Menée au Japon à partir de données portant sur 180 patients atteints d'un cancer gastrointestinal, cette étude prospective analyse l'efficacité d'un traitement à base de zinc pour prendre en charge une dysgueusie induite par la chimiothérapie

Multicenter, prospective, observational study of chemotherapy-induced dysgeusia in gastrointestinal cancer

Ito, Ken ; Yuki, Satoshi ; Nakatsumi, Hiroshi ; Kawamoto, Yasuyuki ; Harada, Kazuaki ; Nakano, Shintaro ; Saito, Rika ; Ando, Takayuki ; Sawada, Kentaro ; Yagisawa, Masataka ; Ishiguro, Atsushi ; Dazai, Masayoshi ; Iwanaga, Ichiro ; Hatanaka, Kazuteru ; Sato, Atsushi ; Matsumoto, Ryusuke ; Shindo, Yoshiaki ; Tateyama, Miki ; Muranaka, Tetsuhito ; Katagiri, Masaki ; Yokota, Isao ; Sakata, Yuh ; Sakamoto, Naoya ; Komatsu, Yoshito

Purpose : Dysgeusia is an adverse event caused by chemotherapy. Although retrospective studies have shown zinc administration improves dysgeusia, there have been no prospective studies. The present study examined effects of zinc therapy on dysgeusia in patients with gastrointestinal cancer. Methods : This multicenter, prospective, observational study enrolled patients with dysgeusia during chemotherapy treatment. Patients received no intervention (control), polaprezinc p.o., or zinc acetate [...]

A partir d'une revue systématique de la littérature publiée jusqu'en août 2020 (65 articles), cette méta-analyse d'essais randomisés évalue la sécurité, du point de vue de l'absence de survenue d'événements indésirables, de l'acupuncture chez les patients atteints d'un cancer

Safety of acupuncture in oncology: A systematic review and meta-analysis of randomized controlled trials

Höxtermann, Melanie D. ; Haller, Heidemarie ; Aboudamaah, Shaimaa ; Bachemir, Armin ; Dobos, Gustav ; Cramer, Holger ; Voiss, Petra

Background : Acupuncture is frequently used to treat the side effects of cancer treatment, but the safety of this intervention remains uncertain. The current meta-analysis was conducted to assess the safety of acupuncture in oncological patients. Methods : The PubMed, Cochrane Central Register of Controlled Trials, and Scopus databases were searched from their inception to August 7, 2020. Randomized controlled trials in oncological patients comparing invasive acupuncture with sham acupuncture, [...]

Menée en Australie par enquête auprès de 2 115 patients ayant survécu à un cancer, cette étude transversale analyse les facteurs associés à leur qualité de vie, leurs difficultés socioéconomiques et leur situation professionnelle

Disparities in quality of life, social distress and employment outcomes in Australian cancer survivors

White, Victoria M. ; Lisy, Karolina ; Ward, Andrew ; Ristevski, Eli ; Clode, Melanie ; Webber, Kate ; Emery, Jon ; IJzerman, Maarten J. ; Afshar, Nina ; Millar, Jeremy ; Gibbs, Peter ; Evans, Sue ; Jefford, Michael

Purpose : To examine how socio-demographic, comorbidities and information needs influence quality of life (QoL) outcomes of survivors of breast, colorectal, or prostate cancer, non-Hodgkin lymphoma or melanoma. Methods : Cross-sectional postal survey with eligible participants identified through a population-based cancer registry. QoL outcomes were assessed by EQ-5D-5L, social difficulties index (SDI) and, for those employed at diagnosis, current employment. Regression analyses explored [...]

Menée en Corée à partir de données portant sur 124 patientes atteintes d'un cancer du sein diagnostiqué entre 2004 et 2006, cette étude de cohorte analyse l'évolution de leur qualité de vie pendant les 15 ans qui suivent le diagnostic

Long-term trajectory of postoperative health-related quality of life in young breast cancer patients: a 15-year follow-up study

Tran, Thi Xuan Mai ; Jung, So-Youn ; Lee, Eun-Gyeong ; Cho, Heeyoun ; Cho, Juhee ; Lee, Eunsook ; Chang, Yoon Jung ; Cho, Hyunsoon

Purpose : Breast cancer (BC) patients often experience various long-term sequelae due to aggressive treatment. We analyzed and illustrated long-term trajectory during different phases of treatment and survivorship. Methods : Data were obtained from a cohort of 298 BC patients diagnosed between 2004 and 2006 and were followed up until 2020. We measured HRQoL using EORTC QLQ-C30, QLQ-BR23, and EuroQoL-5D questionnaires and conducted eight assessments right after initial diagnosis, during [...]

Menée en France à partir de données portant sur 4 173 patientes ayant survécu à un cancer du sein traité entre 2012 et 2015, cette étude analyse les facteurs associés à l'évolution de leur fatigue, 1, 2 et 4 ans après le diagnostic

Long-Term Longitudinal Patterns of Patient-Reported Fatigue After Breast Cancer: A Group-Based Trajectory Analysis

Ines Vaz-Luis ; Antonio Di Meglio ; Julie Havas ; Mayssam El-Mouhebb ; Pietro Lapidari ; Daniele Presti ; Davide Soldato ; Barbara Pistilli ; Agnes Dumas ; Gwenn Menvielle ; Cecile Charles ; Sibille Everhard ; Anne-Laure Martin ; Paul H. Cottu ; Florence Lerebours ; Charles Coutant ; Sarah Dauchy ; Suzette Delaloge ; Nancy U. Lin ; Patricia A. Ganz ; Ann H. Partridge ; Fabrice André ; Stefan Michiels

PURPOSE : Fatigue is recognized as one of the most burdensome and long-lasting adverse effects of cancer and cancer treatment. We aimed to characterize long-term fatigue trajectories among breast cancer survivors. METHODS : We performed a detailed longitudinal analysis of fatigue using a large ongoing national prospective clinical study (CANcer TOxicity, ClinicalTrials.gov identifier: NCT01993498) of patients with stage I-III breast cancer treated from 2012 to 2015. Fatigue was assessed at [...]

Menée à partir de données 1990-2019 portant sur 204 pays et territoires, cette étude analyse l'évolution de l'incidence et de la prévalence de différents types de maladies (dont les cancers) et l'évolution des causes de décès chez les personnes âgées de plus de 70 ans

Global, regional, and national burden of diseases and injuries for adults 70 years and older: systematic analysis for the Global Burden of Disease 2019 Study

Objectives : To use data from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) to estimate mortality and disability trends for the population aged ≥70 and evaluate patterns in causes of death, disability, and risk factors. Design : Systematic analysis. Setting : Participants were aged ≥70 from 204 countries and territories, 1990-2019. Main outcomes measures : Years of life lost, years lived with disability, disability adjusted life years, life expectancy at age 70 [...]

Menée aux Etats-Unis à partir des données 2012 de la base Medicaid, cette étude analyse la pévalence des cancers chez les hommes âgés de 18 à 64 ans et infectés par le VIH

Excess cancer prevalence in men with HIV: A nationwide analysis of Medicaid data

Koroukian, Siran M. ; Zhou, Guangjin ; Navale, Suparna M. ; Schiltz, Nicholas K. ; Kim, Uriel ; Rose, Johnie ; Cooper, Gregory S. ; Moore, Scott Emory ; Mintz, Laura J. ; Avery, Ann K. ; Mukherjee, Sudipto ; Markt, Sarah C.

Background : Cancer is one of the most common comorbidities in men living with HIV (MLWH). However, little is known about the MLWH subgroups with the highest cancer burden to which cancer prevention efforts should be targeted. Because Medicaid is the most important source of insurance for MLWH, we evaluated the excess cancer prevalence in MLWH on Medicaid relative to their non-HIV counterparts. Methods : In this cross-sectional study using 2012 Medicaid Analytic eXtract data nationwide, we [...]

Menée auprès de 160 patients présentant des métastases hépatiques et pulmonaires ayant pour origine un cancer colorectal et diagnostiquées simultanément entre 2010 et 2018, cette étude analyse l'adéquation entre le traitement curatif décidé lors de la réunion de concertation pluridisciplinaire, le traitement reçu réellement et la survie

Treatment intention and outcome in patients with simultaneously diagnosed liver and lung metastases from colorectal cancer

Engstrand, Jennie ; Sterner, Johanna ; Hasselgren, Kristina ; Strömberg, Cecilia ; Sturesson, Christian

Background: The aim was to assess the likelihood of patients with simultaneously diagnosed liver and lung metastases (SLLM) from colorectal cancer (CRC) to receive the curative treatment decided upon multidisciplinary team meeting (MDT) and to elaborate on the reasons for treatment intention failure and survival outcomes depending on final treatment strategy. Method: The study included a retrospective review of all patients discussed at the MDT at a single centre between 2010 to 2018 to [...]

A partir des données 2020 de la base GLOBOCAN, cette étude présente l'incidence du cancer du testicule et la mortalité spécifique

Global patterns in testicular cancer incidence and mortality in 2020

Znaor, Ariana ; Skakkebaek, Niels Erik ; Meyts, Ewa Rajpert-De ; Kulis, Tomislav ; Laversanne, Mathieu ; Gurney, Jason ; Sarfati, Diana ; McGlynn, Katherine A. ; Bray, Freddie

With 74,500 new cases worldwide in 2020, testicular cancer ranks as the 20th leading cancer type, but is the most common cancer in young men of European ancestry. While testicular cancer incidence has been rising in many populations, mortality trends, at least those in high-income settings, have been in decline since the 1970s following the introduction of platinum-based chemotherapy. To examine current incidence and mortality patterns, we extracted the new cases of, and deaths from cancers of [...]

Menée en Chine sur la période 2005-2020, cette étude analyse l'évolution de la mortalité par carcinome du rhinopharynx et des années de vie perdues en lien avec la maladie

Trend of nasopharyngeal carcinoma mortality and years of life lost in China and Its Provinces from 2005 to 2020

Long, Zheng ; Wang, Wei ; Liu, Wei ; Wang, Feixue ; Meng, Shidi ; Liu, Jiangmei ; Liu, Yunning ; Qi, Jinlei ; Wang, Lijun ; Zhou, Maigeng ; Yin, Peng

To examine the trends of nasopharyngeal carcinoma (NPC) mortality and years of life lost (YLL) in China and its provinces from 2005 to 2020, our study used data from China National Mortality Surveillance System (NMSS) to estimate the number and rate of mortality and YLL of NPC by age and sex. We calculated average annual percent change (AAPC) to describe the trend of NPC mortality and YLL over time. We also analyzed the proportion of NPC deaths in all cancer deaths and explored the drivers of [...]

Menée au Japon à partir de données portant sur 711 dyades patient/aidant, cette étude longitudinale analyse les expériences de fin de vie des patients atteints d'un cancer de stade avancé, les circonstances de leur décès et les facteurs associés aux symptômes de dépression chez les aidants endeuillés

Association between experiences of advanced cancer patients at the end of life and depression in their bereaved caregivers

Hatano, Yutaka ; Morita, Tatsuya ; Mori, Masanori ; Aoyama, Maho ; Yoshida, Saran ; Amano, Koji ; Terabayashi, Toru ; Oya, Kiyofumi ; Tsukuura, Hiroaki ; Hiratsuka, Yusuke ; Maeda, Isseki ; Kizawa, Yoshiyuki ; Tsuneto, Satoru ; Shima, Yasuo ; Masukawa, Kento ; Miyashita, Mitsunori

Objective : Research on the association between circumstances of death in advanced cancer patients and depression in their bereaved caregivers is limited. Methods : A longitudinal study was performed on patients admitted to 21 inpatient hospices/palliative care units (PCUs) in Japan. Patient symptoms were assessed at admission and in the last 3 days of life. Data on distressing events (unexpected death, bleeding) and received treatments (morphine prescriptions, continuous deep sedation, [...]

A partir d'une revue systématique de la littérature publiée jusqu'en mars 2021 (54 articles), cette étude analyse l'effet, sur la santé psychique des parents, du cancer de leur enfant (âge inférieur ou égal à 21 ans)

The impact of cancer on the mental health of patients parenting minor children: A systematic review of quantitative evidence

Johannsen, Lene ; Brandt, Maja ; Frerichs, Wiebke ; Inhestern, Laura ; Bergelt, Corinna

Objective : To provide an overview of quantitative data on the impact of cancer on the mental health of patients parenting minor children. We focused on mental health outcomes, their levels and prevalence, and applied measurement tools. Methods : MEDLINE, CINAHL, PsycInfo and Web of Science were searched up to March 2021. We included quantitative studies, published in a peer-reviewed journal and reporting outcomes on the mental health (e.g., depression, anxiety) of cancer patients parenting [...]

Menée en Allemagne, cette étude analyse les coûts associés à la prise en charge des patients ayant survécu à un carcinome à cellules rénales (durée moyenne de suivi : 10 ans)

Socio-economic burden of disease: Survivorship costs for renal cell carcinoma

Michaeli, Julia Caroline ; Michaeli, Daniel Tobias ; Boch, Tobias ; Albers, Sebastian ; Michaeli, Thomas

Objective : The objective of this study is to assess the risk-stratified 10-year socio-economic burden of renal cell carcinoma (RCC) follow-up costs after initial treatment in Germany from 2000 to 2020. Methods :A micro-costing method considering direct and indirect medical expenditure associated with follow-up procedures was employed to calculate survivorship costs per patient. The frequencies of physician–patient visits, examinations and diagnostic tests were extracted from guidelines, whilst [...]

Menée dans un contexte néerlandais, cette étude analyse le rapport coût-efficacité de 920 stratégies de dépistage du cancer du sein, en prenant en compte différentes tranches d'âge et différents délais entre deux examens

Finding the optimal mammography screening strategy: a cost-effectiveness analysis of 920 modelled strategies

Kregting, Lindy M. ; Sankatsing, Valerie D.V. ; Heijnsdijk, Eveline A.M. ; de Koning, Harry J. ; van Ravesteyn, Nicolien T.

Breast cancer screening policies have been designed decades ago, but current screening strategies may not be optimal anymore. Next to that, screening capacity issues may restrict feasibility. This cost-effectiveness study evaluates an extensive set of breast cancer screening strategies in the Netherlands. Using the Microsimulation Screening Analysis-Breast (MISCAN-Breast) model, the cost-effectiveness of 920 breast cancer screening strategies with varying starting ages (40-60), stopping ages [...]

Cette étude présente les recommandations de l'"American Cancer Society" concernant la nutrition et l'activité physique pour les patients ayant survécu à un cancer

American Cancer Society nutrition and physical activity guideline for cancer survivors

Rock, Cheryl L. ; Thomson, Cynthia A. ; Sullivan, Kristen R. ; Howe, Carol L. ; Kushi, Lawrence H. ; Caan, Bette J. ; Neuhouser, Marian L. ; Bandera, Elisa V. ; Wang, Ying ; Robien, Kimberly ; Basen-Engquist, Karen M. ; Brown, Justin C. ; Courneya, Kerry S. ; Crane, Tracy E. ; Garcia, David O. ; Grant, Barbara L. ; Hamilton, Kathryn K. ; Hartman, Sheri J. ; Kenfield, Stacey A. ; Martínez, María Elena ; Meyerhardt, Jeffrey A. ; Nekhlyudov, Larissa ; Overholser, Linda ; Patel, Alpa V. ; Pinto, Bernardine M. ; Platek, Mary E. ; Rees-Punia, Erika ; Spees, Colleen K. ; Gapstur, Susan M. ; McCullough, Marjorie L.

The overall 5-year relative survival rate for all cancers combined is now 68%, and there are over 16.9 million survivors in the United States. Evidence from laboratory and observational studies suggests that factors such as diet, physical activity, and obesity may affect risk for recurrence and overall survival after a cancer diagnosis. The purpose of this American Cancer Society guideline is to provide evidence-based, cancer-specific recommendations for anthropometric parameters, physical [...]