Cette étude passe en revue les différents agents, anciens et émergents, utilisés pour prévenir et traiter une neutropénie induite par la chimiothérapie chez des patients atteints d'un cancer

Chemotherapy-Induced Neutropenia and Emerging Agents for Prevention and Treatment: A Review

Blayney, Douglas W. ; Schwartzberg, Lee

Chemotherapy-induced neutropenia can lead to poor clinical outcomes. CIN can lead to infections, hospitalizations, mortality, and lower chemotherapy doseintensity. G-CSF agents have been the standard of care for the prevention of CIN for 30 years. Emerging therapies will likely change the standard approach for CIN prevention.

Menée au Québec par questionnaire auprès de 358 patients atteints d'un cancer et recevant du cannabis thérapeutique pour soulager les symptômes liés à la maladie (douleur, fatigue, anxiété, nausées, perte d'appétit, etc.), cette étude analyse, selon le sexe du patient, leurs perceptions relatives à l'efficacité de cette thérapie

Sex differences exist in the perceived relief of cancer symptoms with medical cannabis: results from the Quebec Cannabis Registry

Kasvis, Popi ; Canac-Marquis, Michelle ; Aprikian, Saro ; Vigano, MariaLuisa ; Vigano, Antonio

Purpose : This study explored whether symptom relief differs by sex in patients with cancer receiving medical cannabis (MC) therapy. Methods : This is an analysis of data collected from patients with cancer enrolled in the Quebec Cannabis Registry. MC was initiated for the therapeutic management of cancer symptoms. Patients completed the revised Edmonton Symptom Assessment System (ESAS-r) questionnaire at baseline and 3-month follow-up. We examined the interaction between sex and time on each [...]

Cette étude analyse les revues systématiques de la littérature (15 revues incluant 76 études différentes et un total de 5 404 patients) évaluant l'intérêt des interventions d'activité physique pour les patients âgés de plus de 65 ans et atteints d'un cancer

Physical activity interventions in older people with cancer: A review of systematic reviews

Knowles, Reegan ; Kemp, Emma ; Miller, Michelle ; Davison, Kade ; Koczwara, Bogda

Introduction : Whilst there has been a wealth of research on benefits of physical activity (PA) in people with cancer, with three published reviews of reviews, no review of reviews has focused on older adults (65 years or older) who may have unique biological characteristics and barriers. We summarised PA effectiveness from reviews where majority of study participants were 65 years or older. Methods : Six databases were searched for systematic reviews of randomised controlled studies [...]

A partir d'une revue de la littérature (35 études), cette étude analyse les outils permettant de détecter, avant et après un traitement chirurgical, le risque de malnutrition chez des patients atteints d'un cancer colorectal

Early identification of cancer-related malnutrition in patients with colorectal cancer before and after surgery: a literature review

Wimmer, Elke ; Glaus, Agnes

Purpose : The aim of this literature review is to provide a comprehensive overview of methods for early identification of cancer-related malnutrition and/or risk of malnutrition in patients with colorectal cancer. The focus is also on applicability and feasibility of the use of nutritional tools in oncology clinical practice. Methods : The literature search was conducted from November to December 2020 in the health science databases by two independent persons. Inclusion criteria were English [...]

Menée à partir des données 1995-2016 des registres californien et texan des cancers, cette étude analyse les disparités ethniques dans l'évolution de l'incidence du cancer gastrique d'apparition précoce

Ethnic disparities in early-onset gastric cancer: a population-based study in Texas and California

Tavakkoli, Anna ; Pruitt, Sandi L. ; Hoang, Anh Q. ; Zhu, Hong ; Hughes, Amy E. ; McKey, Thomas A. ; Elmunzer, B Joseph. ; Kwon, Richard S. ; Murphy, Caitlin C. ; Singal, Amit G.

Background: Incidence rates of gastric cancer are increasing in young adults (age <50 years), particularly among Hispanic persons. We estimated incidence rates of early-onset gastric cancer (EOGC) among Hispanic and non-Hispanic White persons by census tract poverty level and county-level metro/non-metro residence. Methods: We used population-based data from the California and Texas Cancer Registries from 1995-2016 to estimate age-adjusted incidence rates of EOGC among Hispanic and [...]

A partir d'une revue systématique de la littérature (10 études longitudinales incluant un total de 17 645 participants), cette étude analyse la santé psychosociale et physique des adolescents et jeunes adultes ayant survécu à un cancer diagnostiqué entre l'âge de 12 et 29 ans

Psychological, functional and social outcomes in adolescent and young adult cancer survivors over time: A systematic review of longitudinal studies

Bradford, N ; McDonald, F ; Bibby, H ; Kok, C. ; Patterson, P.

Objective : Most adolescents and young adults (AYA) can expect to survive a cancer diagnosis and treatment, but all will be left with the potential of long-term negative effects that can impact their ability to reach their full potential in life. Understanding aspects of psychological, functional, and social health and well-being outcomes, is pivotal for optimising long-term well-being. Methods : We completed a systematic review of longitudinal studies reporting outcomes after anti-cancer [...]

Menée au Canada, cette étude de cohorte rétrospective analyse le risque de cancer et le stade au diagnostic chez des personnes atteintes de troubles psychotiques

Cancer incidence and stage at diagnosis among people with recent-onset psychotic disorders: A retrospective cohort study using health administrative data from Ontario, Canada

Wootten, Jared C. ; Richard, Lucie ; Blanchette, Phillip S. ; Wiener, Joshua C. ; Anderson, Kelly K.

Objective : Prior evidence on the relative risk of cancer among people with psychotic disorders is equivocal. The objective of this study was to compare incidence and stage at diagnosis of cancer for people with psychotic disorders relative to the general population. Method : We constructed a retrospective cohort of people with a first diagnosis of non-affective psychotic disorder and a comparison group from the general population using linked health administrative databases in Ontario, Canada. [...]

Menée aux Etats-Unis à partir de données portant sur 1 310 témoins et sur 1 369 patients ayant survécu 2 ans à une leucémie myéloïde aiguë et ayant reçu une greffe de sang (cellules souches, sang de cordon) ou de moelle, cette étude identifie les facteurs associés au risque de maladie chronique sévère ou fatale

Burden of Long-Term Morbidity Borne by Survivors of Acute Myeloid Leukemia Treated With Blood or Marrow Transplantation: The Results of the BMT Survivor Study

Saro H. Armenian ; Yanjun Chen ; Lindsay Hageman ; Jessica Wu ; Wendy Landier ; Alysia Bosworth ; Liton Francisco ; Elizabeth Schlichting ; Ravi Bhatia ; Donna Salzman ; F. Lennie Wong ; Daniel J. Weisdorf ; Stephen J. Forman ; Mukta Arora ; Smita Bhatia

PURPOSE : Blood or marrow transplantation (BMT) is an integral part of consolidation and/or salvage therapy for patients with acute myeloid leukemia (AML). With the growing population of AML survivors, there is a need to understand the quality of their survival. MATERIALS AND METHODS : This multisite study included 1,369 2-year survivors who underwent BMT for AML between 1974 and 2014 at age ≥ 21 years and 1,310 siblings. Using Common Terminology Criteria for Adverse Events, [...]

Menée au Danemark à partir de données 2000-2014 portant sur 3 776 patientes atteintes d'un cancer épithélial de l'ovaire non localisé, cette étude analyse l'impact, sur la survie à long terme, d'un traitement hormonal substitutif de la ménopause antérieur au diagnostic de cancer

Long-term survival of non-localized epithelial ovarian cancer among women using menopausal hormone therapy prior to diagnosis - the Extreme study

Baandrup, Louise ; Galanakis, Michael ; Hannibal, Charlotte G ; Dehlendorff, Christian ; Hertzum-Larsen, Rasmus ; Mørch, Lina S ; Kjaer, Susanne K

Prediagnostic use of menopausal hormone therapy (MHT) has been suggested to be associated with improved survival of epithelial ovarian cancer (EOC). We investigated the potential long-term survival benefit of prediagnostic MHT use in women ≥50 years with non-localized EOC using the Extreme study including all women in Denmark registered with non-localized EOC during 2000–2014 (N=3,776). We obtained individual-level information on prediagnostic use of systemic estrogen therapy (ET) and estrogen [...]

Menée à partir des données 2000-2017 de l'Organisation mondiale de la santé, cette étude analyse, en fonction du sexe et de l'âge, l'évolution de la mortalité par cancer du poumon en Europe et en Amérique du Nord

Trends in age- and sex-specific lung cancer mortality in Europe and Northern America: Analysis of vital registration data from the WHO Mortality Database between 2000 and 2017

Baum, Philip ; Winter, Hauke ; Eichhorn, Martin E. ; Roesch, Romina M. ; Taber, Samantha ; Christopoulos, Petros ; Wiegering, Armin ; Lenzi, Jacopo

Background : In the context of new targeted therapies and immunotherapy as well as screening modalities for lung cancer patients, detailed mortality trends in Europe and Northern America are unknown. Methods : Time-trend analysis using vital registration data of Northern America and Europe from the WHO Mortality Database (years 2000/2017). To assess improvements in lung cancer mortality, we performed a population-averaged Poisson autoregressive analysis. The average annual percent change (AAPC) [...]

A partir d'une revue de la littérature et de données portant sur des patientes atteintes d'un cancer du sein diagnostiqué entre 2004 et 2018 en Norvège (30 060 patientes au total ; durée médiane de suivi : 5,1 ans), cette méta-analyse évalue l'association entre une utilisation de béta-bloquants (4 461 utilisatrices) et la survie spécifique selon le sous-type moléculaire

Beta-blockers and breast cancer survival by molecular subtypes: a population-based cohort study and meta-analysis

Løfling, L. Lukas ; Støer, Nathalie C. ; Sloan, Erica K. ; Chang, Aeson ; Gandini, Sara ; Ursin, Giske ; Botteri, Edoardo

Background : The association between use of

Menée aux Etats-Unis à partir de données de deux cohortes incluant des patients bénéficiant soit de la couverture Medicaid soit d'une assurance médicale privée, cette étude compare, pour ces deux populations, les facteurs associés au risque de développer un cancer de la cavité buccale ou de l'oropharynx, la prévalence de la maladie, les coûts des traitements anticancéreux et la mortalité

Oral Cancer Prevalence, Mortality, and Costs in Medicaid and Commercial Insurance Claims Data

Tranby, Eric P. ; Heaton, Lisa J. ; Tomar, Scott L. ; Kelly, Abigail L. ; Fager, Gulielma Leonard. ; Backley, Mary ; Frantsve-Hawley, Julie

Background: This study compared prevalence, incidence, mortality rates, treatment costs, and risk factors for oral and oropharyngeal cancer (OC/OPC) between two large United States (U.S.) adult cohorts in 2012–2019. Methods: Medicaid and commercial claims data came from the IBM Watson Health MarketScan Database. Logistic regression analyses estimated incidence and risk factors for OC/OPC. Mortality was calculated by merging deceased individuals’ files with those of the existing cancer cohort. [...]

A partir d'une revue de la littérature (21 études), cette étude analyse les facteurs associés au risque de déficiences cognitives chez des adolescents et jeunes adultes ayant survécu à un cancer du système nerveux périphérique

Cancer-related cognitive impairment in survivors of adolescent and young adult non-central nervous system cancer: A scoping review

Vizer, Lisa M. ; Mikles, Sean P. ; Piepmeier, Aaron T.

Objectives : Cancer-related cognitive impairments (CRCI) are common after treatment and can have important impacts on the lives of adolescent and young adult (AYA) cancer survivors—those cancer survivors diagnosed between ages 15 and 39. However, most research focuses on survivors diagnosed under age 15 or over age 39 so we know relatively little about CRCI among AYA survivors of non-central nervous system (CNS) cancers. Here we review the research on CRCI among AYA survivors of non-CNS cancers [...]

Menée aux Etats-Unis auprès de 56 femmes atteintes d'un cancer du poumon non à petites cellules, cette étude transversale analyse les facteurs (pleine conscience, auto-compassion, soutien social, etc.) pouvant modérer l'association entre la stigmatisation du cancer du poumon et les symptômes psychologiques liés à la maladie

Moderators of the association between stigma and psychological and cancer-related symptoms in women with non-small cell lung cancer

Snyder, Stella ; Kroll, Juliet L. ; Chen, Aileen B. ; Antonoff, Mara B. ; Yang, Claire Chunyi ; Milbury, Kathrin

Objective : Lung cancer patients, particularly women, are vulnerable to experience disease-related stigma, which is linked to greater psychological distress and worse treatment outcomes. To inform future stigma-resilience interventions, we examined if mindfulness, self-compassion, and social support might buffer the associations between perceived lung cancer stigma and psychological and cancer-related symptoms. Methods : In this cross-sectional study, women with recently diagnosed non-small [...]

Menée en Espagne à partir de données portant sur des patients atteints d'un cancer colorectal traité par chirurgie, cette étude de cohorte prospective analyse l'évolution de leurs symptômes d'anxiété, de dépression et de leur qualité de vie sur une période de 5 ans après les traitements anticancéreux, identifie les facteurs associés puis analyse la mortalité

Anxiety, depression, health-related quality of life, and mortality among colorectal patients: 5-year follow-up

Orive, Miren ; Anton-Ladislao, Ane ; Lázaro, Santiago ; Gonzalez, Nerea ; Baré, Marisa ; Fernandez de Larrea, Nerea ; Redondo, Maximino ; Bilbao, Amaia ; Sarasqueta, Cristina ; Aguirre, Urko ; Quintana, José M. ; for the, Redissec-Caress C. C. R. group

Purpose : Health-related quality of life (HRQoL) measurement represents an important outcome in cancer patients. We describe the evolution of HRQoL over a 5-year period in colorectal cancer patients, identifying predictors of change and how they relate to mortality. Methods : Prospective observational cohort study including colorectal cancer (CRC) patients having undergone surgery in nineteen public hospitals who were monitored from their diagnosis, intervention and at 1-, 2-, 3-, and 5-year [...]

Menée aux Etats-Unis par entretien auprès de 21 aidants de patients atteints d'un gliome (âge moyen des aidants : 54,8 ans), cette étude analyse leur détresse et identifie leurs préférences en matière d'interventions psychosociales

Characterizing Distress and Identifying Modifiable Intervention Targets for Family Caregivers of Patients with Malignant Gliomas

Deborah A. Forst ; Emilia R. Kaslow-Zieve ; Andrea Hansen ; Michelle Mesa ; Sophia L. Landay ; Kit M. Quain ; Isabella Sereno ; Areej El-Jawahri ; Joseph A. Greer ; Jennifer S. Temel ; and Jamie M. Jacobs

Background: Individuals caring for patients with malignant gliomas experience high rates of anxiety; however, an in-depth understanding of their distress and evidence-based interventions to target their needs are lacking. Objective: We conducted semistructured interviews with caregivers with elevated anxiety to characterize their drivers of anxiety, identify modifiable intervention targets, and capture their preferences for a psychosocial intervention. Design: From 9/2017 to 3/2019, we [...]

Menée aux Etats-Unis auprès de 10 oncologues, de 39 patients atteints d'un cancer du poumon de stade avancé recevant une thérapie ciblée et de 14 aidants, cette étude qualitative analyse leurs discussions et la communication concernant le pronostic

Prognostic communication about lung cancer in the precision oncology era: A multiple-perspective qualitative study

Petrillo, Laura A. ; Shimer, Sophia E. ; Zhou, Ashley Z. ; Sommer, Robert K. ; Feldman, Jill E. ; Hsu, Kelly E. ; Greer, Joseph A. ; Traeger, Lara N. ; Temel, Jennifer S.

Background : Although most patients with cancer prefer to know their prognosis, prognostic communication between oncologists and patients is often insufficient. Targeted therapies for lung cancer improve survival yet are not curative and produce variable responses. This study sought to describe how oncologists communicate about prognosis with patients receiving targeted therapies for lung cancer. Methods : This qualitative study included 39 patients with advanced lung cancer with targetable [...]