Menée aux Pays-Bas auprès de 269 patients pédiatriques atteints de cancer (âge inférieur à 18 ans), cette étude analyse l'association entre une malnutrition ou une perte de poids pendant les traitements et les risques d'infection et de décès

Clinical implications of malnutrition in childhood cancer patients—infections and mortality

Loeffen, E. A. H. ; Brinksma, A. ; Miedema, K. G. E. ; de Bock, G. H. ; Tissing, W. J. E.

Purpose : In childhood cancer patients, malnutrition has been proposed to increase infection rates and reduce survival. We investigated whether malnutrition at diagnosis and during treatment and weight loss during treatment are prognostic factors for infection rates and survival, within a heterogeneous childhood cancer population. Methods : From two previous studies, all children ≤18 years of age diagnosed with cancer between October 2004 and October 2011 were included in this study. Data [...]

Menée en Australie par enquête auprès de 657 patients atteints de cancer et de 148 partenaires de vie, cette étude analyse leurs expériences et difficultés rencontrées dans les discussions relatives à leur sexualité avec les professionnels de santé

Talking about sex with health professionals: the experience of people with cancer and their partners

Gilbert, E. ; Perz, J. ; Ussher, J. M.

Changes to sexuality can be one of the most difficult aspects of life following cancer. This study examines the experience of discussing sexuality post cancer with health care professionals (HCPs), from the perspective of women and men with cancer (PWC), and their partners (PPWC), across a range of cancer types. A total of 657 PWC (535 women, 122 men) and 148 PPWC (87 women, 61 men) completed a survey containing closed and open-ended items, analysed by analysis of variance and thematic [...]

Menée aux Pays-Bas par questionnaire auprès de 130 parents d'enfants atteints de leucémie lymphoblastique aiguë, cette étude analyse les facteurs associés à la qualité de vie des patients pédiatriques pendant un traitement d'induction

Determinants of quality of life during induction therapy in pediatric acute lymphoblastic leukemia

van Litsenburg, RaphaëleR L. ; Huisman, Jaap ; Pieters, Rob ; Verhaak, Chris ; Kaspers, GertjanJ L. ; Gemke, ReinoudJ B. J.

Purpose : Improvement in survival of pediatric acute lymphoblastic leukemia (ALL) has increased the attention to quality of life (QoL) . QoL is impaired during maintenance treatment, but little is known about QoL during induction therapy. Identification of patients with poor QoL during induction will provide opportunities for early interventions, and may subsequently improve future QoL. This national multi-center study aimed to assess QoL and its determinants during ALL induction treatment. [...]

Menée aux Etats-Unis auprès de 162 survivants à long terme d'une leucémie lymphoblastique aiguë pédiatrique, cette étude prospective transversale analyse les morbidités neurologiques liées aux effets des traitements et leur qualité de vie

Neurologic morbidity and quality of life in survivors of childhood acute lymphoblastic leukemia: a prospective cross-sectional study

Khan, RajaB ; Hudson, MelissaM ; Ledet, DavonnaS ; Morris, E. Brannon ; Pui, Ching-Hon ; Howard, ScottC ; Krull, KevinR ; Hinds, PamelaS ; Crom, Debbie ; Browne, Emily ; Zhu, Liang ; Rai, Shesh ; Srivastava, Deokumar ; Ness, KirstenK

Purpose : Childhood acute lymphoblastic leukemia (ALL) is treated with potentially neurotoxic drugs and neurologic complications in long-term survivors are inadequately studied. This study investigated neurologic morbidity and its effect on quality of life in long-term survivors of childhood ALL. Methods : Prospective, single institution, cross-sectional, institutional review board-approved study of long-term ALL survivors. Participants were recruited from institutional clinics. Participants [...]

Menée sur 5 383 patients atteints d'un cancer du poumon ou du côlon-rectum, cette étude analyse, en fonction de leur statut tabagique, la sévérité des symptômes associés à la douleur et les traitements reçus

Pain experiences among a population-based cohort of current, former, and never regular smokers with lung and colorectal cancer

Gonzalez, Adam ; Japuntich, Sandra ; Keating, Nancy L. ; Wallace, Robert ; He, Yulei ; Streck, Joanna M. ; Park, Elyse R.

BACKGROUND: Smoking and pain are prevalent and comorbid among patients with cancer. Limited work has compared pain experiences among current, former, and never (regular) smokers with lung and colorectal cancer. METHODS: We studied pain experiences of patients with lung (n = 2390) and colorectal (n = 2993) cancer participating in the multi-regional Cancer Care Outcomes Research and Surveillance study. We examined reports of pain, pain treatment, pain severity, and pain-related interference [...]

Menée aux Etats-Unis auprès de 770 survivantes d'un cancer du sein de stade O à IIIA, cette étude évalue l'impact d'une meilleure hygiène de vie alimentaire après le diagnostic sur la fatigue liée au cancer

Better postdiagnosis diet quality is associated with less cancer-related fatigue in breast cancer survivors

George, StephanieM ; Alfano, CatherineM ; Neuhouser, MarianL ; Smith, AshleyW ; Baumgartner, RichardN ; Baumgartner, KathyB ; Bernstein, Leslie ; Ballard-Barbash, Rachel

Purpose : A comprehensive understanding of the role of modifiable health behaviors in effective management of cancer-related fatigue is needed. Among breast cancer survivors, we examined how postdiagnosis diet quality, independently and jointly with physical activity, is related to fatigue, and the potential mediating role of inflammation. Methods : Seven hundred seventy women diagnosed with stage 0–IIIA breast cancer in the Health, Eating, Activity, and Lifestyle study completed food frequency [...]

A partir d'une revue systématique de la littérature (6 études prospectives, 71 654 individus), cette méta-analyse évalue l'association entre les capacités cardio-respiratoires et la mortalité par cancer

Cardiorespiratory fitness as predictor of cancer mortality: a systematic review and meta-analysis

Schmid, D. ; Leitzmann, M. F.

Background : Epidemiologic studies have reported that cardiorespiratory fitness is inversely associated with mortality from cancer. However, the evidence relating cardiorespiratory fitness to cancer mortality has not yet been quantitatively summarized. Methods : Following the preferred reporting items for sytematic reviews and meta-analyses (PRISMA) checklist, we conducted a systematic review and meta-analysis of the association between cardiorespiratory fitness and total cancer mortality. [...]

Menée à partir des données de deux registres nationaux des cancers de l'enfance portant sur 15 479 patients pédiatriques atteints d'un cancer diagnostiqué entre 2000 et 2008 en France métropolitaine, cette étude évalue les taux de survie globale à 1, 2 et 5 ans en fonction du type de cancer

Childhood cancer survival in France, 2000-2008

Lacour, Brigitte ; Goujon, Stéphanie ; Guissou, Sandra ; Guyot-Goubin, Aurélie ; Desmée, Solène ; Désandes, Emmanuel ; Clavel, Jacqueline

This paper reports the latest survival data for French childhood cancer patients at the national level. Data from the two French National Registries of Childhood Cancer (Haematopoietic Malignancies and Solid Tumours) were used to describe survival outcomes for 15 479 children diagnosed with cancer between 2000 and 2008 in mainland France. The overall survival was 91.7% at 1 year, 86.9% at 2 years and 81.6% at 5 years. Relative survival did not differ from overall survival even for infants. [...]

Menée sur 94 patients pédiatriques atteints d'un rétinoblastome, cette étude analyse, en fonction de la présence ou non d'une délétion chromosomique 13q, l'évolution des capacités cognitives et d'adaptation des patients entre le diagnostic et l'âge de 5 ans

Developmental and Adaptive Functioning in Children With Retinoblastoma: A Longitudinal Investigation

Willard, Victoria W. ; Qaddoumi, Ibrahim ; Chen, Si ; Zhang, Hui ; Brennan, Rachel ; Rodriguez-Galindo, Carlos ; Wilson, Matthew W. ; Phipps, Sean

Purpose : To determine the developmental trajectory of early cognitive and adaptive skills in young children with retinoblastoma from diagnosis to 5 years of age. Patients and Methods : Ninety-four patients with retinoblastoma treated according to an institutional protocol underwent serial assessments of cognitive and adaptive functioning at age 6 months and 1, 2, 3, and 5 years. Data were analyzed by treatment strata, with patients with 13q deletion analyzed separately. Results : At baseline, [...]

Menée à partir des données de 7 études de cohorte portant au total sur 239 597 participants afro-américains, cette étude évalue l'association entre l'indice de masse corporelle et le risque de décès par cancer du pancréas

A pooled analysis of body mass index and pancreatic cancer mortality in African Americans

Bethea, Traci N. ; Kitahara, Cari M. ; Sonderman, Jennifer S. ; Patel, Alpa V. ; Harvey, Chinonye ; Knutsen, Synnove F. ; Park, Yikyung ; Park, Song-Yi ; Fraser, Gary E. ; Jacobs, Eric J. ; Purdue, Mark P. ; Stolzenberg-Solomon, Rachael Z. ; Gillanders, Elizabeth M. ; Blot, William J. ; Palmer, Julie R. ; Kolonel, Laurence N.

Background : Pancreatic cancer is a leading cause of cancer-related mortality in the U.S. and both incidence and mortality are highest in African Americans. Obesity is also disproportionately high in African Americans, but limited data are available on the relation of obesity to pancreatic cancer in this population. Methods : Seven large prospective cohort studies pooled data from African American participants. Body mass index (BMI) was calculated from self-reported height and weight at [...]

Mené en Finlande auprès de 78 615 participants, cet essai évalue l'association entre une utilisation de médicaments anti-inflammatoires non stéroïdiens et le risque de cancer de la prostate

Prostate cancer risk and nonsteroidal antiinflammatory drug use in the Finnish prostate cancer screening trial

Veitonmaki, T. ; Murtola, T. J. ; Maattanen, L. ; Taari, K. ; Stenman, U. H. ; Tammela, T. L. J. ; Auvinen, A.

Background: The association between nonsteroidal antiinflammatory drugs (NSAIDs) and prostate cancer risk remains controversial. We examined the risk among NSAID users in 78 615 men in the Finnish Prostate Cancer Screening Trial. Methods: We obtained information on NSAID prescription usage from Finnish nationwide prescription database and on over-the-counter use by a questionnaire. Prostate cancer cases were identified from the Finnish Cancer Registry. Results: Prostate cancer risk was elevated [...]

Menée à partir de données portant sur 935 patients atteints d'un cancer de la prostate et présentant un diabète de type 2 (durée moyenne de suivi : 3,7 ans), cette étude britannique évalue l'association entre l'utilisation de metformine après diagnostic et la mortalité toutes causes confondues ou la mortalité par cancer

The use of metformin in patients with prostate cancer and the risk of death

Bensimon, Leah ; Yin, Hui ; Suissa, Samy ; Pollak, Michael N. ; Azoulay, Laurent

Background : Given the conflicting results from observational studies, we assessed whether the use of metformin after a prostate cancer diagnosis is associated with a decreased risk of cancer-specific and all-cause mortality. Methods : This study was conducted linking four databases from the United Kingdom. A cohort of men newly-diagnosed with non-metastatic prostate cancer with a history of treated type 2 diabetes, between April 1, 1998 and December 31, 2009, was followed until October 1, [...]

Menée en Californie à partir de données portant sur 33 146 individus d'origine hispanique entre 1988 et 2010, cette étude analyse la mortalité par cancer colorectal en fonction du statut socioéconomique et du lieu de naissance

Colorectal cancer mortality among Hispanics in California: Differences by neighborhood socioeconomic status and nativity

Tao, Li ; Ladabaum, Uri ; Gomez, Scarlett Lin ; Cheng, Iona

BACKGROUND Socioeconomic status (SES) plays an important role in colorectal cancer (CRC) mortality, although the independent and joint effects with nativity and neighborhood factors have yet to be evaluated. METHODS With nearly one-third of all US Hispanics residing in California, the authors obtained information from the California Cancer Registry to examine the associations between neighborhood SES and mortality in all 33,146 Hispanic individuals diagnosed with CRC from 1988 through 2010, [...]

Menée en Allemagne à partir des données de 4 322 085 individus ayant participé à un dépistage de cancer par coloscopie, cette étude analyse l'évolution de l'incidence des adénomes colorectaux sur la période 2003-2012

Incidence of colorectal adenomas: Birth cohort analysis among 4.3 million participants of screening colonoscopy

Brenner, Hermann ; Altenhofen, Lutz ; Stock, Christian ; Hoffmeister, Michael

BACKGROUND. Most colorectal cancers develop from adenomas. We aimed to estimate sex and age specific incidence rates of colorectal adenomas and to assess their potential implications for colorectal cancer screening strategies. METHODS. Sex and age specific incidence rates of colorectal adenomas were derived by a birth cohort analysis using data from 4,322,085 screening colonoscopies conducted in Germany and recorded in a national database in 2003-2012. In addition, cumulative risks of [...]

Menée à partir des données des registres américains des cancers portant sur la période 1992-2010, cette étude met en évidence une augmentation de l'incidence du cancer à cellules germinales du testicule chez les adolescents d'origine hispanique et chez les jeunes adultes

Increase in testicular germ cell tumor incidence among Hispanic adolescents and young adults in the United States

Chien, Franklin L. ; Schwartz, Stephen M. ; Johnson, Rebecca H.

BACKGROUND : Although rising incidence rates of testicular germ cell tumors have been well documented in white men, relatively little is known about rates in men of Hispanic origin. In the current study, the authors compared germ cell tumor trends between men of Hispanic and non-Hispanic origin as a function of age at diagnosis. METHODS : Trends in testicular germ cell tumor incidence among white men were analyzed according to Hispanic ethnicity in 2 data sets of the National Cancer Institute's [...]

Menée aux Pays-Bas à partir des données de patients atteints d'un cancer de la vessie diagnostiqué entre 1995 et 2010 (invasif: 250, non invasif: 1 465 ), cette étude évalue l'association entre une histoire familiale de cancer de la vessie et le pronostic de la maladie

The prognostic value of family history among patients with urinary bladder cancer

Egbers, Lieke ; Grotenhuis, Anne J. ; Aben, Katja K. ; Alfred Witjes, J. ; Kiemeney, Lambertus A. ; Vermeulen, Sita H.

A history of urinary bladder cancer (UBC) in first-degree relatives increases UBC risk by twofold. The influence of positive family history on UBC prognosis is unknown. Here, we investigated association of first-degree UBC family history with clinicopathological characteristics and prognosis of UBC patients. Detailed clinical data of 1,465 non-muscle-invasive bladder cancer (NMIBC) and 250 muscle-invasive or metastatic bladder cancer (MIBC) patients, diagnosed from 1995 to 2010, were collected [...]

Menée à partir de données du registre national américain des cancers portant sur 73 088 patients atteints d'un cancer de la tête et du cou, cette étude analyse, sur la période 1998-2011 et en fonction des types de cancer, l'évolution de l'utilisation de la radiothérapie ou de la chimioradiothérapie comme traitements adjuvants

Trends and variations in the use of adjuvant therapy for patients with head and neck cancer

Chen, Michelle M. ; Roman, Sanziana A. ; Yarbrough, Wendell G. ; Burtness, Barbara A. ; Sosa, Julie A. ; Judson, Benjamin L.

BACKGROUND : The National Comprehensive Cancer Network guidelines recommend that patients with surgically resected head and neck cancers that have adverse pathologic features should receive adjuvant therapy in the form of radiotherapy (RT) or chemoradiation (CRT). To the authors' knowledge, the current study is the first analysis of temporal trends and use patterns of adjuvant therapy for these patients. METHODS : Patients with head and neck cancer and adverse pathologic features were [...]

Menée à partir d'une enquête auprès de professionnels de santé et de parents d'enfants atteints d'un cancer récidivant ou réfractaire aux traitements (104 cas), cette étude américaine analyse les différences de perception vis-à-vis du pronostic et de l'objectif des soins prodigués

Differences in Parent-Provider Concordance Regarding Prognosis and Goals of Care Among Children With Advanced Cancer

Rosenberg, Abby R. ; Orellana, Liliana ; Kang, Tammy I. ; Geyer, J. Russell ; Feudtner, Chris ; Dussel, Veronica ; Wolfe, Joanne

Purpose : Concordance between parents of children with advanced cancer and health care providers has not been described. We aimed to describe parent-provider concordance regarding prognosis and goals of care, including differences by cancer type. Patients and Methods : A total of 104 pediatric patients with recurrent or refractory cancer were enrolled at three large children’s hospitals. On enrollment, their parents and providers were invited to complete a survey assessing perceived prognosis [...]

Menée en Australie auprès de 108 patientes atteintes d'un cancer de l'ovaire, cette étude évalue la prévalence des symptômes de stress post-traumatique, puis identifie les facteurs démographiques, médicaux et psychosociaux associés

Symptoms of posttraumatic stress in Australian women with ovarian cancer

Shand, Lyndel K. ; Brooker, Joanne E. ; Burney, Sue ; Fletcher, Jane ; Ricciardelli, Lina A.

Objective : The aim of the study was to assess the prevalence and nature of symptoms of posttraumatic stress disorder (PTSD) in women with ovarian cancer. A further aim was to examine the demographic, medical and psychosocial factors associated with PTSD symptoms. Method : One hundred and eight women with ovarian cancer were assessed for PTSD, quality of life, depression, anxiety, posttraumatic growth, optimism, coping and social support. Results : Clinically significant symptoms were [...]

Menée à Taïwan auprès de 143 aidants de patients atteints d'un cancer de la tête et du cou, cette étude analyse la prévalence ainsi que les facteurs associés au risque de symptômes de dépression

Prevalence and risk factors of depressive disorder in caregivers of patients with head and neck cancer

Lee, Yu ; Lin, Pao-Yen ; Chien, Chih-Yen ; Fang, Fu-Min

Objective : The purpose of this study is to examine the prevalence and risk factors of depressive disorder in caregivers of patients with head and neck cancer. Methods : Study subjects were recruited from a multidisciplinary outpatient clinic for head and neck cancer in a medical center from February to July 2012. Caregivers of patients with head and neck cancer were enrolled and assessed using the Structured Clinical Interview for the DSM-IV, Clinician Version, the Short Form 36 Health Survey, [...]

Menée à l'aide d'un guide méthodologique de l'Organisation Mondiale de la Santé, cette étude estime le coût économique des effets du tabac sur la santé au Royaume-Uni chez les personnes présentant des troubles mentaux

Economic cost of smoking in people with mental disorders in the UK

Wu, Qi ; Szatkowski, Lisa ; Britton, John ; Parrott, Steve

Background : Smoking is the largest preventable cause of death in the UK and imposes a huge economic burden on society. Both the prevalence and extent of smoking are significantly higher among people with mental disorders than among the general population. Aims : To estimate the economic costs of the health effects of cigarette smoking among people with mental disorders in the UK from a societal perspective. Methods : This study uses the WHO's economics of tobacco toolkit to assess the costs of [...]

Menée à partir des données du registre national des cancers portant sur 23 279 patients atteints d'un carcinome urothélial de stade II ou supérieur traité par cystectomie radicale entre 2003 et 2010, cette étude américaine évalue, en fonction du type d'hôpital, la qualité de la prise en charge thérapeutique des patients

Variation in performance of candidate surgical quality measures for muscle-invasive bladder cancer by hospital type

Corcoran, Anthony T. ; Handorf, Elizabeth ; Canter, Daniel ; Tomaszewski, Jeffrey J. ; Bekelman, Justin E. ; Kim, Simon P. ; Uzzo, Robert G. ; Kutikov, Alexander ; Smaldone, Marc C.

Objective : To test the association between hospital type and performance of candidate quality measures for treatment of muscle-invasive bladder cancer (MIBC) using a large national tumour registry. Proposed quality measures include receipt of neoadjuvant chemotherapy, timely treatment, adequate lymph node dissection, and continent urinary diversion. Patients and Methods : Using the National Cancer Database, patients with stage ≥II urothelial carcinoma treated with radical cystectomy (RC) from [...]

Menée en Espagne par enquête auprès de 110 parents d'enfants atteints de cancer et de 74 oncologues, cette étude analyse l'utilisation d'internet par les parents pour accéder à de l'information ainsi que l'impact de cette pratique sur la communication entre parents et médecins

Pediatric Cancer and the Internet: Exploring the Gap in Doctor-Parents Communication

Domínguez, Martí ; Sapiña, Lucía

The aim of this study is to examine the use of the Internet to obtain information by parents of children with cancer and how pediatric oncologists understand this new scenario and the shifting relationship between patients and doctors. With this goal in mind, we conducted two surveys: one was answered by 110 parents of pediatric cancer patients and another one was answered by 74 oncologists, members of the Spanish Society of Pediatric Hematology and Oncology (SEHOP). Less than half of the [...]