Menée en Belgique auprès de 31 patients adultes ayant survécu à une leucémie pédiatrique et n'ayant pas reçu de rayonnements ionisants, et auprès de 35 témoins, cette étude analyse, par IRM, la connectivité fonctionnelle et structurelle de leur cerveau, ainsi que leur flexibilité et fonctionnement cognitifs associés

Brain Connectivity and Cognitive Flexibility in Nonirradiated Adult Survivors of Childhood Leukemia

Billiet, Thibo ; Elens, Iris ; Sleurs, Charlotte ; Uyttebroeck, Anne ; D’Hooge, Rudi ; Lemiere, Jurgen ; Deprez, Sabine

Background : This study aimed to assess functional and structural brain connectivity in adult childhood leukemia survivors and the link with cognitive functioning and previously identified risk factors such as intrathecal methotrexate dose and age at start of therapy. Methods : Thirty-one nonirradiated adult childhood leukemia survivors and 35 controls underwent cognitive testing and multimodal magnetic resonance imaging (resting state functional MRI, T1-weighted, diffusion-weighted, and myelin [...]

Menée au Canada à partir des données auto-déclarées par 120 745 patients atteints d'un cancer diagnostiqué entre 2007 et 2014, cette étude rétrospective évalue l'évolution des symptômes durant la première année suivant le diagnostic de la maladie

Symptom Burden in the First Year After Cancer Diagnosis: An Analysis of Patient-Reported Outcomes

Lev D. Bubis ; Laura Davis ; Alyson Mahar ; Lisa Barbera ; Qing Li ; Lesley Moody ; Paul Karanicolas ; Rinku Sutradhar ; Natalie G. Coburn

Purpose : Improvement in the quality of life of patients with cancer requires attention to symptom burden across the continuum of care, with the use of patient-reported outcomes key to achieving optimal care. Yet there have been few studies that have examined symptoms in the early postdiagnosis period during which suboptimal symptom control may be common. A comprehensive analysis of temporal trends and risk factors for symptom burden in newly diagnosed patients with cancer is essential to guide [...]

Menée en Suède par questionnaire auprès de 540 patients adolescents et jeunes adultes ayant survécu à un cancer (âge : 15-29 ans), cette étude analyse les difficultés physiques et psychiques rencontrées dans leur vie sexuelle en lien avec les traitements anticancéreux

Sexual function in adolescent and young adult cancer survivors—a population-based study

Olsson, Maria ; Steineck, Gunnar ; Enskär, Karin ; Wilderäng, Ulrica ; Jarfelt, Marianne

Purpose : Previous research has established that treatments for cancer can result in short- and long-term effects on sexual function in adult cancer patients. The purpose was to investigate patient-reported physical and psychosexual complications in adolescents and young adults after they have undergone treatment for cancer. Methods : In this population-based study, a study-specific questionnaire was developed by a method used in several previous investigations carried out by our research [...]

Menée en Italie auprès de 130 patients atteints d'une leucémie myéloïde chronique en phase chronique, cette étude évalue l'effet, sur la qualité de vie, du nilotinib en traitement de première ligne

Health-related quality of life in patients with chronic myeloid leukemia receiving first-line therapy with nilotinib

Efficace, Fabio ; Castagnetti, Fausto ; Martino, Bruno ; Breccia, Massimo ; D'Adda, Mariella ; Angelucci, Emanuele ; Stagno, Fabio ; Cottone, Francesco ; Malato, Alessandra ; Trabacchi, Elena ; Capalbo, Silvana Franca ; Gobbi, Marco ; Visani, Giuseppe ; Salvucci, Marzia ; Capodanno, Isabella ; Tosi, Patrizia ; Tiribelli, Mario ; Scortechini, Anna Rita ; Levato, Luciano ; Maino, Elena ; Binotto, Gianni ; Gugliotta, Gabriele ; Vignetti, Marco ; Baccarani, Michele ; Rosti, Gianantonio

BACKGROUND: Although a wealth of efficacy and safety data is available for many tyrosine kinase inhibitors used in chronic myeloid leukemia (CML), there is a dearth of information on their impact on patients' health-related quality of life (HRQOL). The primary objective of this study was to evaluate HRQOL and fatigue outcomes in patients with CML receiving first-line therapy with nilotinib. METHODS: This was a multicenter, prospective study enrolling 130 patients with chronic-phase CML. HRQOL [...]

A partir d'une revue de la littérature, cette étude fait le point sur l'effet des divers traitements anticancéreux (radiothérapie, chimiothérapie, chirurgie) sur les fonctions cognitives et la qualité de vie des patients adultes atteints d'une tumeur cérébrale

Cognitive disability in adult patients with Brain tumors

Ali, Faisal S. ; Hussain, Maryam R. ; Gutierrez, Carolina ; Demireva, Petya ; Ballester, Leomar Y. ; Jay Zhu, Jiguang ; Blanco, Angel ; Esquenazi, Yoshua

Cognitive dysfunction is common among patients with intracranial tumors. Most cognitive deficits are subtle, lack specificity, may mimic depression or other neurological disorders and may be recognized in retrospect by the physician. In certain cases, distinguishing between tumor recurrence and cognitive deficits that arise as a consequence of the treatment becomes challenging. Late treatment effects have also become an area of focus as the overall survival and prognosis of patients with brain [...]

A partir des données des registres américains des cancers et des données de 12 bases allemandes sur la période 2002-2013, cette étude compare, pour ces deux pays, la survie relative à 5 ans chez des patients atteints d'un cancer hépato-biliaire

Survival of patients with hepatobiliary tract and duodenal cancer sites in Germany and the United States in the early 21st century

Pulte, Dianne ; Weberpals, Janick ; Schröder, Chloé Charlotte ; Emrich, Katharina ; Holleczek, Bernd ; Katalinic, Alexander ; Luttmann, Sabine ; Sirri, Eunice ; Jansen, Lina ; Brenner, Hermann ; for the, Gekid Cancer Survival Working Group

Hepatobiliary tract cancers (HBTCs) are a heterogeneous group of cancers with high mortality. Because most of these cancers, with the exception of hepatocellular carcinoma (HCC), are rare, few data are available concerning the population level survival expectations of patients with HBTC. Here, we describe survival of patients with HBTC in Germany with comparison to survival in the US. Therefore, data were extracted from 12 databases in Germany and the Surveillance, Epidemiology and End Results [...]

A partir de données de 12 pays européens portant sur 115 596 patients ayant survécu à un cancer diagnostiqué pendant l'enfance entre 1940 et 2011 (dont 83 333 patients ayant survécu 5 ans à un cancer pédiatrique), cette étude analyse les facteurs associés à la survenue d'événements indésirables tardifs et au risque de second cancer

The PanCareSurFup cohort of 83,333 five-year survivors of childhood cancer: a cohort from 12 European countries

Grabow, Desiree ; Kaiser, Melanie ; Hjorth, Lars ; Byrne, Julianne ; Alessi, Daniela ; Allodji, Rodrigue S. ; Bagnasco, Francesca ; Bárdi, Edit ; Bautz, Andrea ; Bright, Chloe J. ; de Vathaire, Florent ; Feijen, Elizabeth A. M. ; Garwicz, Stanislaw ; Hagberg, Oskar ; Haupt, Riccardo ; Hawkins, Mike M. ; Jakab, Zsuzsanna ; Kremer, Leontien C. M. ; Kuehni, Claudia E. ; Kuonen, Rahel ; Lähteenmäki, Päivi Maria ; Reulen, Raoul C. ; Ronckers, Cecile M. ; Sacerdote, Carlotta ; Vu-Bezin, Giao ; Wesenberg, Finn ; Wiebe, Thomas ; Winter, David L. ; Winther, Jeanette Falck ; Zaletel, Lorna Zadravec ; Kaatsch, Peter

Childhood cancer survivors face risks from a variety of late effects, including cardiac events, second cancers, and late mortality. The aim of the pan-European PanCare Childhood and Adolescent Cancer Survivor Care and Follow-Up Studies (PanCareSurFup) Consortium was to collect data on incidence and risk factors for these late effects among childhood cancer survivors in Europe. This paper describes the methodology of the data collection for the overall PanCareSurFup cohort and the [...]

A partir de données françaises portant sur des patients âgés entre 30 à 74 ans sur la période 2006-2009, cette étude analyse les disparités socioéconomiques dans la part des cancers attribuable à une pratique tabagique

Tobacco-attributable burden of cancer according to socioeconomic position in France

Menvielle, Gwenn ; Kulhánová, Ivana ; Bryere, Josephine ; Launoy, Guy ; Eilstein, Daniel ; Delpierre, Cyrille ; Soerjomataram, Isabelle

Smoking is a major preventable cause of cancers and is increasingly concentrated among the most deprived individuals leading to increasing socioeconomic inequalities in the incidence of cancers linked to smoking. We aimed to estimate the tobacco-attributable cancer burden according to socioeconomic position in France. The analysis was restricted to cancer sites for which tobacco smoking was recognized as a risk factor. Cancer cases by sex, age group and European Deprivation Index (EDI) among [...]

Menée en Angleterre à partir de données portant sur 176 225 patients atteints d’un cancer du poumon sur la période 2010-2014, cette étude analyse les disparités géographiques dans les traitements reçus et leur impact et la survie, deux ans après le diagnostic

Geographical variations in the use of cancer treatments are associated with survival of lung cancer patients

Møller, Henrik ; Coupland, Victoria H ; Tataru, Daniela ; Peake, Michael D ; Mellemgaard, Anders ; Round, Thomas ; Baldwin, David R ; Callister, Matthew E J ; Jakobsen, Erik ; Vedsted, Peter ; Sullivan, Richard ; Spicer, James

Introduction Lung cancer outcomes in England are inferior to comparable countries. Patient or disease characteristics, healthcare-seeking behaviour, diagnostic pathways, and oncology service provision may contribute. We aimed to quantify associations between geographic variations in treatment and survival of patients in England.Methods We retrieved detailed cancer registration data to analyse the variation in survival of 176,225 lung cancer patients, diagnosed 2010-2014. We used Kaplan-Meier [...]

A partir des données des registres américains des cancers portant sur 486 118 patientes atteintes d'un cancer du sein de stade I à IV diagnostiqué entre 2000 et 2012, cette étude de cohorte évalue la survie spécifique, en fonction du sous-type de la maladie et de la tranche d'âge (65-74 ans, 75-84 ans, plus de 85 ans)

Breast cancer-specific survival by age: Worse outcomes for the oldest patients

Freedman, Rachel A. ; Keating, Nancy L. ; Lin, Nancy U. ; Winer, Eric P. ; Vaz-Luis, Ines ; Lii, Joyce ; Exman, Pedro ; Barry, William T.

BACKGROUND: Although breast cancer often is perceived to be indolent in older women, breast cancer outcomes in the oldest patients are variable. In the current study, the authors examined breast cancer-specific death by age, stage, and disease subtype in a large, population-based cohort. METHODS: Using Surveillance, Epidemiology, and End Results data, a total of 486,118 women diagnosed with American Joint Committee on Cancer stage I to IV breast cancer between 2000 and 2012 were identified. [...]

Menée à partir des données des registres américains des cancers portant sur 747 763 patientes atteintes d'un cancer du sein entre 1973 et 2010, cette étude évalue, en fonction de l'appartenance ethnique, l'age des patientes et le stade de la tumeur au diagnostic

Race/ethnicity and age distribution of breast cancer diagnosis in the United States

Stapleton, S. M. ; Oseni, T. O. ; Bababekov, Y. J. ; Hung, Y. ; Chang, D. C.

The US Preventive Services Task Force (USPSTF) currently recommends initiating breast cancer screening at 50 years of age in patients at average risk.1 However, we hypothesize that these guidelines may not be sensitive to racial differences and may be inappropriately extrapolating data from largely white populations for use in racially diverse populations. This process could result in underscreening of nonwhite female patients. These concerns are similar to broader discussions regarding sex [...]

Menée aux Etats-Unis à partir de données portant sur 1 442 patientes atteintes d'un cancer primitif du sein, cette étude de cohorte évalue l'association entre une utilisation d'aspirine avant le diagnostic, l'indice de masse corporelle et la mortalité spécifique

Pre-diagnostic aspirin use and mortality after breast cancer

Wang, Tengteng ; Parada, Humberto ; McClain, Kathleen M. ; Bradshaw, Patrick T. ; Terry, Mary Beth ; Teitelbaum, Susan L. ; Neugut, Alfred I. ; Gammon, Marilie D.

Background : Whether aspirin or other nonsteroidal anti-inflammation drug (NSAID) use is associated with mortality following breast cancer remains unclear. Consideration of use patterns and interaction with obesity may help to clarify the inconsistent results. Methods : Pre-diagnosis NSAID use, weight, and height were assessed ~ 3 months after diagnosis through in-person interviews with a population-based cohort of 1,442 women with first primary breast cancer. Vital status was determined [...]

A partir de données américaines portant sur la période 1992-2010, cette étude évalue l'association entre une hystérectomie et l'incidence du cancer de l'endomètre chez des patientes âgées entre 20 et 49 ans

Hysterectomy-corrected rates of endometrial cancer among women younger than age 50 in the United States

Temkin, Sarah M. ; Kohn, Elise C. ; Penberthy, Lynne ; Cronin, Kathleen A. ; Rubinsak, Lisa ; Dickie, Lois A. ; Minasian, Lori ; Noone, Anne-Michelle

Purpose : This analysis describes the impact of hysterectomy on incidence rates and trends in endometrioid endometrial cancer in the United States among women of reproductive age. Methods : Hysterectomy prevalence for states containing Surveillance, Epidemiology, and End Results (SEER) registry was estimated using data from the Behavioral Risk Factor Surveillance System (BRFSS) between 1992 and 2010. The population was adjusted for age, race, and calendar year strata. Age-adjusted incidence [...]

A partir d'une revue systématique de la littérature publiée entre 1999 et 2017 (30 études), cette étude analyse la méthodologie et l'efficacité des interventions psychologiques utilisant le concept de la pleine conscience pour améliorer la qualité de vie psychique de patients atteints d'un cancer

Being mindful of mindfulness interventions in cancer: A systematic review of intervention reporting and study methodology

Shaw, Joanne M. ; Sekelja, Natasha ; Frasca, Diana ; Dhillon, Haryana M. ; Price, Melanie A.

Objectives: While mindfulness-based stress reduction (MBSR) and mindfulness-based cognitive therapy (MBCT) have demonstrated efficacy in clinical populations, the potential therapeutic benefit of mindfulness in the context of cancer is less clear. The aim of this review was to critically appraise mindfulness intervention reporting and study methodology. Methods: Studies using randomized control trial design and/or a control arm were included. PubMed, Medline, PsycINFO, CINAHL, and Embase [...]

Menée aux Etats-Unis à partir de données portant sur 420 patients atteints d'une tumeur hématologique et âgés de plus de 75 ans, cette étude de cohorte prospective analyse la présence de déficiences cognitives et leur impact sur la survie

Prevalence of cognitive impairment and association with survival among older patients with hematologic cancers

Hshieh, T. T. ; Jung, W. F. ; Grande, L. J. ; et al.,

Importance:  As the population ages, cognitive impairment has promised to become increasingly common among patients with cancer. Little is known about how specific domains of cognitive impairment may be associated with survival among older patients with hematologic cancers. Objective  : To determine the prevalence of domain-specific cognitive impairment and its association with overall survival among older patients with blood cancer. Design, Setting, and Participants : This prospective [...]

Menée dans un contexte britannique, cette étude analyse le rapport coût-efficacité du ponatinib pour traiter les patients atteints d'une leucémie lymphoblatique aiguë Ph+ récidivante et/ou réfractaire

Ponatinib for Treating Acute Lymphoblastic Leukaemia: An Evidence Review Group Perspective of a NICE Single Technology Appraisal

Stevenson, Matt ; Pandor, Abdullah ; Hamilton, Jean ; Stevens, John ; Rowntree, Clare ; Martyn-St James, Marrissa ; Rawdin, Andrew ; Wong, Ruth

As part of its single technology appraisal (STA) process, the UK National Institute for Health and Care Excellence (NICE) invited the manufacturer (Incyte Corporation) of ponatinib (Inclusig®) to submit evidence of its clinical and cost effectiveness for previously treated Philadelphia-chromosome-positive acute lymphoblastic leukaemia (Ph+ ALL) and chronic myeloid leukaemia. This paper focusses on Ph+ ALL. The School of Health and Related Research Technology Appraisal Group at the University of [...]

Menée dans un contexte américain, cette étude compare le rapport coût-efficacité du crizotinib et de l'alectinib en traitement de première ligne chez des patients atteints d'un cancer du poumon non à petites cellules ALK+

Cost Effectiveness of Alectinib vs. Crizotinib in First-Line Anaplastic Lymphoma Kinase-Positive Advanced Non-Small-Cell Lung Cancer

Carlson, Josh J. ; Suh, Kangho ; Orfanos, Panos ; Wong, William

Background : The recently completed ALEX trial demonstrated that alectinib improved progression-free survival, and delayed time to central nervous system progression compared with crizotinib in patients with anaplastic lymphoma kinase-positive non-small-cell lung cancer. However, the long-term clinical and economic impact of using alectinib vs. crizotinib has not been evaluated. The objective of this study was to determine the potential cost utility of alectinib vs. crizotinib from a US payer [...]

Mené sur 968 participants, cet essai randomisé compare l'efficacité, sur leur niveau de compréhension et sur leur niveau d'anxiété, de deux façons de communiquer les résultats d'un test génétique pour évaluer le risque de cancer, soit par entretien téléphonique, soit par entretien en face à face

Randomized Noninferiority Trial of Telephone vs In-Person Disclosure of Germline Cancer Genetic Test Results

Bradbury, Angela R. ; Patrick-Miller, Linda J. ; Egleston, Brian L. ; Hall, Michael J. ; Domchek, Susan M. ; Daly, Mary B. ; Ganschow, Pamela ; Grana, Generosa ; Olopade, Olufunmilayo I. ; Fetzer, Dominique ; Brandt, Amanda ; Chambers, Rachelle ; Clark, Dana F. ; Forman, Andrea ; Gaber, Rikki ; Gulden, Cassandra ; Horte, Janice ; Long, Jessica M. ; Lucas, Terra ; Madaan, Shreshtha ; Mattie, Kristin ; McKenna, Danielle ; Montgomery, Susan ; Nielsen, Sarah ; Powers, Jacquelyn ; Rainey, Kim ; Rybak, Christina ; Savage, Michelle ; Seelaus, Christina ; Stoll, Jessica ; Stopfer, Jill E. ; Yao, Xinxin

Background : Germline genetic testing is standard practice in oncology. Outcomes of telephone disclosure of a wide range of cancer genetic test results, including multigene panel testing (MGPT) are unknown. Methods : Patients undergoing cancer genetic testing were recruited to a multicenter, randomized, noninferiority trial (NCT01736345) comparing telephone disclosure (TD) of genetic test results with usual care, in-person disclosure (IPD) after tiered-binned in-person pretest counseling. [...]

Menée au Japon par questionnaire auprès de 121 patients atteints d'un cancer de stade avancé, souffrant de cachéxie et traités dans des unités de soins palliatifs, cette étude analyse leurs perceptions relatives à leurs besoins en soins de support nutritionnels (conseils nutritionnels, supplémentation par voie orale, nutrition parentérale, alimentation par sonde...)

Perception of need for nutritional support in advanced cancer patients with cachexia: a survey in palliative care settings

Amano, Koji ; Morita, Tatsuya ; Miyamoto, Jiro ; Uno, Teruaki ; Katayama, Hirofumi ; Tatara, Ryohei

Purpose : Few studies have investigated the need for nutritional support in advanced cancer patients in palliative care settings. Therefore, we conducted a questionnaire to examine the relationship between the perception of need for nutritional support and cancer cachexia and the prevalence of specific needs, perceptions, and beliefs in nutritional support. Methods : We conducted a questionnaire in palliative care settings. Patients were classified into two groups: (1) non-cachexia/pre-cachexia [...]

Menée en France à partir de données portant sur 536 patients atteints de cancer et décédés en 2010, cette étude rétrospective analyse les caractéristiques sociodémographiques et cliniques associées aux patients décédés de divers types de cancer dans des unités de soins intensifs, et évalue l'accès aux soins palliatifs

Cancer Patients Dying in the Intensive Care Units and Access to Palliative Care

Ledoux, Mathilde ; Tricou, Colombe ; Roux, Maxime ; Dreano-Hartz, Soazic ; Ruer, Murielle ; Filbet, Marilene

Background: In France, cancer has become the leading cause of death. Intensive care units (ICU) focus on survival, which may not be an appropriate setting to provide palliative care (PC) as needed by cancer patients and families. Objective: To describe the cancer patients who died in the ICU in 2010 in a French academic medical center. Design: Retrospective study Measurements: We reviewed medical records of all cancer patients who died in the ICU in 2010. The information collected from [...]

Mené aux Etats-Unis sur 44 patientes atteintes d'un cancer du sein de stade précoce, cet essai randomisé évalue la faisabilité et l'efficacité d'une application en ligne leur permettant de déclarer leurs symptômes en temps réel, d'améliorer la prise en charge de ces symptômes et d'augmenter leur adhésion à un traitement à base d'inhibiteurs de l'aromatase

Use of a web-based app to improve breast cancer symptom management and adherence for aromatase inhibitors: a randomized controlled feasibility trial

Graetz, Ilana ; McKillop, Caitlin N. ; Stepanski, Edward ; Vidal, Gregory A. ; Anderson, Janeane N. ; Schwartzberg, Lee S.

Purpose : For postmenopausal women with hormone receptor-positive breast cancer, long-term use of aromatase inhibitors (AIs) significantly reduces the risk of cancer recurrence and improves survival. Still, many patients are nonadherent due to adverse side effects. We conducted a pilot randomized controlled trial to test the use of a web-based application (app) designed with and without weekly reminders for patients to report real-time symptoms and AI use outside of clinic visits with built-in [...]