Menée par questionnaire auprès de 101 680 personnes incluses dans l'essai "the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial" (âge moyen : 65 ans), cette étude analyse l'association entre un score évaluant le potentiel inflammatoire de l'alimentation avec ou sans supplémentation et le risque de cancer colorectal (3 172 cas), en fonction du stade de développement de la tumeur

Inflammatory potential of diet and colorectal carcinogenesis: a prospective longitudinal cohort

Li, Zhuyue ; Wang, Kang ; Shivappa, Nitin ; Hebert, James R. ; Chen, Hong ; Liu, Hui ; Jiang, Xiaolian

Background: Acknowledging the role of inflammation in colorectal carcinogenesis, this study aimed to evaluate the associations between diet-associated inflammation, as measured by the energy-adjusted dietary inflammatory index (E-DIITM), and distinct stages of colorectal carcinogenesis. Methods: The Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial enrolled participants without a colorectal cancer history, who were asked to complete baseline questionnaires and food frequency [...]

Menée au Danemark auprès de 18 997 témoins et à l'aide de données 1989-2014 d'un registre portant sur 6 390 patients atteints d'un cancer du testicule, cette étude analyse l'association entre une exposition aux polluants de l'air ambiant et le risque de développer la maladie

Long-term residential exposure to air pollution and risk of testicular cancer in Denmark: A population-based case-control study

Taj, Tahir ; Harbo Poulsen, Aslak ; Ketzel, Matthias ; Geels, Camilla ; Brandt, Jorgen ; Christensen, Jesper Heile ; Hvidtfeldt, Ulla Arthur ; Sørensen, Mette ; Raaschou-Nielsen, Ole

Background: The incidence rate risk of testicular cancer has increased over the last four decades, and most significant increase has been among Caucasian men in Nordic countries. Second-generation immigrant studies indicate a significant role of environmental exposure in testicular cancer. Methods: We conducted a nationwide register-based case-control study, including 6,390 testicular cancer cases registered in the Danish Cancer Registry between 1989 and 2014. Up to four age-matched controls [...]

Menée à l'aide de données d'une étude japonaise portant sur 8 040 patients atteints d'un cancer (durée médiane de suivi : 15,6 ans), cette étude analyse l'association entre une inflammation chronique de bas grade, mesurée par le niveau de protéine C-réactive, et le risque de cancer (18 localisations)

Association between C-reactive protein and risk of overall and 18 site-specific cancers in a Japanese case-cohort

Suzuki, Shiori ; Katagiri, Ryoko ; Yamaji, Taiki ; Sawada, Norie ; Imatoh, Takuya ; Ihira, Hikaru ; Inoue, Manami ; Tsugane, Shoichiro ; Iwasaki, Motoki ; Sawada, N. ; Tsugane, S. ; Iwasaki, M. ; Inoue, M. ; Yamaji, T. ; Katagiri, R. ; Miyamoto, Y. ; Ihira, H. ; Abe, S. K. ; Tanaka, S. ; Moriya, T. ; Minamizono, T. ; Shirai, Y. ; Kuniyoshi, H. ; Yoshimi, T. ; Sonoda, H. ; Tagami, T. ; Ando, T. ; Kimura, T. ; Kokubo, Y. ; Yamagishi, K. ; Mizoue, T. ; Nakamura, K. ; Takachi, R. ; Ishihara, J. ; Iso, H. ; Kitamura, T. ; Saito, I. ; Yasuda, N. ; Mimura, M. ; Sakata, K. ; Noda, M. ; Goto, A. ; Yatsuya, H. ; for the Japan Public Health Center-based Prospective Study, Group

Background: Evidence of the association between chronic low-grade inflammation, as reflected by C-reactive protein (CRP) measurements, and cancer risk is equivocal. Specifically, few studies have examined this in uncommon cancers and Asian populations. Methods: We utilised a case-cohort design consisting of multi-types of cancer (N = 3608), and a random subcohort (N = 4432) in a Japanese large population-based study, with a median follow-up time of 15.6 years, and measured baseline plasma CRP [...]

Menée à partir de données de la cohorte "the Nurses’ Health Study" portant sur 371 patientes atteintes d'un cancer du sein et 731 témoins, cette étude analyse l'association entre l'activité oestrogénique totale et le risque de développer la maladie après la ménopause

Estrogenic activity and risk of invasive breast cancer among postmenopausal women in the Nurses' Health Study

Holder, Etienne X ; Houghton, Serena C ; Sanchez, Sylvia S ; Eliassen, A Heather ; Qian, Jing ; Bertone-Johnson, Elizabeth R ; Liu, Zhenhua ; Tworoger, Shelley S ; Smith, Martyn T ; Hankinson, Susan E

Background: Estrogens increase breast cancer risk through estrogen receptor (ER) mediated pathway activation. It is unclear whether a broader assessment of plasma compounds that lead to ER activation would be more strongly related to risk than measurement of individual estrogens. Methods: A prospective nested case-control study was conducted among postmenopausal women in the Nurses' Health Study, that included 371 cases with blood samples collected prior to breast cancer diagnosis and 731 [...]