Menée en Norvège auprès de 585 583 participants, cette étude de cohorte évalue les disparités, selon le sexe, dans l'association entre une pratique tabagique et le risque de cancer du poumon

Sex Differences in Risk of Smoking- Associated Lung Cancer: Results From a Cohort of 600,000 Norwegians

Hansen, Merethe S. ; Licaj, Idlir ; Braaten, Tonje ; Langhammer, Arnulf ; Le Marchand, Loic ; Gram, Inger T.

Whether women are more susceptible than men to smoking-related lung cancer has been a topic of controversy. To address this question we compared risk of lung cancer associated with smoking by sex. Altogether 585,583 participants from three Norwegian cohorts (Norwegian Counties Study, 40 Years Study and CONOR) were followed until December 31, 2013 through linkage of data to national registries. We used Cox proportional hazards models and 95% confidence intervals (CIs). During nearly 12 million [...]

Menée aux Etats-Unis par questionnaire auprès de 34 242 femmes sur la période 1986-2011, cette étude évalue l'association entre une ingestion de nitrates et de nitrites contenus dans l'eau et dans l'alimentation et le risque de cancer du pancréas après la ménopause (313 cas)

Ingested nitrate and nitrite, disinfection by-products, and pancreatic cancer risk in postmenopausal women

Quist, Arbor J. L. ; Inoue-Choi, Maki ; Weyer, Peter J. ; Anderson, Kristin E. ; Cantor, Kenneth P. ; Krasner, Stuart ; Freeman, Laura E. Beane ; Ward, Mary H. ; Jones, Rena R.

Nitrate and nitrite are precursors of N-nitroso compounds (NOC), probable human carcinogens that cause pancreatic tumors in animals. Disinfection by-products (DBP) exposures have also been linked with digestive system cancers, but few studies have evaluated relationships with pancreatic cancer. We investigated the association of pancreatic cancer with these drinking water contaminants and dietary nitrate/nitrite in a cohort of postmenopausal women in Iowa (1986–2011). We used historical [...]

A partir d'une revue systématique de la littérature (15 études), cette méta-analyse évalue l'association entre l'indice de masse corporelle et le surpoids avant l'âge de 30 ans et le risque de cancer colorectal

Body fatness at an early age and risk of colorectal cancer

Hidayat, Khemayanto ; Yang, Chun-Mei ; Shi, Bi-Min

While there is convincing evidence that excess body fatness in adulthood is positively associated with colorectal cancer risk, the association between body fatness at an early age (≤30 years) and the risk of colorectal cancer has been equivocal. The present meta-analysis was performed to clarify this association. PubMed and Web of Science databases were searched for relevant studies that investigated this association. The risk estimates from each study were transformed into a continuous [...]

A partir d'une revue systématique de la littérature (8 études), cette méta-analyse évalue l'association entre un indicateur caractérisant une alimentation pro-inflammatoire et le risque de cancer colorectal

Association Between Dietary Inflammation Index and The Risk of Colorectal Cancer: A Meta-Analysis

Zhang, Caixia ; Wang, Weijing ; Zhang, Dongfeng

Objectives: We performed a meta-analysis to assess the association and possible dose?response relationship between dietary inflammation index (DII)? and colorectal cancer (CRC). Methods: A literature search was performed in PubMed, Web of Science and Chinese National Knowledge Infrastructure (CNKI) database for all relevant studies. The pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated by random effects model. Results: A total of eight studies were included in this [...]

Menée en Israël à partir de données portant sur 1 382 093 hommes âgés de 16 à 19 ans sur la période 1967-2011, cette étude évalue l'association entre une obésité pendant l'adolescence et le risque de cancer du sein chez l'homme

Adolescent obesity and adult male breast cancer in a cohort of 1,382,093 men

Keinan-Boker, Lital ; Levine, Hagai ; Leiba, Adi ; Derazne, Estela ; Kark, Jeremy D.

Male breast cancer (MBC) accounts for 1% of all breast cancer. Adult obesity and tallness are risk factors for MBC, but the role of adolescent fatness is largely unknown. We aimed to assess the association between body mass index (BMI) in adolescence and the incidence of MBC in a large cohort of 16- to 19-year-old Israeli males. 1,382,093 Jewish Israeli males aged 16–19 who underwent anthropometric measurements, a general intelligence test (GIT) and other examinations during 1967–2011, were [...]

Menée aux Etats-Unis par entretien téléphonique auprès de parents de 187 enfants atteints d'un rétinoblastome sporadique unilatéral et de 95 enfants atteints d'un rétinoblastome sporadique bilatéral et auprès de 155 témoins, cette étude évalue l'association entre une exposition professionnelle des parents à des produits chimiques dans les 10 années précédant la conception de l'enfant et le risque pour l'enfant de développer la maladie

Parental occupational exposures and the risk of childhood sporadic retinoblastoma: a report from the Children’s Oncology Group

Omidakhsh, Negar ; Bunin, Greta R ; Ganguly, Arupa ; Ritz, Beate ; Kennedy, Nola ; von Ehrenstein, Ondine S ; Krause, Niklas ; Heck, Julia E

Objectives : We examined associations between parental occupational chemical exposures up to 10 years before conception and the risk of sporadic retinoblastoma among offspring. Methods : In our multicentre study on non-familial retinoblastoma, parents of 187 unilateral and 95 bilateral cases and 155 friend controls were interviewed by telephone. Exposure information was collected retroactively through a detailed occupational questionnaire that asked fathers to report every job held in the 10 [...]

Menée aux Etats-Unis à partir de données portant sur 44 932 utilisateurs de glyphosate à partir de 1993, cette étude de cohorte prospective évalue l'association entre une exposition à cet herbicide et le risque de cancer (5 779 cas ; période de suivi : jusqu'à 2012/2013)

Glyphosate Use and Cancer Incidence in the Agricultural Health Study

Andreotti, Gabriella ; Koutros, Stella ; Hofmann, Jonathan N. ; Sandler, Dale P. ; Lubin, Jay H. ; Lynch, Charles F. ; Lerro, Catherine C. ; De Roos, Anneclaire J. ; Parks, Christine G. ; Alavanja, Michael C. ; Silverman, Debra T. ; Beane Freeman, Laura E.

Background : Glyphosate is the most commonly used herbicide worldwide, with both residential and agricultural uses. In 2015, the International Agency for Research on Cancer classified glyphosate as “probably carcinogenic to humans,” noting strong mechanistic evidence and positive associations for non-Hodgkin lymphoma (NHL) in some epidemiologic studies. A previous evaluation in the Agricultural Health Study (AHS) with follow-up through 2001 found no statistically significant associations with [...]

A partir des données de trois études de cohorte incluant 213 536 participants, cette étude prospective analyse l'association entre une utilisation de tétracyclines et le risque de cancer de la peau (36 377 cas de carcinome basocellulaire, 1 831 cas de mélanome, 3 332 cas de carcinome épidermoïde)

Tetracycline use and risk of incident skin cancer: a prospective study

Li, Wen-Qing ; Drucker, Aaron M. ; Cho, Eunyoung ; Laden, Francine ; VoPham, Trang ; Li, Suyun ; Weinstock, Martin A. ; Qureshi, Abrar A.

Background: Tetracycline is a photosensitising medication that increases skin vulnerability to UV-related damage. Methods: We prospectively examined tetracycline use and risk of incident melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC) based on 213 536 participants from the Nurses’ Health Study (NHS), NHS2, and Health Professionals Follow-up Study. Information on ever use of tetracycline was asked via questionnaire. Diagnoses of melanoma and SCC were pathologically [...]

Menée en Chine à partir de données portant sur 59 503 hommes sur la période 2002-2013, cette étude de cohorte prospective évalue l'association entre divers facteurs liés au mode de vie (tabagisme, consommation d'alcool, alimentation, activité physique) et le risque de cancer colorectal (durée médiane de suivi : 9,28 ans ; 671 cas)

The joint effects of major lifestyle factors on colorectal cancer risk among Chinese men: A prospective cohort study

Zhang, Qing-Li ; Zhao, Long-Gang ; Li, Hong-Lan ; Gao, Jing ; Yang, Gong ; Wang, Jing ; Zheng, Wei ; Shu, Xiao-Ou ; Xiang, Yong-Bing

Previous studies have suggested individual healthy lifestyle factors are related to lower risk of colorectal cancer. Their joint effects, however, have rarely been investigated. We aimed to assess the combined lifestyle impact on colorectal cancer risk and to estimate the population attributable risks of these lifestyle factors. Using data from the Shanghai Men's Health Study (2002–2013), we constructed healthy lifestyle index composing the following lifestyle factors: smoking, alcohol [...]

Menée aux Etats-Unis à partir de données portant sur 113 124 participantes âgées entre 25 et 42 ans et sur 33 490 participantes âgées de plus de 45 ans et incluses dans deux cohortes prospectives, cette étude évalue l'association, en fonction du statut ménopausique, entre des migraines et le risque de cancer épithélial de l'ovaire

Migraine and invasive epithelial ovarian cancer risk in the Nurses’ Health Study II and the Women's Health Study

Rice, Megan S. ; Rist, Pamela M. ; Winter, Anke C. ; Kurth, Tobias ; Tworoger, Shelley S.

Migraine is a common primary headache disorder, which predominantly impacts women. Recently, migraine has been hypothesized to be associated with hormonally related cancers; however, the potential association between migraine and ovarian cancer has not been studied. Therefore, we evaluated the association between migraine and invasive epithelial ovarian cancer risk in two prospective cohorts, the Nurses’ Health Study II (NHSII) and the Women's Health Study (WHS). Our prospective analysis [...]

Menée en Norvège auprès de 6 500 participants, cette étude de cohorte prospective évalue l'association entre le niveau sérique de la 25-hydroxyvitamine-D et le risque de cancer du poumon par sous-type histologique (696 cas)

Associations of serum 25-hydroxyvitamin D level with incidence of lung cancer and histologic types in Norwegian adults: a case-cohort analysis of the HUNT study

Sun, Yi-Qian ; Langhammer, Arnulf ; Wu, Chunsen ; Skorpen, Frank ; Chen, Yue ; Nilsen, Tom Ivar Lund ; Romundstad, Pål Richard ; Mai, Xiao-Mei

Previous prospective studies have shown inconsistent associations between serum 25-hydroxyvitamin D [25(OH)D] level and lung cancer incidence. The aim of the present study was to explore the associations of serum 25(OH)D levels with incidence of lung cancer overall and different histologic types. We performed a population-based prospective case-cohort study including 696 incident lung cancer cases and 5804 individuals in a subcohort who participated in the second survey of the Nord-Trøndelag [...]

A partir de données portant sur 652 patients atteints d'un carcinome à cellules rénales et sur 1 366 témoins, cette étude analyse l'association entre une consommation d'alcool, des variants des gènes liés au métabolisme de l'alcool et le risque de développer la maladie

Alcohol consumption, variability in alcohol dehydrogenase genes and risk of renal cell carcinoma

Antwi, Samuel O. ; Eckel-Passow, Jeanette E. ; Diehl, Nancy D. ; Serie, Daniel J. ; Custer, Kaitlynn M. ; Wu, Kevin J. ; Cheville, John C. ; Thiel, David D. ; Leibovich, Bradley C. ; Parker, Alexander S.

Alcohol consumption has been associated inversely with renal cell carcinoma (RCC) risk; however, no study has examined effect modification by germline variation in alcohol-metabolizing genes. We investigated whether the association between alcohol intake and RCC risk is modulated by germline variants in alcohol dehydrogenase genes in a large case–control study. Data from 652 RCC cases and 1,366 non-cancer controls were analyzed. Alcohol intake was assessed using a standardized risk factor [...]