Menée en Australie auprès de 495 patients atteints d'un gliome et 371 témoins, cette étude analyse l'association entre la pratique d'une activité physique à différents âges de la vie (15–18 ans, 19–29 ans, 30–39 ans, pendant les 10 dernières années) et le risque de développer la maladie, ainsi que la mortalité toutes causes confondues

Physical activity and glioma: a case–control study with follow-up for survival

Basiri, Zohreh ; Yang, Yi ; Bruinsma, Fiona J. ; Nowak, Anna K. ; McDonald, Kerrie L. ; Drummond, Katharine J. ; Rosenthal, Mark A. ; Koh, Eng-Siew ; Harrup, Rosemary ; Hovey, Elizabeth ; Joseph, David ; Benke, Geza ; Leonard, Robyn ; MacInnis, Robert J. ; Milne, Roger L. ; Giles, Graham G. ; Vajdic, Claire M. ; Lynch, Brigid M.

Purpose : High-grade disease accounts for ~ 70% of all glioma, and has a high mortality rate. Few modifiable exposures are known to be related to glioma risk or mortality. Methods : We examined associations between lifetime physical activity and physical activity at different ages (15–18 years, 19–29 years, 30–39 years, last 10 years) with the risk of glioma diagnosis, using data from a hospital-based family case–control study (495 cases; 371 controls). We followed up cases over a median of 25 [...]

Menée à partir des données de 17 études incluant au total 6 097 patients atteints d'un cancer gastrique et 13 017 témoins, cette étude évalue l'association entre la consommation d'alliacées (ail, oignon, poireau, etc.) et le risque de développer la maladie

Allium vegetables intake and the risk of gastric cancer in the Stomach cancer Pooling (StoP) Project

Dalmartello, Michela ; Turati, Federica ; Zhang, Zuo-Feng ; Lunet, Nuno ; Rota, Matteo ; Bonzi, Rossella ; Galeone, Carlotta ; Martimianaki, Georgia ; Palli, Domenico ; Ferraroni, Monica ; Yu, Guo-Pei ; Morais, Samantha ; Malekzadeh, Reza ; López-Carrillo, Lizbeth ; Zaridze, David ; Maximovitch, Dmitry ; Aragonés, Nuria ; Fernández-Tardón, Guillermo ; Martin, Vicente ; Vioque, Jesús ; Garcia de la Hera, Manoli ; Curado, Maria Paula ; Coimbra, Felipe Jose Fernandez ; Assumpcao, Paulo ; Pakseresht, Mohammadreza ; Hu, Jinfu ; Hernández-Ramírez, Raúl Ulises ; Ward, Mary H. ; Pourfarzi, Farhad ; Mu, Lina ; Tsugane, Shoichiro ; Hidaka, Akihisa ; Lagiou, Pagona ; Lagiou, Areti ; Trichopoulou, Antonia ; Karakatsani, Anna ; Boffetta, Paolo ; Camargo, M. Costanza ; Negri, Eva ; La Vecchia, Carlo ; Pelucchi, Claudio

Background : The role of allium vegetables on gastric cancer (GC) risk remains unclear. Methods : We evaluated whether higher intakes of allium vegetables reduce GC risk using individual participant data from 17 studies participating in the “Stomach cancer Pooling (StoP) Project”, including 6097 GC cases and 13,017 controls. Study-specific odds ratios (ORs) were pooled using a two-stage modelling approach. Results : Total allium vegetables intake was inversely associated with GC risk. The [...]

Menée à l'aide de lignées cellulaires de cancer de la prostate et d'un modèle murin, cette étude met en évidence l'intérêt de la forme delta du tocophérol d'origine alimentaire pour inhiber la carcinogenèse et la croissance des cellules cancéreuses

Delta-Tocotrienol is the most potent vitamin E form in inhibiting prostate cancer cell growth and inhibits prostate carcinogenesis in Ptenp-/- mice

Wang, Hong ; Yan, William ; Sun, Yuhai ; Yang, Chung S.

Vitamin E compounds, consisting of α, β, γ, and δ forms of tocopherols and tocotrienols, display different cancer preventive activities in experimental models. Tocotrienols may have higher potential for clinical use due to their lower effective doses in laboratory studies. However, most studies on tocotrienols have been carried out using cancer cell lines. Strong data from animal studies may encourage the use of tocotrienols for human cancer prevention research. To examine the cancer inhibitory [...]

Mené auprès de 19 114 participants âgés (âge médian : 74 ans ; durée médiane de suivi : 6,3 ans), cet essai international évalue l'effet d'une consommation quotidienne d'une faible quantité d'aspirine (100 mg) sur l'incidence des mélanomes cutanés

Effect of aspirin on melanoma incidence in older persons: extended follow-up of a large randomised double-blind placebo-controlled trial

Yan, Mabel K. ; Orchard, Suzanne G. ; Adler, Nikki R. ; Wolfe, Rory ; McLean, Catriona ; Rodriguez, Luz Maria ; Woods, Robyn L. ; Gibbs, Peter ; Chan, Andrew T. ; Haydon, Andrew ; Mar, Victoria J.

The effects of aspirin on melanoma are unclear, with studies reporting conflicting results. Data from 2 periods of the ASPirin in Reducing Events in the Elderly (ASPREE) study; the randomised placebo-controlled trial period examining daily 100mg aspirin in older adults with a median follow-up of 4.7 years, and the 2nd period, an additional 2 years of observational follow up, were utilised in this secondary analysis to examine whether aspirin exposure is associated with a reduced cutaneous [...]