is a rare and aggressive cancer that has a poor prognosis. An earlier population-based study found that the majority of Dutch patients do not receive anti-cancer treatment. In 2015, Dutch Malignant Mesothelioma care was centralized in two expert centers. We reviewed treatment patterns at these centers, to assess the impact of centralization of MPM care in the Netherlands. Methods : Data from all patients referred to the Dutch MPM expert [...]

Menée en Australie, cette étude met à jour les données concernant le rapport coût-efficacité du dépistage du cancer du poumon

Updated cost-effectiveness analysis of lung cancer screening for Australia, capturing differences in the health economic impact of NELSON and NLST outcomes

Behar Harpaz, Silvia ; Weber, Marianne F. ; Wade, Stephen ; Ngo, Preston J. ; Vaneckova, Pavla ; Sarich, Peter E. A. ; Cressman, Sonya ; Tammemägi, Martin C. ; Fong, Kwun ; Marshall, Henry ; McWilliams, Annette ; Zalcberg, John R. ; Caruana, Michael ; Canfell, Karen

Background : A national, lung cancer screening programme is under consideration in Australia, and we assessed cost-effectiveness using updated data and assumptions. Methods : We estimated the cost-effectiveness of lung screening by applying screening parameters and outcomes from either the National Lung Screening Trial (NLST) or the NEderlands–Leuvens Longkanker Screenings ONderzoek (NELSON) to Australian data on lung cancer risk, mortality, health-system costs, and smoking trends using a [...]

Menée en Suède par enquête auprès de 135 mères et 97 pères d'enfants décédés d'un cancer, cette étude analyse la communication avec les professionnels de santé et l'information reçue concernant le diagnostic et le pronostic de la maladie

Communication about diagnosis and prognosis - A population-based survey among bereaved parents in pediatric oncology

Bartholdson, Cecilia ; Kreicbergs, Ulrika ; Sveen, Josefin ; Lövgren, Malin ; Pohlkamp, Lilian

Introduction : When a child is diagnosed with cancer, the whole family is affected, and parents struggle to grasp challenging information regarding diagnosis and prognosis. Most parents and children want honest communication and openness, yet this remains a complex and challenging task for healthcare professionals. Objectives : To describe bereaved mothers’ and fathers’ reports of communication of their child’s cancer diagnosis and when the illness became incurable. Methods : Data from a [...]

A partir d'une revue systématique de la littérature publiée jusqu'en mars 2022 (38 revues systématiques incluant 134 études et 129 méta-analyses), cette étude fait le point sur l'intérêt des pratiques corps-esprit (qigong, tai chi, yoga) pour prendre en charge les symptômes des patients atteints d'un cancer

Mind–body practices for cancer-related symptoms management: an overview of systematic reviews including one hundred twenty-nine meta-analyses

Casuso-Holgado, María Jesús ; Heredia-Rizo, Alberto Marcos ; Gonzalez-Garcia, Paula ; Muñoz-Fernández, María Jesús ; Martinez-Calderon, Javier

Purpose : Mind–body practices such as qigong, tai chi, or yoga combine physical movements, deep breathing, and meditation techniques aiming to improve how people self-care. Our purpose was to develop an overview of systematic reviews to summarize the available evidence on the effectiveness of mind–body practices for cancer-related symptoms management. Methods : CINAHL, Embase, PsycINFO, PubMed, and the Cochrane Library were used to search systematic reviews with meta-analysis from inception [...]

Menée aux Pays-Bas par entretiens auprès de 19 patients ayant survécu à un cancer et de 18 professionnels de santé, cette étude identifie les facteurs entravant ou facilitant la mise en place d'une intervention psychologique dans le système de soins dédiés à l'après-cancer

Barriers and facilitators for implementation of the SWORD evidence-based psychological intervention for fear of cancer recurrence in three different healthcare settings

Deuning-Smit, Esther ; Kolsteren, Evie E. M. ; Kwakkenbos, Linda ; Custers, José A. E. ; Hermens, Rosella P. M. G. ; Prins, Judith B.

Purpose : Fear of cancer recurrence (FCR) interventions are effective, but few are implemented. This study aimed to identify barriers and facilitators for implementing the evidence-based blended SWORD intervention in routine psycho-oncological care. Methods : Semi-structured interviews with 19 cancer survivors and 18 professionals from three healthcare settings assessed barriers and facilitators in six domains as described by the determinant frameworks of Grol and Flottorp: (1) innovation, (2) [...]