A partir d'une revue systématique de la littérature publiée entre 1980 et 2020 (82 méta-analyses), cette étude évalue l'association entre la consommation de thé vert et le risque de cancer ou de maladie cardiométabolique

Green tea and cancer and cardiometabolic diseases: a review of the current epidemiological evidence

Abe, Sarah Krull ; Inoue, Manami

Green tea is commonly consumed in China, Japan, and Korea and certain parts of North Africa and is gaining popularity in other parts of the world. The aim of this review was to objectively evaluate the existing evidence related to green tea consumption and various health outcomes, especially cancer, cardiovascular disease and diabetes. This review captured evidence from meta-analyses as well as expert reports and recent individual studies. For certain individual cancer sites: endometrial, lung, [...]

Menée à partir d'une revue systématique de la littérature (21 articles incluant 980 008 participants), cette étude évalue l'association entre la consommation de vitamine D et de calcium et le risque de cancer de l'ovaire

Association between vitamin D/calcium intake and 25-hydroxyvitamin D and risk of ovarian cancer: a dose-response relationship meta-analysis

Xu, Jiawei ; Chen, Kelie ; Zhao, Fan ; Huang, Dongdong ; Zhang, Honghe ; Fu, Zhiqin ; Xu, Jinming ; Wu, Yongfeng ; Lin, Hui ; Zhou, Yexinyi ; Lu, Weiguo ; Wu, Yihua ; Xia, Dajing

Background : The association between vitamin D/calcium and risk of ovarian cancer is still a debatable point. The aim of our study was to systematically investigate the association between vitamin D/calcium, and the risk of ovarian cancer and estimate their dose-response association quantitatively. Methods : PubMed, EMBASE, and Web of Science databases were searched to identify relevant observational studies. Two investigators screened citations and extracted data independently. Data were [...]

Menée à l'aide d'un modèle murin, cette étude met en évidence l'intérêt d'un traitement anti-PD1 pour prévenir le risque de carcinome hépatocellulaire

Immune Checkpoint Inhibition is Safe and Effective for Liver Cancer Prevention in a Mouse Model of Hepatocellular Carcinoma

Chung, Andrew S. ; Mettlen, Marcel ; Ganguly, Debolina ; Lu, Tianshi ; Wang, Tao ; Brekken, Rolf A. ; Hsiehchen, David ; Zhu, Hao

Cirrhosis is a high-risk state for hepatocellular carcinoma (HCC) development and represents an opportunity to prevent cancer. In the pre-cancerous state of cirrhosis, there is an accumulation of neoantigens that may be specifically targetable through immunotherapy. We asked if immune checkpoint inhibition could prevent tumorigenesis in a mouse model of diethylnitrosamine (DEN) and carbon tetrachloride (CCl4) induced HCC. We found that initiation of anti-PD-1 therapy prior to tumorigenesis [...]