Menée par enquête auprès de 375 médecins oncologues et/ou hématologues issus de 9 pays européens, cette étude analyse leurs pratiques relatives au diagnostic et aux traitements d'une anémie induite par la chimiothérapie chez des patients atteints de cancer

A European patient record study on diagnosis and treatment of chemotherapy-induced anaemia

Ludwig, Heinz ; Aapro, M. ; Bokemeyer, C. ; Glaspy, J. ; Hedenus, M. ; Littlewood, T. J. ; Österborg, A. ; Rzychon, B. ; Mitchell, D. ; Beguin, Y.

Purpose : Patients with cancer frequently experience chemotherapy-induced anaemia (CIA) and iron deficiency. Erythropoiesis-stimulating agents (ESAs), iron supplementation and blood transfusions are available therapies. This study evaluated routine practice in CIA management. Methods : Medical oncologists and/or haematologists from nine European countries (n = 375) were surveyed on their last five cancer patients treated for CIA (n = 1,730). Information was collected on tests performed at [...]

Menée en Suède auprès de 171 participants (âge moyen : 50 ans), cette étude analyse l'incidence d'une mucite orale liée aux rayonnements et à une chimiothérapie intensive chez des patients ayant reçu une greffe allogénique de cellules souches avec conditionnement à intensité réduite et évalue l'efficacité de mesures orales préventives

Reduced intensity conditioning and oral care measures prevent oral mucositis and reduces days of hospitalization in allogeneic stem cell transplantation recipients

Legert, KarinGarming ; Remberger, Mats ; Ringdén, Olle ; Heimdahl, Anders ; Dahllöf, Göran

Purpose : Oral mucositis (OM) is a side effect of intensive chemotherapy and radiation and has been reported to affect 75–100 % of hematopoietic stem cell transplantation (HSCT) recipients. The purpose of this study was to compare the incidence of OM in patients conditioned with myeloablative conditioning (MAC) to reduced-intensity conditioning (RIC) and to determine the effect of a new oral care protocol. Methods : The study involved 171 HSCT recipients, with hematological malignancies [...]

Menée au Canada auprès de patients pédiatriques atteints d'une leucémie lymphoblastique aiguë, cette étude de cohorte rétrospective analyse les facteurs de risque associés à des ponctions lombaires traumatiques

The risk of traumatic lumbar punctures in children with acute lymphoblastic leukaemia

Shaikh, Furqan ; Voicu, Laura ; Tole, Soumitra ; To, Teresa ; Doria, Andrea S. ; Sung, Lillian ; Alexander, Sarah

Traumatic lumbar punctures with blasts (TLP+) in children with acute lymphoblastic leukaemia (ALL) obscure central nervous system status and are associated with a poorer event-free survival (EFS). We conducted a retrospective cohort study of all lumbar punctures (LPs) for children with ALL diagnosed at our institution from 2005 to 2009. We utilised random-effects and fixed-effects repeated-measures logistic regression analyses to identify risk factors for TLPs. Fixed-effects models use each [...]

A partir de données d'enquête et des registres américains des cancers, cette étude analyse l'évolution de la qualité de vie, avant et après le diagnostic de cancer, et le temps de récupération après les traitements, chez des patientes atteintes d'un cancer du sein après 65 ans

Quality of life changes during the pre- to postdiagnosis period and treatment-related recovery time in older women with breast cancer

Stover, Angela M. ; Mayer, Deborah K. ; Muss, Hyman ; Wheeler, Stephanie B. ; Lyons, Jessica C. ; Reeve, Bryce B.

BACKGROUND Health care providers have little population-based evidence about health-related quality of life (HRQOL) changes, from the pre- to postdiagnosis period, and treatment-related recovery time for women aged 65 years and older diagnosed with breast cancer. METHODS Older women with and without breast cancer completed self-reports of HRQOL at baseline and 2 years later as part of annual Medicare Health Outcomes Surveys (MHOS). MHOS was linked to Surveillance, Epidemiology, and End Results [...]

A partir des données de l'Organisation Mondiale de la Santé, cette étude analyse l'évolution mondiale de la mortalité par cancer de l'estomac et présente les projections d'incidence, par sous-type histologique, jusqu'en 2015

Worldwide trends in gastric cancer mortality (1980–2011), with predictions to 2015, and incidence by subtype

Ferro, Ana ; Peleteiro, Bárbara ; Malvezzi, Matteo ; Bosetti, Cristina ; Bertuccio, Paola ; Levi, Fabio ; Negri, Eva ; La Vecchia, Carlo ; Lunet, Nuno

Gastric cancer incidence and mortality decreased substantially over the last decades in most countries worldwide, with differences in the trends and distribution of the main topographies across regions. To monitor recent mortality trends (1980–2011) and to compute short-term predictions (2015) of gastric cancer mortality in selected countries worldwide, we analysed mortality data provided by the World Health Organization. We also analysed incidence of cardia and non-cardia cancers using data [...]

A partir d'une revue systématique de la littérature (23 études, 49 095 survivants de cancer), cette méta-analyse évalue l'association entre une activité physique et la mortalité chez des survivants d'un cancer du sein ou du côlon-rectum

Association between physical activity and mortality among breast cancer and colorectal cancer survivors: a systematic review and meta-analysis

Schmid, D. ; Leitzmann, M. F.

Background : Physical activity improves physical function during and after cancer treatment, but whether physical activity imparts survival benefit remains uncertain. Design : Using prospective studies published through June 2013, we conducted a systematic review and random-effects meta-analysis of pre- and post-diagnosis physical activity in relation to total and cancer mortality among breast or colorectal cancer survivors. Results : Sixteen studies of breast cancer survivors and seven studies [...]

Menée aux Etats-Unis auprès de 140 398 participants, cette étude de cohorte multiethnique analyse les disparités ethniques dans la participation au dépistage des cancers, par coloscopie, dosage du PSA ou mammographie

Ethnic differences and predictors of colonoscopy, prostate-specific antigen, and mammography screening participation in the multiethnic cohort

Harmon, Brook E. ; Little, Melissa A. ; Woekel, Erica D. ; Ettienne, Reynolette ; Long, Camonia R. ; Wilkens, Lynne R. ; Le Marchand, Loic ; Henderson, Brian E. ; Kolonel, Laurence N. ; Maskarinec, Gertraud

Purpose : Given the relation between screening and improved cancer outcomes and the persistence of ethnic disparities in cancer mortality, we explored ethnic differences in colonoscopy, prostate-specific antigen (PSA), and mammography screening in the Multiethnic Cohort Study. Methods : Logistic regression was applied to examine the influence of ethnicity as well as demographics, lifestyle factors, comorbidities, family history of cancer, and previous screening history on self-reported [...]

Menée en Allemagne, cette étude analyse l'évolution des disparités régionales dans la mortalité par mésothéliome, sur la période 2000-2010

Regional variations in German mesothelioma mortality rates: 2000–2010

Schonfeld, SaraJ ; McCormack, Valerie ; Rutherford, MarkJ ; Schüz, Joachim

Purpose : Germany has one of the highest age-adjusted mesothelioma mortality rates worldwide. As mesothelioma occurs ≥30 years after asbestos exposure, contemporary rates likely reflect exposures in the 1960–1970s. During this period, political division between West and East Germany led to differences regarding the import and consumption of asbestos. It is unclear whether mesothelioma rates also differ between these formerly separate countries which are now served by similar health and [...]

Menée en Belgique, un pays autrefois producteur d'amiante, cette étude analyse, sur la période 1969-2009, l'évolution de la mortalité par mésothéliome

Asbestos in Belgium: an underestimated health risk. The evolution of mesothelioma mortality rates (1969–2009)

Borre, Laura Van den ; Deboosere, Patrick

Background: Although Belgium was once a major international manufacturer of asbestos products, asbestos-related diseases in the country have remained scarcely researched. Objectives:The aim of this study is to provide a descriptive analysis of Belgian mesothelioma mortality rates in order to improve the understanding of asbestos health hazards from an international perspective. Methods:Temporal and geographical analyses were performed on cause-specific mortality data (1969–2009) using [...]

A partir d'une revue systématique de la littérature (124 études, 13 832 cas), cette méta-analyse évalue la prévalence d'une infection par le papillomavirus humain dans les cas de carcinomes épidermoïdes de l'œsophage

Prevalence of human papillomavirus among oesophageal squamous cell carcinoma cases: systematic review and meta-analysis

Petrick, J. L. ; Wyss, A. B. ; Butler, A. M. ; Cummings, C. ; Sun, X. ; Poole, C. ; Smith, J. S. ; Olshan, A. F.

Background: Oncogenic human papillomavirus (HPV) has been hypothesised as a risk factor for oesophageal squamous cell carcinoma (OSCC), but aetiological research has been limited by the varying methodology used for establishing HPV prevalence. The aims of this systematic review and meta-analysis were to estimate the prevalence of HPV DNA detected in OSCC tumours and the influence of study characteristics. Methods: Study-level estimates of overall and type-specific HPV prevalence were [...]

A partir des données croisées des registres des cancers et des admissions hospitalières, cette étude australienne ré-évalue l'incidence des syndromes myélodysplasiques, sur la période 2003 à 2010

Underestimation of myelodysplastic syndrome incidence by cancer registries: Results from a population-based data linkage study

McQuilten, Zoe K. ; Wood, Erica M. ; Polizzotto, Mark N. ; Campbell, Lynda J. ; Wall, Meaghan ; Curtis, David J. ; Farrugia, Helen ; McNeil, John J. ; Sundararajan, Vijaya

BACKGROUND Myelodysplastic syndromes (MDS) appear to be underreported to cancer registries, with important implications for cancer and transfusion support service planning and delivery. Two population-based databases were linked to estimate MDS incidence more accurately. METHODS Data from the statewide Victorian Cancer Registry (VCR) and Victorian Admitted Episode Dataset (VAED, capturing all inpatient admissions), in Australia, were linked. Incidence rates were calculated based on VCR reported [...]

Menée aux Pays-Bas auprès de 1 325 patientes ayant été incluses dans un essai de traitement adjuvant ("Tamoxifen Exemestane Adjuvant Multinational trial") et de 1 056 autres patientes (âge supérieur à 65 ans), cette étude compare la mortalité des deux cohortes et analyse les enjeux associés à la généralisation en population des résultats d'un essai contrôlé

External Validity of a Trial Comprised of Elderly Patients With Hormone Receptor–Positive Breast Cancer

van de Water, Willemien ; Kiderlen, Mandy ; Bastiaannet, Esther ; Siesling, Sabine ; Westendorp, Rudi G. J. ; van de Velde, Cornelis J. H. ; Nortier, Johan W. R. ; Seynaeve, Caroline ; de Craen, Anton J. M. ; Liefers, Gerrit-Jan

Background : Inclusion in trials is selective, and thus results may not be generalizable to the general population. The aim of this study was to investigate the external validity of randomized clinical trial outcomes for elderly breast cancer patients. Methods : We compared characteristics and outcomes of breast cancer patients (n = 1325) who participated in a randomized clinical trial (Tamoxifen Exemestane Adjuvant Multinational trial) with unselected breast cancer patients of corresponding [...]

A partie d'une revue systématique de la littérature publiée jusqu'en 2013 (11 études, 29 239 cas), cette méta-analyse évalue l'association entre une consommation d'alcool après le diagnostic d'un cancer du sein et la survie des patientes

Alcohol Consumption and Survival after a Breast Cancer Diagnosis: A Literature-based Meta-analysis and Collaborative Analysis of Data for 29,239 Cases

Ali, Alaa M.G. ; Schmidt, Marjanka K. ; Bolla, Manjeet ; Wang, Qin ; Gago-Dominguez, Manuela ; Esteban Castelao, J. ; Carracedo, Angel ; Muñoz Garzón, Victor ; Bojesen, Stig E. ; Nordestgaard, Børge G ; Flyger, Henrik ; Chang-Claude, Jenny ; Vrieling, Alina ; Rudolph, Anja ; Seibold, Petra ; Nevanlinna, Heli ; Muranen, Taru A. ; Aaltonen, Kirsimari ; Blomqvist, Carl ; Matsuo, Keitaro ; Ito, Hidemi ; Iwata, Hiroji ; Horio, Akiyo ; John, Esther M. ; Sherman, Mark ; Lissowska, Jolanta ; Figueroa, Jonine D. ; Garcia-Closas, Montserrat ; Anton-Culver, Hoda ; Shah, Mitul ; Hopper, John L. ; Trichopoulou, Antonia ; Bueno-de-Mesquita, H. Bas ; Krogh, Vittorio ; Weiderpass, Elisabete ; Andersson, Ann ; Clavel-Chapelon, Françoise ; Dossus, Laure ; Fagherazzi, Guy ; Peeters, Petra H. M. ; Olsen, Anja ; Wishart, Gordon C. ; Easton, Douglas F. ; Borgquist, Signe ; Overvad, Kim ; Barricarte, Aurelio ; Gonzalez, Carlos A ; Sánchez, María-José ; Amiano Etxezarreta, Pilar ; Riboli, Elio ; Key, Timothy J. ; Pharoah, Paul D. P.

Background : Evidence for the association of alcohol consumption with prognosis after a diagnosis of breast cancer has been inconsistent. We have reviewed and summarised the published evidence and evaluated the association using individual patient data from multiple case cohorts. Materials and Methods : A MEDLINE search to identify studies published up to January 2013 was performed. We combined published estimates for survival time in "moderate drinkers" versus non-drinkers. An analysis of [...]

Menée dans le cadre de l'étude internationale "Cancer in Pregnancy", cette étude analyse les caractéristiques des tumeurs intracraniennes (tumeurs primitives du cerveau, méningiomes, métastases cérébrales) chez 27 patientes (âge moyen : 31 ans) durant leur grossesse, les traitements reçus et les modalités d'accouchement

Primary brain tumours, meningiomas and brain metastases in pregnancy: Report on 27 cases and review of literature

Verheecke, Magali ; Halaska, Michael J. ; Lok, Christianne A. ; Ottevanger, Petronella B. ; Fruscio, Robert ; Dahl-Steffensen, Karina ; Kolawa, Wojciech ; Gziri, Mina Mhallem ; Han, Sileny Naeyu ; Van Calsteren, Kristel ; Van den Heuvel, Frank ; De Vleeschouwer, Steven ; Clement, Paul M. ; Menten, Johannes ; Amant, Frederic

The concurrence of intracranial tumours with pregnancy is rare. The purpose of this study was to describe all reported patients registered in the international Cancer in Pregnancy registration study (CIP study; http://www.cancerinpregnancy.org), and to review the literature in order to obtain better insight into outcome and possibilities of treatment in pregnancy. We collected all intracranial tumours (primary brain tumour, cerebral metastasis, or meningioma) diagnosed during pregnancy, [...]

A partir des données des registres américains des cancers portant sur 10 429 patients atteints d'un cancer localisé du larynx entre 1995 et 2009, cette étude de cohorte rétrospective analyse les disparités dans les traitements reçus ainsi que dans la survie des patients

Treatment and survival in 10,429 patients with localized laryngeal cancer: A population-based analysis

Misono, Stephanie ; Marmor, Schelomo ; Yueh, Bevan ; Virnig, Beth A.

BACKGROUND The objectives of this study were to identify factors associated with treatment differences, characterize changes in treatment patterns over time, and compare survival across treatment types in patients who received treatment for localized laryngeal cancer. METHODS Using the Surveillance, Epidemiology, and End Results database, we conducted a retrospective cohort analysis of patients who were treated from 1995 to 2009 for localized laryngeal cancer. Four treatment groups were [...]

Menée en Chine auprès de 764 patients atteints de cancer, cette étude transversale analyse les disparités en termes de statut socioéconomique et leur association avec des sentiments d'auto-efficacité

Self-efficacy difference among patients with cancer with different socioeconomic status: Application of latent class analysis and standardization and decomposition analysis

Yuan, Changrong ; Wei, Chunlan ; Wang, Jichuan ; Qian, Huijuan ; Ye, Xianghong ; Liu, Yingyan ; Hinds, Pamela S.

Introduction : Although the relationship between partial socioeconomic status (SES) and self-efficacy has been studied in previous studies, few research have examined self-efficacy difference among patients with cancer with different SES. Methods : A cross-sectional survey involving 764 patients with cancer was completed. Latent class analysis (LCA) was applied to identify distinct groups of patients with cancer using four SES indicators (education, income, employment status and health [...]

Mené en Angleterre, cet essai randomisé multicentrique analyse l'impact de visites de contrôle par une autre équipe médicale sur les traitements administrés et la qualité de vie des patients atteints d'un cancer du poumon

A multicentre randomised controlled trial of reciprocal lung cancer peer review and supported quality improvement: results from the improving lung cancer outcomes project

Russell, G. K. ; Jimenez, S. ; Martin, L. ; Stanley, R. ; Peake, M. D. ; Woolhouse, I.

Background : Results from the National Lung Cancer Audit demonstrate unexplained variation in outcomes. Peer review with supported quality improvement has been shown to reduce variation in other areas of health care but has not been formally tested in cancer multidisciplinary teams. The aim of the current study is to assess the impact of reciprocal peer-to-peer review visits with supported quality improvement and collaborative working on lung cancer process and outcome measures. Methods: [...]

A partir des données des registres américains des cancers et menée par enquête auprès de 3 133 participantes, cette étude longitudinale évalue les disparités ethniques dans les problèmes financiers rencontrés par des survivantes à long terme d'un cancer du sein non métastatique diagnostiqué de 2005 à 2007

Long-Term Financial Burden of Breast Cancer: Experiences of a Diverse Cohort of Survivors Identified Through Population-Based Registries

Jagsi, Reshma ; Pottow, John A.E. ; Griffith, Kent A. ; Bradley, Cathy ; Hamilton, Ann S. ; Graff, John ; Katz, Steven J. ; Hawley, Sarah T.

Purpose : To evaluate the financial experiences of a racially and ethnically diverse cohort of long-term breast cancer survivors (17% African American, 40% Latina) identified through population-based registries. Methods : Longitudinal study of women diagnosed with nonmetastatic breast cancer in 2005 to 2007 and reported to the SEER registries of metropolitan Los Angeles and Detroit. We surveyed 3,133 women approximately 9 months after diagnosis and 4 years later. Multivariable models evaluated [...]

Menée aux Etats-Unis auprès de 374 survivants d'un cancer diagnostiqué avant l'âge de 35 ans et âgés de 18 à 55 ans lors de l'étude, cette étude analyse leurs perceptions du risque relatif à une pratique tabagique

Perceptions of risk among childhood and young adult cancer survivors who smoke

Ford, JenniferS ; Puleo, Elaine ; Sprunck-Harrild, Kim ; deMoor, Janet ; Emmons, KarenM

Purpose : Despite the fact that childhood and young adult cancer survivors are at increased risk for chronic health problems as a result of their cancer treatment, many use tobacco, thereby increasing their risks. Perceptions of risk related to tobacco use can be targeted for interventions aimed at improving health behaviors for childhood, adolescent, and young adult cancer survivors. Understanding the covariates of perceptions of health risks among young adult survivors who smoke will help to [...]

Menée par enquête auprès de 160 professionnels de santé, cette étude américaine analyse leurs points de vue relatifs aux tests de génétique moléculaire des cancers de type Multiplex et leur utilisation de ces tests dans la pratique

Physicians’ Attitudes About Multiplex Tumor Genomic Testing

Gray, Stacy W. ; Hicks-Courant, Katherine ; Cronin, Angel ; Rollins, Barrett J. ; Weeks, Jane C.

Purpose : Although predictive multiplex somatic genomic tests hold the potential to transform care by identifying targetable alterations in multiple cancer genes, little is known about how physicians will use such tests in practice. Participants and Methods : Before the initiation of enterprise-wide multiplex testing at a major cancer center, we surveyed all clinically active adult cancer physicians to assess their current use of somatic testing, their attitudes about multiplex testing, and [...]