Menée auprès de 24 668 personnes ayant subi une polypectomie endoscopique (durée médiane de suivi : 10 ans), cette étude analyse l'association entre un score évaluant le mode de vie sain (indice de masse corporelle, tabagisme, activité physique, consommation d'alcool et alimentation) et l'incidence du cancer colorectal (161 cas) ainsi que la mortalité toutes causes confondues

Adherence to a healthy lifestyle in relation to colorectal cancer incidence and all-cause mortality after endoscopic polypectomy: a prospective study in three U.S. cohorts

Wang, Liang ; Knudsen, Markus D ; Lo, Chun-Han ; Wang, Kai ; He, Mingming ; Polychronidis, Georgios ; Hang, Dong ; He, Xiaosheng ; Zhong, Rong ; Wu, Kana ; Chan, Andrew T. ; Ogino, Shuji ; Giovannucci, Edward L. ; Song, Mingyang

It remains unknown whether maintenance of a healthy lifestyle after endoscopic polypectomy could still confer benefit for colorectal cancer (CRC) incidence and mortality. In this study, we defined a healthy lifestyle score based on body mass index, smoking, physical activity, alcohol consumption, and diet (range, 0-5). We used Cox proportional hazards regression to estimate the hazard ratios (HRs) for the associations of healthy lifestyle score and individual lifestyle factors with CRC [...]

A partir d'une revue systématique de la littérature publiée entre octobre 2019 et mars 2021 (5 articles), cette étude analyse l'association entre les niveaux d'activité physique, au cours de l'adolescence et au début de l'âge adulte, et le risque de cancer du sein chez les porteuses d'une mutation BRCA

Physical Activity in Young BRCA Carriers and Reduced Risk of Breast Cancer

Bucy, Ana M. ; Valencia, Celina I. ; Howe, Carol L. ; Larkin, Tyler J. ; Conard, Kelly D. ; Anderlik, Eric W. ; Valdivi, Sarah I. ; Bea, Jennifer W.

Introduction: A systematic literature review was conducted to determine whether physical activity levels during adolescent and young adult years were associated with a reduced lifetime risk of breast cancer among carriers of deleterious mutations in BRCA1 and BRCA2 genes. Methods: Ovid/MEDLINE, Embase, CENTRAL, WOS, and CINAHL were searched for articles including information about adolescent and young adult physical activity and breast cancer incidence among women carrying deleterious BRCA1 and [...]

Menée en Suède sur la période 2005-2018 auprès de 1 911 560 témoins et de 191 156 utilisateurs de médicaments anti-androgènes inhibiteurs de la 5-alpha-réductase (5-ARI), cette étude analyse l'association entre cette utilisation et le risque de cancer oesophagien ou gastrique, par sous-type anatomique et type histologique

Use of anti-androgenic 5alpha-reductase inhibitors and risk of oesophageal and gastric cancer by histological type and anatomical sub-site

Lagergren, Jesper ; Xie, Shao-Hua ; Santoni, Giola ; Rabbani, Sirus

Background: To investigate if anti-androgenic medications 5α-reductase inhibitors (5-ARIs) decrease the risk of developing oesophageal and gastric tumours, analysed by histological type and anatomical sub-site. Methods: A Swedish population-based cohort study between 2005 and 2018 where men using 5-ARIs were considered exposed. For each exposed participant, ten male age-matched non-users of 5-ARIs (non-exposed) were included. Multivariable Cox regression provided hazard ratios (HR) with 95% [...]

Menée à partir de données d'enquêtes réalisées auprès d'adolescents, cette étude analyse l'évolution de la couverture vaccinale contre le papillomavirus humain entre 2015 et 2020 et identifie les facteurs associés à la vaccination

Human Papillomavirus Vaccination Trends Among Adolescents: 2015 to 2020

Lu, Peng–jun ; Yankey, David ; Fredua, Benjamin ; Hung, Mei–Chun ; Sterrett, Natalie ; Markowitz, Lauri E. ; Elam–Evans, Laurie D.

To assess trends in recent human papillomavirus (HPV) vaccination initiation and factors associated with vaccination among adolescents.The 2015 to 2020 National Immunization Survey–Teen data were used to assess vaccination trends. Multivariable logistic regression analysis were conducted to assess factors associated with vaccination.Overall, HPV vaccination coverage (≥1 dose) among adolescents significantly increased from 56.1% in 2015 to 75.4% in 2020. There were larger increases in coverage [...]

Menée à partir de données de la "UK Biobank" portant sur 232 848 femmes (durée moyenne de suivi : 6,9 ans), cette étude analyse l'association entre un score évaluant l'adhésion aux recommandations pour la prévention des cancers émises par "the World Cancer Research Fund" et l'"American Institute for Cancer Research" et le risque de cancer du sein in situ (957 cas), en fonction de la participation au dépistage

Adherence to cancer prevention recommendations and risk of breast cancer in situ in the United Kingdom Biobank

Karavasiloglou, Nena ; Pestoni, Giulia ; Kühn, Tilman ; Rohrmann, Sabine

A health-conscious lifestyle may protect against breast cancer in situ. However, breast cancer in situ is mainly detected by screening, and many studies lack information on screening participation. Thus, we evaluated the association between pre-diagnostic lifestyle and risk of breast cancer in situ, accounting for screening participation at recruitment. A score reflecting the adherence to the World Cancer Research Fund / American Institute for Cancer Research cancer prevention recommendations [...]