A partir de données de 9 études cas-témoins, cette étude évalue l'association entre une consommation de vitamine D contenue dans l'alimentation et le risque de cancer du pancréas

Vitamin D and pancreatic cancer: a pooled analysis from the Pancreatic Cancer Case-Control Consortium

Waterhouse, M. ; Risch, H. A. ; Bosetti, C. ; Anderson, K. E. ; Petersen, G. M. ; Bamlet, W. R. ; Cotterchio, M. ; Cleary, S. P. ; Ibiebele, T. ; La Vecchia, C. ; Skinner, H. ; Strayer, L. ; Bracci, P. M. ; Maisonneuve, P. ; Bueno-de-Mesquita, H. Bas ; Zatonski, W. ; Lu, L. ; Yu, H. ; Janik-Koncewicz, K. ; Neale, R. E.

Background : The potential role of vitamin D in the aetiology of pancreatic cancer is unclear, with recent studies suggesting both positive and negative associations. Patients and methods : We used data from 9 case-control studies from the International Pancreatic Cancer Case-Control Consortium (PanC4) to examine associations between pancreatic cancer risk and dietary vitamin D intake. Study-specific odds ratios (ORs) were estimated using multivariable logistic regression, and ORs were then [...]

A partir d'une revue systématique de la littérature (21 études observationnelles), cette méta-analyse fait le point sur l'association entre des comportements sédentaires et le risque de cancer du sein

Association of sedentary behavior with the risk of breast cancer in women: update meta-analysis of observational studies

Zhou, Yingchun ; Zhao, Hongyang ; Peng, Cheng

Background : Increasing studies focus on the health consequences of sedentary behavior, and whether sedentary behavior is associated with the risk of breast cancer remains uncertain. We applied quantitative techniques to synthesize relevant original observational studies to investigate this issue. Methods : PubMed and Embase were searched through September 2014 to identify cohort and case-control studies that evaluated the association between sedentary behavior and breast cancer risk in women. [...]

Menée en Suède par questionnaire auprès de 37 004 participantes (1 603 cas), cette étude de cohorte évalue la relation entre un régime alimentaire associé à un niveau élevé d'œstrogènes et le risque de cancer du sein

An estrogen-associated dietary pattern and breast cancer risk in the Swedish Mammography Cohort

Harris, Holly R. ; Bergkvist, Leif ; Wolk, Alicja

High endogenous hormone levels have been associated with breast cancer and dietary factors have the potential to influence breast cancer risk through effects on hormone levels. Dietary patterns derived from reduced rank regression provide a way to identify food groups correlated with hormones and subsequently examine food patterns that may be associated with breast cancer risk. We investigated whether a dietary pattern previously correlated with estradiol and estrone sulfate was associated with [...]

A partir de données portant sur 5 409 patients vivant en Finlande, Islande, Norvège et Suède et sur 27 045 témoins, cette étude évalue l'association entre une exposition professionnelle à des chocs électriques et à des champs magnétiques d'extrêmement basse fréquence et le risque de leucémie myéloïde aiguë

Occupational exposure to extremely low-frequency magnetic fields and electrical shocks and acute myeloid leukemia in four Nordic countries

Talibov, Madar ; Guxens, Mònica ; Pukkala, Eero ; Huss, Anke ; Kromhout, Hans ; Slottje, Pauline ; Martinsen, JanIvar ; Kjaerheim, Kristina ; Sparén, Pär ; Weiderpass, Elisabete ; Tryggvadottir, Laufey ; Uuksulainen, Sanni ; Vermeulen, Roel

Objective : We studied the association between occupational exposure to extremely low-frequency magnetic fields (ELF-MF) and electrical shocks and acute myeloid leukemia (AML) in the Nordic Occupational Cancer cohort (NOCCA). Methods : We included 5,409 adult AML cases diagnosed between 1961 and 2005 in Finland, Iceland, Norway, and Sweden and 27,045 controls matched by age, sex, and country. Lifetime occupational ELF-MF exposure and risk of electrical shocks were assigned to jobs reported in [...]

Menée aux Etats-Unis à partir de données portant sur 1 706 cas et 3 381 témoins, cette étude évalue l'association entre une exposition professionnelle à des particules minérales et le risque de cancer du poumon chez des salariés travaillant dans une mine de taconite

Occupational exposures and lung cancer risk among Minnesota taconite mining workers

Allen, Elizabeth M ; Alexander, Bruce H ; MacLehose, Richard F ; Nelson, Heather H ; Ryan, Andrew D ; Ramachandran, Gurumurthy ; Mandel, Jeffrey H

Objective : To examine the association between employment duration, elongate mineral particle (EMP) exposure, silica exposure and the risk of lung cancer in the taconite mining industry. Methods : We conducted a nested case–control study of lung cancer within a cohort of Minnesota taconite iron mining workers employed by any of the mining companies in operation in 1983. Lung cancer cases were identified by vital records and cancer registry data through 2010. Two age-matched controls were [...]

Menée en Italie sur 198 femmes présentant des résultats de frottis anormaux, cette étude évalue les facteurs associés au risque d'infection par le papillomavirus humain et à un diagnostic de néoplasies cervicales

HPV infection and cervical neoplasia: associated risk factors

Ribeiro, Andrea ; Costa, Maria ; Alves, Rosane ; Villa, Luisa ; Saddi, Vera ; Carneiro, Megmar ; Zeferino, Luiz ; Rabelo-Santos, Silvia

Background : Behavioral risks such as age at first sexual intercourse, number of sexual partners and partner's sexual behavior are associated with an increased risk of HPV infection, persistence of the infection and the development of neoplastic precursor lesions. The objective of this study was to evaluate the risk factors associated with HPV positivity and with a diagnosis of cervical neoplasia in women referred with an abnormal cervical smear. Methods : This study evaluated a series of 198 [...]

Menée en Italie auprès de 294 cas et 279 témoins, cette étude évalue l'association entre des maladies chroniques, une histoire familiale de cancer et le risque de leucémie ou de lymphome non hodgkinien chez l'adulte

Chronic diseases, medical history and familial cancer, and risk of leukemia and non-Hodgkin’s lymphoma in an adult population: a case–control study

Parodi, Stefano ; Santi, Irene ; Marani, Enza ; Casella, Claudia ; Puppo, Antonella ; Sola, Simona ; Fontana, Vincenzo ; Stagnaro, Emanuele

Purpose : This investigation was aimed at evaluating the association between chronic diseases, medical history and familial cancer, and the risk of developing hematological malignancies. Methods : Data were drawn from a population-based case–control study carried out to assess the risk of non-Hodgkin’s lymphoma and leukemia in an adult population exposed to environmental air pollution in Northern Italy. Each case was classified according to the WHO ICD-O-3 classification. Statistical analyses [...]

Menée en France à partir de données portant sur 415 patients pour lesquels un syndrome de Li-Fraumeni est suspecté et qui sont porteurs de mutations du gène TP53, cette étude analyse l'hétérogénéité des types de cancer en fonction du sexe des patients, de l'âge au diagnostic et de la nature des mutations

Revisiting Li-Fraumeni Syndrome From TP53 Mutation Carriers

Bougeard, Gaelle ; Renaux-Petel, Mariette ; Flaman, Jean-Michel ; Charbonnier, Camille ; Fermey, Pierre ; Belotti, Muriel ; Gauthier-Villars, Marion ; Stoppa-Lyonnet, Dominique ; Consolino, Emilie ; Brugières, Laurence ; Caron, Olivier ; Benusiglio, Patrick R. ; Bressac-de Paillerets, Brigitte ; Bonadona, Valerie ; Bonaïti-Pellié, Catherine ; Tinat, Julie ; Baert-Desurmont, Stephanie ; Frebourg, Thierry

Purpose : The aim of the study was to update the description of Li-Fraumeni syndrome (LFS), a remarkable cancer predisposition characterized by extensive clinical heterogeneity. Patients and Methods : From 1,730 French patients suggestive of LFS, we identified 415 mutation carriers in 214 families harboring 133 distinct TP53 alterations and updated their clinical presentation. Results : The 322 affected carriers developed 552 tumors, and 43% had developed multiple malignancies. The mean age of [...]

Menée aux Etats-Unis auprès de 517 cas et 783 témoins, cette étude analyse l'association entre une histoire familiale de cancer et le risque de lymphome hodgkinien avant l'âge de 15 ans

Family history of cancer and risk of pediatric and adolescent Hodgkin lymphoma: A Children's Oncology Group study

Linabery, Amy M. ; Erhardt, Erik B. ; Richardson, Michaela R. ; Ambinder, Richard F. ; Friedman, Debra L. ; Glaser, Sally L. ; Monnereau, Alain ; Spector, Logan G. ; Ross, Julie A. ; Grufferman, Seymour

Family history of lymphoid neoplasm (LN) is a strong and consistently observed Hodgkin lymphoma (HL) risk factor, although it has been only marginally examined in pediatric/adolescent patients. Here, healthy control children identified by random digit dialing were matched on sex, race/ethnicity and age to HL cases diagnosed at 0–14 years at Children's Oncology Group institutions in 1989–2003. Detailed histories were captured by structured telephone interviews with parents of 517 cases and 783 [...]

Menée à partir de données portant sur 10 226 cas et 10 286 témoins ayant des ancêtres européens, cette étude évalue l'association entre l'indice de masse corporelle et le risque de cancer colorectal, en utilisant un score de risque basé sur 77 variants liés à l'obésité et précédemment identifiés dans des études d'association sur le génome entier

Mendelian randomization study of body mass index and colorectal cancer risk

Thrift, Aaron P. ; Gong, Jian ; Peters, Ulrike ; Chang-Claude, Jenny ; Rudolph, Anja ; Slattery, Martha L. ; Chan, Andrew T. ; Locke, Adam E. ; Kahali, Bratati ; Justice, Anne E. ; Pers, Tune H. ; Gallinger, steven ; Hayes, Richard B. ; Baron, John A. ; Caan, Bette J. ; Ogino, Shuji ; Berndt, Sonja I. ; Chanock, Stephen J. ; Casey, Graham ; Haile, Robert W. ; Du, Mengmeng ; Harrison, Tabitha A. ; Thornquist, Mark ; Duggan, David J. ; Le Marchand, Loic ; Lindor, Noralane M. ; Seminara, Daniela ; Song, Mingyang ; Wu, Kana ; Thibodeau, Stephen N. ; Cotterchio, Michelle ; Win, Aung Ko ; Jenkins, Mark A. ; Hopper, John L. ; Ulrich, Cornelia M. ; Potter, John D. ; Newcomb, Polly A. ; Hoffmeister, Michael ; Brenner, Hermann ; White, Emily ; Hsu, Li ; Campbell, Peter T.

Background: High body mass index (BMI) is consistently linked to increased risk of colorectal cancer (CRC) for men, whereas the association is less clear for women. As risk estimates from observational studies may be biased and/or confounded, we conducted a Mendelian randomization study to estimate the causal association between BMI and CRC. Methods: We used data from 10,226 CRC cases and 10,286 controls of European ancestry. The Mendelian randomization analysis used a weighted genetic risk [...]

Menée aux Etats-Unis à partir de données portant sur 10 226 cas et 10 286 témoins et en utilisant un score de risque basé sur 696 variants génétiques associés à la taille, cette étude évalue l'association entre la taille de l'individu et le risque de cancer colorectal

Mendelian randomization study of height and risk of colorectal cancer

Thrift, Aaron P ; Gong, Jian ; Peters, Ulrike ; Chang-Claude, Jenny ; Rudolph, Anja ; Slattery, Martha L ; Chan, Andrew T ; Esko, Tonu ; Wood, Andrew R ; Yang, Jian ; Vedantam, Sailaja ; Gustafsson, Stefan ; Pers, Tune H ; GIANT Consortium ; Baron, John A ; Bézieau, Stéphane ; Küry, Sébastien ; Ogino, Shuji ; Berndt, Sonja I ; Casey, Graham ; Haile, Robert W ; Du, Mengmeng ; Harrison, Tabitha A ; Thornquist, Mark ; Duggan, David J ; Le Marchand, Loic ; Lemire, Mathieu ; Lindor, Noralane M ; Seminara, Daniela ; Song, Mingyang ; Thibodeau, Stephen N ; Cotterchio, Michelle ; Win, Aung Ko ; Jenkins, Mark A ; Hopper, John L ; Ulrich, Cornelia M ; Potter, John D ; Newcomb, Polly A ; Schoen, Robert E ; Hoffmeister, Michael ; Brenner, Hermann ; White, Emily ; Hsu, Li ; Campbell, Peter T

Background: For men and women, taller height is associated with increased risk of all cancers combined. For colorectal cancer (CRC), it is unclear whether the differential association of height by sex is real or is due to confounding or bias inherent in observational studies. We performed a Mendelian randomization study to examine the association between height and CRC risk. Methods: To minimize confounding and bias, we derived a weighted genetic risk score predicting height (using 696 genetic [...]

A partir des données de deux études prospectives incluant 2 862 cas et d'une méta-analyse de 11 études incluant 5 371 cas, cette étude évalue l'association entre le niveau plasmatique de protéine C réactive et le risque de cancer du sein

Plasma C - reactive Protein and Risk of Breast Cancer in two Prospective Studies and a Meta-analysis

Wang, Jun ; Lee, I-Min ; Tworoger, Shelley S. ; Buring, Julie E ; Ridker, Paul M. ; Rosner, Bernard ; Hankinson, Susan E.

Background: C-reactive protein has been evaluated as a risk factor for breast cancer in epidemiologic studies. However, results from prospective studies are inconsistent. Methods: We evaluated the association using pre-diagnostic blood samples in a case-control study nested within the Nurses' Health Study (NHS) and the full cohort of the Women's Health Study (WHS). 943 cases in the NHS and 1919 cases in the WHS contributed to the analysis. Conditional logistic regression and Cox proportional [...]

A partir de données portant sur 690 cas et 665 témoins, cette étude italienne évalue l'association entre un diabète et le risque de cancer de la vessie

Diabetes mellitus and the risk of bladder cancer: an Italian case-control study

Turati, F. ; Polesel, J. ; Di Maso, M. ; Montella, M. ; Libra, M. ; Grimaldi, M. ; Tavani, A. ; Serraino, D. ; La Vecchia, C. ; Bosetti, C.

Background: Diabetes mellitus has been associated with an increased risk of bladder cancer, although the evidence is still open to discussion. Methods: We examined this association using data from a multicentre Italian case–control study, conducted between 2003 and 2014 on 690 bladder cancer cases and 665 frequency-matched hospital controls. Odds ratios (ORs) for diabetes were estimated by unconditional multiple logistic regression models, after allowance for major known risk factors for [...]

A partir de données de deux études, l'une menée en Israël (638 cas et 496 témoins) et l'autre aux Etats-Unis (5 093 cas et 4 735 témoins), cette étude compare l'association entre le tabagisme et le risque de cancer du poumon entre des populations juives et non juives, en fonction de variants génétiques précédemment identifiés dans des études d'association sur le génome entier

Lower lung cancer rates in Jewish smokers in Israel and the USA

Rennert, Gad ; Kremer, Ran ; Rennert, Hedy S. ; Wollner, Mira ; Agbarya, Abed ; Pinchev, Mila ; Lejbkowicz, Flavio ; Spitz, Margaret R. ; Muscat, Joshua E.

Lung cancer rates in Israeli Jews have remained stable over the last five decades and are much lower than in most developed countries despite high historical smoking rates. We compared lung cancer risk in Jews and non-Jews in Israel and in the United States. Data were derived from a population-based, case–control study in Israel (638 cases, 496 controls) to estimate lung cancer risk associated with smoking. Data were also acquired from a case–control study in the United States with information [...]