A partir d'une revue systématique de la littérature (4 essais randomisés), cette méta-analyse évalue l'efficacité de l'anamoréline pour traiter les syndromes d'anorexie et de cachexie chez les patients atteints de cancer

Anamorelin for cancer anorexia-cachexia syndrome: a systematic review and meta-analysis

Bai, Yu ; Hu, Yunxia ; Zhao, Yanhua ; Yu, Xizhong ; Xu, Junwei ; Hua, Zhiyun ; Zhao, Zhiqiang

Purpose : The aim of this study was to evaluate the therapeutic effects of Anamorelin on patients with cancer anorexia-cachexia syndrome (CACS) based on a meta-analysis of published randomized trials. Methods : We searched PubMed, Embase, Medline, and the Cochrane Central Register of Controlled Trials databases. Data from each selected study were evaluated individually. All continuous outcomes were calculated by the mean difference or standardized mean difference with 95% confidence interval [...]

A partir d'une revue de la littérature publiée jusqu'en octobre 2015 (25 essais dont 13 essais randomisés), cette étude analyse l'efficacité d'interventions à base de yoga pour améliorer, pendant les traitements, la qualité de vie physique et psychique des patients atteints de cancer

Review of yoga therapy during cancer treatment

Danhauer, Suzanne C. ; Addington, Elizabeth L. ; Sohl, Stephanie J. ; Chaoul, Alejandro ; Cohen, Lorenzo

Purpose : Reviews of yoga research that distinguish results of trials conducted during (versus after) cancer treatment are needed to guide future research and clinical practice. We therefore conducted a review of non-randomized studies and randomized controlled trials of yoga interventions for children and adults undergoing treatment for any cancer type. Methods : Studies were identified via research databases and reference lists. Inclusion criteria were the following: (1) children or adults [...]

Mené sur 104 patients atteints d'un myélome multiple, cet essai randomisé évalue l'efficacité de l'acupuncture combinée à la méthylcobalamine (forme active de la vitamine B12) pour soulager une neuropathie périphérique induite par la chimiothérapie

Acupuncture combined with methylcobalamin for the treatment of chemotherapy-induced peripheral neuropathy in patients with multiple myeloma

Han, Xiaoyan ; Wang, Lijuan ; Shi, Hongfei ; Zheng, Gaofeng ; He, Jingsong ; Wu, Wenjun ; Shi, Jimin ; Wei, Guoqing ; Zheng, Weiyan ; Sun, Jie ; Huang, He ; Cai, Zhen

Background : Chemotherapy-induced peripheral neuropathy (CIPN) seriously affects the quality of life of patients with multiple myeloma (MM) as well as the response rate to chemotherapy. Acupuncture has a potential role in the treatment of CIPN, but at present there have been no randomized clinical research studies to analyze the effectiveness of acupuncture for the treatment of CIPN, particularly in MM patients. Methods : The MM patients (104 individuals) who met the inclusion criteria were [...]

Menée au Canada par questionnaire auprès de 817 patients ayant survécu à un cancer de la prostate diagnostiqué entre 1997 et 2000, cette étude prospective évalue les facteurs cliniques et comportementaux associés à l'évolution de leur qualité de vie physique et psychologique

Identification and prediction of health-related quality of life trajectories after a prostate cancer diagnosis

Farris, Megan S. ; Kopciuk, Karen A. ; Courneya, Kerry S. ; McGregor, S. Elizabeth ; Wang, Qinggang ; Friedenreich, Christine M.

The aim of our study was to identify physical and mental health-related quality of life (HRQoL) trajectories after a prostate cancer diagnosis and systematically characterize trajectories by behaviours and prognostic factors. Prostate cancer survivors (n = 817) diagnosed between 1997 and 2000 were recruited between 2000 and 2002 into a prospective repeated measurements study. Behavioural/prognostic data were collected through in-person interviews and questionnaires. HRQoL was collected at three [...]

Menée aux Etats-Unis auprès de patientes atteintes d'un cancer du sein de stade de I à III recevant une chimiothérapie adjuvante ou néoadjuvante, cette étude analyse les indicateurs physiques, neurocognitifs et sérologiques associés à une fatigue auto-déclarée, avant et après un traitement combinant doxorubicine et cyclophosphamide

Objective physical and mental markers of self-reported fatigue in women undergoing (neo)adjuvant chemotherapy for early-stage breast cancer

Mortimer, Joanne E. ; Waliany, Sarah ; Dieli-Conwright, Christina M. ; Patel, Sunita K. ; Hurria, Arti ; Chao, Joseph ; Tiep, Brian ; Behrendt, Carolyn E.

BACKGROUND: Objective, treatment-independent markers of cancer-related fatigue are needed to advance clinical trials. In the current study, the authors evaluated physical, neurocognitive, and serologic markers for correlation with self-reported fatigue before and after (neo)adjuvant chemotherapy for patients with early-stage breast cancer. METHODS: Women with AJCC TNM Stage I-III breast cancer consented to assessment before and after the completion of 4 cycles of dose-dense doxorubicin and [...]

Menée aux Etats-Unis à partir des données de 3 études incluant un total de 1 443 patientes atteintes d'un cancer du sein HER2+ de stade précoce ou métastatique traité par pertuzumab, cette étude évalue l'incidence et la sévérité d'une diarrhée induite par le traitement anticancéreux

Incidence and management of diarrhea in patients with HER2-positive breast cancer treated with pertuzumab

Swain, S.M. ; Schneeweiss, A. ; Gianni, L. ; Gao, J.J. ; Stein, A. ; Waldron-Lynch, M. ; Heeson, S. ; Beattie, M.S. ; Yoo, B. ; Cortés, J. ; Baselga, J.

Background : Pertuzumab disrupts heterodimerization between human epidermal growth factor receptor 2 (HER2) and epidermal growth factor receptor (EGFR), HER3, and HER4. Thus, pertuzumab could result in adverse events similar to those observed with EGFR antagonists, such as diarrhea. We report the incidence and severity of diarrhea observed with pertuzumab in the CLEOPATRA, NeoSphere, and TRYPHAENA studies. Patients and Methods : Patients (n=1443) had metastatic (CLEOPATRA [n=804]) or [...]

A partir des données d'un registre néerlandais des cancers portant sur 13 715 patients atteints d'un cancer gastrointestinal diagnostiqué entre 1998 et 2011, cette étude observationnelle évalue les effets d'une utilisation d'aspirine après le diagnostic sur la survie

Effect of low-dose aspirin use on survival of patients with gastrointestinal malignancies; an observational study

Frouws, M. A. ; Bastiaannet, E. ; Langley, R. E. ; Chia, W. K. ; van Herk-Sukel, M. P. P. ; Lemmens, V. E. P. P. ; Putter, H. ; Hartgrink, H. H. ; Bonsing, B. A. ; van de Velde, C. J. H. ; Portielje, J. E. A. ; Liefers, G. J.

Background: Previous studies suggested a relationship between aspirin use and mortality reduction. The mechanism for the effect of aspirin on cancer outcomes remains unclear. The aim of this study was to evaluate aspirin use and survival in patients with gastrointestinal tract cancer. Methods: Patients with gastrointestinal tract cancer diagnosed between 1998 and 2011 were included. The population-based Eindhoven Cancer Registry was linked to drug-dispensing data from the PHARMO Database [...]

Menée au Danemark à partir de données portant sur 1 320 jeunes participants (âge moyen : 15,2 ans) ayant survécu à un cancer pendant l'enfance, cette étude analyse leurs difficultés d'apprentissage pendant l'adolescence, en fonction de la localisation du cancer et du stade au diagnostic

Ninth grade school performance in Danish childhood cancer survivors

Andersen, Klaus Kaae ; Duun-Henriksen, Anne Katrine ; Frederiksen, Marie Hoffmann ; Winther, Jeanette Falck

Background: Childhood cancer survivors can experience learning problems resulting in lower-than-expected attained education as adults. It is unclear whether learning problems manifest already during adolescence. Methods: We analysed nationwide Danish registries on school grades for Danish children during 2001–2014. Applying a matched design we compared grades of childhood cancer survivors to children without cancer at ninth grade. We estimated grade differences by subject and its correlation to [...]

Menée en Australie à partir de données portant sur 7 498 participants non fumeurs et 1 409 participants fumeurs, cette étude évalue l'association entre le temps passé à regarder la télévision, le tabagisme et la mortalité par cancer (durée médiane de suivi : 13,6 ans ; 346 décès par cancer)

Joint associations of smoking and television viewing time on cancer and cardiovascular disease mortality

Grace, Megan S. ; Lynch, Brigid M. ; Dillon, Francis ; Barr, Elizabeth L. M. ; Owen, Neville ; Dunstan, David W.

Excessive sitting time and smoking are pro-inflammatory lifestyle factors that are associated with both cancer and cardiovascular disease (CVD) mortality. However, their joint associations have not been investigated. We examined the associations of television (TV) viewing time with cancer and CVD mortality, according to smoking status, among 7,498 non-smokers (34% ex-smokers) and 1,409 current-smokers in the Australian Diabetes, Obesity and Lifestyle Study. During 117,506 person-years (median [...]

A partir des données des registres américains des cancers, cette étude présente une estimation de l'incidence des cancers et de la mortalité spécifique pour l'année 2017 (1 688 780 nouveaux cas, 600 920 décès)

Cancer Statistics, 2017

Siegel, Rebecca L. ; Miller, Kimberly D. ; Jemal, Ahmedin

Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths that will occur in the United States in the current year and compiles the most recent data on cancer incidence, mortality, and survival. Incidence data were collected by the Surveillance, Epidemiology, and End Results Program; the National Program of Cancer Registries; and the North American Association of Central Cancer Registries. Mortality data were collected by the National Center for Health [...]

A partir des données des registres américains des cancers portant sur 797 patients âgés de moins de 15 ans, 1 994 patients âgés entre 40 et 70 ans et 757 patients âgés de plus de 70 ans tous atteints d'un lymphome de Burkitt, cette étude analyse, en fonction de ces différentes tranches d'âge, les facteurs associés à la survie, sur la période 2000-2013

Survival predictors of Burkitt's lymphoma in children, adults and elderly in the United States during 2000–2013

Mukhtar, Fahad ; Boffetta, Paolo ; Risch, Harvey A. ; Park, Jong Y. ; Bubu, Omonigho M. ; Womack, Lindsay ; Tran, Thuan V. ; Zgibor, Janice C. ; Luu, Hung N.

Burkitt's Lymphoma (BL) has three peaks of occurrence, in children, adults and elderly, at 10, 40 and 70 years respectively. To the best of our knowledge, no study has been conducted to assess predictors of survival in the three age groups. We hypothesized that survival predictors may differ by age group. We, therefore, sought to determine survival predictors for BL in these three groups: children (<15 years of age), adults (40–70 years of age) and elderly (>70 years of age). Using the [...]

Menée en Irlande sur 84 patients atteints d'un mélanome de stade métastatique traité par ipilimumab entre 2009 et 2015, cette étude analyse l'association entre des paramètres de la composition corporelle évaluée par tomodensitométrie (notamment indicateurs d'une sarcopénie) et les événements indésirables liés au traitement et la survie

The impact of body composition parameters on ipilimumab toxicity and survival in patients with metastatic melanoma

Daly, Louise E. ; Power, Derek G. ; O'Reilly, Aine ; Donnellan, Paul ; Cushen, Samantha J. ; O'Sullivan, Kathleen ; Twomey, Maria ; Woodlock, David P. ; Redmond, Henry P. ; Ryan, Aoife M.

Background: Body composition is an important predictor of drug toxicity and outcome. Ipilimumab (Ipi), a monoclonal antibody used to treat metastatic melanoma, has specific toxicities. No validated biomarkers that predict Ipi toxicity and efficacy exist. Also, the impact of Ipi on body composition has not been established. Methods: Patients with metastatic melanoma treated with Ipi between 2009 and 2015 were included. Body composition was assessed by computed tomography at baseline and after [...]

A partir des données des registres américains des cancers portant sur des patients atteints d'un cancer métastatique de la prostate, sensible à une thérapie anti-androgénique, cette étude analyse les disparités ethniques dans la survie globale et la mortalité spécifique selon les traitements reçus (hormonothérapie avec ou sans docétaxel)

Impact of ethnicity on the outcome of men with metastatic, hormone-sensitive prostate cancer

Bernard, Brandon ; Muralidhar, Vinayak ; Chen, Yu-Hui ; Sridhar, Srikala S. ; Mitchell, Edith P. ; Pettaway, Curtis A. ; Carducci, Michael A. ; Nguyen, Paul L. ; Sweeney, Christopher J.

BACKGROUND: Prostate cancer (PCa) outcomes are impacted by socioeconomic and biologic factors. Ethnicity plays a role in the former, but little is known about the responsiveness of metastatic PCa to androgen-deprivation therapy (ADT) among races. METHODS: The Surveillance, Epidemiology, and End Results (SEER) registry was used to identify men who were diagnosed with distant, de novo, metastatic PCa from 2004 to 2012. Patterns of presentation, overall survival (OS), and PCa-specific mortality [...]

Menée aux Etats-Unis par enquête auprès de 357 participants, cette étude analyse les pratiques des oncologues en matière d'échanges avec les médecins généralistes pour la coordination des soins de l'après-cancer

Oncologists’ perspectives on post-cancer treatment communication and care coordination with primary care physicians

Klabunde, C. N. ; Haggstrom, D. ; Kahn, K. L. ; Gray, S. W. ; Kim, B. ; Liu, B. ; Eisenstein, J. ; Keating, N. L.

Post-treatment cancer care is often fragmented and of suboptimal quality. We explored factors that may affect cancer survivors’ post-treatment care coordination, including oncologists’ use of electronic technologies such as e-mail and integrated electronic health records (EHRs) to communicate with primary care physicians (PCPs). We used data from a survey (357 respondents; participation rate 52.9%) conducted in 2012–2013 among medical oncologists caring for patients in a large US study of [...]

Menée en Australie par enquête auprès de 597 patients atteints d'un cancer de la tête et du cou (âge moyen : 58 ans), cette étude analyse leurs besoins en information sur la maladie et ses traitements ainsi que leurs préférences relatives au mode de diffusion de cette information

Education and support needs in patients with head and neck cancer: A multi-institutional survey

Jabbour, Joe ; Milross, Chris ; Sundaresan, Puma ; Ebrahimi, Ardalan ; Shepherd, Heather L. ; Dhillon, Haryana M. ; Morgan, Gary ; Ashford, Bruce ; Abdul-Razak, Muzib ; Wong, Eva ; Veness, Michael ; Palme, Carsten E. ; Froggatt, Cate ; Cohen, Ruben ; Ekmejian, Rafael ; Tay, Jessica ; Roshan, David ; Clark, Jonathan R.

BACKGROUND: Head and neck cancer (HNC) encompasses a diverse group of tumors, and thus providing appropriate and tailored information to patients before, during, and after treatment is a challenge. The objective of the current study was to characterize the experience and unmet needs of patients with HNC with regard to information and support provision. METHODS: A 28-question, cross-sectional survey was completed by patients treated for HNC at 1 of 4 institutions in New South Wales, Australia [...]