A partir d'une revue systématique de la littérature (47 études), cette étude fait le point sur les mécanismes biologiques impliqués dans la fatigue liée au cancer

The biology of cancer-related fatigue: a review of the literature

Saligan, LeoreyN ; Olson, Karin ; Filler, Kristin ; Larkin, David ; Cramp, Fiona ; Sriram, Yennu ; Escalante, CarmenP ; del Giglio, Auro ; Kober, KordM ; Kamath, Jayesh ; Palesh, Oxana ; Mustian, Karen

Purpose : Understanding the etiology of cancer-related fatigue (CRF) is critical to identify targets to develop therapies to reduce CRF burden. The goal of this systematic review was to expand on the initial work by the National Cancer Institute CRF Working Group to understand the state of the science related to the biology of CRF and, specifically, to evaluate studies that examined the relationships between biomarkers and CRF and to develop an etiologic model of CRF to guide researchers on [...]

Menée au Japon auprès de 33 patients atteints d'un cancer de la cavité buccale, cette étude analyse l'efficacité de soins médicaux buccaux pour diminuer la douleur liée à une mucite chez des patients traités par chimiothérapie supersélective intra-artérielle et par radiothérapie concomitante

Professional oral health care reduces oral mucositis pain in patients treated by superselective intra-arterial chemotherapy concurrent with radiotherapy for oral cancer

Kubota, Kosei ; Kobayashi, Wataru ; Sakaki, Hirotaka ; Nakagawa, Hiroshi ; Kon, Takao ; Mimura, Mayu ; Ito, Ryohei ; Furudate, Ken ; Kimura, Hiroto

Purpose : Oral mucositis (OM) is a painful complication of radiation therapy (RT) for head and neck cancer. OM can compromise nutrition, require opioid analgesics and hospitalization for pain control, and lead to interruption of treatment. Severe oral mucositis appears inevitable in superselective intra-arterial chemotherapy concurrent with radiotherapy (SSIACRT), requiring management of OM for the patient. The objective of this study was to assess the utility of professional oral health care [...]

Mené auprès de 1 205 patients atteints d'un cancer de la prostate localisé de stade avancé, cet essai randomisé analyse l'efficacité de l'ajout d'une radiothérapie à une hormonothérapie anti-androgénique pour améliorer la qualité de vie et la survie des patients

Impact of Radiotherapy When Added to Androgen-Deprivation Therapy for Locally Advanced Prostate Cancer: Long-Term Quality-of-Life Outcomes From the NCIC CTG PR3/MRC PR07 Randomized Trial

Brundage, Michael ; Sydes, Matthew R. ; Parulekar, Wendy R. ; Warde, Padraig ; Cowan, Richard ; Bezjak, Andrea ; Kirkbride, Peter ; Parliament, Matthew ; Moynihan, Clare ; Bahary, Jean-Paul ; Parmar, Mahesh K.B. ; Sanders, Karen ; Chen, Bingshu E. ; Mason, Malcolm D.

Purpose : The NCIC CTG PR3/MRC PR07 randomized phase III trial compared androgen-deprivation therapy (ADT) alone versus ADT with radiotherapy (RT) for patients with locally advanced prostate cancer. This article reports the health-related quality-of-life (HRQOL) outcomes of this trial. Patients and Methods : A total of 1,205 patients were randomly allocated to either ADT alone or ADT with RT. HRQOL was assessed at baseline and every 6 months thereafter using the European Organisation for [...]

Menée dans le cadre d'un essai européen de phase III, cette étude analyse les effets du bévacizumab, ajouté à un traitement combinant radiothérapie et témozolomide, sur la qualité de vie des patients atteints d'un glioblastome récemment diagnostiqué

Health-Related Quality of Life in a Randomized Phase III Study of Bevacizumab, Temozolomide, and Radiotherapy in Newly Diagnosed Glioblastoma

Taphoorn, Martin J.B. ; Henriksson, Roger ; Bottomley, Andrew ; Cloughesy, Timothy ; Wick, Wolfgang ; Mason, Warren P. ; Saran, Frank ; Nishikawa, Ryo ; Hilton, Magalie ; Theodore-Oklota, Christina ; Ravelo, Arliene ; Chinot, Olivier L.

Purpose : As glioblastoma progresses, patients experience a decline in health-related quality of life (HRQoL). Delaying this decline is an important treatment goal. In newly diagnosed glioblastoma, progression-free survival was prolonged when bevacizumab was added to radiotherapy plus temozolomide (RT/TMZ) versus placebo plus RT/TMZ (phase III AVAglio study; hazard ratio, 0.64; 95% CI, 0.55 to 0.74; P < .001). To ensure that addition of bevacizumab to standard-of-care therapy was not associated [...]

A partir des données de trois cohortes européennes incluant 15 486 participants âgés (âge moyen : 63 ans), cette étude évalue l'association entre le niveau de concentration sérique de vitamine D avant le diagnostic et le risque de cancer

Pre-diagnostic vitamin D concentrations and cancer risks in older individuals: an analysis of cohorts participating in the CHANCES consortium

Ordóñez-Mena, JoséManuel ; Schottker, Ben ; Fedirko, Veronika ; Jenab, Mazda ; Olsen, Anja ; Halkjær, Jytte ; Kampman, Ellen ; de Groot, Lisette ; Jansen, Eugene ; Bueno-de-Mesquita, H. Bas ; Peeters, PetraH ; Siganos, Galatios ; Wilsgaard, Tom ; Perna, Laura ; Holleczek, Bernd ; Pettersson-Kymmer, Ulrika ; Orfanos, Philippos ; Trichopoulou, Antonia ; Boffetta, Paolo ; Brenner, Hermann

The associations of circulating 25-hydroxyvitamin D [25(OH)D] concentrations with total and site-specific cancer incidence have been examined in several epidemiological studies with overall inconclusive findings. Very little is known about the association of vitamin D with cancer incidence in older populations. We assessed the association of pre-diagnostic serum 25(OH)D levels with incidence of all cancers combined and incidence of lung, colorectal, breast, prostate and lymphoid malignancies [...]

A partir d'une revue systématique de la littérature (9 études de cohorte), cette méta-analyse fait le point sur l'association entre le niveau de cadmium mesuré dans les urines et la mortalité par cancer et toutes causes confondues en population générale

Urinary cadmium and mortality from all causes, cancer and cardiovascular disease in the general population: systematic review and meta-analysis of cohort studies

Larsson, Susanna C ; Wolk, Alicja

Background: Cadmium is a toxic heavy metal distributed in the environment. We conducted a systematic review and meta-analysis to examine the association between urinary cadmium concentration and mortality from all causes, cancer and cardiovascular disease (CVD) in the general population. Methods: Studies were identified by searching PubMed and Embase (to 30 March 2015) and the reference lists of retrieved articles. We included prospective studies that reported hazard ratios (HR) with 95% [...]

Menée au Danemark à partir des données de registres en population, cette étude évalue l'association entre le tabagisme et une consommation d'alcool sur l'évolution des disparités socioéconomiques dans la mortalité, sur la période 1985-2009

What is the association of smoking and alcohol use with the increase in social inequality in mortality in Denmark? A nationwide register-based study

Koch, Mette Bjerrum ; Diderichsen, Finn ; Grønbæk, Morten ; Juel, Knud

Objectives : The aim of this paper is to estimate the impact of smoking and alcohol use on the increase in social inequality in mortality in Denmark in the period 1985–2009. Design : A nationwide register-based study.Setting Denmark. Participants : whole Danish population aged 30 years or more in the period 1985–2009. Primary and secondary outcome measures : The primary outcome is mortality rates in relation to educational attainments calculated with and without deaths related to smoking and [...]

A partir de données de trois essais randomisés du "Children's Oncology Group" incluant un total de 1 008 patients pédiatriques atteints de lymphome ou de leucémie, cette étude analyse l'effet du dexrazoxane sur la survie à long terme (durée médiane de suivi : 12,6 ans)

Late Mortality After Dexrazoxane Treatment: A Report From the Children's Oncology Group

Chow, Eric J. ; Asselin, Barbara L. ; Schwartz, Cindy L. ; Doody, David R. ; Leisenring, Wendy M. ; Aggarwal, Sanjeev ; Scott Baker, K. ; Bhatia, Smita ; Constine, Louis S. ; Freyer, David R. ; Lipshultz, Steven E. ; Armenian, Saro H.

Purpose : Given concerns that dexrazoxane may reduce treatment efficacy, induce second cancers, and thus compromise overall survival among children, we examined long-term overall and cause-specific mortality and disease relapse rates from three randomized clinical trials. Patients and Methods : Children's Oncology Group trials P9404 (T-cell acute lymphoblastic leukemia/lymphoma; n = 537), P9425 (intermediate/high-risk Hodgkin lymphoma; n = 216), and P9426 (low-risk Hodgkin lymphoma; n = 255) [...]

Menée par enquête auprès de 150 oncologues et dermatologues en France, en Allemagne, en Italie, en Espagne et au Royaume-Uni, cette étude analyse l'évolution des modalités de traitement des patients atteints d'un mélanome de stade avancé, après l'introduction de l'ipilimumab et du vémurafenib

Treatment patterns in advanced melanoma: findings from a survey of European oncologists

Jones, C. ; Zhao, Z. ; Barber, B. ; Bagijn, M. ; Corrie, P. ; Saltman, D.

With the emergence of new therapies, established patterns of treating advanced melanoma are changing. The aim of this study was to understand how advanced melanoma is treated in clinical practice in Europe following the introduction of ipilimumab and vemurafenib. An online survey was conducted between August and November 2012 with 150 oncologists and dermatologists, from France, Germany, Italy, Spain and the UK; respondents reported treating the majority of patients with one or two lines of [...]

A partir des données des registres américains des cancers, cette étude analyse les facteurs associés à la survie des patients atteints d'un ostéosarcome de haut grade, sur la période 1991-2010

Prognostic factors for survival in patients with high-grade osteosarcoma using the Surveillance, Epidemiology, and End Results (SEER) Program database

Duchman, Kyle R. ; Gao, Yubo ; Miller, Benjamin J.

Background : The current study aims to determine cause-specific survival in patients with high-grade osteosarcoma while reporting risk factors for decreased survival out to 10 years. Methods : The Surveillance, Epidemiology, and End Results (SEER) Program database was used to identify all patients diagnosed with high-grade osteosarcoma from 1991 to 2010. Patient, tumor, and county-level socioeconomic measures were analyzed to determine prognostic factors for survival. Results : Cause-specific [...]

Menée en France à partir de données portant sur 435 patients atteints de tumeurs neuroendocrines du pancréas, cette étude rétrospective analyse les facteurs associés à la survenue de syndromes hormonaux métachrones, ainsi que la survie des patients

Metachronous Hormonal Syndromes in Patients With Pancreatic Neuroendocrine Tumors - A Case-Series Study

de Mestier, Louis ; Hentic, Olivia ; Cros, Jérôme ; Walter, Thomas ; Roquin, Guillaume ; Brixi, Hedia ; Lombard-Bohas, Catherine ; Hammel, Pascal ; Diebold, Marie-Danièle ; Couvelard, Anne ; Ruszniewski, Philippe ; Cadiot, Guillaume

Background: Pancreatic neuroendocrine tumors (PNETs) may evolve and cause hormonal hypersecretion–related symptoms that were not present at the initial diagnosis, termed metachronous hormonal syndromes (MHSs). Their setting, characteristics, and outcomes are not well-described. Objective: To describe MHSs in patients with sporadic PNETs. Design: Retrospective, multicenter study. Setting: 4 French referral centers. Patients: Patients with PNETs who developed MHSs related to hypersecretion of [...]

Menée en Angleterre à partir de données portant sur 93 783 patients atteints d'un cancer du poumon entre 2006 et 2008, cette étude analyse les effets d'une résection chirurgicale, pratiquée rapidement après une admission dans les services hospitaliers d'urgence, sur la survie des patients

The effect of emergency presentation on surgery and survival in lung cancer patients in England, 2006–2008

Tataru, Daniela ; Jack, Ruth H. ; Lind, Michael J. ; Møller, Henrik ; Lüchtenborg, Margreet

Background : A large proportion of lung cancer patients in England are diagnosed through an emergency route, which is associated with poorer outcomes. Here, we investigated the association between emergency presentation and the odds of undergoing surgical resection and subsequent survival among lung cancer patients undergoing surgical resection as well as those who did not. Methods : Details of 93,783 lung cancers were extracted from the National Cancer Data Repository. For non-small cell lung [...]

A partir des données d'un registre australien des cancers portant sur 32 643 patients atteints d'un cancer de la prostate non métastatique au moment du diagnostic (entre 1993 et 2002), cette étude en population analyse les facteurs associés à la progression vers un cancer métastatique

A population-based study of progression to metastatic prostate cancer in Australia

Luo, Qingwei ; Yu, Xue Qin ; Smith, David Paul ; O’Connell, Dianne Lesley

Background : We used population-based data from the New South Wales Central Cancer Registry (CCR) to describe the patterns of progression to metastatic disease in Australian men diagnosed with non-metastatic prostate cancer. Methods : Data for all non-metastatic prostate cancer cases diagnosed 1993–2002 and followed to the end of 2007 were analysed. The outcome was progression to metastatic disease, identified by metastatic episode notifications in the CCR or by prostate cancer death. Factors [...]

Menée aux Etats-Unis à partir de données portant sur 242 patients atteints d'un cancer colorectal métastatique, cette étude analyse les effets de l'obésité et d'une inflammation systémique chronique sur la survie

Joint prognostic effect of obesity and chronic systemic inflammation in patients with metastatic colorectal cancer

Shah, Manasi S. ; Fogelman, David R. ; Raghav, Kanwal Pratap Singh ; Heymach, John V. ; Tran, Hai T. ; Jiang, Zhi-Qin ; Kopetz, Scott ; Daniel, Carrie R.

BACKGROUND Obesity is strongly linked with chronic systemic inflammation, and each has been linked with disease progression and survival in patients with colorectal cancer (CRC). The authors investigated the joint prognostic effects of obesity and circulating cytokines in patients with metastatic CRC (mCRC), an understudied patient group. METHODS In 242 chemotherapy-naive patients with mCRC, the authors measured a multiplex cytokine panel and abstracted clinicopathological features, height, and [...]

Menée au Royaume-Uni à partir de données portant sur 4 791 patients atteints d'un cancer colorectal, cette étude de cohorte en population analyse l'association entre une utilisation de bisphosphonates oraux après le diagnostic de cancer et la mortalité spécifique

Post-diagnostic oral bisphosphonate use and colorectal cancer mortality: a population-based cohort study within the UK Clinical Practice Research Datalink

Hicks, B. M. ; Murray, L. J. ; Hughes, C. ; Cardwell, C. R.

Background: We conducted the first study to investigate post-diagnostic oral bisphosphonates use and colorectal cancer-specific mortality. Methods: Colorectal cancer patients were identified from the National Cancer Data Repository (1998–2007) and linked to the UK Clinical Practice Research Datalink, providing prescription records, and Office of National Statistics mortality data. Time-dependent Cox regression models investigated colorectal cancer-specific mortality in post-diagnostic [...]

A partir des données d'un registre américain des cancers familiaux portant sur 1 309 patients atteints d'un cancer colorectal diagnostiqué entre 1998 et 2007, cette étude évalue l'association entre une activité physique avant le diagnostic et la survie des patients, en fonction des caractéristiques de la tumeur et la présence de mutations des gènes BRAF et KRAS

Prediagnostic physical activity and colorectal cancer survival: overall and stratified by tumor characteristics

Hardikar, Sheetal ; Newcomb, Polly A. ; Campbell, Peter T. ; Win, Aung Ko ; Lindor, Noralane M. ; Buchanan, Daniel D. ; Makar, Karen W. ; Jenkins, Mark A. ; Potter, John D. ; Phipps, Amanda I.

Background: Physical activity is associated with a lower incidence of colorectal cancer (CRC); however, the relationship of physical activity with CRC survival is not yet clear. We evaluated the association between pre-diagnostic physical activity and CRC survival, overall and accounting for tumor-markers associated with CRC survival: BRAF and KRAS mutation status and microsatellite instability (MSI) status. Methods: Participants were 20-74 year old CRC patients diagnosed between 1998 and 2007 [...]

Menée au Royaume-Uni à partir de données portant sur 664 patients ayant survécu à un sarcome osseux pédiatrique, cette étude analyse l'évolution des effets indésirables des traitements et la survie des patients, sur une période de suivi de 25 ans

Long-term adverse outcomes in survivors of childhood bone sarcoma: the British Childhood Cancer Survivor Study

Fidler, M. M. ; Frobisher, C. ; Guha, J. ; Wong, K. ; Kelly, J. ; Winter, D. L. ; Sugden, E. ; Duncan, R. ; Whelan, J. ; Reulen, R. C. ; Hawkins, M. M.

Background: With improved survival, more bone sarcoma survivors are approaching middle age making it crucial to investigate the late effects of their cancer and its treatment. We investigated the long-term risks of adverse outcomes among 5-year bone sarcoma survivors within the British Childhood Cancer Survivor Study. Methods: Cause-specific mortality and risk of subsequent primary neoplasms (SPNs) were investigated for 664 bone sarcoma survivors. Use of health services, health and marital [...]

A partir des données des registres français des cancers, cette étude analyse l'évolution géographique de l'incidence du cancer papillaire de la thyroïde et de la survie des patients, sur la période 1982-2010

Recent trends in incidence, geographical distribution, and survival of papillary thyroid cancer in France

Colonna, M. ; Uhry, Z. ; Guizard, A. V. ; Delafosse, P. ; Schvartz, C. ; Belot, A. ; Grosclaude, P.

Background : Over the past few decades, the incidence of thyroid cancer has dramatically increased in many countries. This increase was mainly seen in papillary cancer. The role of diagnostic practices and the effects of other risk factors were suggested to explain this increase. We provide a descriptive analysis in terms of changes in incidence, geographical distribution, and survival to check the relevance of assumptions about the increase. Methods : A detailed analysis of changes in [...]

Menée aux Etats-Unis à partir de données portant sur 890 patientes atteintes d'un cancer de l'endomètre, cette étude analyse l'association entre l'utilisation d'un traitement hormonal substitutif de la ménopause avant le diagnostic et la mortalité spécifique ou toutes causes confondues sur une durée de 10 ans

Menopausal hormone therapy and mortality among endometrial cancer patients in the NIH-AARP Diet and Health Study

Felix, AshleyS ; Arem, Hannah ; Trabert, Britton ; Gierach, GretchenL ; Park, Yikyung ; Pfeiffer, RuthM ; Brinton, LouiseA

Background : While menopausal hormone therapy (MHT) is an established endometrial cancer risk factor, its relationship with mortality among endometrial cancer patients is understudied. Methods : Within the NIH-AARP Diet and Health Study, we examined the associations of pre-diagnosis MHT use with 10-year all-cause and endometrial cancer-specific mortality among 890 endometrial cancer patients. We used Cox proportional hazards regression models to estimate hazard ratios (HRs) and 95 % confidence [...]

A partir d'une revue systématique de la littérature (33 articles), cette étude fait le point sur l'association entre divers types d'émotions ressenties par les individus et leur décision de consulter un médecin pour des sympômes suggérant un cancer

The role of emotions in time to presentation for symptoms suggestive of cancer: a systematic literature review of quantitative studies

Balasooriya-Smeekens, Chantal ; Walter, Fiona M. ; Scott, Suzanne

Background : Emotions may be important in patients' decisions to seek medical help for symptoms suggestive of cancer. Objectives : The aim of this systematic literature review was to examine quantitative literature on the influence of emotion on patients' help-seeking for symptoms suggestive of cancer. The objectives were to identify the following: (a) which types of emotions influence help-seeking behaviour, (b) whether these form a barrier or trigger for seeking medical help and (c) how the [...]

Menée aux Etats-Unis par questionnaire auprès de 70 participantes, cette étude analyse l'image corporelle et la sexualité des femmes après des traitements pour un cancer du rectum ou de l'anus

Body image and sexual function in women after treatment for anal and rectal cancer

Benedict, Catherine ; Philip, Errol J. ; Baser, Raymond E. ; Carter, Jeanne ; Schuler, Tammy A. ; Jandorf, Lina ; DuHamel, Katherine ; Nelson, Christian

Objective : Treatment for anal and rectal cancer (ARCa) often results in side effects that directly impact sexual functioning; however, ARCa survivors are an understudied group, and factors contributing to the sexual sequelae are not well understood. Body image problems are distressing and may further exacerbate sexual difficulties, particularly for women. This preliminary study sought to (1) describe body image problems, including sociodemographic and disease/treatment correlates, and (2) [...]

Mené aux Etats-Unis auprès de 331 patientes âgées atteintes d'un cancer du sein de stade précoce (âge compris entre 65 et 90 ans), cet essai randomisé analyse l'association entre le soutien social, la survenue d'événements indésirables liés aux traitements et la survie des patientes

Social support and its implications in older, early-stage breast cancer patients in CALGB 49907 (Alliance A171301)

Jatoi, Aminah ; Muss, Hyman ; Allred, Jake B. ; Cohen, Harvey J. ; Ballman, Karla ; Hopkins, Judith O. ; Gajra, Ajeet ; Lafky, Jacqueline ; Wolff, Antonio ; Kottschade, Lisa ; Gralow, Julie ; Hurria, Arti

Background : Studies point to a direct association between social support and better cancer outcomes. This study examined whether baseline social support is associated with better survival and fewer chemotherapy-related adverse events in older, early-stage breast cancer patients. Methods : This study is a pre-planned secondary analysis of CALGB 49907/Alliance A171301, a randomized trial that compared standard adjuvant chemotherapy versus capecitabine in breast cancer patients 65 years of age or [...]

Menée aux Etats-Unis, cette étude analyse l'évolution de l'utilisation des thérapies ciblées et des coûts associés, pour des patients atteints de cancer bénéficiant d'une couverture médicale privée, sur la période 2001-2011

Trends in the Cost and Use of Targeted Cancer Therapies for the Privately Insured Nonelderly: 2001 to 2011

Shih, Ya-Chen Tina ; Smieliauskas, Fabrice ; Geynisman, Daniel M. ; Kelly, Ronan J. ; Smith, Thomas J.

Purpose : This study sought to define and identify drivers of trends in cost and use of targeted therapeutics among privately insured nonelderly patients with cancer receiving chemotherapy between 2001 and 2011. Methods : We classified oncology drugs as targeted oral anticancer medications, targeted intravenous anticancer medications, and all others. Using the LifeLink Health Plan Claims Database, we studied and disaggregated trends in use and in insurance and out-of-pocket payments per patient [...]

A partir de données administratives en France, en Allemagne et au Royaume-Uni, cette étude analyse et compare, dans ces trois pays, les coûts associés aux traitements du cancer du poumon non à petites cellules

Treatment cost of non-small cell lung cancer in three European countries: comparisons across France, Germany, and England using administrative databases

McGuire, A. ; Martín, M. ; Lenz, C. ; Sollano, J. A.

Introduction: Lung cancer is a highly prevalent condition with non-small cell lung cancer (NSCLC), representing ∼ 80%. Given its high prevalence and poor survival rates, it is important to understand costs associated with NSCLC treatment. Objectives: To carry out an incidence-based study in three European countries: France, Germany, and the UK, to estimate the cost of NSCLC treatment. Methods: Three similar administrative databases were accessed; Hospital Episode Statistics (England), [...]

Menée au Canada, cette étude analyse le rapport coût-efficacité d'un traitement de première ligne par bévacizumab pour les patients atteints d'un glioblastome multiforme récemment diagnostiqué

Economic Evaluation of Bevacizumab for the First-Line Treatment of Newly Diagnosed Glioblastoma Multiforme

Kovic, Bruno ; Xie, Feng

Purpose : The Avastin in Glioblastoma trial has shown that patients newly diagnosed with glioblastoma multiforme (GBM) treated with bevacizumab plus radiotherapy and temozolomide versus radiotherapy and temozolomide alone showed improvement in progression-free survival, possibly leading to a new indication for first-line use of bevacizumab in GBM. The cost-utility of this new intervention remains unknown; therefore, we developed a Markov model estimating the incremental cost-utility ratio [...]

Menée aux Etats-Unis à partir de données de trois enquêtes annuelles conduites de 2006 à 2008 auprès de patients ayant survécu à un cancer diagnostiqué en 2005, cette étude longitudinale analyse l'évolution de leurs besoins en informations, notamment relatives au risque de récidive, aux effets indésirables des traitements et au risque de cancer chez des membres de leur famille

Evolving information needs among colon, breast, and prostate cancer survivors: Results from a longitudinal mixed-effects analysis

Tan, Andy S.L. ; Nagler, Rebekah H. ; Hornik, Robert C. ; DeMichele, Angela

Background: This study describes how cancer survivors' information needs about recurrence, late effects, and family risks of cancer evolve over the course of their survivorship period. Methods: Three annual surveys were conducted from 2006 to 2008 in a cohort of Pennsylvania cancer survivors diagnosed with colon, breast, or prostate cancer in 2005 (Round 1 N=2013, Round 2 N=1293, Round 3 N = 1,128). Outcomes were information seeking about five survivorship topics. Key predictors were survey [...]

Menée en France par questionnaire auprès de 426 patientes ayant survécu à un cancer du sein, cette étude analyse leurs besoins en information, leurs perceptions relatives aux compétences de communication des soignants et leur satisfaction relative aux soins reçus

Breast cancer survivors' perceived medical communication competence and satisfaction with care at the end of treatment

Brédart, Anne ; Kop, Jean-Luc ; Fiszer, Chavie ; Sigal-Zafrani, Brigitte ; Dolbeault, Sylvie

Background : Information is a care priority in most breast cancer survivors (BCS). We assessed whether BCS information needs at 8 months after hospital cancer treatment could be related to their age, education level, perceived medical communication competence, satisfaction with care, attachment style, and self-esteem. Methods : Of 426 BCS approached during the last week of treatment (T1), 85% completed the Medical Communication Competence Scale, European Organisation for Research and Treatment [...]

Menée aux Etats-Unis auprès de 353 patients atteints d'un cancer métastatique, cette étude de cohorte prospective analyse les disparités, entre femmes et hommes, dans leurs choix relatifs aux soins de fin de vie

Male-female patient differences in the association between end-of-life discussions and receipt of intensive care near death

Sharma, Rashmi K. ; Prigerson, Holly G. ; Penedo, Frank J. ; Maciejewski, Paul K.

BACKGROUND Patient gender plays a significant role in patient-physician communication, patients’ understanding of illness, and the aggressiveness of end-of-life (EoL) care. However, little is known about the extent to which gender differences in the effects of EoL discussions on EoL care contribute to gender differences in EoL care. The current study was aimed at determining whether gender differences exist in the receipt of intensive care unit (ICU) care near death and in the association [...]

Cette étude présente un cadre théorique, inspiré des industries à haut risque technologique (aviation, industrie nucléaire), visant à promouvoir la sécurité des patients en oncologie clinique, puis l'illustre par des exemples mis en oeuvre dans un Centre de lutte contre le cancer en Caroline du nord

Improving patient safety in clinical oncology: Applying lessons from normal accident theory

Chera, B. S. ; Mazur, L. ; Buchannan, I. ; et al.,

Concerns for patient safety persist in clinical oncology. Within several nonmedical areas (eg, aviation, nuclear power), concepts from Normal Accident Theory (NAT), a framework for analyzing failure potential within and between systems, have been successfully applied to better understand system performance and improve system safety. Clinical oncology practice is interprofessional and interdisciplinary, and our therapies often have narrow therapeutic windows. Thus, many of our processes are, in [...]