Menée aux Etats-Unis à partir d'une enquête téléphonique réalisée sur la période 2012-2013 auprès de 9 656 adultes, cette étude analyse la relation entre l'utilisation de la cigarette électronique et l'abstinence tabagique ou les tentatives d'arrêter de fumer

Profile of e-cigarette use and its relationship with cigarette quit attempts and abstinence in Kansas adults

Christensen, Trevor ; Welsh, Ericka ; Faseru, Babalola

Objective : Describe electronic cigarette use in Kansas adults and its relationship with cigarette cessation. Methods : The Kansas Adult Tobacco Survey (ATS) is a 2012–2013 phone survey of non-institutionalized Kansas adults (N = 9,656). The ATS was analyzed to create a profile of cigarette and e-cigarette users, and demonstrate associations between e-cigarette use and cigarette cessation attempts and cigarette abstinence. Results : In 2013, 45% of adult cigarette smokers had tried e-cigarettes [...]

Menée à partir des données d'une étude italienne incluant 230 patients atteints d'un cancer gastrique et 547 témoins et à partir d'une revue de la littérature (26 études), cette méta-analyse évalue l'association entre la consommation de légumes appartenant au genre Allium (oignon, ail, poireau, ...) et le risque de développer la maladie

Allium vegetable intake and gastric cancer: a case-control study and meta-analysis

Turati, F. ; Pelucchi, C. ; Guercio, V. ; La Vecchia, C. ; Galeone, C.

Aim : To provide new epidemiological data and summarize evidence on the association between allium vegetable intake and gastric cancer risk. Methods : Data were from an Italian case-control study including 230 cases and 547 controls. Odds ratios (OR) were derived using multiple logistic regression. We combined results from all published studies using random-effect models. Results : In our case-control study, the ORs were 0.59 (95% confidence interval, CI, 0.25-1.41) for ≥2 portions of [...]

Menée à partir de données de 12 études cas-témoins incluant au total 7 548 patients pédiatriques atteints d'une leucémie lymphoblastique aiguë ou d'une leucémie myéloïde aiguë et 11 635 témoins, cette étude évalue l'association entre la consommation d'acide folique et de vitamines en supplémentation durant la grossesse et le risque de leucémie chez l'enfant

Maternal Supplementation with Folic Acid and Other Vitamins and Risk of Leukemia in Offspring: A Childhood Leukemia International Consortium Study

Metayer, Catherine ; Milne, Elizabeth ; Dockerty, John D. ; Clavel, Jacqueline ; Pombo-de-Oliveira, Maria S. ; Wesseling, Catharina ; Spector, Logan G. ; Schüz, Joachim ; Petridou, Eleni ; Ezzat, Sameera ; Armstrong, Bruce K. ; Rudant, Jérémie ; Koifman, Sergio ; Kaatsch, Peter ; Moschovi, Maria ; Rashed, Wafaa M. ; Selvin, Steve ; McCauley, Kathryn ; Hung, Rayjean J. ; Kang, Alice Y. ; Infante-Rivard, Claire

Background : Maternal prenatal supplementation with folic acid and other vitamins has been inconsistently associated with a reduced risk of childhood acute lymphoblastic leukemia (ALL). Little is known regarding the association with acute myeloid leukemia (AML), a rarer subtype. Methods : We obtained original data on prenatal use of folic acid and vitamins from 12 case-control studies participating in the Childhood Leukemia International Consortium (enrollment period: 1980-2012), including [...]

A partir d'une revue systématique de la littérature publiée jusqu'en décembre 2012 (8 études cas-témoins et 6 études de cohorte), cette méta-analyse évalue l'association entre la consommation de thé et le risque de cancer du pancréas

Consumption of Tea and Risk for Pancreatic Cancer : A Meta-Analysis of Published Epidemiological Studies

Chang, Bing ; Sang, Lixuan ; Wang, Ying ; Tong, Jing ; Wang, Bing-Yuan

Epidemiologic studies on the relationship between tea consumption and pancreatic cancer are inconsistent. Therefore, we conducted a systematic search of databases and performed a meta-analysis to analyze the association between tea consumption and risk of pancreatic cancer. We searched Medline, EMBASE, ISI Web of Science, and the Cochrane library for studies of tea consumption and pancreatic cancer published up to December 2012. Subgroup analysis was conducted by study type, study region, sex, [...]

Menée sur une lignée cellulaire de cancer du côlon surexprimant le récepteur ER

In Vitro Effects of Extracts of Extra Virgin Olive Oil on Human Colon Cancer Cells

Pampaloni, Barbara ; Mavilia, Carmelo ; Fabbri, Sergio ; Romani, Annalisa ; Ieri, Francesca ; Tanini, Annalisa ; Tonelli, Francesco ; Brandi, Maria Luisa

The Mediterranean diet is associated with a lower incidence of atherosclerosis, cardiovascular diseases, and some types of cancer. Recent interest has been focused on the biological activity of phenolic compounds present in extra virgin olive oils (EVOOs). Both in vivo and in vitro studies have shown that EVOO components have positive effects on metabolic parameters, such as plasma lipoproteins, oxidative damage, inflammatory markers, platelet function, and antimicrobial activity. We have [...]

Menée sur une lignée cellulaire de cancer colorectal, cette étude montre que la lutéoline, un composé chimique de la famille des flavonoïdes, peut induire l'apoptose des cellules tumorales en réduisant l'expression de la calpaïne, de UHRF1 et de DNMT1

Luteolin Induces Apoptosis in BE Colorectal Cancer Cells by Downregulating Calpain, UHRF1, and DNMT1 Expressions

Krifa, Mounira ; Leloup, Ludovic ; Ghedira, Kamel ; Mousli, Marc ; Chekir-Ghedira, Leila

In this study, we have investigated the effects of luteolin on colorectal cancer cells. Our results demonstrate that luteolin is able to induce cytotoxicity and cell cycle perturbation in a dose-dependent manner. By triggering poly(ADP-ribose) polymerase (PARP) cleavage, this molecule is able to induce the apoptosis of BE colorectal cancer cells. We have also studied the potential involvement of calpains in the proapoptotic effects of luteolin. Our data show that luteolin exhibits moderate [...]

Menée sur des lignées cellulaires de cancer du sein humain, cette étude identifie des agents chimiques pouvant inhiber la carcinogenèse associée à une mutation du gène BRCA1

Therapeutic targeting of BRCA1-mutated breast cancers with agents that activate DNA repair

Alli, Elizabeth ; Solow-Cordero, David ; Casey, Stephanie C ; Ford, James M

Cancers due to germline mutations in the BRCA1 gene tend to lack targets for approved chemoprevention agents. This study aimed at a targeted chemoprevention strategy for BRCA1-associated malignancies. Mutant BRCA1 limits the base-excision DNA repair activity that addresses oxidative DNA damage, the accumulation of which heightens one's risk for cancer. Therefore, we conducted a high-throughput chemical screen to identify drug candidates that could attenuate the inhibitory effects of mutant [...]

Menée à partir de données portant sur 2 392 patients atteints d'un cancer des voies aérodigestives supérieures diagnostiqué entre 1996 et 2010 et sur 7 165 témoins (âge moyen : 66 ans ; 63 % d'hommes), cette étude évalue l'association entre l'utilisation d'aspirine ou d'anti-inflammatoires non stéroïdiens et le risque de cancer des voies aérodigestives supérieures

Aspirin and non-steroidal anti-inflammatory drug use and the risk of upper aerodigestive tract cancer

Macfarlane, T. V. ; Lefevre, K. ; Watson, M. C.

Background : Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) are widely used as analgesics and preventative agents for vascular events. It is unclear whether their long-term use affects cancer risk. Data on the chemopreventative role of these drugs on the risk of the upper aerodigestive tract cancer (UADT) are insufficient and mostly refer to oesophageal cancer. The aim of this study was to investigate the effect of aspirin and other NSAIDs on the risk of UADT cancers. Methods [...]