Menée en Finlande auprès de 6 410 pêcheurs et de 4 260 épouses, cette étude évalue l'association entre une consommation alimentaire importante de poissons, certaines caractéristiques de la profession de pêcheur et le risque de cancer

Cancer incidence in a cohort with high fish consumption

Turunen, AnuW ; Suominen, AnnaL ; Kiviranta, Hannu ; Verkasalo, PiaK ; Pukkala, Eero

Purpose : Evidence suggests that fish-derived omega-3 polyunsaturated fatty acids inhibit cancer promotion and progression. On the other hand, fish may contain endocrine-disrupting and potentially carcinogenic environmental contaminants. Our objective was to describe cancer incidence among the Finnish professional fishermen and their wives who are presumed to eat a lot of fish, partly from the contaminated Baltic Sea. Additionally, we wanted to see whether occupational characteristics are [...]

A partir d'une revue systématique de la littérature (19 études de cohorte prospective), cette étude évalue l'association entre une exposition aux particules fines atmosphériques, le risque de cancer du poumon et la mortalité spécifique chez les adultes

Ambient particulate matter and lung cancer incidence and mortality: a meta-analysis of prospective studies

Cui, Ping ; Huang, Yubei ; Han, Jiali ; Song, Fengju ; Chen, Kexin

Background: Chronic exposure to ambient particulate matter (PM) has been suggested to be associated with an increased risk of lung cancer, but the results were inconsistent. We performed a systematic review and meta-analysis of prospective studies to assess the association between exposure to PM and the incidence and mortality of lung cancer in adults. Methods: We searched PUBMED and EMBASE databases for prospective cohort studies that evaluated the association between PM2.5 (diameter < 2.5 [...]

Menée aux Etats-Unis auprès de 2 667 participantes, cette étude analyse l'association entre une infection par des variants de papillomavirus humain autres que les sous-types 16 et 18 et le risque de néoplasie cervicale intraépithéliale

Lineages of Oncogenic Human Papillomavirus Types Other Than Type 16 and 18 and Risk for Cervical Intraepithelial Neoplasia

Xi, Long Fu ; Schiffman, Mark ; Koutsky, Laura A. ; Hughes, James P. ; Winer, Rachel L. ; Mao, Constance ; Hulbert, Ayaka ; Lee, Shu-Kuang ; Shen, Zhenping ; Kiviat, Nancy B.

Background : Data on clinical outcomes of infection with variants of oncogenic human papillomavirus (HPV) types other than HPV16 and HPV18 are rare. We investigated intratypic variations in non-HPV16/18 oncogenic types and their corresponding relationships with cervical intraepithelial neoplasia grades 2–3 (CIN2/3). Methods : Study subjects were women who were positive for one or more of 11 non-HPV16/18 oncogenic types. Subjects were followed every six months for two years for detection of HPV [...]

A partir d'une revue systématique de la littérature, cette étude fait le point sur l'association entre des polymorphismes génétiques et le risque de lymphome hodgkinien, le pronostic de la maladie, le risque de second cancer induit par les traitements et les toxicités

Genetic associations in classical Hodgkin lymphoma: a systematic review and insights into susceptibility mechanisms

Kushekhar, Kushi ; van den Berg, Anke ; Nolte, Ilja ; Hepkema, Bouke ; Visser, Lydia ; Diepstra, Arjan

Both targeted and genome-wide studies have revealed genetic associations for susceptibility, prognosis and treatment-induced secondary malignancies and toxicities in classical Hodgkin lymphoma (cHL). This review gives a systematic and comprehensive overview of significant associations and places them into a biological context. The strongest susceptibility polymorphisms have been found for the Human Leukocyte Antigen (HLA) genes. These associations are specific for cHL overall or for subgroups [...]

A partir des données de l'essai "Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial" portant sur 39 070 participants, cette étude de cohorte prospective analyse l'association entre une forme de calvitie à l'âge de 45 ans et le risque de cancer agressif de la prostate

Relationship Between Male Pattern Baldness and the Risk of Aggressive Prostate Cancer: An Analysis of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

Zhou, Cindy Ke ; Pfeiffer, Ruth M. ; Cleary, Sean D. ; Hoffman, Heather J. ; Levine, Paul H. ; Chu, Lisa W. ; Hsing, Ann W. ; Cook, Michael B.

Purpose : Male pattern baldness and prostate cancer appear to share common pathophysiologic mechanisms. However, results from previous studies that assess their relationship have been inconsistent. Therefore, we investigated the association of male pattern baldness at age 45 years with risks of overall and subtypes of prostate cancer in a large, prospective cohort—the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. Methods : We included 39,070 men from the usual care and [...]

A partir de données portant sur 43 303 cas de cancer de la prostate et 43 737 témoins dans diverses populations, cette méta-analyse d'études d'association sur le génome entier identifie 23 nouveaux loci de susceptibilité à la maladie

A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer

Al Olama, Ali Amin ; Kote-Jarai, Zsofia ; Berndt, Sonja I. ; Conti, David V. ; Schumacher, Fredrick ; Han, Ying ; Benlloch, Sara ; Hazelett, Dennis J. ; Wang, Zhaoming ; Saunders, Ed ; Leongamornlert, Daniel ; Lindström, Sara ; Jugurnauth-Little, Sara ; Dadaev, Tokhir ; Tymrakiewicz, Malgorzata ; Stram, Daniel O. ; Rand, Kristin ; Wan, Peggy ; Stram, Alex ; Sheng, Xin ; Pooler, Loreall C. ; Park, Karen ; Xia, Lucy ; Tyrer, Jonathan ; Kolonel, Laurence N. ; Le Marchand, Loic ; Hoover, Robert N. ; Machiela, Mitchell J. ; Yeager, Merideth ; Burdette, Laurie ; Chung, Charles C. ; Hutchinson, Amy ; Yu, Kai ; Goh, Chee ; Ahmed, Mahbubl ; Govindasami, Koveela ; Guy, Michelle ; Tammela, Teuvo L. J. ; Auvinen, Anssi ; Wahlfors, Tiina ; Schleutker, Johanna ; Visakorpi, Tapio ; Leinonen, Katri A. ; Xu, Jianfeng ; Aly, Markus ; Donovan, Jenny ; Travis, Ruth C. ; Key, Tim J. ; Siddiq, Afshan ; Canzian, Federico ; Khaw, Kay-Tee ; Takahashi, Atsushi ; Kubo, Michiaki ; Pharoah, Paul ; Pashayan, Nora ; Weischer, Maren ; Nordestgaard, Borge G. ; Nielsen, Sune F. ; Klarskov, Peter ; Roder, Martin Andreas ; Iversen, Peter ; Thibodeau, Stephen N. ; McDonnell, Shannon K. ; Schaid, Daniel J. ; Stanford, Janet L. ; Kolb, Suzanne ; Holt, Sarah ; Knudsen, Beatrice ; Coll, Antonio Hurtado ; Gapstur, Susan M. ; Diver, W. Ryan ; Stevens, Victoria L. ; Maier, Christiane ; Luedeke, Manuel ; Herkommer, Kathleen ; Rinckleb, Antje E. ; Strom, Sara S. ; Pettaway, Curtis ; Yeboah, Edward D. ; Tettey, Yao ; Biritwum, Richard B. ; Adjei, Andrew A. ; Tay, Evelyn ; Truelove, Ann ; Niwa, Shelley ; Chokkalingam, Anand P. ; Cannon-Albright, Lisa ; Cybulski, Cezary ; Wokolorczyk, Dominika ; Kluzniak, Wojciech ; Park, Jong ; Sellers, Thomas ; Lin, Hui-Yi ; Isaacs, William B. ; Partin, Alan W. ; Brenner, Hermann ; Dieffenbach, Aida Karina ; Stegmaier, Christa ; Chen, Constance ; Giovannucci, Edward L. ; Ma, Jing ; Stampfer, Meir ; Penney, Kathryn L. ; Mucci, Lorelei ; John, Esther M. ; Ingles, Sue A. ; Kittles, Rick A. ; Murphy, Adam B. ; Pandha, Hardev ; Michael, Agnieszka ; Kierzek, Andrzej M. ; Blot, William ; Signorello, Lisa B. ; Zheng, Wei ; Albanes, Demetrius ; Virtamo, Jarmo ; Weinstein, Stephanie ; Nemesure, Barbara ; Carpten, John ; Leske, Cristina ; Wu, Suh-Yuh ; Hennis, Anselm ; Kibel, Adam S. ; Rybicki, Benjamin A. ; Neslund-Dudas, Christine ; Hsing, Ann W. ; Chu, Lisa ; Goodman, Phyllis J. ; Klein, Eric A. ; Zheng, S. Lilly ; Batra, Jyotsna ; Clements, Judith ; Spurdle, Amanda ; Teixeira, Manuel R. ; Paulo, Paula ; Maia, Sofia ; Slavov, Chavdar ; Kaneva, Radka ; Mitev, Vanio ; Witte, John S. ; Casey, Graham ; Gillanders, Elizabeth M. ; Seminara, Daniella ; Riboli, Elio ; Hamdy, Freddie C. ; Coetzee, Gerhard A. ; Li, Qiyuan ; Freedman, Matthew L. ; Hunter, David J. ; Muir, Kenneth ; Gronberg, Henrik ; Neal, David E. ; Southey, Melissa ; Giles, Graham G. ; Severi, Gianluca ; The, Breast ; Prostate Cancer Cohort, Consortium ; The, Practical Consortium ; The, Cogs Consortium ; The, Game- O. N. Ellipse Consortium ; Cook, Michael B. ; Nakagawa, Hidewaki ; Wiklund, Fredrik ; Kraft, Peter ; Chanock, Stephen J. ; Henderson, Brian E. ; Easton, Douglas F. ; Eeles, Rosalind A. ; Haiman, Christopher A.

Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility loci for this common cancer, we conducted a meta-analysis of >10 million SNPs in 43,303 prostate cancer cases and 43,737 controls from studies in populations of European, African, Japanese and Latino ancestry. Twenty-three new susceptibility loci were identified at association P < 5 × 10−8; 15 variants [...]