Menée dans l'Etat de New York à partir de données portant sur 11 590 patients atteints d'un cancer, cette étude analyse les facteurs associés à une utilisation de cannabis thérapeutique entre 2016 et 2017

Patterns of Medical Cannabis Use among Cancer Patients from a Medical Cannabis Dispensary in New York State

Kim Arum ; Kaufmann Christopher N. ; Ko Roxanne ; Li Zujun ; Han Benjamin H.

Background: Research on the patterns of use of medical cannabis among cancer patients is lacking. Objective: To describe patterns of medical cannabis use by patients with cancer, and how patterns differ from patients without cancer. Design/Measurements: We performed secondary data analysis using data from a medical cannabis licensee in New York State, analyzing demographic information, qualifying conditions, and symptoms, and the medical cannabis product used, including tetrahydrocannabinol [...]

A partir d'une revue systématique des essais randomisés (19 essais, 1 276 patients), cette méta-analyse évalue les effets du miel pour prévenir et traiter une mucite buccale induite par une radiochimiothérapie

Prophylactic and therapeutic effects of honey on radiochemotherapy-induced mucositis: a meta-analysis of randomized controlled trials

Liu, Tzu-Ming ; Luo, Yu-Wei ; Tam, Ka-Wai ; Lin, Chia-Chin ; Huang, Tsai-Wei

Purpose : Oral mucositis is a common side effect of radiochemotherapy and may adversely affect the patients’ quality of life (QoL). Honey application may reduce the mucositis grade in patients. Here, we conducted a meta-analysis of randomized controlled trials (RCTs) to evaluate the prophylactic and therapeutic effects of honey on radiochemotherapy-induced oral mucositis. Methods : Publications on RCTs were extracted from the PubMed, Embase, CINAHL, and Cochrane Library databases. The primary [...]

Menée en Corée à partir de données portant sur 1 588 patients hospitalisés pour un cancer, cette étude de cohorte prospective analyse leur statut nutritionnel selon la localisation cancéreuse et le type de traitement reçu, puis évalue leur qualité de vie

Nutritional Status of Patients with Cancer: A Prospective Cohort Study of 1,588 Hospitalized Patients

Na, Byung-Gon ; Han, Sung-Sik ; Cho, Yeong-Ah ; Wie, Gyung-Ah ; Kim, Ji-Yeon ; Lee, Jong-Mog ; Lee, Seung Duk ; Kim, Seong Hoon ; Park, Sang-Jae

Background: We aimed to assess the nutritional status of cancer patients according to site or treatment type. Methods: We prospectively evaluated the nutritional status of 1,588 patients based on cancer site and treatment type using the Patient-Generated Subjective Global Assessment tool. We also investigated length of stay (LOS), complication rates after surgery and quality of life (QoL). Results: The patients with esophageal, pancreaticobiliary, and lung cancer had higher malnutrition rates [...]

A partir d'une revue systématique de la littérature (14 études, 1 254 patients), cette étude analyse les facteurs associés à la qualité de vie d'enfants atteints d'un cancer entre 2 et 18 ans et ayant survécu jusqu'à 5 ans après la fin des traitements

Health-related quality of life in paediatric patients up to five years post-treatment completion for acute lymphoblastic leukaemia: a systematic review

Garas, Andrew ; McLean, Louise A. ; De Luca, Cinzia R. ; Downie, Peter ; McCarthy, Maria C.

Purpose : Despite survival rates greater than 90%, treatment for paediatric acute lymphoblastic leukaemia (ALL) remains challenging for families. The early post-treatment phase is an especially unique time of adjustment. The primary aim of this review was to identify and synthesise research on health-related quality of life (HRQoL) for patients up to five years post-treatment. The secondary aim was to identify if theorised risk/resistance model factors could explain any variance in reported [...]

Menée en France par questionnaire auprès de 3 317 patients ayant survécu à un lymphome non hodgkinien (1 671 répondants, âge médian : 64 ans), cette étude transversale analyse le degré de sévérité de la fatigue à long terme associée aux traitements anticancéreux

Long-term fatigue in survivors of non-Hodgkin lymphoma: The Lymphoma Study Association SIMONAL cross-sectional study

Mounier, Nicolas ; Anthony, Sabine ; Busson, Raphaël ; Thieblemont, Catherine ; Ribrag, Vincent ; Tilly, Herve ; Haioun, Corinne ; Casasnovas, Rene-Olivier ; Morschhauser, Franck ; Feugier, Pierre ; Delarue, Richard ; Ysebaert, Loic ; Sebban, Catherine ; Broussais-Guillaumot, Florence ; Damaj, Gandhi ; Nerich, Virginie ; Jais, Jean-Philippe ; Laborde, Lilian ; Salles, Gilles ; Henry-Amar, Michel

Background : Long-term survivors of non-Hodgkin lymphoma (NHL) must cope with treatment complications and late toxicities that affect their health-related quality of life. Little is known about the risk-to-benefit ratio of new agents like rituximab. The impact of treatment regimens and health disorders on long-term fatigue levels was investigated in a cross-sectional study. Methods : Two self-administered questionnaires, the 20-item Multidimensional Fatigue Inventory (MFI-20) and a Life [...]

A partir d'une revue systématique de la littérature (47 études, 20 083 patients, âge médian : 61 ans), cette étude analyse les facteurs facilitant ou entravant le retour au travail après un diagnostic de cancer de la prostate

Work after prostate cancer: a systematic review

McLennan, Vanette ; Ludvik, Dominika ; Chambers, Suzanne ; Frydenberg, Mark

Purpose : Research in the field of vocational rehabilitation, specifically for prostate cancer, remains rare despite increasing recognition of the role of vocational interventions in other cancer groups. The aim of this review was to compile and evaluate current trends, facilitators and barriers associated with returning to work after a prostate cancer diagnosis. Method : The literature search was conducted in March 2018 using the Preferred Reporting Items for Systematic Reviews and [...]

Mené sur 100 patientes atteintes d'un cancer du sein de stade I à III (âge moyen : 53,5 ans), cet essai randomisé évalue l'intérêt, du point de vue de la réduction du risque de maladie cardiovasculaire, d'une intervention combinant des exercices d'aérobie et de résistance, et dispensée pendant 16 semaines

Effect of Aerobic and Resistance Exercise Intervention on Cardiovascular Disease Risk in Women With Early-Stage Breast Cancer: A Randomized Clinical Trial

Lee, Kyuwan ; Tripathy, Debu ; Demark-Wahnefried, Wendy ; Courneya, Kerry S. ; Sami, Nathalie ; Bernstein, Leslie ; Spicer, Darcy ; Buchanan, Thomas A. ; Mortimer, Joanne E. ; Dieli-Conwright, Christina M.

Importance : The Framingham Risk Score (FRS) is a valid method for predicting the 10-year risk of developing cardiovascular disease. Higher FRS is reported in patients with early-stage breast cancer who are overweight than in healthy, age-matched women, but whether exercise reduces FRS in this patient population is unclear. Objective : To examine the effects of a 16-week aerobic and resistance exercise intervention on the FRS in women with early-stage breast cancer and with overweight condition [...]

Mené en Suède sur 240 patientes atteintes d'un cancer du sein de stade I-IIIa, cet essai randomisé évalue l'intérêt, 12 mois après le début de la chimiothérapie et du point de vue de la réduction de la fatigue et des symptômes ainsi que du point de vue de la reprise du travail, d'une intervention à base d'exercices physiques de haute intensité dispensée pendant la chimiothérapie

High-intensity exercise during chemotherapy induces beneficial effects 12 months into breast cancer survivorship

Mijwel, Sara ; Jervaeus, Anna ; Bolam, Kate A. ; Norrbom, Jessica ; Bergh, Jonas ; Rundqvist, Helene ; Wengström, Yvonne

Purpose : Whether the benefits of exercise during chemotherapy continue into survivorship is not well-known. Here, the aim was to examine the effects of two exercise interventions on self-reported health-related and objectively measured physiological outcomes 12 months following commencement of chemotherapy. Methods : Two hundred and forty women with breast cancer stage I–IIIa were randomized to 16 weeks of high-intensity aerobic interval training combined with either resistance training [...]

Menée en France auprès de patientes ayant survécu à un cancer du sein (âge : 40-69 ans), cette étude analyse l'intérêt d'un questionnaire, traduit en langue française, permettant d'identifier et de prendre en charge leurs besoins en soins

Translation and perceptions of the French version of the Cancer Survivor Profile-Breast Cancer (CSPro-BC): a tool to identify and manage unmet needs

Tremblay, Dominique ; Bilodeau, Karine ; Durand, Marie-José ; Coutu, Marie-France

Purpose : Worldwide healthcare systems continue to struggle to reduce the unmet needs of a growing population of breast cancer survivors (BCSs). The Cancer Survivor Profile-Breast Cancer (CSPro-BC) survey was developed to address BCS’s specific needs. This study aims to produce a culturally adapted French version of the CSPro-BC. Methods : The CSPro-BC(French) was developed through five steps including back translation, use of a multidisciplinary committee, and pretest with BCS (n = 22). [...]

Menée à partir de données de 25 études conduites en Europe, en Asie et en Amérique et portant sur 9 773 patients atteints d'un cancer de l'estomac et sur 24 373 témoins, cette méta-analyse évalue l'association entre le statut socio-économique (niveau d'éducation, revenus du foyer) et le risque de développer la maladie

Education and gastric cancer risk – An individual participant data meta-analysis in the StoP project consortium

Rota, Matteo ; Alicandro, Gianfranco ; Pelucchi, Claudio ; Bonzi, Rossella ; Bertuccio, Paola ; Hu, Jinfu ; Zhang, Zuo-Feng ; Johnson, Kenneth C. ; Palli, Domenico ; Ferraroni, Monica ; Yu, Guo-Pei ; Galeone, Carlotta ; López-Carrillo, Lizbeth ; Muscat, Joshua ; Lunet, Nuno ; Ferro, Ana ; Ye, Weimin ; Plymoth, Amelie ; Malekzadeh, Reza ; Zaridze, David ; Maximovitch, Dmitry ; Kogevinas, Manolis ; de Larrea, Nerea Fernàndez ; Vioque, Jesús ; Navarrete-Muñoz, Eva M. ; Tsugane, Shoichiro ; Hamada, Gerson S. ; Hidaka, Akihisa ; Pakseresht, Mohammadreza ; Wolk, Alicja ; Håkansson, Niclas ; Hernández-Ramírez, Raúl Ulises ; López-Cervantes, Malaquias ; Ward, Mary ; Pourfarzi, Farhad ; Mu, Lina ; Kurtz, Robert C. ; Lagiou, Areti ; Lagiou, Pagona ; Boffetta, Paolo ; Boccia, Stefania ; Negri, Eva ; La Vecchia, Carlo

Low socioeconomic position (SEP) is a strong risk factor for incidence and premature mortality from several cancers. This study aimed at quantifying the association between SEP and gastric cancer (GC) risk through an individual participant data meta-analysis within the “Stomach cancer Pooling (StoP) Project”. Educational level and household income were used as proxies for the SEP. We estimated pooled odds-ratios (ORs) and the corresponding 95% confidence intervals (CIs) across levels of [...]

Menée aux Etats-Unis à partir de données portant sur 7 114 patients ayant survécu à un cancer colorectal et sur 25 979 témoins, cette étude analyse le risque de développer une maladie endocrinienne ou métabolique

Endocrine and Metabolic Diseases among Colorectal Cancer Survivors in a Population-Based Cohort

JournalBlackburn, Brenna E ; Hawkins, Makenzie L ; Hashibe, Mia ; Snyder, John ; Rowe, Kerry ; Newman, Michael ; Deshmukh, Vikrant G ; Fraser, Alison ; Smith, Ken ; Herget, Kimberly ; Ganz, Patricia A ; Samadder, N Jewel

Background : There are an estimated 1.4 million colorectal cancer (CRC) survivors in the United States. Research on endocrine and metabolic diseases over the long term in CRC survivors is limited. Obesity is a risk factor for CRC, thus it is of interest to investigate diseases that may share this risk factor such as diabetes for long-term health outcomes among CRC survivors. Methods : A total of 7,114 CRC patients were identified from Utah Population Database and matched to a general population [...]

Menée aux Pays-Bas à partir de données portant sur 5 843 patients ayant survécu plus de 5 ans à un cancer pédiatrique diagnostiqué entre 1963 et 2001 et portant sur 883 témoins, cette étude analyse les facteurs associés au risque de développer une tumeur bénigne solide (durée médiane de suivi : 22,7 ans ; 542 cas)

Incidence of and Risk Factors for Histologically Confirmed Solid Benign Tumors Among Long-term Survivors of Childhood Cancer

Kok, Judith L. ; Teepen, Jop C. ; van der Pal, Helena J. ; van Leeuwen, Flora E. ; Tissing, Wim J. E. ; Neggers, Sebastian J. C. M. M. ; Loonen, Jacqueline J. ; Louwerens, Marloes ; Versluys, Birgitta ; van den Heuvel-Eibrink, Marry M. ; van Dulmen-den Broeder, Eline ; Jaspers, Monique M. W. ; van Santen, Hanneke M. ; van der Heiden-van der Loo, Margriet ; Janssens, Geert O. ; Maduro, John H. ; Bruggink, Annette H. ; Jongmans, Marjolijn C. ; Kremer, Leontien C. M. ; Ronckers, Cecile M. ; for the DCOG-LATER Study Group

Importance : Survivors of childhood cancer (CCSs) face risk of developing subsequent tumors. Solid benign tumors may be cancer precursors; benign tumors and cancers may share etiologic factors. However, comprehensive data on the risk for solid benign tumors are lacking. Objective : To quantify the incidence of and treatment-related risk factors for histologically confirmed solid nonskin benign tumors among CCSs. Design, Setting, and Participants : This record linkage study involves the Dutch [...]

Menée en Suisse à partir des données d'une enquête menée entre 1988 et 1994 auprès de 17 483 participants suivis jusqu'en 2011, cette étude analyse l'association entre l'indice de masse corporelle, une pratique tabagique, la mortalité toutes causes confondues et la mortalité par cancer

Joints effects of BMI and smoking on mortality of all-causes, CVD, and cancer

Luijckx, Eefje ; Lohse, Tina ; Faeh, David ; Rohrmann, Sabine

Obesity, underweight, and smoking are associated with an increased mortality. We investigated the joint effects of body mass index and smoking on all-cause and cause-specific mortality. Data of the Third National Health and Nutrition Examination Survey (1988–1994) including mortality follow-up until 2011 were used (n = 17,483). Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause, cardiovascular disease (CVD), and cancer [...]

Cette étude passe en revue les recommandations et les essais récents concernant la prise en charge de patients atteints d'une thromboembolie veineuse associée aux traitements anticancéreux

Treatment of cancer-associated venous thromboembolism in the age of direct oral anticoagulants

Pabinger, I ; Ay, C ; Beyer-Westendorf, J

Anticoagulation for cancer-associated venous thromboembolism (VTE) can be challenging due to complications—including bleeding and potential drug-drug interactions with chemotherapy—associated with vitamin K antagonists and inconvenience of low-molecular-weight heparin (LMWH). Direct oral anticoagulants (DOACs) could partially overcome these issues, but until recently there were no large clinical trials assessing their efficacy and safety in cancer patients.This review summarizes clinical [...]

A partir d'une revue systématique de la littérature publiée jusqu'en décembre 2018 (32 études), cette méta-analyse évalue l'association entre la durée du sommeil et la mortalité par cancer, chez des patients ayant survécu à la maladie

The association between sleep duration and cancer-specific mortality: a systematic review and meta-analysis

Stone, Chelsea R. ; Haig, Tiffany R. ; Fiest, Kirsten M. ; McNeil, Jessica ; Brenner, Darren R. ; Friedenreich, Christine M.

Purpose : In this systematic review and meta-analysis, we aimed to estimate cancer-specific mortality and all-cause mortality among cancer survivors associated with both short (typically 5 or 6 h/night) and long (typically 9 or 10 h/night) sleep duration (versus recommendations), separately by sex, cancer site, and sampling frame. Methods : We completed a systematic literature search in five databases and captured relevant literature published through December 2018. Two reviewers independently [...]

Menée à partir des données de 13 études portant sur 7 022 patientes atteintes d'un carcinome épithélial de l'ovaire de stade invasif, cette étude analyse l'association entre une pratique tabagique, un surpoids ou une obésité, l'absence d'activité physique et la survie globale ainsi que la survie sans progression

Joint exposure to smoking, excessive weight, and physical inactivity and survival of ovarian cancer patients, evidence from the Ovarian Cancer Association Consortium

Minlikeeva, Albina N. ; Cannioto, Rikki ; Jensen, Allan ; Kjaer, Susanne K. ; Jordan, Susan J. ; Diergaarde, Brenda ; Szender, J. Brian ; Odunsi, Kunle ; Almohanna, Hani ; Mayor, Paul ; Starbuck, Kirsten ; Zsiros, Emese ; Bandera, Elisa V. ; Cramer, Daniel W. ; Doherty, Jennifer A. ; Defazio, Anna ; Edwards, Robert ; Goode, Ellen L. ; Goodman, Marc T. ; Høgdall, Estrid ; Matsuo, Keitary ; Mizuno, Mika ; Nagle, Christina M. ; Ness, Roberta B. ; Paddock, Lisa E. ; Pearce, Celeste L. ; Risch, Harvey A. ; Rossing, Mary Anne ; Terry, Kathryn L. ; Wu, Anna H. ; Modugno, Francesmary ; Webb, Penelope M. ; Moysich, Kirsten B. ; the Australian Ovarian Cancer Study Group ; the Ovarian Cancer Association Consortium

Purpose : Previous epidemiologic studies have shown that smoking, obesity, and physical inactivity are associated with poor survival following a diagnosis of ovarian cancer. Yet, the combined relationship of these unfavorable lifestyle factors on ovarian cancer survival has not been sufficiently investigated. Methods : Using data pooled from 13 studies, we examined the associations between combined exposures to smoking, overweight/obesity weight, and physical inactivity and overall survival [...]

A partir des données des registres américains des cancers portant sur 1 450 837 patients ayant survécu à un cancer localisé non pulmonaire diagnostiqué entre 1992 et 2008, cette étude analyse les facteurs associés au risque de développer un cancer primitif du poumon et au risque de décès lié à la maladie (durée moyenne de suivi : 5,7 ans ; 25 472 cas de second cancer)

Second primary lung cancer in United States Cancer Survivors, 1992–2008

Donin, Nicholas M. ; Kwan, Lorna ; Lenis, Andrew T. ; Drakaki, Alexandra ; Chamie, Karim

Purpose : Lung cancer is common and lethal, and can occur in survivors of previous cancers. We sought to describe the incidence and mortality attributable to second primary lung cancers (SPLC) among survivors of other cancers, and to identify survivors at highest risk. Methods : We identified adults diagnosed with a localized malignancy from non-pulmonary cancer sites from surveillance, epidemiology, and end results (SEER) data from 1992 to 2008. We explored factors associated with the [...]

Menée en France à partir de données portant sur 529 patients atteints d'un cancer du poumon à petites cellules, cette étude analyse, sur la période 1997-2017, les facteurs associés à l'évolution de la réponse aux chimiothérapies et de la survie associée

Trends in Response Rate and Survival in Small-Cell Lung Cancer Patients Between 1997 and 2017

Lattuca-Truc, Mickaël ; Timsit, Jean-François ; Levra, Matteo Giaj ; Ruckly, Stéphane ; Villa, Julie ; Dumas, Isabelle ; Pinsolle, Julian ; Ferrer, Léonie ; Guillem, Pascale ; Moro-Sibilot, Denis ; Toffart, Anne-Claire

Introduction : Median survival of small-cell lung cancer (SCLC) patients is usually around 1 year. The advent of new drugs may have slightly improved their prognosis. We aimed to assess whether SCLC response to chemotherapy and survival had changed over time. Methods : Consecutive SCLC patients were included at Grenoble University Hospital, France. We compared the patients’ characteristics, response to chemotherapy and survival between 1997-2009 (period 1) and 2010-2017 (period 2). Results : A [...]

Menée au Japon à partir de données portant sur 1 547 patients atteints d'un cancer du poumon non à petites cellules de stade IV, cette étude analyse l'évolution de la survie globale sur la période 1995-2017

Improvement in the survival of patients with stage IV non-small-cell lung cancer: Experience in a single institutional 1995-2017

Takano, Natsuki ; Ariyasu, Ryo ; Koyama, Junji ; Sonoda, Tomoaki ; Saiki, Masafumi ; Kawashima, Yosuke ; Oguri, Tomoyo ; Hisakane, Kakeru ; Uchibori, Ken ; Nishikawa, Shingo ; Kitazono, Satoru ; Yanagitani, Noriko ; Ohyanagi, Fumiyoshi ; Horiike, Atsushi ; Gemma, Akihiko ; Nishio, Makoto

Objectives : In the past two decades several antineoplastic agents have been approved for the treatment of advanced non-small-cell lung cancer (NSCLC), and the management of these patients has drastically changed. However, there is limited information regarding the impact of these advances on patient survival in clinical practice. Materials and methods : We analyzed the survival of patients with stage IV NSCLC who received any treatment in the Cancer Institute Hospital of the Japanese [...]

Menée en Guadeloupe à partir de données portant sur 326 patients atteints d'un cancer localisé de la prostate traité par prostatectomie radicale, cette étude de cohorte évalue l'effet, sur le risque de récidive biochimique (durée médiane de suivi : 6,1 ans après le traitement chirurgical), d'une exposition au chlordécone, au DDE (dichlorodiphényldichloroéthylène) ou au PCB-135 (biphényle polychloré non apparenté à la dioxine)

Endocrine Disrupting-Chemicals and Biochemical Recurrence of Prostate Cancer after Prostatectomy: A cohort study in Guadeloupe (French West Indies)

Brureau, Laurent ; Emeville, Elise ; Helissey, Carole ; Thome, Jean Pierre ; Multigner, Luc ; Blanchet, Pascal

Previous studies have suggested that exposure to environmental chemicals with hormonal properties, also called endocrine disrupting chemicals, may be involved in the occurrence of prostate cancer. Such exposure may also influence the treatment outcome as it is still present at the time of diagnosis, the beginning of therapy, and beyond. We followed 326 men in Guadeloupe (French West Indies) who underwent radical prostatectomy as primary treatment of localized prostate cancer. We analyzed the [...]

Menée aux Etats-Unis à partir des données de deux cohortes incluant au total 8 936 patientes atteintes d'un cancer du sein de stade I-III, cette étude évalue l'association entre une exposition à des particules fines et la mortalité spécifique

Particulate Matter and Traffic-Related Exposures in Relation to Breast Cancer Survival

DuPré, Natalie C. ; Hart, Jaime E. ; Holmes, Michelle D. ; Poole, Elizabeth M. ; James, Peter ; Kraft, Peter ; Laden, Francine ; Tamimi, Rulla M.

Background: Although particulate matter (PM) has not been consistently associated with breast cancer risk, two studies have reported harmful associations for breast cancer survival. We examined PM exposures and breast cancer survival in two U.S.-based prospective cohort studies. Methods: The Nurses' Health Study (NHS) and NHSII are cohorts with detailed data on medical history, lifestyle factors, and causes of death. Women with Stage I–III breast cancer (n = 8,936) were followed through June [...]

Menée au Royaume-Uni à partir de données portant sur 2 540 patientes atteintes d'un cancer du sein traité par mastectomie, cette étude analyse l'impact, sur le délai avant le traitement adjuvant, d'une reconstruction mammaire consécutive au traitement chirurgical

The impact of immediate breast reconstruction on the time to delivery of adjuvant therapy: the iBRA-2 study

O’Connell, Rachel L. ; Rattay, Tim ; Dave, Rajiv V. ; Trickey, Adam ; Skillman, Joanna ; Barnes, Nicola L. P. ; Gardiner, Matthew ; Harnett, Adrian ; Potter, Shelley ; Holcombe, Chris ; Blazeby, Jane ; Conroy, Elizabeth ; O’Brien, Ciara ; O’Connell, Rachel ; Williamson, Paula ; Curnier, Alain ; Tadros, Amir ; Depasquale, Ivan ; Smyth, Yazan A. Masannat Elizabeth ; Fuller, Mairi ; Bourne, Roger ; Heys, Steven ; Hamo, Ishrak ; Aloraifi, Fatima ; Fopp, Laura ; Bali, Radhika ; Bache, Sarah ; Benyon, Sarah L. ; Irwin, Michael S. ; Agrawal, Amit ; Malata, Charles M. ; Murphy, Claire ; Misky, Adam ; Chicken, Dennis Wayne ; Abdullah, Nassreen ; Hill, Arnold D. K. ; Cullinane, Carolyn ; Irwin, Gareth ; McIntosh, Stuart A. ; Refsum, Sigi ; Sloan, Samantha ; Mallon, Peter ; Sirianni, Chiara ; Khattak, Ilyas ; Nagachandra, Geerthan ; Kiruparan, Pasupathy ; Debanth, Debasish ; Davey, Simon ; Curran, Terry-Ann ; Svenning, Matilda ; Govindarajulu, Sasirekha ; Rayter, Zenon ; Ainsworth, Rachel ; Cawthorn, Simon ; Sahu, Ajay ; Wilson, Sherif ; Prousskaia, Elena ; Accurso, Antonello ; Rocco, Nicola ; Micco, Rosa Di ; Limite, Gennaro ; Ceccarino, Raffaele ; Liccardo, Raffaele ; Coco, Guido ; Nizamoglu, Metin ; Morgan, Mary ; Ramakrishnan, Venkat ; Catanuto, Giuseppe ; Wilkins, Alex ; McManus, Penelope ; Kneeshaw, Peter ; Grover, Kartikae ; Mahapatra, Tapan ; Wooler, Brendan ; Elahi, Bilal ; Ihsan, Naila ; Bucknor, Alexandra ; Reissis, Dimitris ; Hunter, Judith ; Wood, Simon ; Jallali, Navid ; Henry, Francis P. ; Verjee, Liaquat S. ; Lee, Jason ; Khan, Shazia M. ; Azmy, Iman ; Massey, Julia ; Hollywood, Ciaran ; Oluwajana, Michael ; Bathla, Sonia ; Seward, Joanna ; Harding-MacKean, Claudia ; Lane, Risha ; Murali, Kothandaraman ; Biswas, Bashishta ; Trapszo, Pawel ; Seetharam, Seema ; Kennedy, Katy ; Alder, Louise ; Graja, Tomasz ; Amin, Khalid ; Kokan, Jalal ; Roshanlall, Chandeena ; Gill, Emma ; Kulkarni, Dhananjay ; Dixon, J. M. ; Young, Oliver ; Saleem, Talha ; Biddle, M. ; Kearns, Marie ; Weiler-Mithoff, Eva ; Chew, Ben ; Malyon, Andy ; Scott, John ; McGill, David ; Mackay, Iain ; Bains, Salena ; Barrows, Sara ; Pilgrim, Simon ; Shokuhi, Sheila ; Lambert, Kelly ; Kenny, Frances ; Valassiadou, Kalliope ; Kaushik, Monika ; Krupa, Jaroslaw ; Dragoumis, Dimitris ; Ain, Quratul ; Lampropoulos, Pavlos ; Moss, Sarah ; Khalil, Haitham ; Haq, Anwar ; Balasubramanian, Balapathiran ; Charalampoudis, Petros ; Hamed, Hisham ; Kothari, Ashutosh ; Kovacs, Tibor ; Douek, Michael ; Mehmood, Iftikhar ; Ray, Biswajit ; Adelekan, Matthew ; Humphreys, Laura ; Tayeh, Salim ; Choy, Christina ; Parvanta, Laila ; Michieletto, Silvia ; Saibene, Tania ; O’Brien, James ; Down, Sue ; Downey, Sarah ; Pereira, Jerome ; Sami, A. S. ; Gvaramadze, Anzors ; Jibril, Jibril A. ; Thekkinkattil, Dinesh ; Udayasankar, S. ; Khawaja, Saira ; Shariaha, Yousef ; Holt, Simon ; James, Ruth ; Rizki, Hirah ; Kirkpatrick, Katharine ; Ravichandran, Duraisamy ; Shrestha, Deepak ; Barua, Ellora ; Akolekar, Deepika ; Hamad, Ahmed ; Kleidi, Eleftheria ; Hignett, Susan ; Pope, Vanessa ; Naseem, Salma ; Isherwood, Jennifer ; Soulsby, Rachel ; Taylor, Amanda ; Chin, Kian ; Nguyen, Dai ; Guest, Francesca ; Thorne, Amanda ; Lefemine, Valentina ; Kirchhoff, Chris ; Murphy, Declan C. ; Lo, Michelle ; Harcourt, Ruth ; Pain, Simon J. ; Hussien, Maged I. ; Zechmeister, Katalin ; Sassoon, E. M. ; Figus, Andrea ; Haywood, Richard M. ; Ali, Rozina ; Alexander, Susanna ; Geropantas, Konstantinos ; Epurescu, Daniel ; Lewis, Rebecca ; Fafemi, Oladapo ; Gahir, Jasdeep ; Gandamihardja, Tasha ; Kelsall, Jennett ; Muhibullah, Nazli ; Otieno, Charlene ; Mazari, Fayyaz ; Dauria, Marta ; Whisker, Lisa ; Macmillan, Douglas ; Gutteridge, Eleanor ; Rasheed, Tuabin ; Khout, Hazem ; Asgeirsson, Kristjan ; McCulley, Stephen ; Mariniello, Maria Donatella ; Roncella, Manuela ; Ghilli, Matteo ; Colizzi, Livio ; Rossetti, Elena ; Marzia, Lo Russo ; Fustaino, Loredana ; Li, Alessandro Quattrini ; Harvey, Kate L. ; Windle, Rebecca ; Remoundos, Dionysios Dennis ; Roy, Pankaj ; MacLean, Gael ; Adwani, Asha ; Popa, Elena ; Goh, Steven ; Shetty, Geeta ; Clark, Sarah ; Bernaudo, Lorenzo ; Agrawal, Avi ; Mansfield, Lucy ; Tebbal, Sally ; Patel, Ashraf ; Grassi, Veronica ; Pujji, Ojas ; Hamnett, Kathryn ; Basu, Naren ; Granger, Emily ; Durbar, Michael ; Pikoulas, Panagiotis ; Garnsey, Clare ; Walker, Philip ; Vollermere, Angela J. ; Michalakis, Ioannis ; Jones, Robin ; Youssef, Mina ; Ives, Charlotte ; Masood, Mohammad ; Dunn, Julie ; Olsen, Sisse ; Ferguson, Douglas ; Tillett, Rachel ; Allan, Anna ; Woollard, Alex ; Canny, Rebecca ; Woollard, Alexander ; Mosahebi, Afshin ; Hamilton, Stephen ; Ghali, Shadi ; Marsh, Daniel ; Chana, Jagdeep ; Sojitra, Nilesh ; Younis, Ibby ; Rainsbury, Dick ; Chand, Natalie ; Kalles, Vasileios ; Stebbing, Anne ; Harris, Kevin ; Laws, Siobhan ; Tansley, Anne ; Mitchell, Geraldine ; de Sousa, Emma ; Henderson, Julia ; Chandrashekar, Mysore ; Pereira, Bernadette ; Constantinou, Chloe ; Elfadl, Dalia ; Irakleidis, Foivos ; Hernan, Izaro ; Byrne, Miriam ; To, Natalie ; Rusby, Jennifer ; Barry, Peter ; Krupa, Katerine ; Allum, William ; MacNeill, Fiona ; on behalf of the i, B. R. A. Steering Group ; the Breast Reconstruction Research, Collaborative

Background : Immediate breast reconstruction (IBR) is routinely offered to improve quality-of-life for women requiring mastectomy, but there are concerns that more complex surgery may delay adjuvant oncological treatments and compromise long-term outcomes. High-quality evidence is lacking. The iBRA-2 study aimed to investigate the impact of IBR on time to adjuvant therapy. Methods : Consecutive women undergoing mastectomy ± IBR for breast cancer July–December, 2016 were included. Patient [...]

A partir d'une revue de la littérature (6 articles), cette étude analyse le processus de prise de décision thérapeutique chez les soignants de personnes âgées souffrant de démence et atteintes d'un cancer récemment diagnostiqué

How are caregivers involved in treatment decision-making for older people with dementia and a new diagnosis of cancer?

Martin, Charlene ; Shrestha, Anne ; Burton, Maria ; Collins, Karen ; Wyld, Lynda

Objective : To explore how caregivers are involved in making treatment decisions for older people living with dementia and a new diagnosis of cancer. Method : A systematic review of PubMed, CINAHL, PsycINFO, Web of Science and Scopus databases was conducted. Studies recruiting formal or informal caregivers for older people with dementia and a diagnosis of cancer were considered for inclusion. Results : Of 1761 articles screened, 36 full texts were assessed for eligibility and 6 were included in [...]

Menée en Grèce par questionnaire auprès de 102 patients atteints d'un cancer de stade avancé, cette étude analyse l'association entre une dépression et leur désir d'une mort précipitée

Depression as mediator and or moderator on the relationship between hopelessness and patients’ desire for hastened death

Parpa, Efi ; Tsilika, Eleni ; Galanos, Antonis ; Nikoloudi, Maria ; Mystakidou, Kyriaki

Purpose : Previous findings have shown that depression in advanced stages of cancer is associated with hopelessness and frequently with wishes for hastened death. The current study tries to investigate the relationship between hopelessness and desire for hastened death and if depression may be a moderator and/or mediator role in patients with advanced cancer. Method : The participants were 102 patients with advanced cancer which they completed the Beck Hopelessness Scale (BHS), the Greek [...]

Menée en Suède à partir de données portant sur 151 201 patients décédés d'un cancer entre 2007 et 2013 (âge moyen : 81,3 ans), cette étude analyse les coûts associés à l'utilisation de médicaments préventifs (anti-hypertenseurs, anti-coagulants, statines, anti-diabétiques oraux) pendant la dernière année de vie

Preventive drugs in the last year of life of older adults with cancer: Is there room for deprescribing?

Morin, Lucas ; Todd, Adam ; Barclay, Stephen ; Wastesson, Jonas W. ; Fastbom, Johan ; Johnell, Kristina

Background : The continuation of preventive drugs among older patients with advanced cancer has come under scrutiny because these drugs are unlikely to achieve their clinical benefit during the patients’ remaining lifespan. Methods : A nationwide cohort study of older adults (those aged ≥65 years) with solid tumors who died between 2007 and 2013 was performed in Sweden, using routinely collected data with record linkage. The authors calculated the monthly use and cost of preventive drugs [...]

Menée aux Etats-Unis à partir de données portant sur 386 patients atteints d'un cancer et hospitalisés dans une unité de soins palliatifs, cette étude analyse l'impact, sur la prise en charge de la douleur, d'une pénurie d'opioïdes dispensés par voie parentérale

Implications of the Parenteral Opioid Shortage for Prescription Patterns and Pain Control Among Hospitalized Patients With Cancer Referred to Palliative Care

Haider, Ali ; Qian, Yu ; Lu, Zhanni ; Naqvi, Syed ; Zhuang, Amy ; Reddy, Akhila ; Dalal, Shalini ; Arthur, Joseph ; Tanco, Kimberson ; Dev, Rony ; Williams, Janet ; Wu, Jimin ; Liu, Diane ; Bruera, Eduardo

Importance : The recent parenteral opioid shortage (POS) has potential implications for cancer-related pain management in hospitalized patients. Objective : This study compared changes in opioid prescriptions and clinically improved pain (CIP) among patients treated by an inpatient palliative care (PC) team before and after our institution first reported the POS. Design, Setting, and Participants : A cohort study of 386 eligible patients with cancer treated at a comprehensive cancer center 1 [...]

Menée en Malaisie auprès de 47 patientes atteintes d'un cancer du sein de stade précoce, cette étude analyse l'effet, sur les toxicités induites par le traitement anticancéreux et sur la qualité de vie, d'une utilisation d'herbes de la médecine traditionnelle chinoise en complément d'une chimiothérapie conventionnelle (5-fluorouracile, épirubicine et cyclophosphamide)

Evaluation of chemotherapy-induced toxicity and health-related quality of life amongst early-stage breast cancer patients receiving Chinese herbal medicine in Malaysia

Liew, Ai Ch’i ; Peh, Kok-Khiang ; Tan, Boon Seang ; Zhao, Wei ; Tangiisuran, Balamurugan

Purpose : This observational study aimed to compare the outcome and health-related quality of life (HRQOL) amongst breast cancer patients using Chinese herbal medicine (CHM) and those not using CHM during chemotherapy. Methods : A prospective, non-randomised longitudinal study was conducted in two government integrated hospitals over an 8-month period. Early-stage breast cancer patients who were (1) either already using complementary and alternative medicine (CAM) or not and (2) who were on a [...]