A partir des données de la cohorte européenne EPIC portant sur 476 160 personnes (durée moyenne de suivi : 13,9 ans), cette étude évalue l’association entre le caractère pro-inflammatoire de l’alimentation et le risque de lymphome (3 136 cas)

Inflammatory potential of diet and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition

Solans, Marta ; Benavente, Yolanda ; Saez, Marc ; Agudo, Antonio ; Jakszyn, Paula ; Naudin, Sabine ; Hosnijeh, Fatemeh Saberi ; Gunter, Marc ; Huybrechts, Inge ; Ferrari, Pietro ; Besson, Caroline ; Mahamat-Saleh, Yahya ; Boutron-Ruault, Marie-Christine ; Kühn, Tilman ; Kaaks, Rudolf ; Boeing, Heiner ; Lasheras, Cristina ; Sánchez, María-José ; Amiano, Pilar ; Chirlaque, María Dolores ; Ardanaz, Eva ; Schmidt, Julie A. ; Vineis, Paolo ; Riboli, Elio ; Trichopoulou, Antonia ; Karakatsani, Anna ; Valanou, Elisavet ; Masala, Giovanna ; Agnoli, Claudia ; Tumino, Rosario ; Sacerdote, Carlotta ; Mattiello, Amalia ; Skeie, Guri ; Weiderpass, Elisabete ; Jerkeman, Mats ; Dias, Joana Alves ; Späth, Florentin ; Nilsson, Lena Maria ; Dahm, Christina C. ; Overvad, Kim ; Petersen, Kristina Elin Nielsen ; Tjønneland, Anne ; de Sanjose, Silvia ; Vermeulen, Roel ; Nieters, Alexandra ; Casabonne, Delphine

Introduction : Chronic inflammation plays a critical role in lymphomagenesis and several dietary factors seem to be involved its regulation. The aim of the current study was to assess the association between the inflammatory potential of the diet and the risk of lymphoma and its subtypes in the European Investigation into Cancer and Nutrition (EPIC) study. Methods : The analysis included 476,160 subjects with an average follow-up of 13.9 years, during which 3,136 lymphomas (135 Hodgkin lymphoma [...]

Menée à partir de données portant sur 303 patients atteints d'un cancer du pancréas diagnostiqué entre 1993 et 2009 et sur 606 témoins, cette étude évalue l'association entre le niveau sérique de sélénium mesuré avant le diagnostic et le risque de développer la maladie (durée de suivi : 17 ans)

Serum selenium and pancreatic cancer: a prospective study in the Prostate, Lung, Colorectal and Ovarian Cancer Trial cohort

Chatterjee, Sharmila ; Combs, Gerald F. ; Chattopadhyay, Amit ; Stolzenberg-Solomon, Rachael

Purpose : Pancreatic cancer(PCa) is one of the most lethal cancers with few known consistent nutrition-related risk factors. Epidemiologic associations between the trace element selenium and PCa are inconsistent. This study examined the association of pre-diagnostic serum selenium with incident PCa. Methods : We conducted a nested case–control study within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Study (PLCO) cohort of men and women 55–70 years old at baseline (1993–2001). [...]

Cet article présente les effets de l'obésité et de la perte de poids sur la structure des mitochondries et le risque de cancer colorectal

Effects of obesity and weight loss on mitochondrial structure and function and implications for colorectal cancer risk

Breininger, S. P. ; Malcomson, F. C. ; Afshar, S. ; Turnbull, D. M. ; Greaves, L. ; Mathers, J. C.

Colorectal cancer (CRC) is the third most common cancer globally. CRC risk is increased by obesity, and by its lifestyle determinants notably physical inactivity and poor nutrition. Obesity results in increased inflammation and oxidative stress which cause genomic damage and contribute to mitochondrial dysregulation and CRC risk. The mitochondrial dysfunction associated with obesity includes abnormal mitochondrial size, morphology and reduced autophagy, mitochondrial biogenesis and expression [...]

Menée à partir de données portant sur 114 patients américains, cette étude analyse l'association entre l'utilisation de cabines de bronzage et le risque de mélanome, en prenant en compte l'âge et la présence d'une mutation V600E sur le gène BRAF

Association of Indoor Tanning Exposure with Age at Melanoma Diagnosis and BRAF V600E Mutations

Burbidge, Toni E ; Bastian, Boris C ; Guo, Danny ; Li, Haocheng ; Cheng, Tina ; Morris, Don G ; Monzon, Jose G ; Leung, Gabriella ; Yang, Huiming

There is limited information on how indoor tanning (IT) promotes melanoma development. We investigated IT use in patients with melanomas in sun-exposed skin and studied the clinicopathological and molecular characteristics in relation to IT exposure. We accrued patients from December 2013 to May 2015. The 114 patients who reported IT exposure were younger at diagnosis than the 222 patients who did not (51.5 vs 64.0 years, P < .001). BRAF V600E genotype was more prevalent in ever-users than [...]

Menée à partir de données portant sur des participantes afro-américaines âgées de 33 à 81 ans, cette étude de cohorte prospective analyse l'association entre la santé buccale (perte de dents, maladie parodontale) et le risque de cancer du pancréas (période de suivi : 2007-2016 ; 78 cas)

Oral Health in Relation to Pancreatic Cancer Risk in African American Women

Gerlovin, Hanna ; Michaud, Dominique S. ; Cozier, Yvette C. ; Palmer, Julie R.

Background: Incidence of pancreatic cancer is higher in African Americans than in U.S. whites. We hypothesized that poor oral health, disproportionately common in African Americans and associated with increased risk of pancreatic cancer in several studies of predominantly white populations, may play a role in this disparity. Methods: We examined the relation of self-reported measures of oral health (periodontal disease and adult tooth loss) in relation to pancreatic cancer incidence in the [...]

Menée aux Etats-Unis à partir de données portant sur 74 481 participantes, cette étude de cohorte évalue l'association entre la durée du sommeil, l'indice de masse corporelle et le risque de cancer du sein (5 790 cas)

Association between sleep duration and breast cancer incidence: The Multiethnic Cohort

Shigesato, Maryssa ; Kawai, Yosuke ; Guillermo, Cherie ; Youkhana, Fadi ; Shvetsov, Yurii B. ; Setiawan, Veronica W. ; Haiman, Christopher A. ; Le Marchand, Loic ; Maskarinec, Gertraud

Breast cancer is the most common cancer and the second-leading cause of cancer-related death among women. Inconsistent findings for the relationship between melatonin levels, sleep duration, and breast cancer have been reported. We investigated the association of sleep duration at cohort entry and its interaction with body mass index (BMI) with risk of developing breast cancer in the large population-based Multiethnic Cohort study. Among the 74,481 at-risk participants, 5,790 breast cancer [...]

Menée au Royaume-Uni auprès de 757 185 personnes (durée de suivi : 2 874 059 années ; 33 367 cas), cette étude évalue l'association entre une concentration plasmatique élevée en vitamine B12 et le risque de cancer

Elevated Vitamin B12 Levels and Cancer Risk in UK Primary Care: A THIN Database Cohort Study

Arendt, Johan F.H. ; Sørensen, Henrik T. ; Horsfall, Laura J. ; Petersen, Irene

Background : Elevated vitamin B12 levels (B12) are associated with increased short-term cancer risk. However, the implications for early cancer detection in primary care have not been assessed. Methods : Individuals with plasma B12 measurements were sampled from The Health Improvement Network primary care database, UK. Persons with low B12 levels were excluded together with persons with cancer or B12 treatment before date of B12 measurement. Incident cancer was the outcome of interest and was [...]

A partir de données d'études d'association sur le génome entier portant sur 3 238 personnes atteintes d'un cancer de l'ovaire et sur 4 083 témoins, cette étude identifie des loci de susceptibilité à la maladie spécifiques à la population asiatique

Genome-wide association studies identify susceptibility loci for epithelial ovarian cancer in east Asian women

Lawrenson, Kate ; Song, Fengju ; Hazelett, Dennis J. ; Kar, Siddhartha P. ; Tyrer, Jonathan ; Phelan, Catherine M. ; Corona, Rosario I. ; Rodríguez-Malavé, Norma I. ; Seo, Ji-Hei ; Adler, Emily ; Coetzee, Simon G. ; Segato, Felipe ; Fonseca, Marcos A. S. ; Amos, Christopher I. ; Carney, Michael E. ; Chenevix-Trench, Georgia ; Choi, Jiyeob ; Doherty, Jennifer A. ; Jia, Weihua ; Jin, Gang J. ; Kim, Byoung-Gie ; Le, Nhu D. ; Lee, Juyeon ; Li, Lian ; Lim, Boon K. ; Adenan, Noor A. ; Mizuno, Mika ; Park, Boyoung ; Pearce, Celeste L. ; Shan, Kang ; Shi, Yongyong ; Shu, Xiao-Ou ; Sieh, Weiva ; Thompson, Pamela J. ; Wilkens, Lynne R. ; Wei, Qingyi ; Woo, Yin L. ; Yan, Li ; Karlan, Beth Y. ; Freedman, Matthew L. ; Noushmehr, Houtan ; Goode, Ellen L. ; Berchuck, Andrew ; Sellers, Thomas A. ; Teo, Soo-Hwang ; Zheng, Wei ; Matsuo, Keitaro ; Park, Sue ; Chen, Kexin ; Pharoah, Paul D. P. ; Gayther, Simon A. ; Goodman, Marc T.

Objective : Genome-wide association studies (GWASs) for epithelial ovarian cancer (EOC) have focused largely on populations of European ancestry. We aimed to identify common germline variants associated with EOC risk in Asian women. Methods : Genotyping was performed as part of the OncoArray project. Samples with >60% Asian ancestry were included in the analysis. Genotyping was performed on 533,631 SNPs in 3238 Asian subjects diagnosed with invasive or borderline EOC and 4083 unaffected [...]

Menée auprès de 2 253 patients afro-américains atteints d'un cancer de la prostate et auprès de 2 423 témoins, cette étude évalue l'association entre les interactions des polymorphismes à simple nucléotide des gènes CASC11, MYC et PVT1 et le risque de développer la maladie

Interactions of PVT1 and CASC11 on Prostate Cancer Risk in African Americans

Lin, Hui-Yi ; Callan, Catherine Y. ; Fang, Zhide ; Tung, Heng-Yuan ; Park, Jong Y.

Background : African American (AA) men have a higher risk of developing prostate cancer (PCa) than White men. Single nucleotide polymorphisms (SNPs) are known to play an important role in developing PCa. The impact of PVT1 and its neighborhood genes (CASC11 and MYC) on PCa risk are getting more attention recently. The interactions among these three genes associated with PCa risk are understudied, especially for AA men. The objective of this study is to investigate SNP-SNP interactions in the [...]

Menée en Europe auprès de 221 patients atteints d'un cancer colorectal et auprès de 2 329 témoins (âge moyen : 50 ans), cette étude évalue l’association entre les concentrations plasmatiques de chimérine et le risque de développer la maladie

Association of Chemerin Plasma Concentration With Risk of Colorectal Cancer

Eichelmann, Fabian ; Schulze, Matthias B. ; Wittenbecher, Clemens ; Menzel, Juliane ; Weikert, Cornelia ; di Giuseppe, Romina ; Biemann, Ronald ; Isermann, Berend ; Fritsche, Andreas ; Boeing, Heiner ; Aleksandrova, Krasimira

Inflammatory processes have been suggested to have an important role in colorectal cancer (CRC) etiology. Chemerin is a recently discovered inflammatory biomarker thought to exert chemotactic, adipogenic, and angiogenic functions. However, its potential link with CRC has not been sufficiently explored.To evaluate the prospective association of circulating plasma chemerin concentrations with incident CRC.Prospective case-cohort study based on 27 548 initially healthy participants from the [...]

A partir d'une revue systématique de la littérature (62 études, 4 178 patientes incluses), cette méta-analyse met en évidence un risque élevé de cancer du sein chez les patientes atteintes d'une neurofibromatose de type 1 (286 cas, âge médian au diagnostic : 46 ans)

Increased breast cancer risk in women with neurofibromatosis type 1: a meta-analysis and systematic review of the literature

Suarez-Kelly, Lorena P. ; Yu, Lianbo ; Kline, David ; Schneider, Eric B. ; Agnese, Doreen M. ; Carson, William E.

Background : Neurofibromatosis type 1 (NF1) is a cancer predisposing syndrome. Studies suggest that women < 50 years old (y.o.) with NF1 have an increased breast cancer (BC) incidence and BC associated mortality. However, this has not been widely recognized secondary to small study populations. Methods : A systematic literature review was conducted through database searches for BC and NF1: 3456 articles identified, 166 reviewed, 58 used for descriptive analysis and 4 utilized for meta-analysis. [...]