Menée en Pologne auprès de 128 patients atteints de cancer, cette étude analyse l'efficacité d'un traitement à libération prolongée à base d'oxycodone et de naloxone pour soulager les douleurs modérées et sévères liées au cancer

Long-term safety and efficacy of oxycodone/naloxone prolonged-release tablets in patients with moderate-to-severe chronic cancer pain

Ahmedzai, SamH ; Leppert, Wojciech ; Janecki, Marcin ; Pakosz, Artur ; Lomax, Mark ; Duerr, Heike ; Hopp, Michael

Aim : To evaluate the long-term safety and efficacy of prolonged-release oxycodone/naloxone (OXN PR) and its impact on quality of life (QoL), in patients with moderate-to-severe cancer pain. Methods : This was an open-label extension (OLE) of a 4 week, randomized, double-blind (DB) study in which patients with moderate-to-severe cancer pain had been randomized to OXN PR or oxycodone PR (OxyPR). During the OLE phase, patients were treated with OXN PR capsules (≤20/60 mg/day) for ≤24 weeks. [...]

Mené auprès de 362 patients atteints de myélome multiple, cet essai randomisé de phase III analyse l'efficacité d'un traitement composé d'aprépitant, de granisétron et de dexaméthasone pour prévenir les nausées et vomissements induits par une chimiothérapie associant le melphalan à haute dose et une greffe autologue de cellules souches

Aprepitant, Granisetron, and Dexamethasone for Prevention of Chemotherapy-Induced Nausea and Vomiting After High-Dose Melphalan in Autologous Transplantation for Multiple Myeloma: Results of a Randomized, Placebo-Controlled Phase III Trial

Schmitt, Thomas ; Goldschmidt, Hartmut ; Neben, Kai ; Freiberger, Anja ; Hüsing, Johannes ; Gronkowski, Martina ; Thalheimer, Markus ; Pelzl, Le Hang ; Mikus, Gerd ; Burhenne, Jürgen ; Ho, Anthony D. ; Egerer, Gerlinde

Purpose : The optimal regimen to prevent chemotherapy-induced nausea and vomiting (CINV) for patients undergoing high-dose chemotherapy and autologous stem-cell transplantation (ASCT) is unclear. To evaluate the effect of aprepitant in addition to a standard regimen, we conducted this randomized, placebo-controlled phase III trial. Patients and Methods : Patients with multiple myeloma were randomly assigned at a one-to-one ratio to receive either aprepitant (125 mg orally on day 1 and 80 mg [...]

Menée en Norvège par questionnaire auprès de 330 patients ayant subi une prostatectomie radicale, cette étude prospective analyse les facteurs associés à leur retour à l'emploi trois ans après l'intervention

Influence of radical prostatectomy for prostate cancer on work status and working life 3 years after surgery

Dahl, Sigrun ; Loge, JonHåvard ; Berge, Viktor ; Dahl, AlvAndreas ; Cvancarova, Milada ; Fosså, SophieDorothea

Purpose : The purpose of this study is to study the influence of radical prostatectomy (RP) for prostate cancer on work status and working life in men 3 years after surgery. Methods : In a prospective, questionnaire-based study on adverse effects after RP, 330 prostate cancer (PCa) patients who had been active in the workforce before RP described their work status 3 years after having surgery. We dichotomized their postoperative work status into “unchanged or increased” versus “reduced.” The [...]

Menée en Australie auprès de 72 patients atteints d'un cancer colorectal de stade I à III (âge médian : 59 ans) et de 72 témoins, cette étude longitudinale analyse les facteurs associés à une fatigue et à une dégradation de leurs fonctions cognitives

Cognitive function and fatigue after diagnosis of colorectal cancer

Vardy, J.L. ; Dhillon, H.M. ; Pond, G.R. ; Rourke, S.B. ; Xu, W. ; Dodd, A. ; Renton, C. ; Park, A. ; Bekele, T. ; Ringash, J. ; Zhang, H. ; Burkes, R. ; Clarke, S.J. ; Tannock, I.F.

Background : Cognitive impairment and fatigue have been associated with cancer and its treatment. We present baseline data from a large longitudinal study that evaluates cognitive function, fatigue, and potential underlying mechanisms following diagnosis of colorectal cancer (CRC). Patients and methods : We evaluated CRC patients with stage I-III disease before or after surgery, participants with limited metastatic disease and healthy controls (HC). Neuropsychological evaluation included [...]

Menée en Chine auprès de 1 286 hommes âgés de 25 à 65 ans (durée médiane de suivi : 31,8 mois), cette étude de cohorte analyse l'incidence et la prévalence d'une infection génitale par le papillomavirus huamin ainsi que les facteurs associés

Prevalence, Incidence, Clearance and Associated Factors of Genital Human papillomavirus Infection among Men: a population-based cohort study in rural China

Liu, Mengfei ; He, Zhonghu ; Zhang, Chanyuan ; Liu, Fangfang ; Liu, Ying ; Li, Jingjing ; Xu, Zhongyao ; Wang, Qiyan ; Hang, Dong ; Shen, Na ; Pan, Yaqi ; Guo, Chuanhai ; Cai, Hong ; Ke, Yang

Background:The natural history of Human papillomavirus (HPV) infection in men on a population base has rarely been studied in general, particularly among Chinese men. Methods:1286 men aged 25-65 years from rural China were enrolled during 2009-2010 and their genital HPV infection status were assessed bi-annually for up to 7 visits using PCR and sequencing method. Prevalence analysis was performed among men with at least one valid HPV result (N=1279) and men with at least two consecutive HPV [...]

Menée à partir des données du registre international des blastomes pleuropulmonaires portant sur 350 cas, cette étude analyse la survie des patients en fonction des sous-types cliniques de la maladie

Pleuropulmonary blastoma: A report on 350 central pathology–confirmed pleuropulmonary blastoma cases by the International Pleuropulmonary Blastoma Registry

Messinger, Yoav H. ; Stewart, Douglas R. ; Priest, John R. ; Williams, Gretchen M. ; Harris, Anne K. ; Schultz, Kris Ann P. ; Yang, Jiandong ; Doros, Leslie ; Rosenberg, Philip S. ; Hill, D. Ashley ; Dehner, Louis P.

BACKGROUND Pleuropulmonary blastoma (PPB) has 3 subtypes on a tumor progression pathway ranging from type I (cystic) to type II (cystic/solid) and type III (completely solid). A germline mutation in DICER1 is the genetic cause in the majority of PPB cases. METHODS Patients confirmed to have PPB by central pathology review were included, and their clinical characteristics and outcomes were reported. Germline DICER1 mutations were sought with Sanger sequencing. RESULTS There were 435 cases, and a [...]

Menée en Suède à partir de données de 285 040 participants masculins, cette étude prospective évalue l'association entre des anomalies du métabolisme, les risques de cancer de la prostate, de décès par cancer de la prostate et de décès par d'autres causes

Prostate Cancer, Prostate Cancer Death, and Death from Other Causes, Among Men with Metabolic Aberrations

Häggström, Christel ; Stocks, Tanja ; Nagel, Gabriele ; Manjer, Jonas ; Bjørge, Tone ; Hallmans, Göran ; Engeland, Anders ; Ulmer, Hanno ; Lindkvist, Björn ; Selmer, Randi ; Concin, Hans ; Tretli, Steinar ; Jonsson, Håkan ; Stattin, Pär

Background: Few previous studies of metabolic aberrations and prostate cancer risk have taken into account the fact that men with metabolic aberrations have an increased risk of death from causes other than prostate cancer. The aim of this study was to calculate, in a real-life scenario, the risk of prostate cancer diagnosis, prostate cancer death, and death from other causes. Methods: In the Metabolic Syndrome and Cancer Project, prospective data on body mass index, blood pressure, glucose, [...]

A partir des données de trois registres français et d'un registre anglais des cancers portant sur 40 613 cas, cette étude analyse, en France et en Angleterre, l'association entre l'accès géographique aux soins de santé, la pauvreté et la survie de patients atteints d'un cancer colorectal diagnostiqué entre 1997 et 2004

The influence of geographical access to health care and material deprivation on colorectal cancer survival : Evidence from France and England

O. Dejardin ; A.P.Jones ; B.Rachet ; E.Morris ; V.Bouvier ; V.Jooste ; E.Coombes ; D. Formand ; A.M.Bouvier ; G.Launoy

This article investigates the influence of distance to health care and material deprivation on cancer survival for patients diagnosed with a colorectal cancer between 1997 and 2004 in France and England. This population- based study included all cases of colorectal cancer diagnosed between 1997 and 2004 in 3 cancer registries in France and 1cancer registry in England (N : 40 613). After adjustment for material deprivation, travel times in England were no longer significantly associated with [...]

Menée au Danemark auprès de 320 425 individus nés entre 1930 et 1989, cette étude prospective évalue l'association entre le poids à la naissance, l'indice de masse corporelle et la taille durant l'enfance, et le risque de gliome chez l'adulte

A Prospective Study of Height and Body Mass Index in Childhood, Birth Weight, and Risk of Adult Glioma Over 40 Years of Follow-up

Kitahara, Cari M. ; Gamborg, Michael ; Rajaraman, Preetha ; Sørensen, Thorkild I. A. ; Baker, Jennifer L.

Greater attained height and greater body mass index (BMI; weight (kg)/height (m)2) in young adulthood have been associated with glioma risk, but few studies have investigated the association with body size at birth or during childhood, when the brain undergoes rapid cell growth and differentiation. The Copenhagen School Health Records Register includes data on 320,425 Danish schoolchildren born between 1930 and 1989, with height and weight measurements from ages 7–13 years and parentally [...]

A partir des données de 63 études menées aux Etats-Unis, en Europe et dans des pays à revenus élevés, cette étude analyse la prévalence d'une infection par le papillomavirus humain dans le cancer de l'oropharynx, chez les femmes et les hommes

Prevalence of human papillomavirus in cancer of the oropharynx by gender

Combes, Jean-Damien ; Chen, Alyce A. ; Franceschi, Silvia

Oropharyngeal cancer (OPC) is more frequent in men than women mainly due to the heavier and longer-duration of smoking in men. Human papillomavirus (HPV) has a role in the rising incidence of OPC in the US and other high-income countries. To determine if there is a difference in the proportion of HPV-attributable OPC between men and women, we systematically retrieved HPV prevalence data from 63 studies reporting separately on OPC by gender. The male/female (M/F) ratios of HPV prevalence in OPC [...]

Menée aux Pays-Bas auprès de 30 professionnels de santé en oncologie, cette étude analyse leurs pratiques en matière de diagnostic et de prise en charge des troubles de la sexualité chez les patientes atteintes d'un cancer gynécologique

Psychosexual support for gynecological cancer survivors: professionals’ current practices and need for assistance

Vermeer, WillemijnM ; Bakker, RinskeM ; Stiggelbout, AnneM ; Creutzberg, CarienL ; Kenter, GemmaG ; ter Kuile, MoniekM

Purpose : About half of the gynecological cancer (GC) survivors suffer from sexual dysfunctions and report a need for professional psychosexual support. The current study assessed (1) health care professionals’ (HCP) current psychosexual support practices, (2) barriers to providing psychosexual support, and (3) HCP needs for training and assistance. Methods : Semistructured interviews were conducted with gynecological oncologists (n = 10), radiation oncologists (n = 10), and oncology nurses [...]

Menée aux Etats-Unis par enquête auprès de 1 517 aidants familiaux d'un conjoint atteint d'un cancer, cette étude évalue l'association entre leur expérience d'aidant, le stress subi et la survenue de problèmes de santé 5 et 8 ans après le diagnostic de cancer

Cancer caregiving predicts physical impairments: Roles of earlier caregiving stress and being a spousal caregiver

Kim, Youngmee ; Carver, Charles S. ; Shaffer, Kelly M. ; Gansler, Ted ; Cannady, Rachel S.

BACKGROUND The objective of this study was to investigate associations between earlier caregiving experience and the development of physical impairments over the subsequent 6 years among family caregivers of patients with cancer. METHODS Family caregivers of cancer survivors participated in a nationwide survey 2 years after their relative's cancer diagnosis (T1) (N=1517) with follow-up at 5 years (T2) and 8 years (T3) postdiagnosis. Caregivers self-reported their demographics and levels of [...]

A partir d'une revue de la littérature, cette méta-analyse évalue l'efficacité d'interventions destinées à faciliter la réintégration scolaire d'enfants atteints de cancer et leur acceptation par les camarades de classe

Facilitation of school re-entry and peer acceptance of children with cancer: a review and meta-analysis of intervention studies

Helms, A. S. ; Schmiegelow, K. ; Brok, J. ; Johansen, C. ; Thorsteinsson, T. ; Simovska, V. ; Larsen, H. B.

Increased survival rates from childhood cancer call for efforts to reintegrate children with cancer back into their academic and social environments. The aims of this study were to: (1) review and analyse the existing literature on school re-entry interventions for children with cancer; and (2) discuss the importance of peer involvement in the treatment. Relevant databases were searched using equivalent search algorithms and six studies were selected that target children with cancer and/or [...]

Mené aux Etats-Unis auprès de 39 patients atteints d'un cancer du poumon de stade avancé et de leurs aidants familiaux, cet essai randomisé analyse l'efficacité d'une intervention psychosociale visant à développer leur sentiment d'auto-efficacité et d'autonomie et à réduire leurs symptômes de dépression et d'anxiété

Dyadic psychosocial intervention for advanced lung cancer patients and their family caregivers: Results of a randomized pilot trial

Badr, Hoda ; Smith, Cardinale B. ; Goldstein, Nathan E. ; Gomez, Jorge E. ; Redd, William H.

BACKGROUND Advanced lung cancer (LC) patients and their families have reported low self-efficacy for self-care/caregiving and high rates of distress, yet few programs exist to address their supportive care needs during treatment. This pilot study examined the feasibility, acceptability, and preliminary efficacy of a 6-session, telephone-based dyadic psychosocial intervention that was developed for advanced LC patients and their caregivers. The program was grounded in self-determination theory [...]

Cet article analyse un rapport de l'Institut de médecine américain publié en 2013, "Delivering High-Quality Cancer Care: Charting a New Course for a System in Crisis", et passe en revue les principales recommandations pertinentes pour les praticiens

Patient-centered, evidence-based, and cost-conscious cancer care across the continuum: Translating the Institute of Medicine report into clinical practice

Nekhlyudov, Larissa ; Levit, Laura ; Hurria, Arti ; Ganz, Patricia A.

In 2013, the Institute of Medicine (IOM) concluded that cancer care in the United States is in crisis. Patients and their families are not receiving the information that they need to make informed decisions about their cancer care. Many patients do not have access to palliative care and too few are referred to hospice at the appropriate point in their disease trajectory. Simultaneously, there is a growing demand for cancer care with increases in new cancer diagnoses and the number of patients [...]

A partir des données des registres britanniques des cancers portant sur 28 733 patients atteints d'un cancer du poumon diagnostiqué entre 2006 et 2010, cette étude analyse les facteurs (situation sociéconomique du patient, âge, comorbidités, ...) associés aux délais entre une consultation chez le médecin généraliste et la prise en charge thérapeutique

Factors associated with timeliness of post-primary care referral, diagnosis and treatment for lung cancer: population-based, data-linkage study

Forrest, L. F. ; Adams, J. ; White, M. ; Rubin, G.

Background : The NHS Cancer Plan for England set waiting time targets for cancer referral (14 days from GP referral to first hospital appointment) and treatment (31 days from diagnosis, 62 days from urgent GP referral). Interim diagnostic intervals can also be calculated. The factors that influence timely post-primary care referral, diagnosis and treatment for lung cancer are not known. Methods :Northern and Yorkshire Cancer Registry, Hospital Episode Statistics and lung cancer audit data sets [...]

Menée aux Etats-Unis, cette étude passe en revue les facteurs associés à la mise en oeuvre d'une prise de décision partagée entre le médecin et son patient dans la pratique clinique en oncologie

Implementing and evaluating shared decision making in oncology practice

Kane, Heather L. ; Halpern, Michael T. ; Squiers, Linda B. ; Treiman, Katherine A. ; McCormack, Lauren A.

Engaging individuals with cancer in decision making about their treatments has received increased attention; shared decision making (SDM) has become a hallmark of patient-centered care. Although physicians indicate substantial interest in SDM, implementing SDM in cancer care is often complex; high levels of uncertainty may exist, and health care providers must help patients understand the potential risks versus benefits of different treatment options. However, patients who are more engaged in [...]