A novel colorectal cancer risk locus at 4q32.2 identified from an international genome-wide association study

Menée sur deux cohortes (1 616 cas et 1 329 témoins pour l'une, 1 977 cas et 999 témoins pour l'autre), cette méta-analyse identifie, sur la région chromosomique 4q32.2, un locus de susceptibilité au cancer colorectal

Résumé en anglais

Only a fraction of colorectal cancer heritability is explained by known risk-conferring genetic variation. This study was designed to identify novel risk alleles in Europeans. We conducted a genome-wide association study (GWAS) meta-analysis of colorectal cancer in participants from a population-based case control study in Israel (n = 1,616 cases, 1,329 controls) and a consortium study from the Colon Cancer Family Registry (n=1,977 cases, 999 controls). We used a two-stage (discovery-replication) GWAS design, followed by a joint meta-analysis. A combined analysis identified a novel susceptibility locus that reached genome-wide significance on chromosome 4q32.2 (rs35509282, risk allele = T (minor allele frequency = 0.09); odds ratio per risk allele = 1.53; p-value = 8.2x10-9; nearest gene = FSTL5). The direction of the association was consistent across studies. In addition, we confirmed that 14 of 29 previously identified susceptibility variants were significantly associated with risk of colorectal cancer in this study. Genetic variation on chromosome 4q32.2 is significantly associated with risk of colorectal cancer in Ashkenazi Jews and Europeans in this study.