Menée aux Etats-Unis à partir de données portant sur 463 049 participants âgés de 50 à 71 ans lors de leur inclusion dans la cohorte (1995-1996), cette étude prospective analyse l’association entre l’alimentation (consommation de fruits, de sucres, de graisses, de protéines, etc.) et le risque de tumeur myéloproliférative (durée médiane de suivi : 15,5 ans, 490 cas)

Diet and Risk of Myeloproliferative Neoplasms in Older Individuals from the NIH-AARP Cohort

Nikolai A Podoltsev, Xiaoyi Wang, Rong Wang, Jonathan N. Hofmann (et al.)

Background:The etiology of myeloproliferative neoplasms (MPN) is obscure, and no previous studies have evaluated the role of diet. Methods:In the NIH-AARP Diet and Health Study, a prospective cohort of 463,049 participants aged 50-71 years at baseline(1995-1996), we identified 490 MPN cases after a median follow-up of 15.5 years, including 190 with polycythemia vera(PV) and 146 with essential thrombocythemia(ET). We examined possible associations between various dietary factors and the risk of [...]

A partir d’une revue de la littérature publiée jusqu’en juillet 2019 (31 études de cohorte, 24 964 cas, 2 302 décès), cette méta-analyse évalue l’association entre une consommation de produits laitiers et le risque de cancer colorectal, ainsi que la mortalité spécifique

Dairy consumption and risks of colorectal cancer incidence and mortality: a meta-analysis of prospective cohort studies

Shaoyue Jin, Youngyo Kim, Youjin Je

Background: Previous studies of dairy consumption and colorectal cancer incidence have shown inconsistent results, and there was no meta-analysis of dairy consumption with colorectal cancer mortality. Thus, we conducted a comprehensive analysis of prospective cohort studies to investigate these associations. Methods: PubMed and Web of Science databases were searched for eligible studies published up to July 2019, and random effects model was used to estimate pooled RR. Results: We identified 31 [...]

Menée au Japon à partir de données portant sur 102 925 participants, cette étude de cohorte prospective analyse l'association entre l'indice de masse corporelle, la taille, et le risque de tumeur du cerveau

Body mass index and height in relation to brain tumor risk in a Japanese population

Ogawa, Takahiro ; Sawada, Norie ; Iwasaki, Motoki ; Budhathoki, Sanjeev ; Yamaji, Taiki ; Shimazu, Taichi ; Narita, Yoshitaka ; Tsugane, Shoichiro

Purpose : Although height and BMI are reported to be positively associated with several common cancers, evidence regarding their association with brain tumor risk remains sparse, particularly in Asian populations. In this study, we analyzed the association between height and BMI and brain tumor risk in a Japanese population using a large population-based prospective cohort study. Method : A total of 102,925 subjects (48,213 men and 54,712women) enrolled in the Japan Public Health Center-based [...]

Menée en Corée à partir de données portant sur 770 880 participants, cette étude de cohorte analyse l'association entre une utilisation à long terme de glucocorticoïdes et le risque de cancer (1 602 utilisateurs, 36 157 cas de cancers entre 2011 et 2015)

Long-term glucocorticoid use and cancer risk: A population-based cohort study in South Korea

Oh, Tak Kyu ; Song, In-Ae

Long-term glucocorticoid (GC) exposure causes immunosuppression; therefore, the risk of cancer may be increased in long-term GC users. We investigated whether long-term GC use is associated with a higher risk of cancer in the population without cancer. A population-based cohort study using data from the National Health Insurance Service was conducted among the South Korean adult population in 2010. Long-term GC users were defined as those who were prescribed a continuous supply of oral GC for [...]

Menée aux Etats-Unis à partir de données portant sur 117 200 femmes, cette étude de cohorte prospective analyse l'association entre une utilisation personnelle de produits capillaires de coloration, le risque de cancer et la mortalité

Personal use of permanent hair dyes and cancer risk and mortality in US women: prospective cohort study

Zhang, Yin ; Birmann, Brenda M ; Han, Jiali ; Giovannucci, Edward L ; Speizer, Frank E ; Stampfer, Meir J ; Rosner, Bernard A ; Schernhammer, Eva S

Objective : To evaluate the associations between personal use of permanent hair dyes and cancer risk and mortality. Design : Prospective cohort study. Setting and participants : 117 200 women enrolled in the Nurses’ Health Study, an ongoing prospective cohort study of female nurses in the United States. The women were free of cancer at baseline, reported information on personal use of permanent hair dyes, and were followed for 36 years.Exposure Status, duration, frequency, and integral use [...]

A partir des données de 3 cohortes prospectives incluant 4 497 patients atteints d'un cancer (sein, poumon, tumeur à cellules B matures) et 4 497 témoins, cette méta-analyse évalue l'association entre des mutations épigénétiques stochastiques et le risque de développer la maladie

Stochastic Epigenetic Mutations Are Associated with Risk of Breast Cancer, Lung Cancer, and Mature B-cell Neoplasms

Gagliardi, Amedeo ; Dugué, Pierre-Antoine ; Nøst, Therese H. ; Southey, Melissa C. ; Buchanan, Daniel D. ; Schmidt, Daniel F. ; Makalic, Enes ; Hodge, Allison M. ; English, Dallas R. ; Doo, Nicole W. ; Hopper, John L. ; Severi, Gianluca ; Baglietto, Laura ; Naccarati, Alessio ; Tarallo, Sonia ; Pace, Luigia ; Krogh, Vittorio ; Palli, Domenico ; Panico, Salvatore ; Sacerdote, Carlotta ; Tumino, Rosario ; Lund, Eiliv ; Giles, Graham G. ; Pardini, Barbara ; Sandanger, Torkjel M. ; Milne, Roger L. ; Vineis, Paolo ; Polidoro, Silvia ; Fiorito, Giovanni

Background: Age-related epigenetic dysregulations are associated with several diseases, including cancer. The number of stochastic epigenetic mutations (SEM) has been suggested as a biomarker of life-course accumulation of exposure-related DNA damage; however, the predictive role of SEMs in cancer has seldom been investigated. Methods: A SEM, at a given CpG site, was defined as an extreme outlier of DNA methylation value distribution across individuals. We investigated the association of the [...]

Menée en Corée à partir de données portant sur 1 418 180 femmes avant la ménopause et sur 4 854 187 femmes ménopausées, cette étude analyse l’association entre l’obésité et le risque de cancer colorectal en fonction du statut ménopausique (durée moyenne de suivi : 7,2 ans ; 7 094 et 57 449 cas)

Obesity Has a Stronger Relationship with Colorectal Cancer in Postmenopausal Women Than Premenopausal Women

Dong Wook Shin, Ji Won Chang, Kyung-Do Han, Keun Hye Jeon (et al.)

Background: To examine the relationship between obesity measured by waist circumference (WC) and body mass index (BMI) and the incidence of colorectal cancer (CRC) in premenopausal and postmenopausal women. Methods: A total of 1,418,180 premenopausal and 4,854,187 postmenopausal women without cancer at baseline and aged over 40 were identified using the Korean National Health Insurance System Cohort during 2009-2014. The hazard ratio (HR) for CRC incidence was assessed according to menopausal [...]