A partir d'une revue systématique de la littérature publiée jusqu'en mars 2019 (32 études, 1 445 732 participants), cette méta-analyse évalue l'association entre un apport alimentaire en acides gras polyinsaturés à longue chaîne n-3 ou n-6 et le risque de cancer colorectal, de cancer du sein et de la prostate

Dietary Intake of N-3 and N-6 Polyunsaturated Fatty Acids and Risk of Cancer: Meta-Analysis of Data from 32 Studies

Liu, Jian ; Li, Xianqing ; Hou, Jinfei ; Sun, Jiaming ; Guo, Nengqiang ; Wang, Zhenxing

Background: Large epidemiological studies have yielded conflicting results regarding the relationship between polyunsaturated fatty acids (PUFAs) and cancers. Here, we performed a meta-analysis to examine the link between dietary intake of n-3 and n-6 PUFAs and cancer risk. Materials and methods: We performed a search on PubMed, EMBASE, and the Cochrane Library. Studies that reported adjusted relative risk (RR) estimates with 95% confidence intervals (CI) for the associations of interest were [...]

Mené entre 1999 et 2005 sur 861 patients atteints d'un syndrome de Lynch (âge moyen : 45 ans ; durée moyenne de suivi : 56 mois), cet essai randomisé multicentrique évalue l'effet, du point de vue du développement d'un cancer colorectal, d'une utilisation régulière d'aspirine

Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial

Burn, John ; Sheth, Harsh ; Elliott, Faye ; Reed, Lynn ; Macrae, Finlay ; Mecklin, Jukka-Pekka ; Möslein, Gabriela ; McRonald, Fiona E. ; Bertario, Lucio ; Evans, D. Gareth ; Gerdes, Anne-Marie ; Ho, Judy W. C. ; Lindblom, Annika ; Morrison, Patrick J. ; Rashbass, Jem ; Ramesar, Raj ; Seppälä, Toni ; Thomas, Huw J. W. ; Pylvanainen, Kirsi ; Borthwick, Gillian M. ; Mathers, John C. ; Bishop, D. Timothy ; Boussioutas, Alex ; Brewer, Carole ; Cook, Jackie ; Eccles, Diana ; Ellis, Anthony ; Hodgson, Shirley V. ; Lubinski, Jan ; Maher, Eamonn R. ; Porteous, Mary E. M. ; Sampson, Julian ; Scott, Rodney J. ; Side, Lucy

Background: Lynch syndrome is associated with an increased risk of colorectal cancer and with a broader spectrum of cancers, especially endometrial cancer. In 2011, our group reported long-term cancer outcomes (mean follow-up 55·7 months [SD 31·4]) for participants with Lynch syndrome enrolled into a randomised trial of daily aspirin versus placebo. This report completes the planned 10-year follow-up to allow a longer-term assessment of the effect of taking regular aspirin in this high-risk [...]

Menée au Danemark à l'aide de prélèvements cervico-vaginaux réalisés auprès de 18 924 jeunes femmes nées en 1994 et ayant reçu à 14 ans une invitation pour une vaccination contre le papillomavirus humain HPV, cette étude analyse la prévalence de HPV chez ces personnes à l'âge d'au moins 23 ans

Prevalence of high-risk human papillomavirus after HPV-vaccination in Denmark

Lynge, Elsebeth ; Thamsborg, Lise ; Larsen, Lise Grupe ; Christensen, Jette ; Johansen, Tonje ; Hariri, Jalil ; Christiansen, Sanne ; Rygaard, Carsten ; Andersen, Berit

Vaccination against human papillomavirus (HPV) has been introduced as a public health initiative in many countries, including Denmark since October 2008. It is important to monitor post-implementation effectiveness of HPV-vaccination at the population-level. We studied HPV-prevalence after first invitation to screening at age 23 years in women offered the quadrivalent HPV-vaccine at the age of 14 years. Randomly selected screening samples from women born in 1994 in four out of five Danish [...]

Mené aux Etats-Unis sur 16 136 enfants et adolescents (âge moyen : 12 ans), cet essai randomisé évalue l'intérêt, pour améliorer le taux de vaccination contre le papillomavirus humain et le respect du schéma vaccinal complet, d'interventions prodiguées en 7 étapes à différents intervenants (professionnels de santé et patients)

Improving HPV Vaccination Rates: A Stepped-Wedge Randomized Trial

Perkins, Rebecca B. ; Legler, Aaron ; Jansen, Emily ; Bernstein, Judith ; Pierre-Joseph, Natalie ; Eun, Terresa J. ; Biancarelli, Dea L. ; Schuch, Thomas J. ; Leschly, Karin ; Fenton, Anny T.H.R. ; Adams, William G. ; Clark, Jack A. ; Drainoni, Mari-Lynn ; Hanchate, Amresh

OBJECTIVES: To evaluate the effectiveness of a stepped-wedge randomized trial of Development of Systems and Education for Human Papillomavirus Vaccination (DOSE HPV), a multilevel intervention. METHODS: DOSE HPV is a 7-session program that includes interprofessional provider education, communication training, data feedback, and tailored systems change. Five primary care pediatric and/or family medicine practices completed interventions between 2016 and 2018; all chose to initiate vaccination at [...]

A partir d'une revue systématique de la littérature (13 articles), cette étude décrit les facteurs individuels, interpersonnels, organisationnels, sociétaux entravant ou facilitant la vaccination contre le papillomavirus humain dans les populations rurales des États-Unis

Barriers and facilitators to HPV vaccine uptake among US rural populations: a scoping review

Peterson, Caryn E. ; Silva, Abigail ; Holt, Hunter K. ; Balanean, Alexandrina ; Goben, Abigail H. ; Dykens, Jon Andrew

Purpose: Compared to US urban populations, rural residents have a higher incidence of HPV-related cancer and lower HPV vaccine coverage. This study determined what is known about barriers and facilitators to vaccine uptake in US rural settings. Methods: A scoping review was conducted to describe individual, interpersonal, organizational, and community/societal barriers and facilitators to HPV vaccine initiation and completion among US rural populations and to identify gaps in the current [...]

Menée par questionnaire auprès de 955 jeunes patients ayant survécu à un cancer et ne recevant plus de traitement depuis 1 à 5 ans (âge moyen : 16,3 ans ; 54 % de garçons), cette étude analyse les facteurs associés à un manque d'information concernant la vaccination contre le papillomavirus humain

Patient-Level Factors Associated With Lack of Health Care Provider Recommendation for the Human Papillomavirus Vaccine Among Young Cancer Survivors

Jocelyn M. York ; James L. Klosky ; Yanjun Chen ; James A. Connelly ; Karen Wasilewski-Masker ; Anna R. Giuliano ; Leslie L. Robison ; F. Lennie Wong ; Melissa M. Hudson ; Smita Bhatia ; Wendy Landier

PURPOSE: Young cancer survivors are at increased risk for morbidities related to infection with the human papillomavirus (HPV), yet their HPV vaccine initiation rates remain low. Patient-/parent-reported lack of health care provider recommendation for HPV vaccination is strongly associated with vaccine noninitiation. We aimed to identify patient-level factors associated with survivor-/parent-reported lack of provider recommendation for HPV vaccination among young cancer survivors. METHODS: [...]