Menée aux Etats-Unis à partir de données portant sur 213 patients atteints d’un cancer, cette étude rétrospective analyse l’association entre une utilisation de vitamine D et le risque de colite induite par les inhibiteurs de points de contrôle immunitaire

Vitamin D intake is associated with decreased risk of immune checkpoint inhibitor-induced colitis

Shilpa Grover, Michael Dougan, Kevin Tyan (et al.)

Background : There is a lack of predictive markers informing on the risk of colitis in patients treated with immune checkpoint inhibitors (ICIs). The aim of this study was to identify potential factors associated with development of ICI colitis. Methods : We performed a retrospective analysis of melanoma patients at Dana-Farber Cancer Institute who received PD-1, CTLA-4, or combination ICIs between May 2011 to October 2017. Clinical and laboratory characteristics associated with pathologically [...]

A partir d’une revue systématique de la littérature publiée jusqu’en août 2019 (12 études, 587 patients), cette méta-analyse évalue les effets de l’art-thérapie sur la qualité de vie de patients atteints d’un cancer

Effects of art therapy in cancer care: A systematic review and meta-analysis

Xiao-Han Jiang, Xi-Jie Chen, Qin-Qin Xie, Yong-Shen Feng (et al.)

Objective : To evaluate the effect of art therapy on cancer patients' quality of life and physical and psychological symptoms. Methods : The databases PubMed, Embase, Web of Science, The Cochrane Library, Clinical Trial.gov, the China National Knowledge Infrastructure (CNKI), Wanfang and the Chinese Biomedical Literature Database (CBM) were searched from their inception up to 20 August 2019. Trials examining the effects of art therapy on physical and psychological symptoms and quality of life [...]

Menée auprès de 45 patients pédiatriques ayant survécu à une leucémie lymphoblastique aiguë, de 27 frères et sœurs des patients, auprès de 45 témoins et de 41 frères et sœurs des témoins (âge : 8-18 ans), cette étude analyse les facteurs associés à des troubles du sommeil

Sleep Disturbances in Survivors of Pediatric Acute Lymphoblastic Leukemia and Their Siblings

K Brooke Russell, Erin L Merz, Kathleen Reynolds, Fiona Schulte, Lianne Tomfohr-Madsen (et al.)

Objective : Sleep disturbances have been identified by patients with cancer as common and distressing; however, conflicting evidence about the prevalence of these outcomes exists for survivors of childhood cancers. Additionally, little is known about how the experience of cancer might impact survivor siblings’ sleep. The current study compared the sleep of survivors of acute lymphoblastic leukemia who were 2–7?years off therapy and their siblings to healthy control/sibling dyads. Methods : [...]

A partir d’une revue systématique de la littérature (20 études, 1 223 patients), cette méta-analyse évalue l’efficacité des interventions d’exercices physiques pour améliorer la santé physique et psychique de patients ayant survécu à un cancer colorectal

Exercise intervention for post-treatment colorectal cancer survivors: a systematic review and meta-analysis

Ruitong Gao, Tianzhuo Yu, Lu Liu, Jiasi Bi, Huiying Zhao(et al.)

Purpose : This study aimed to explore the effects of exercise on post-treatment colorectal cancer survivors through a systematic review and meta-analysis as the current information is limited and controversial. Methods : We searched PubMed, Web of Science, Embase, and Cochrane Library databases for randomized controlled trials that focused on exercise intervention for adult colorectal cancer survivors who had completed primary cancer treatment. We extracted and pooled information regarding [...]

Menée en Corée à partir de données portant sur 67 patients adultes ayant survécu plus de 2 ans à un cancer (âge médian : 46 ans), cette étude rétrospective analyse les effets, sur la qualité de vie, d’une greffe de cellules souches hématopoïétiques

Late complications and quality of life assessment for survivors receiving allogeneic hematopoietic stem cell transplantation

Jaekyung Cheon, Yoo Jin Lee, Jae-Cheol Jo, Kukju Kweon (et al.)

Purpose : The survival rates of patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT) have improved. However, HSCT can induce significant long-term complications. Therefore, we investigated the late complications and risk factors for quality of life (QOL) post-HSCT. Methods : We retrospectively analyzed 67 adult survivors over 2 years after HSCT between 2015 and 2018 at Ulsan University Hospital, Ulsan, Korea. The survey data including FACT-BMT, Hospital Anxiety and [...]

Menée en Allemagne auprès de 54 patientes atteintes d’un cancer du sein, cette étude compare l’intérêt de deux méthodes, une subjective par questionnaire et une objective par accéléromètre, pour caractériser et mesurer leurs troubles du sommeil au début d’une chimiothérapie néoadjuvante

Comparison of subjectively and objectively assessed sleep problems in breast cancer patients starting neoadjuvant chemotherapy

Charlotte Kreutz, Jana Müller, Martina E. Schmidt, Karen Steindorf

Purpose : To characterize sleep problems and to compare subjective and objective assessments in breast cancer patients starting neoadjuvant chemotherapy. Methods : Sleep characteristics of 54 breast cancer patients starting neoadjuvant chemotherapy were analyzed. Subjective sleep characteristics were assessed with the Pittsburgh Sleep Quality Index (PSQI) and objective sleep measurements with an accelerometer (ActiGraph wGT3X-BT) worn on the wrist for 7 consecutive days. Results : According to [...]

Menée aux Pays-Bas à partir de données portant sur 560 patients atteints d’un cancer de la tête et du cou, cette étude transversale analyse les facteurs associés à des troubles du sommeil

Poor sleep quality among newly diagnosed head and neck cancer patients: prevalence and associated factors

Angelina M. M. Santoso, Femke Jansen, Birgit I. Lissenberg-Witte (et al.)

Background : Head and neck cancer (HNC) patients often suffer from distress attributed to their cancer diagnosis which may disturb their sleep. However, there is lack of research about poor sleep quality among newly diagnosed HNC patients. Therefore, our aim was to investigate the prevalence and the associated factors of poor sleep quality among HNC patients before starting treatment. Materials and methods : A cross-sectional study was conducted using the baseline data from NET-QUBIC study, an [...]

Menée au Japon à partir de données portant sur 38 patients atteints d’un cancer de l’oropharynx ou de l’hypopharynx, cette étude prospective analyse l’association entre des difficultés de déglutition et leurs capacités d'ingestion pendant une chimioradiothérapie

Simultaneous evaluation of symptoms, swallowing functions, and patient-reported swallowing difficulties and their correlations with ingestion status during definitive chemoradiotherapy for oropharyngeal and hypopharyngeal cancer

Ryo Ishii, Kengo Kato, Akira Ohkoshi, Takeshi Sato (et al.)

Purpose : To clarify the correlations among symptoms, swallowing functions, and ingestion status and to validate a method of swallowing evaluation during chemoradiotherapy (CRT) for head and neck cancer. Methods : Oropharyngeal and hypopharyngeal cancer patients who were to receive definitive CRT as initial treatment were included in this prospective, single-center, observational study. The Functional Oral Intake Scale (FOIS) for ingestion status and grades of symptoms (dryness, dysgeusia, [...]

Menée aux Etats-Unis auprès de 8 002 participants âgés de 45 ans ou plus (âge moyen : 69.8 ans), cette étude de cohorte prospective analyse l’association entre des comportements sédentaires et la mortalité par cancer (durée moyenne de suivi : 5,3 ans)

Association of Sedentary Behavior With Cancer Mortality in Middle-aged and Older US Adults

Susan C. Gilchrist, Virginia J. Howard, Tomi Akinyemiju (et al.)

Importance : Sedentary behavior is associated with several health outcomes, including diabetes, cardiovascular disease, and all-cause mortality. Less is known about the association between objectively measured sedentary behavior and cancer mortality, as well as the association with physical activity. Objective : To examine the association between accelerometer-measured sedentary behavior (total volume and accrual in prolonged, uninterrupted bouts) and cancer mortality. Design, Setting, and [...]

Menée en Australie à partir de données portant sur 678 et 512 patientes atteintes d’un cancer de l’ovaire, cette étude de cohorte analyse l’impact, sur la survie, d’un mode de vie sain mesuré avant et après le diagnostic de la maladie, et défini par un indicateur prenant en compte les pratiques tabagiques, l’indice de masse corporelle, l’activité physique et la consommation d’alcool

A healthy lifestyle and survival among women with ovarian cancer

Jessy M Hansen, Christina M Nagle, Torukiri I Ibiebele (et al.)

Ovarian cancer has a poor survival rate and, understandably, women often want to know whether there is anything they can do to improve their prognosis. Our goal was to investigate the association between a healthy lifestyle pre? and post?diagnosis and survival in a cohort of Australian women with invasive epithelial ovarian cancer. We calculated a healthy lifestyle index (HLI) based on women's self?reported smoking status, height, weight, physical activity, diet and alcohol consumption before [...]

Menée aux Etats-Unis à partir de données portant sur 44 patients ayant reçu une greffe d’organe, cette étude analyse les facteurs associés au risque de développer un cancer du poumon ainsi que la survie globale

Characteristics and Outcomes of Lung Cancer in Solid Organ Transplant Recipients

Lanyi Nora Chen, John Spivack, Thu Cao (et al.)

Objectives : Lung cancer is the third most common malignancy that develops in patients following solid organ transplantation and is the leading cause of cancer deaths in the general population. The aims of this study are to examine the characteristics of patients who developed lung cancer following solid organ transplantation at our institution and to compare their outcomes to those of lung cancer patients without a history of transplant. Materials and methods : We performed a [...]

Menée en Finlande sur la période 2000-2015 à partir de données portant sur 1 671 patients atteints d’un cancer colorectal, cette étude analyse les facteurs associés au risque de métastases colorectales synchrones et métachrones

Incidence and management of patients with colorectal cancer and synchronous and metachronous colorectal metastases: a population-based study

V. Väyrynen, E.-V. Wirta, T. Seppälä (et al.)

Background : This population?based study aimed to examine the incidence, patterns and results of multimodal management of metastatic colorectal cancer. Methods : A retrospective population?based study was conducted on patients with metastatic colorectal cancer in Central Finland in 2000–2015. Clinical and histopathological data were retrieved and descriptive analysis was conducted to determine the pattern of metastatic disease, defined as synchronous, early metachronous (within 12?months of [...]

Menée à partir des données du registre écossais des cancers portant sur 72 217 patientes atteintes d’un cancer primitif du sein diagnostiqué entre 1997 et 2016, cette étude analyse l’évolution de l’incidence de la maladie par sous-type moléculaire

Distinct temporal trends in breast cancer incidence from 1997 to 2016 by molecular subtypes: a population-based study of Scottish cancer registry data

Ines Mesa-Eguiagaray, Sarah H. Wild, Philip S. Rosenberg (et al.)

Background : We describe temporal trends in breast cancer incidence by molecular subtypes in Scotland because public health prevention programmes, diagnostic and therapeutic services are shaped by differences in tumour biology. Methods : Population-based cancer registry data on 72,217 women diagnosed with incident primary breast cancer from 1997 to 2016 were analysed. Age-standardised rates (ASR) and age-specific incidence were estimated by tumour subtype after imputing the 8% of missing [...]

A partir d’une revue de la littérature publiée sur la période 2000-2019, cette étude analyse les changements dans la composition corporelle des patients atteints d’un cancer de la tête et du cou pendant les traitements anticancéreux à visée curative

Body composition changes in patients with head and neck cancer under active treatment: a scoping review

Bárbara Ferrão, Pedro Miguel Neves, Teresa Santos (et al.)

Background : Head and neck cancer patients have the second highest malnutrition prevalence, when compared with other oncological patients. They experience significant weight loss before diagnosis, during and after treatment, and even during the first year of follow-up. However, the prognostic value of weight loss depends on body mass index, and this may be associated with low skeletal muscle mass, masking its loss. Thus, weight loss itself poorly predicts outcome in head and neck cancer [...]

Menée au Royaume-Uni auprès de 17 patients atteints d’un cancer et souffrant de démence, de 22 membres de leur famille et de 19 soignants, cette étude ethnographique analyse leurs expériences concernant le processus de prise de décision thérapeutique

Decision-making in cancer care for people living with dementia

Alys Wyn Griffiths, Laura Ashley, Rachael Kelley (et al.)

Objective : Increasing numbers of people are expected to live with comorbid cancer and dementia. Cancer treatment decision?making for these individuals is complex, particularly for those lacking capacity, requiring support across the cancer care pathway. There is little research to inform practice in this area. This ethnographic study reports on the cancer decision?making experiences of people with cancer and dementia, their families, and healthcare staff. Methods : Participant observations, [...]

Menée en Suède à partir de données portant sur 2 822 patients ayant survécu à un cancer pendant l’adolescence (âge au diagnostic : 13-19 ans) et sur 28 220 témoins, cette étude de cohorte analyse les facteurs associés au risque de troubles psychiques et à l’utilisation de médicaments psychotropes

Increased risk of mental health problems after cancer during adolescence: a register based cohort study

Emma Hovén, Rickard Ljung, Gustaf Ljungman, Lisa Ljungman (et al.)

In this nationwide, register-based study, we estimated the risk of mental health problems in 2,822 individuals diagnosed with cancer in adolescence (13-19 years). Mental health problems were assessed by psychiatric diagnoses and/or prescribed psychotropic drugs. Cox proportional hazards models estimated hazard ratio (HR) for a psychiatric diagnosis and prescription of psychotropic drug compared to a matched comparison group (n=28,220). Estimates were adjusted for calendar period and parent [...]

Menée aux Etats-Unis à partir de données 2011, 2016 et 2017 portant sur des patients ayant survécu à un cancer, cette étude analyse les facteurs associés aux changements de leur situation professionnelle depuis le diagnostic de la maladie

Employment Outcomes among Cancer Survivors in the United States: Implications for Cancer Care Delivery

Janet S de Moor, Erin E Kent, Timothy S McNeel (et al.)

The national prevalence of employment changes after a cancer diagnosis has not been fully documented. Cancer survivors who worked for pay at or since diagnosis (n=1,490) were identified from the 2011, 2016 and 2017 Medical Expenditure Panel Survey and Experiences with Cancer Supplements. Analyses characterized employment changes due to cancer and identified correlates of those employment changes. Employment changes were made by 41.3% (95% CI=38.0% to 44.6%) of cancer survivors, representing [...]

Menée au Danemark à partir de données portant sur 6 644 frères et sœurs d’enfants atteints d’un cancer diagnostiqué entre 1991 et 2009 et sur 128 436 témoins, cette étude analyse les facteurs associés à l’utilisation d’antidépresseurs dans la fratrie

Antidepressant use in siblings of children with cancer: A Danish population-based cohort study

Lasse Wegener Lund, Jeanette Falck Winther, Luise Cederkvist (et al.)

Siblings of children with cancer experience severe stress early in life. Most studies of mental health problems in these siblings are limited by being small, cross-sectional or self-reporting. In a population-based cohort study, we investigated the risk for antidepressant use by linking several nationwide, population-based registries comparing 6644 siblings of children diagnosed with cancer 1991–2009 with 128.436 population-based sibling comparisons using the Cox proportional hazards model. [...]

Menée en Chine par questionnaire auprès de 244 patients atteints d’un cancer, cette étude analyse l’association entre des symptômes de démoralisation et de dépression, un sentiment d’absence d’espoir et des idées de suicide

Serial multiple mediation of demoralization and depression in the relationship between hopelessness and suicidal ideation

Su Ting Liu, Xia Wu, Ning Wang, Qian Qian Zhao (et al.)

Objective : Suicidal ideation is common in cancer patients and may be associated with hopelessness, demoralization, and depression. This study aims to investigate the serial multiple mediation of demoralization and depression in the relationship between hopelessness and suicidal ideation in cancer patients. Methods : A total of 244 cancer patients were investigated by using the following standardized self-reported questionnaires: Self-rating Idea of Suicide scale (SIOSS), Beck Hopelessness [...]

Menée aux Etats-Unis par enquête auprès de 2 656 patients ayant survécu à un cancer et de 112 982 témoins, cette étude analyse la santé psychique de patients ayant survécu à un cancer (épisodes de dépression, détresse psychologique sévère, pensées suicidaires, tentatives de suicide, maladie psychiatrique, etc.) selon la catégorie d’âge (18-34 ans, 35-49 ans et 50-64 ans)

Mental health among nonelderly adult cancer survivors: A national estimate

Xu Ji, Janet R. Cummings, Jordan Gilleland Marchak (et al.)

Background : This study assessed mental health (MH) outcomes across age groups in a nationally representative US sample of adult cancer survivors. Methods : The 2015 to 2017 National Survey on Drug Use and Health was used to identify respondents aged 18 to 64 years. The authors compared MH outcomes between respondents with a cancer history and respondents without a cancer history in adjusted analyses controlling for demographics and socioeconomic status. Outcomes included past-year major [...]

Menée en Allemagne, cette étude cas-témoins analyse les effets à long terme d’une thérapie anti-androgénique sur les fonctions cognitives et sur les prises de décisions socioéconomiques chez des patients atteints d’un cancer de la prostate

The impact of long-term androgen deprivation therapy on cognitive function and socio-economic decision-making in prostate cancer patients

Holtfrerich Sarah Katharina Charlotte, Knipper Sophie, Purwins Janna (et al.)

Objective : Androgen deprivation therapy (ADT) enhances survival of advanced prostate cancer patients and is therefore used as a concomitant therapy. However, ADT has been reported to cause negative side effects on cognition and emotional processing. So far, research referred to the effects of short-term treatment. Since the brain may adapt to androgen deprivation, we were especially interested in the long-term effects of ADT on cognitive and socio-economic decision-making. Methods : [...]

A partir d’une revue systématique de la littérature publiée entre 2004 et 2019 (30 articles), cette étude analyse le rapport coût-efficacité des interventions utilisant les déterminants sociaux de la santé pour améliorer le dépistage du cancer du sein, du col de l'utérus et du cancer colorectal

Cost-effectiveness of Leveraging Social Determinants of Health to Improve Breast, Cervical, and Colorectal Cancer Screening : A Systematic Review

Giridhar Mohan, Sajal Chattopadhyay

Importance : Screening for breast, cervical, and colorectal cancers in the United States has remained below the Healthy People 2020 goals, with evidence indicating that persistent screening disparities still exist. The US Department of Health and Human Services has emphasized cross-sectoral collaboration in aligning social determinants of health with public health and medical services. Examining the economics of intervening through these novel methods in the realm of cancer screening can inform [...]

Menée dans 4 pays européens par questionnaire auprès de 113 adolescents atteints d’un cancer (âge : 13-20 ans), cette étude analyse leurs connaissances sur les risques d’infertilité induite par les traitements anticancéreux, ainsi que l’information et les conseils dispensés concernant les techniques de préservation de la fertilité

Fertility education for adolescent cancer patients: Gaps in current clinical practice in Europe

Elisabeth Korte, Ralph Schilling, Magdalena Balcerek (et al.)

Objective : As adolescent cancer patients may suffer from infertility following treatment, fertility counselling is essential. Our aim was to explore the current situation in four European countries in terms of (I) education about the risk for infertility, (II) counselling on fertility preservation, (III) patients' knowledge on fertility, (IV) sufficiency of information and (V) uptake of cryopreservation. Methods : In total, 113 patients (13–20 years) at 11 study centres completed a self-report [...]