Menée auprès de témoins et de 54 patients atteints d'un cancer traité par oxaliplatine ou paclitaxel, cette étude évalue l'efficacité du cannabidiol dispensé par voie orale pour prévenir une neuropathie périphérique induite par la chimiothérapie

Oral cannabidiol for prevention of acute and transient chemotherapy-induced peripheral neuropathy

Nielsen, Sebastian W. ; Hasselsteen, Simone Dyring ; Dominiak, Helena Sylow Heilmann ; Labudovic, Dejan ; Reiter, Lars ; Dalton, Susanne Oksbjerg ; Herrstedt, Jørn

Purpose : To assess the safety, dosing, and preventive effects of cannabidiol (CBD) on chemotherapy-induced peripheral neuropathy (CIPN) in patients receiving oxaliplatin- or paclitaxel-based chemotherapy. Methods : Patients with cancer scheduled to undergo treatment with carboplatin and paclitaxel (Carbo-Tax) or capecitabine and oxaliplatin (CAPOX) received 150 mg CBD oil twice daily (300 mg/daily) for 8 days beginning 1 day before initiation of chemotherapy. Ten CIPN-specific patient-reported [...]

Mené sur 108 patients atteints d'un syndrome myélodysplasique à faible risque de récidive, cet essai de phase II évalue l'intérêt du luspatercept pour prendre en charge une anémie

Long-Term Efficacy and Safety of Luspatercept for Anemia Treatment in Patients With Lower-Risk Myelodysplastic Syndromes: The Phase II PACE-MDS Study

Uwe Platzbecker ; Katharina S. Götze ; Philipp Kiewe ; Ulrich Germing ; Karin Mayer ; Markus Radsak ; Thomas Wolff ; Joerg Chromik ; Katja Sockel ; Uta Oelschlägel ; Detlef Haase ; Thomas Illmer ; Haifa Kathrin Al-Ali ; Gerda Silling ; Joseph G. Reynolds ; Xiaosha Zhang ; Kenneth M. Attie ; Jeevan K. Shetty ; Aristoteles Giagounidis

Luspatercept has high clinical activity in patients with transfusion-dependent lower-risk myelodysplastic syndromes (LR-MDS) and ring sideroblasts (RS) relapsed or refractory to erythropoietin. We report long-term luspatercept safety and efficacy in 108 patients with LR-MDS in the PACE-MDS study, including 44 non-RS and 34 non–transfusion-dependent or previously untreated patients. The primary end point was safety. Secondary end points included rates of hematologic improvement (HI) erythroid [...]

Menée à partir de données portant sur 37 patients ayant survécu à un cancer de la prostate, sous thérapie anti-androgénique et inclus dans un essai randomisé, cette étude analyse les facteurs associés à l'efficacité d'une activité physique d'intensité modérée à vigoureuse

Factors predicting gains in moderate-to-vigorous physical activity in prostate cancer survivors on androgen deprivation therapy

Papadopoulos, Efthymios ; Leach, Heather J. ; Tomlinson, George ; Durbano, Sara ; Danyluk, Jessica M. ; Sabiston, Catherine M. ; Mina, Daniel Santa ; Alibhai, Shabbir M. H. ; Culos-Reed, S. Nicole

Background : Whether individual, environmental, and psychosocial factors predict changes in moderate-to-vigorous physical activity (MVPA) is poorly addressed in prostate cancer (PC) survivors undergoing androgen deprivation therapy (ADT). Purpose : This secondary analysis of a randomized controlled trial examined changes in MVPA following a supervised personal training (PT), supervised group-based (GROUP) program, or a home-based, smartphone-assisted exercise (HOME) intervention in PC survivors [...]

Menée aux Etats-Unis par enquête postale auprès de patients ayant survécu à un cancer hématologique (53 répondants), cette étude analyse l'association entre leurs besoins sociaux (insécurité alimentaire, précarité du logement) et leur qualité de vie

Social needs and health-related quality of life among hematologic cancer survivors

Coughlin, Steven S. ; Ayyala, Deepak Nag ; Stewart, Jessica L. ; Cortes, Jorge E.

Objectives : Recent studies have examined social needs (social determinants of health) among cancer survivors, but studies have not specifically focused on patients with leukemia or lymphoma. We examined food insecurity and other social needs among hematologic cancer survivors, including individuals who had completed primary therapy for leukemia, lymphoma, or multiple myeloma. A particular focus of the study was on the relationship between social needs and health-related quality of life. [...]

Menée en Espagne auprès de 36 patientes atteintes d'un cancer du sein ayant reçu une reconstruction mammaire immédiate, cette étude prospective analyse leur qualité de vie psychique et sexuelle en lien avec la reconstruction

Psychosocial and sexual well-being in breast cancer survivors undergoing immediate breast reconstruction: The mediating role of breast satisfaction

Gil-Olarte, Paloma ; Gil-Olarte, M. Angeles ; Gómez-Molinero, Rocío ; Guil, Rocío

Objective : This study aimed to explore (1) the levels of quality of life (psychosocial, physical and sexual well-being) and breast satisfaction in breast cancer patients (BCP) after immediate reconstruction (IR), considering surgery reason and surgical technique, and (2) the explanatory and predictive capacity of psychosocial well-being on breast satisfaction, and of both on sexual well-being. Methods : This prospective study included 36 BCP who underwent IR between June 2006 and December [...]

Menée aux Etats-Unis à partir de données portant sur 2 163 témoins et sur 152 patientes ayant survécu à un cancer du sein, cette étude de cohorte analyse l'évolution des troubles du sommeil, de 5 ans avant jusqu'à 5 ans après le diagnostic

Sleep disturbance among breast cancer survivors and controls from midlife to early older adulthood: Pink SWAN

Goyal, Neha ; Levine, Beverly J. ; Crawford, Sybil L. ; Avis, Nancy E.

Purpose : To compare sleep disturbance from 5 years pre- to 5 years post-diagnosis between breast cancer survivors (BCS) and women without cancer over the same period and to identify BCS subgroups exhibiting different sleep trajectories. Methods : Analyses included data from 152 BCS and 2163 controls from 20 years of follow-up in the longitudinal Study of Women’s Health Across the Nation (SWAN), a multi-racial/ethnic cohort study. SWAN participants were assessed approximately annually from 1995 [...]

Menée aux Etats-Unis à partir de données portant sur 629 patients atteints d'une cirrhose, cette étude de cohorte rétrospective identifie les facteurs entravant la surveillance médicale avant le diagnostic d'un carcinome hépatocellulaire

Barriers to Surveillance for Hepatocellular Carcinoma in a Multicenter Cohort

Parikh, Neehar D. ; Tayob, Nabihah ; Al-Jarrah, Taim ; Kramer, Jennifer ; Melcher, Jennifer ; Smith, Donna ; Marquardt, Patrick ; Liu, Po-Hong ; Tang, Runlong ; Kanwal, Fasiha ; Singal, Amit G.

Importance : Hepatocellular carcinoma (HCC) surveillance is underused in clinical practice, which may be owing to patient and clinician barriers. Objective : To characterize HCC surveillance barriers and associations with clinical outcomes in a multicenter cohort of patients with cirrhosis. Design, Setting, and Participants : This retrospective, multicenter cohort study included 5 medical centers in the United States. Patients with cirrhosis and newly diagnosed HCC treated from 2014 to 2018 [...]

Menée aux Etats-Unis à partir de données portant sur 3 152 patients ayant survécu 5 ans ou plus à un cancer diagnostiqué avant l'âge de 20 ans, cette étude rétrospective analyse le risque d'infection en lien avec une hospitalisation

A Population-Based Study of the Long-Term Risk of Infections Associated With Hospitalization in Childhood Cancer Survivors

Leena Chehab ; David R. Doody ; Adam J. Esbenshade ; Gregory M.T. Guilcher ; Christopher C. Dvorak ; Brian T. Fisher ; Beth A. Mueller ; Eric J. Chow ; Jenna Rossoff

PURPOSE : Infections pose a significant risk during therapy for childhood cancer. However, little is known about the risk of infection in long-term survivors of childhood cancer. METHODS : We performed a retrospective observational study of children and adolescents born in Washington State diagnosed with cancer before age 20 years and who survived at least 5 years after diagnosis. Survivors were categorized as having a hematologic or nonhematologic malignancy and were matched to individuals [...]

A partir d'une revue systématique de la littérature (128 articles), cette méta-analyse évalue l'association entre l'adiposité et la survie, chez des patients atteints d'un cancer (10 localisations)

Adiposity and cancer survival: a systematic review and meta-analysis

Cheng, En ; Kirley, Jocelyn ; Cespedes Feliciano, Elizabeth M. ; Caan, Bette J.

Purpose : The increasing availability of clinical imaging tests (especially CT and MRI) that directly quantify adipose tissue has led to a rapid increase in studies examining the relationship of visceral, subcutaneous, and overall adiposity to cancer survival. To summarize this emerging body of literature, we conducted a systematic review and meta-analysis of imaging-measured as well as anthropometric proxies for adipose tissue distribution and cancer survival across a wide range of cancer [...]

Menée à partir des données des registres américains des cancers, cette étude livre une estimation du nombre de patients atteints d'un cancer de stade métastatique en 2018 et présente une projection pour 2025

Estimation of the numbers of individuals living with metastatic cancer in the United States

Gallicchio, Lisa ; Devasia, Theresa P ; Tonorezos, Emily ; Mollica, Michelle A ; Mariotto, Angela

Background : The purpose of this study was to estimate the numbers of individuals living with metastatic cancer of the breast, prostate, lung, colorectal, bladder, and melanoma in the United States (US) using population-based data. Methods : A back-calculation method was used to estimate the number of individuals living with metastatic cancer for each cancer type from US cancer mortality and survival statistics from the Surveillance, Epidemiology and End Results registries. The percentages of [...]

Menée en Corée à partir de données portant sur 11 552 personnes infectées par le VIH (âge moyen : 39,9 ans), cette étude de cohorte rétrospective analyse le risque de cancer

Cancer Incidence Among Adults With HIV in a Population-Based Cohort in Korea

Park, Boyoung ; Ahn, Kyoung Hwan ; Choi, Yunsu ; Kim, Jung Ho ; Seong, Hye ; Kim, Youn Jeong ; Choi, Jun Young ; Song, Joon Young ; Lee, Eunjung ; Jun, Yoon Hee ; Yoon, Young Kyung ; Choi, Won Suk ; Lee, Myungsun ; Seong, Jaehyun ; Kim, Shin-Woo

Importance: In combination with a decreased risk of AIDS-defining cancers and improved survival of people infected with HIV, the burden of non–AIDS-defining cancer has increased markedly. Although a substantial number of studies have measured the cancer risk among people with HIV in developed countries, little research has been conducted on the risk of cancer in HIV-infected people in Asia. Objective : To examine the cancer incidence and the estimated risk of cancer among people in Korea [...]

Menée en Chine à partir de données portant sur 15 889 patients ayant survécu à un lymphome hodgkinien classique diagnostiqué entre 1983 et 2015, cette étude analyse l'évolution de la mortalité par maladie cardiovasculaire

Long-term risk of cardiovascular disease mortality among classic Hodgkin lymphoma survivors

Lu, Zhenxing ; Teng, Yintong ; Ning, Xiaodong ; Wang, Hao ; Feng, Weijing ; Ou, Caiwen

Background : The temporal trend of cardiovascular disease (CVD) mortality in patients with classic Hodgkin lymphoma (cHL) throughout follow-up remains unclear. This study aimed to assess this temporal trend in patients with cHL. Methods : This multicenter cohort included 15,889 patients with cHL diagnosed between 1983 and 2015, covering all ages. The proportional mortality ratio, cumulative incidence of cause-specific mortality accounting for competing risk, standard mortality ratio, and [...]

Menée en Australie à partir de données portant sur 3 855 patientes atteintes d'un cancer épithélial de l'ovaire avec des antécédents de maladies cardiovasculaires, cette étude analyse l'effet, sur la survie, d'une utilisation de bêta-bloquants au moment du traitement chirurgical

Perioperative Beta-Blocker Supply and Survival in Women With Epithelial Ovarian Cancer and a History of Cardiovascular Conditions

Katrina Spilsbury ; Karen M. Tuesley ; Sallie-Anne Pearson ; Michael D. Coory ; Peter Donovan ; Christopher B. Steer ; Louise M. Stewart ; Nirmala Pandeya ; Susan J. Jordan

PURPOSE : Surgery for epithelial ovarian cancer (EOC) may activate stress-inflammatory responses that stimulate tumor growth and increase metastatic growth. Animal and in vitro studies have shown that inhibition of the catecholamine-induced inflammatory response via beta-adrenergic receptor blockade has antitumor potential in EOC. However, observational studies have reported mixed results. We assessed whether beta-blocker (BB) use at the time of primary ovarian cancer surgery was associated [...]

Menée à partir des données 2000–2016 des registres américains des cancers portant sur 557 555 patients atteints d'un cancer du poumon, cette étude analyse les disparités sociodémographiques dans la survie

Sociodemographic survival disparities for lung cancer in the United States, 2000–2016

Brouwer, Andrew F ; Engle, Jason M ; Jeon, Jihyoun ; Meza, Rafael

Background : Understanding the impact of patient and tumor characteristics on lung cancer survival can help to build personalized prognostic models and identify health disparities. Methods : We identified 557,555 patients aged 25+ years diagnosed with lung/bronchus carcinoma from the SEER database, 2000–2016. We estimated hazard ratios (HR) for demographic (sex, age, race and ethnicity), tumor (stage, histology, year of diagnosis), and geographic characteristics (census-tract-level urbanicity, [...]

Menée à une échelle internationale, cette étude analyse l'incidence du cancer du larynx et ses facteurs de risque, les années de vies perdues ajustées sur l'incapacité ainsi que la mortalité sur la période 1990-2019 puis présente des projections jusqu'en 2035

The global, regional, national burden of laryngeal cancer and its attributable risk factors (1990–2019) and predictions to 2035

Lin, Changwei ; Cheng, Wenwei ; Liu, Xiajing ; Li, Heqing ; Song, Yexun

Objective: We aim to report the incidence, mortality and disability-adjusted life years (DALYs) between 1990 and 2019 and provide predictions to 2035. Methods: We use estimates from Global Burden of Disease, Injuries and Risk Factors Study 2019 to analyse the incidence, mortality and DALYs. Results: In 2019, there were more than 209,149 incidence cases, with age-standardised rates (ASRs) of 2.5. Laryngeal cancer accounted for 123,356 death cases, with ASRs of 1.5. Laryngeal cancer was also [...]

Menée aux Etats-Unis à partir de données portant sur 1 602 patients atteints d'un cancer et ayant reçu une greffe allogénique de cellules souches hématopoïétiques, cette étude analyse l'association entre des indicateurs de vulnérabilité sociale et la mortalité à 1 an sans récidive de la maladie

Social vulnerability and risk of non-relapse mortality after allogeneic hematopoietic cell transplantation

Bhandari, Rusha ; The, Jennifer Berano ; He, Tianhui ; Nakamura, Ryotaro ; Artz, Andrew S ; Jankowska, Marta M ; Forman, Stephen J ; Wong, F Lennie ; Armenian, Saro H

Background : Risk of non-relapse mortality (NRM) after hematopoietic cell transplantation (HCT) is high. Patient-level clinical prediction models such as the HCT-comorbidity index (HCT-CI) help identify those at increased risk for NRM, but the independent contribution of social determinants of health on HCT outcomes is not well characterized. Methods : This study included 1,602 patients who underwent allogeneic HCT between 2013–2019 at City of Hope. Census tract-level social vulnerability was [...]

Menée aux Pays-Bas par questionnaire auprès de 52 patients ayant survécu à un cancer, cette étude analyse leurs symptômes de dépression et leurs préférences concernant les soins psychologiques

Looking at individual symptoms: the dynamic network structure of depressive symptoms in cancer survivors and their preferences for psychological care

Bickel, E. A. ; Schellekens, M. P. J. ; Smink, J. G. ; Mul, V. E. M. ; Ranchor, A. V. ; Fleer, J. ; Schroevers, M. J.

Purpose : The majority of depressed cancer survivors do not receive psychological care, possibly because offered care does not align with their experiences and preferences. We examined (1) which depressive symptoms cancer survivors would like to receive psychological care for; (2) how distinct depressive symptoms are related to each other in the contemporaneous and temporal network of depressive symptoms; and (3) whether survivors’ care needs correspond to the interconnectedness of these [...]

A partir d'une revue systématique de la littérature (37 études, 8 956 participants au total), cette méta-analyse évalue l'impact des interventions de e-santé sur le bien-être psychique et la qualité de vie des patients atteints d'un cancer

Impact of connected health interventions on psychological wellbeing and quality of life in patients with cancer A systematic review and meta-analysis

Gitonga, Isaiah ; Desmond, Deirdre ; Duda, Natalia ; Maguire, Rebecca

Objective : Connected health technologies have the potential to improve access to cancer care and support and reduce costs. We aimed to assess the impacts of interventions delivered using connected health technologies on psychological and quality of life (QoL) outcomes in people living with and beyond cancer. Methods : PUBMED, PsycINFO, Web of Science, and EMBASE were searched using terms relating to (i) cancer, (ii) connected health, and (iii) QoL/psychological wellbeing. Studies were included [...]

Menée auprès de 65 patients ayant survécu à un cancer, cette étude analyse l'intérêt d'une intervention numérique pour réduire la peur de la récidive de la maladie

Feasibility and preliminary efficacy of iConquerFear: a self-guided digital intervention for fear of cancer recurrence

Smith, Allan ‘Ben’ ; Bamgboje‐Ayodele, Adeola ; Jegathees, Sharuja ; Butow, Phyllis ; Klein, Britt ; Salter, Marj ; Turner, Jane ; Fardell, Joanna ; Thewes, Belinda ; Sharpe, Louise ; Beatty, Lisa ; Pearce, Alison ; Beith, Jane ; Costa, Daniel ; Rincones, Orlando ; Wu, Verena S. ; Garden, Frances L. ; Kiely, Belinda E. ; Lim, Karen ; Morstyn, Lisa ; Hanley, Brigid ; Hodgkin, Rosemerry ; Beattie, Annette ; Girgis, Afaf

Purpose : Approximately 50% of cancer survivors experience moderate-severe fear of cancer recurrence (FCR). Self-guided digital interventions have potential to address the high level of FCR-related unmet needs at scale, but existing digital interventions have demonstrated variable engagement and efficacy. This study aimed to evaluate the feasibility and preliminary efficacy of iConquerFear, a five-module self-guided digital FCR intervention. Methods : Eligible curatively treated breast cancer [...]

Menée aux Etats-Unis auprès de 175 patients pédiatriques atteints d'une leucémie lymphoïde aiguë diagnostiquée entre 2012 et 2017 (âge : 7-18 ans), cette étude analyse la présence d'idées suicidaires pendant la chimiothérapie

Longitudinal Investigation of Suicidal Ideation and Associated Factors during Pediatric Acute Lymphoblastic Leukemia Chemotherapy

Raghubar, Kimberly P. ; Chambers, Tiffany ; Hill, Ryan M. ; Taylor, Olga ; Hockenberry, Marilyn ; Hooke, M. Casey ; Mitby, Pauline ; Moore, Ida Ki ; Brown, Austin L. ; Scheurer, Michael E.

Objective : This study describes the prevalence of suicidal ideation (SI) during ALL therapy and investigates the influence of clinical factors and physical symptoms on SI. Methods : The Children’s Depressive Inventory (CDI-2) was administered to ALL patients (diagnosed 2012-2017) at start of consolidation, delayed intensification (DI), maintenance cycle 1 (MC1), and maintenance cycle 2 (MC2) in a multi-site study. SI was present if patients endorsed the item “I want to kill myself”. Logistic [...]

Menée aux Etats-Unis à partir de données portant sur 3 575 témoins et 795 patients atteints d'un lymphome hodgkinien diagnostiqué entre 1997 et 2014, cette étude analyse le risque de troubles psychiques (anxiété, dépression, auto-mutilation, pensées suicidaires, etc. ) en lien avec le diagnostic de la maladie, puis analyse l'impact de ces troubles sur la survie globale

Mental health disorders are more common in patients with Hodgkin lymphoma and may negatively impact overall survival

Tao, Randa ; Chen, Yuji ; Kim, Seungmin ; Ocier, Krista ; Lloyd, Shane ; Poppe, Matthew M. ; Lee, Catherine J. ; Glenn, Martha J. ; Smith, Ken R. ; Fraser, Alison ; Deshmukh, Vikrant ; Newman, Michael G. ; Snyder, John ; Rowe, Kerry G. ; Gaffney, David K. ; Haaland, Ben ; Hashibe, Mia

Background : Long-term mental health outcomes were characterized in patients who were diagnosed with Hodgkin lymphoma (HL), and risk factors for the development of mental health disorders were identified. Methods : Patients who were diagnosed with HL between 1997 and 2014 were identified in the Utah Cancer Registry. Each patient was matched with up to five individuals from a general population cohort identified within the Utah Population Database, a unique source of linked records that includes [...]

Menée en Espagne auprès de 2 602 patients atteints d'un cancer colorectal, cette étude de cohorte prospective analyse l'association entre des symptômes de dépression et la survie, 5 ans après le diagnostic

Influence of depression on survival of colorectal cancer patients drawn from a large prospective cohort Depression and survival in colorectal cancer patients

Varela-Moreno, Esperanza ; Rivas-Ruíz, Francisco ; Padilla-Ruiz, Maria ; Alcaide-García, Julia ; Zarcos-Pedrinaci, Irene ; Téllez, Teresa ; Larrea-Baz, Nerea Fernández-de ; Baré, Marisa ; Bilbao, Amaia ; Sarasqueta, Cristina ; Morales-Suárez-Varela, María Manuela ; Aguirre, Urko ; Quintana, José María ; Redondo, Maximino ; Group, CARESS-CCR Study

Objective : The prevalence of depressive symptoms immediately after the diagnosis of colorectal cancer (CRC) is high and has important implications both psychologically and on the course of the disease. The aim of this study is to analyse the association between depressive symptoms and CRC survival at five years after diagnosis. Methods : This multicentre, prospective, observational cohort study was conducted on a sample of 2,602 patients with CRC who completed the Hospital Anxiety and [...]

A partir d'une revue systématique de la littérature publiée jusqu'en juin 2021 (18 articles), cette méta-analyse évalue la présence de symptômes d'anxiété et de dépression chez des patients atteints d'un cancer hématologique recevant des traitements anticancéreux ou sous surveillance active

Examining anxiety and depression in haematology cancer patients in ongoing treatment and under watchful waiting: A systematic review and meta-analysis

Russell, Katie ; Moghaddam, Nima ; Tickle, Anna

Introduction : The present review aimed to establish prevalence rates of anxiety and depression in adults with haematology cancer, with a focus on the differences between patients under treatment and patients under watchful waiting. Method : Five databases (Scopus, Medline, PsycINFO, EThOS, CINAHL) were searched throughout June 2021. Key search terms included haematology cancer, anxiety, depression, in treatment and watchful waiting. Study and sample characteristics, prevalence rates and mean [...]

Menée aux Etats-Unis par questionnaire auprès de 172 patients atteints d'un cancer de la tête et du cou et recevant une radiothérapie avec modulation d'intensité, cette étude analyse leurs symptômes psychologiques et neurologiques auto-déclarés

A network analysis of self-reported psychoneurological symptoms in patients with head and neck cancer undergoing intensity-modulated radiotherapy

Lin, Yufen ; Bruner, Deborah W. ; Paul, Sudeshna ; Miller, Andrew H. ; Saba, Nabil F. ; Higgins, Kristin A. ; Shin, Dong M. ; Zhang, Wenhui ; Miaskowski, Christine ; Xiao, Canhua

Background : Patients with head and neck cancer experience psychoneurological symptoms (PNS) (i.e., depression, fatigue, sleep disturbance, pain, and cognitive dysfunction) during intensity-modulated radiotherapy (IMRT) that decrease their functional status, quality of life, and survival rates. The purpose of this study was to examine and visualize the relationships among PNS within networks over time and evaluate for demographic and clinical characteristics associated with symptom networks. [...]

Menée dans un contexte américain, cette étude analyse le rapport coût-efficacité de l'axicabtagène ciloleucel en traitement de deuxième ligne chez des patients atteints d'un lymphome diffus à grandes cellules B réfractaire ou récidivant

Cost Effectiveness of Second-Line Axicabtagene ciloleucel in Relapsed Refractory Diffuse Large B-cell Lymphoma

Kambhampati, Swetha ; Saumoy, Monica ; Schneider, Yecheskel ; Serrao, Steve ; Solaimani, Pejman ; Budde, Lihua Elizabeth ; Mei, Matthew G. ; Popplewell, Leslie ; Siddiqi, Tanya ; Zain, Jasmine ; Forman, Stephen J. ; Kwak, Larry W. ; Rosen, Steven T ; Danilov, Alexey V ; Herrera, Alex F. ; Thiruvengadam, Nikhil

The ZUMA-7 study demonstrated that Axicabtagene ciloleucel (axi-cel) improved event-free survival (EFS) compared to standard of care (SOC) salvage chemoimmunotherapy followed by autologous stem cell transplant in primary refractory/early relapsed diffuse large B-cell lymphoma (DLBCL) leading to its recent FDA approval in this setting. We modeled a hypothetical cohort of US adults (mean age, 65 years) with primary refractory/early relapsed DLBCL by developing a Markov model (lifetime horizon) to [...]

A partir d'une revue systématique des études qualitatives (12 études), cette étude analyse la façon dont les femmes évaluent leur risque de développer la maladie après avoir été informées qu'elles étaient à risque accru de cancer du sein

How do women who are informed that they are at increased risk of breast cancer appraise their risk? A systematic review of qualitative research

Woof, Victoria G. ; Howell, Anthony ; McWilliams, Lorna ; Gareth Evans, D. ; French, David P.

This review aimed to synthesise qualitative research on how women notified that they are at increased risk of breast cancer view their risk. Five electronic databases were systematically reviewed for qualitative research investigating how women who have received an increased breast cancer risk estimate appraise their risk status. Fourteen records reporting 12 studies were included and critically appraised. Data were thematically synthesised. Four analytical themes were generated. Women appraise [...]

Menée au Danemark par entretiens auprès de patients âgés atteints d'un cancer gastro-intestinal de stade avancé et recevant une chimiothérapie palliative (âge : supérieur à 70 ans), cette étude analyse leur douleur physique et psychologique

Symptoms of total pain experienced by older people with advanced gastrointestinal cancer receiving palliative chemotherapy

Jespersen, Eva ; Minet, Lisbeth Rosenbek ; Nissen, Nina

Objective : Little is known about concurrent physical, psychological, social and spiritual distress experienced by older patients during early stages of advanced cancer while receiving life-prolonging treatment. Drawing on the concept of total pain, this study explored the multi-faceted symptoms of pain in older patients with advanced gastrointestinal cancer while receiving palliative chemotherapy. Methods : A total of 14 in-depth interviews with seven participants were conducted, one interview [...]

Mené sur 168 patients atteints d'un cancer, cet essai randomisé évalue l'effet de l'acupuncture, avec ou sans médecines complémentaires et alternatives, sur une neuropathie périphérique induite par la chimiothérapie et sur la qualité de vie

Impact of acupuncture and integrative therapies on chemotherapy-induced peripheral neuropathy: A multicentered, randomized controlled trial

Ben-Arye, Eran ; Hausner, David ; Samuels, Noah ; Gamus, Dorit ; Lavie, Ofer ; Tadmor, Tamar ; Gressel, Orit ; Agbarya, Abed ; Attias, Samuel ; David, Adi ; Schiff, Elad

Background : To explore the impact of acupuncture with other complementary and integrative medicine (CIM) modalities on chemotherapy-induced peripheral neuropathy (CIPN) and quality of life (QoL) in oncology patients. Methods : In this prospective, pragmatic, and patient-preference study, patients with CIPN were treated with acupuncture and CIM therapies (intervention group) or standard care alone (controls) for 6 weeks. Patients in the intervention arm were randomized to twice-weekly [...]

Menée en Allemagne par enquête auprès de 292 patients atteints d'un cancer ou ayant survécu à la maladie, cette étude analyse les facteurs médicaux, sociodémographiques et psychosociaux associés à leur utilisation de médecines complémentaires

Utilisation of complementary medicine in cancer patients and survivors: Expected benefits and its association to psychosocial factors

Weis, Joachim ; Gschwendtner, Kathrin ; Güthlin, Corina ; Holmberg, Christine ; Horneber, Markus

Introduction : Previous research showed that various factors are associated with the use of complementary medicine (CM) in cancer patients. This study aimed to analyse the expected benefits of CM use in its association with medical, sociodemographic and psychosocial variables. Methods : In a cross-sectional survey, we assessed the use of CM, expected benefits of CM, depression and quality of life. An exploratory factor analysis (EFA) was performed. Multiple regression analysis was carried out [...]

Menée à partir des données portant sur 4 755 adultes ayant survécu à un cancer pédiatrique diagnostiqué entre 1970 et 1986, cette étude analyse l'intérêt d'un outil permettant de prédire l'évolution de leur qualité de vie

Development and Validation of Models to Predict Poor Health-Related Quality of Life Among Adult Survivors of Childhood Cancer

Schulte, Fiona ; Chen, Yan ; Yasui, Yutaka ; Ruiz, Maritza E. ; Leisenring, Wendy ; Gibson, Todd M. ; Nathan, Paul C. ; Oeffinger, Kevin C. ; Hudson, Melissa M. ; Armstrong, Gregory T. ; Robison, Leslie L. ; Krull, Kevin R. ; Huang, I-Chan

Importance : Risk prediction models are important to identify survivors of childhood cancer who are at risk of experiencing poor health-related quality of life (HRQOL) as they age. Objective : To develop and validate prediction models for a decline in HRQOL among adult survivors of childhood cancer. Designs, Setting, and Participants : This prognostic study included 4755 adults from the Childhood Cancer Survivor Study (CCSS) diagnosed between January 5, 1970, and December 31, 1986, who [...]

A partir d'une revue systématique de la littérature, cette étude analyse les caratéristiques des outils permettant d'évaluer la fatigue chez des patients atteints d'un cancer

A review of the content and psychometric properties of cancer-related fatigue (CRF) measures used to assess fatigue in intervention studies

Campbell, Rachel ; Bultijnck, Renée ; Ingham, Gemma ; Sundaram, Chindhu Shunmuga ; Wiley, Joshua F. ; Yee, Jasmine ; Dhillon, Haryana M. ; Shaw, Joanne

Purpose : Cancer-related fatigue (CRF) is a common and debilitating consequence of cancer and its treatment. Numerous supportive care interventions have been developed to alleviate CRF; however, the diversity of outcome measures used to assess CRF limits comparability of findings. We aimed to evaluate the content and psychometric properties of measures used to assess CRF in interventions targeting fatigue, to inform the selection of suitable measures in future research. Methods : Included [...]

Menée auprès de 244 jeunes adultes ayant survécu à un cancer (âge : 18-40 ans), cette étude analyse l'efficacité de deux méthodes (enquête papier ou entretien téléphonique assisté par ordinateur) pour collecter des informations sensibles, notamment des idées suicidaires ou des troubles de la sexualité

Evaluating sensitive symptoms in young adult cancer survivors: acceptability of suicidal ideation and sexual health items across administration modes

Chevalier, Lydia L. ; Blackmon, Jaime E. ; Bober, Sharon L. ; Roman, Anthony ; Chang, Grace ; Recklitis, Christopher J.

Purpose : Patient-reported outcomes (PROs) are essential for assessing potential late effects experienced by young adult cancer survivors (YACS), but stigma and social desirability bias may limit their effectiveness for assessing sensitive topics (e.g., suicidal ideation, sexual health). This study compared two methods of item administration to determine the optimal method for obtaining sensitive information in YACS. Methods : Two hundred forty-four YACS (ages 18–40) were randomized to complete [...]