Menée à l'aide de matrices d'exposition professionnelle et à partir de questionnaires auprès de 2 926 patients atteints d'un cancer du poumon et 3 555 témoins, cette étude française évalue l'association entre une exposition à des solvants chlorés et le risque de développer la maladie

Exposure to chlorinated solvents and lung cancer: results of the ICARE study

Mattei, Francesca ; Guida, Florence ; Matrat, Mireille ; Cenée, Sylvie ; Cyr, Diane ; Sanchez, Marie ; Radoi, Loredana ; Menvielle, Gwenn ; Jellouli, Fatima ; Carton, Matthieu ; Bara, Simona ; Marrer, Emilie ; Luce, Danièle ; Stücker, Isabelle

Objective : To investigate the role of occupational exposure to chlorinated solvents in lung cancer aetiology. Methods : ICARE (Investigation of occupational and environmental CAuses of REspiratory cancers) is a French, multicentre, population-based, case–control study. Information on the lifelong work history of 2926 cases and 3555 controls was collected using standardised questionnaires. Occupational exposures were assessed using job-exposure matrices for five chlorinated solvents. Solvents [...]

A partir des données de la cohorte française E3N conduite de 1992 à 2008 et incluant 65 630 femmes ménopausées, cette étude évalue l'association entre différents traitements hormonaux substitutifs de la ménopause et le risque de cancer de l'endomètre

Risks of Endometrial Cancer Associated With Different Hormone Replacement Therapies in the E3N Cohort, 1992–2008

Fournier, Agnès ; Dossus, Laure ; Mesrine, Sylvie ; Vilier, Alice ; Boutron-Ruault, Marie-Christine ; Clavel-Chapelon, Françoise ; Chabbert-Buffet, Nathalie

We assessed whether different oral progestogens in hormone replacement therapy may differentially affect the risk of endometrial cancer, using data from the Etude Epidémiologique auprès de femmes de l'Education Nationale (E3N), a French cohort study (1992–2008). Hazard ratios and their confidence intervals were derived from Cox models. Among 65,630 postmenopausal women (mean follow-up: 10.8 years), 301 endometrial cancers occurred. Compared with never use, ever use of estrogen + micronized [...]

Menée en Chine à partir de données portant sur 349 patientes atteintes d'un cancer du sein et sur 500 témoins, cette étude évalue, en fonction de l'exposition ou non à un tabagisme passif, l'association entre une infection par le virus d'Epstein-Barr et le risque de développer la maladie

Association of Epstein-Barr virus and passive smoking with the risk of breast cancer among Chinese women

Qi, Mei-Ling ; Xi, Jing ; Chen, Li-Juan ; Su, Yi ; Cen, Yu-Ling ; Su, Feng-Xi ; Lin, Ying ; Zhuang, Zhi-Xiong ; Tang, Lu-Ying ; Ren, Ze-Fang

Reactivation of Epstein-Barr virus (EBV), as indexed by the higher immunoglobulin A (IgA) antibody titers, was reported to be associated with an increased risk of breast cancer. Passive smoking plays a role in host immune responses and may modify the association of EBV with breast cancer. We carried out a case-control study using data from 349 incident breast cancer cases and 500 age-matched controls in the Guangzhou Breast Cancer Study to investigate the interactions of EBV antibodies and [...]

Menée en France auprès de 747 cas et 1 421 témoins, cette étude évalue l'association entre des traitements de l'infertilité des mères, diverses caractéristiques de leur grossesse, une supplémentation en acide folique et le risque de leucémie aiguë chez l'enfant

Maternal reproductive history, fertility treatments and folic acid supplementation in the risk of childhood acute leukemia: the ESTELLE Study

Ajrouche, Roula ; Rudant, Jérémie ; Orsi, Laurent ; Petit, Arnaud ; Baruchel, André ; Nelken, Brigitte ; Pasquet, Marlène ; Michel, Gérard ; Bergeron, Christophe ; Ducassou, Stéphane ; Gandemer, Virginie ; Lutz, Patrick ; Saumet, Laure ; Rialland, Xavier ; Hémon, Denis ; Clavel, Jacqueline

Purpose : To investigate the potential involvement of fertility treatments and other conditions of becoming pregnant (infertility, getting pregnant on birth control, maternal history of fetal loss) and folic acid supplements in the etiology of childhood leukemia (CL). Methods : The ESTELLE study included 747 cases of CL [636 cases of acute lymphoblastic leukemia (ALL) and 100 of acute myeloblastic leukemia (AML)] diagnosed in France in 2010–2011 and 1,421 population controls frequency-matched [...]

Menée aux Etats-Unis auprès de 3 763 participants âgés de 55 à 69 ans, cette étude évalue l'association entre des indicateurs de corpulence, la glycémie et le risque de cancers liés à l'obésité

Metabolic Health Reduces Risk of Obesity-Related Cancer in Framingham Study Adults

Moore, Lynn L. ; Chadid, Susan ; Singer, Martha R. ; Kreger, Bernard E. ; Denis, Gerald V.

Background. It is unknown whether the risk for obesity-related cancers between metabolically unhealthy and healthy overweight/obese adults. Methods. Data on body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR), and random blood glucose in Framingham Heart Study adults (n=3763) ages 55-69 were used to estimate risks of obesity-related cancers (n=385) including post-menopausal breast, female reproductive, colon, liver, gallbladder, pancreas, and kidney cancers, as well as [...]

Menée sur deux cohortes (1 616 cas et 1 329 témoins pour l'une, 1 977 cas et 999 témoins pour l'autre), cette méta-analyse identifie, sur la région chromosomique 4q32.2, un locus de susceptibilité au cancer colorectal

A novel colorectal cancer risk locus at 4q32.2 identified from an international genome-wide association study

Stenzel, Stephanie L. ; Schumacher, Fredrick R. ; Edlund, Christopher K. ; Conti, David V. ; Raskin, Leon ; Lejbkowicz, Flavio ; Pinchev, Mila ; Rennert, Hedy S. ; Jenkins, Mark A. ; Hopper, John L. ; Buchanan, Daniel D. ; Lindor, Noralane M. ; Le Marchand, Loic ; Gallinger, steven ; Haile, Robert W. ; Newcomb, Polly A. ; Huang, Shu-Chen ; Rennert, Gad ; Casey, Graham ; Gruber, Stephen B.

Only a fraction of colorectal cancer heritability is explained by known risk-conferring genetic variation. This study was designed to identify novel risk alleles in Europeans. We conducted a genome-wide association study (GWAS) meta-analysis of colorectal cancer in participants from a population-based case control study in Israel (n = 1,616 cases, 1,329 controls) and a consortium study from the Colon Cancer Family Registry (n=1,977 cases, 999 controls). We used a two-stage [...]

Menée à partir de questionnaires auprès de 2 275 participants âgés de 40 à 49 ans et ayant subi une coloscopie, cette étude évalue l'association entre des antécédents familiaux de cancer colorectal et le risque de polypes adénomateux du côlon-rectum

Association between family history of malignant neoplasm with colorectal adenomatous polyp in 40s aged relative person

Lee, Su Young ; Shin, Aesun ; Kim, Byung Chang ; Lee, Jeong Hee ; Han, Kyung Su ; Hong, Chang Won ; Sohn, Dae Kyung ; Park, Sung Chan ; Chang, Hee Jin ; Oh, Jae Hwan

Purpose : We assessed the association between a family history of malignancy and risk of colorectal adenoma among individuals aged 40–49 years. Methods : The study population consisted of subjects, aged in their 40s, who underwent colonoscopy. Their family histories of cancer were collected with a self-administered questionnaire. A logistic regression model was used to assess the association between a family history of cancer and the risk of colorectal polyp. Results : In total, 2275 [...]

Menée aux Pays-Bas auprès de 120 852 participants âgés de 55 à 69 ans, cette étude de cohorte évalue l'association entre des polymorphismes à simple nucléotide des gènes associés au système rénine-angiotensine-aldostérone (SRAA) et le risque de cancer rénal, en fonction d'une hypertension et de la consommation de sodium et de potassium

Polymorphisms in genes of the renin-angiotensin-aldosterone system and renal cell cancer risk: Interplay with hypertension and intakes of sodium, potassium and fluid

Deckers, Ivette A. ; van den Brandt, Piet A. ; van Engeland, Manon ; van Schooten, Frederik-Jan ; Godschalk, Roger W. ; Keszei, András P. ; Schouten, Leo J.

Hypertension is an established risk factor for renal cell cancer (RCC). The renin-angiotensin-aldosterone system (RAAS) regulates blood pressure and is closely linked to hypertension. RAAS additionally influences homeostasis of electrolytes (e.g. sodium and potassium) and fluid. We investigated single nucleotide polymorphisms (SNPs) in RAAS and their interactions with hypertension and intakes of sodium, potassium and fluid regarding RCC risk in the Netherlands Cohort Study (NLCS), which was [...]