Menée à partir de données américaines portant sur 55 873 applicateurs de produits phytosanitaires, cette étude analyse l'association entre le temps d'exposition à 38 pesticides et le risque de carcinome à cellules rénales (308 cas)

Occupational Pesticide Use and Risk of Renal Cell Carcinoma in the Agricultural Health Study

Gabriella Andreotti ; Laura E. Beane Freeman ; Joseph J. Shearer ; Catherine C. Lerro ; Stella Koutros ; Christine G. Parks ; Aaron Blair ; Charles F. Lynch ; Jay H. Lubin ; Dale P. Sandler ; Jonathan N. Hofmann

Background: Agricultural work and occupational pesticide use have been associated with increased risk of renal cell carcinoma (RCC), the most common form of kidney cancer. However, few prospective studies have investigated links to specific pesticides. Objective: We evaluated the lifetime use of individual pesticides and the incidence of RCC. Methods: We evaluated the associations between intensity-weighted lifetime days (IWDs) of 38 pesticides and incident RCC in the Agricultural Health Study, [...]

Menée en Iran sur la période 2004-2008 auprès de 50 045 personnes (âge moyen : 52 ans ; 57,5 % de femmes), cette étude analyse l'association entre une utilisation domestique de carburant (biomasse, kérosène ou gaz naturel) et le risque de cancer gastro-intestinal (962 cas)

Household Fuel Use and the Risk of Gastrointestinal Cancers: The Golestan Cohort Study

Mahdi Sheikh ; Hossein Poustchi ; Akram Pourshams ; Masoud Khoshnia ; Abdolsamad Gharavi ; Mahdi Zahedi ; Gholamreza Roshandel ; Sadaf G. Sepanlou ; Abdolreza Fazel ; Maryam Hashemian ; Behrooz Abaei ; Masoud Sotoudeh ; Arash Nikmanesh ; Shahin Merat ; Arash Etemadi ; Siavosh Nasseri Moghaddam ; Farhad Islami ; Farin Kamangar ; Paul D. Pharoah ; Sanford M. Dawsey ; Christian C. Abnet ; Paolo Boffetta ; Paul Brennan ; Reza Malekzadeh

Background: Three billion people burn nonclean fuels for household purposes. Limited evidence suggests a link between household fuel use and gastrointestinal (GI) cancers. Objectives: We investigated the relationship between indoor burning of biomass, kerosene, and natural gas with the subsequent risk of GI cancers. Methods: During the period 2004–2008, a total of 50,045 Iranian individuals 40–75 years of age were recruited to this prospective population-based cohort. Upon enrollment, validated [...]

Menée en Suède à partir de données du registre national des cancers portant sur 31 415 hommes atteints d'un cancer de la prostate et sur 154 812 témoins, cette étude analyse l'association entre la durée d'un diabète sucré de type 2 et des traitements anti-diabétiques et le risque de développer un cancer de la prostate

Association of type 2 diabetes mellitus and antidiabetic medication with risk of prostate cancer: a population-based case-control study

Lin, E. ; Garmo, Hans ; Van Hemelrijck, Mieke ; Adolfsson, Jan ; Stattin, Pär ; Zethelius, Björn ; Crawley, Danielle

Background: Prostate cancer (PCa) and type 2 diabetes mellitus (T2DM) are prevalent conditions that often occur concomitantly. However, many aspects of the impact of T2DM, particularly the duration of T2DM and antidiabetic medications, on PCa risk are poorly understood. Methods: To assess the association of duration of T2DM and antidiabetic medication with PCa risk, we designed a matched case-control study, including 31,415 men with PCa and 154,812 PCa-free men in Prostate Cancer data Base [...]

Menée à partir de données des cohortes "the Nurses’ Health Study", "the Nurses’ Health Study II" et "the Health Professionals Follow-Up Study" portant sur 175 871 utilisateurs d'inhibiteurs de la pompe à protons et 208 831 utilisateurs d'antagonistes des récepteurs H2, cette étude analyse l'association entre ces médicaments antiacides et le risque de cancer colorectal (3 668 cas)

Acid-suppressive medications and risk of colorectal cancer: results from three large prospective cohort studies

Babic, Ana ; Zhang, Xuehong ; Morales-Oyarvide, Vicente ; Yuan, Chen ; Khalaf, Natalia ; Khalili, Hamed ; Lochhead, Paul ; Chan, Andrew T. ; Ogino, Shuji ; Wolpin, Brian M. ; Wu, Kana ; Fuchs, Charles S. ; Giovannucci, Edward L. ; Stampfer, Meir J. ; Ng, Kimmie

Background: Despite several plausible biological mechanisms linking proton pump inhibitors (PPIs) and H2 receptor antagonists (H2RAs) with colorectal tumorigenesis, their association with risk of colorectal cancer (CRC) has not been adequately assessed in prospective epidemiological studies. Methods: We evaluated the association of acid-suppressive medication use with CRC risk among 175,871 (PPI) and 208,831 (H2RA) participants from three large prospective cohort studies. Medication use was [...]

Menée en Corée à partir de données de l'assurance maladie portant sur près de 2 millions d'hommes de plus de 50 ans, cette étude analyse l'association entre le tour de taille (obésité abdominale), l'indice de masse corporelle et le risque de cancer de la prostate (22 584 cas)

Does increased body mass index lead to elevated prostate cancer risk? It depends on waist circumference

Choi, Jin Bong ; Myong, Jun-Pyo ; Lee, Yunhee ; Kim, Inah ; Kim, Jung Ho ; Hong, Sung-Hoo ; Ha, U. Syn

Background: We examined the association between obesity and prostate cancer based on both body mass index (BMI) and waist circumference (WC) using the National Health Insurance System (NHIS) database for the entire male population of Korea. Methods: A total of 1,917,430 men who underwent at least one health examination in 2009 without a previous diagnosis of any other cancer were tracked through December 2015. The hazard ratio (HR) and 95% confidence interval (CI) value for the association [...]

Menée auprès de 959 patients pédiatriques atteints d'une leucémie aiguë lymphoblastique et 2 624 témoins, cette étude analyse l'intérêt d'intégrer des données du phénome dans les études d'association sur le génome entier pour identifier des relations génotype-phénotype et des loci de susceptibilité à la maladie

Leveraging Genome and Phenome-Wide Association Studies to Investigate Genetic Risk of Acute Lymphoblastic Leukemia

Semmes, Eleanor C. ; Vijayakrishnan, Jayaram ; Zhang, Chenan ; Hurst, Jillian H. ; Houlston, Richard S. ; Walsh, Kyle M.

Background: Genome-wide association studies (GWAS) of childhood cancers remain limited, highlighting the need for novel analytic strategies. We describe a hybrid GWAS and phenome-wide association study (PheWAS) approach to uncover genotype–phenotype relationships and candidate risk loci, applying it to acute lymphoblastic leukemia (ALL). Methods: PheWAS was performed for 12 ALL SNPs identified by prior GWAS and two control SNP-sets using UK Biobank data. PheWAS-traits significantly associated [...]