Mené auprès de 3 106 patients atteints d'un cancer du sein, de la prostate, du côlon-rectum ou du poumon et traités en ambulatoire, cet essai analyse les facteurs associés à l'évolution du degré de sévérité de la douleur liée à la maladie

Determinants of Pain Severity Changes in Ambulatory Patients With Cancer: An Analysis From Eastern Cooperative Oncology Group Trial E2Z02

Zhao, Fengmin ; Chang, Victor T. ; Cleeland, Charles ; Cleary, James F. ; Mitchell, Edith P. ; Wagner, Lynne I. ; Fisch, Michael J.

Purpose : To understand changes in pain severity over time and to explore the factors associated with pain changes in ambulatory patients with solid tumors. Patients and Methods : We enrolled 3,106 patients with invasive cancer of the breast, prostate, colon/rectum, or lung from multiple sites. At baseline and 4 to 5 weeks later, patients rated their pain level on a 0 to 10 numerical rating scale. A 2-point change in pain score was defined as a clinically significant change in pain. [...]

Menée auprès de 606 survivants d'un cancer du côlon-rectum, de la vessie ou d'une leucémie, cette étude américaine analyse leurs symptômes 2 à 5 ans après le diagnostic, leurs besoins en information relative à ce sujet, leurs perceptions des soins dédiés à leurs symptômes et leur qualité de vie

The importance of symptom surveillance during follow-up care of leukemia, bladder, and colorectal cancer survivors

Kent, ErinE ; Mitchell, SandraA ; Oakley-Girvan, Ingrid ; Arora, NeerajK

Purpose : We examined cancer survivors’ experience of bothersome symptoms, association of symptom bother with health-related quality of life (HRQOL), survivors’ perception of symptom care, and their symptom-related information needs. Methods : Using self-report survey measures, survivors of leukemia, bladder, or colorectal cancer who were 2–5 years post-diagnosis and received follow-up care in the past year (N = 623) provided information about the presence of bothersome symptoms, [...]

Mené au Canada de 2008 à 2011 auprès de 327 participants, cet essai randomisé analyse et compare l'efficacité de deux approches psychothérapeutiques pour traiter les insomnies de patients atteints de cancer

Mindfulness-Based Stress Reduction Compared With Cognitive Behavioral Therapy for the Treatment of Insomnia Comorbid With Cancer: A Randomized, Partially Blinded, Noninferiority Trial

Garland, Sheila N. ; Carlson, Linda E. ; Stephens, Alisa J. ; Antle, Michael C. ; Samuels, Charles ; Campbell, Tavis S.

Purpose : Our study examined whether mindfulness-based stress reduction (MBSR) is noninferior to cognitive behavioral therapy for insomnia (CBT-I) for the treatment of insomnia in patients with cancer. Patients and Methods : This was a randomized, partially blinded, noninferiority trial involving patients with cancer with insomnia recruited from a tertiary cancer center in Calgary, Alberta, Canada, from September 2008 to March 2011. Assessments were conducted at baseline, after the program, and [...]

A partir d'une revue systématique de la littérature (20 études quantittatives et 10 études qualitatitves), cette étude fait le point sur les difficultés physiques et psychologiques de survivants d'un cancer lors de leur retour au travail

Physical and psychosocial problems in cancer survivors beyond return to work: a systematic review

Duijts, Saskia F. A. ; van Egmond, Martine P. ; Spelten, Evelien ; van Muijen, Peter ; Anema, Johannes R. ; van der Beek, Allard J.

Objective : Attention for the expanding group of cancer survivors at work, and the late effects they are confronted with while working, has been limited. The objective of this systematic review is to identify and summarize studies, exploring ongoing physical and/or psychosocial problems related to functioning of employees with a history of cancer, beyond their return to work. Methods : Publications were identified through computerized Medline, Psychinfo, Embase, and Cinahl searches (January [...]

Menée auprès de 230 patients atteints d'un cancer du poumon, cette étude analyse l'efficacité d'un outil permettant de définir les facteurs associés à leurs intentions de participer à des groupes de soutien, en ligne ou en face-à-face

Modeling intention to participate in face-to-face and online lung cancer support groups

Xu, Yangmu ; Testerman, Laura S. ; Owen, Jason E. ; Bantum, Erin O. ; Thornton, Andrea A. ; Stanton, Annette L.

Background : Lung cancer patients and survivors are significantly less likely to use support groups than those with other cancers. In this study, we evaluated the utility and specificity of the Behavioral Model for Vulnerable Populations for modeling intention to participate in face-to-face (F2F) and online lung cancer support groups. Methods : Adults diagnosed with lung cancer (n=230) completed measures assessing predisposing, enabling, and need factors associated with intention to use support [...]

Menée par questionnaire auprès de 183 survivants d'un cancer du poumon non à petites cellules, cette étude analyse l'impact de différents symptômes (douleur, fatigue, dyspnée, dépression, anxiété) sur leur qualité de vie après leurs traitements

Impact of symptom burden in post-surgical non-small cell lung cancer survivors

Lowery, AmyE ; Krebs, Paul ; Coups, ElliotJ ; Feinstein, MarcB ; Burkhalter, JackE ; Park, BernardJ ; Ostroff, JamieS

Purpose : Pain, fatigue, dyspnea, and distress are commonly reported cancer-related symptoms, but few studies have examined the effects of multiple concurrent symptoms in longer-term cancer survivors. We examined the impact of varying degrees of symptom burden on health-related quality of life (HRQOL) and performance status in surgically treated non-small cell lung cancer (NSCLC) survivors. Methods : A sample of 183 NSCLC survivors 1–6 years post-surgical treatment completed questionnaires [...]

Menée aux Etats-Unis auprès de 450 patients atteints d'un cancer du poumon non à petites cellules de stade avancé, cette étude transversale analyse la concordance entre la sévérité des symptômes déclarée par le patient et celle rapportée par le médecin

The symptom burden of non-small cell lung cancer in the USA: a real-world cross-sectional study

Iyer, Shrividya ; Roughley, Adam ; Rider, Alex ; Taylor-Stokes, Gavin

Purpose : Disease symptom management in patients with advanced non-small cell lung cancer (NSCLC) is a critical aspect of therapy. The main objective of our study was to assess patient-reported outcomes and the degree of concordance between physician and patient perceptions of symptom severity in advanced NSCLC in the USA. Methods : Patients with advanced (stage IIIB/IV) NSCLC (N = 450) were recruited in a nationwide (USA) lung cancer study. Patients and their oncologists completed patient and [...]

Mené aux Etats-Unis auprès de 295 survivantes d'un cancer du sein ayant un lymphoedème ou à haut risque de lymphoedème, cet essai randomisé analyse l'impact d'un programme de musculation sur la santé des muscles squelettiques

Influence of weight training on skeletal health of breast cancer survivors with or at risk for breast cancer-related lymphedema

Winters-Stone, KerriM ; Laudermilk, Monica ; Woo, Kaitlin ; Brown, JustinC ; Schmitz, KathrynH

Purpose : This study aimed to determine whether the Physical Activity and Lymphedema (PAL) trial weight training program for breast cancer survivors at risk of or with breast cancer-related lymphedema provided skeletal benefits. Methods : Of the 295 participants in the randomized controlled PAL trial, 258 (weight training; N = 128; control, N = 130) had complete measures of bone mineral density (BMD (in grams per square centimeter)) of the proximal femur and lumbar spine and were also [...]

Menée auprès de 141 survivantes d'un cancer du sein, cette étude analyse les prescriptions médicales pour traiter soi-même un lymphœdème et l'observance thérapeutique

Prescription and adherence to lymphedema self-care modalities among women with breast cancer-related lymphedema

Brown, JustinC ; Cheville, AndreaL ; Tchou, JuliaC ; Harris, SusanR ; Schmitz, KathrynH

Purpose : To profile the prescription for and adherence to breast cancer-related lymphedema (BCRL) self-care modalities among breast cancer (BrCa) survivors with BCRL in a 12-month randomized weightlifting trial. Methods : We developed a questionnaire that assessed prescription for and adherence to 10 BCRL self-care modalities that included physical therapy exercise, pneumatic compression pump, medication, lymphedema bandaging, arm elevation, self-administered lymphatic drainage, [...]

Menée auprès de 159 patients atteints d'un cancer de la tête et du cou, cette étude de cohorte prospective analyse l'impact d'une dysphagie auto-déclarée sur leur qualité de vie, le risque de récidive de la maladie et leur survie

Baseline health perceptions, dysphagia, and survival in patients with head and neck cancer

Lango, Miriam N. ; Egleston, Brian ; Fang, Carolyn ; Burtness, Barbara ; Galloway, Thomas ; Liu, Jeffrey ; Mehra, Ranee ; Ebersole, Barbara ; Moran, Kathleen ; Ridge, John A.

BACKGROUND In head and neck cancer patients prior to treatment, dysphagia noted by patients is more common than aspiration on formal swallow studies. The authors hypothesized that patient-reported dysphagia impacts multiple domains of quality of life (QOL) and predicts disease recurrence and disease-related death. METHODS The Swal-QOL, a dysphagia-specific, swallowing-related, QOL measure, and the EuroQOL-5D-3L were administered to 159 patients before treatment with curative intent in this [...]

A partir des données de cohortes issues de 10 pays différents (93 771 personnes suivies pendant 21,7 années en moyenne), cette étude analyse la mortalité par cancer chez des membres d'équipage travaillant dans l'aviation commerciale

Mortality from cancer and other causes in commercial airline crews: a joint analysis of cohorts from 10 countries

Hammer, Gaël P ; Auvinen, Anssi ; De Stavola, Bianca L ; Grajewski, Barbara ; Gundestrup, Maryanne ; Haldorsen, Tor ; Hammar, Niklas ; Lagorio, Susanna ; Linnersjö, Anette ; Pinkerton, Lynne ; Pukkala, Eero ; Rafnsson, Vilhjálmur ; dos–Santos–Silva, Isabel ; Storm, Hans H ; Strand, Trond-Eirik ; Tzonou, Anastasia ; Zeeb, Hajo ; Blettner, Maria

Background : Commercial airline crew is one of the occupational groups with the highest exposures to ionising radiation. Crew members are also exposed to other physical risk factors and subject to potential disruption of circadian rhythms. Methods : This study analyses mortality in a pooled cohort of 93 771 crew members from 10 countries. The cohort was followed for a mean of 21.7 years (2.0 million person-years), during which 5508 deaths occurred. Results : The overall mortality was strongly [...]

Menée en Ecosse auprès de 5 229 participants atteints d'un cancer diagnostiqué avant l'âge de 25 ans entre 1981 et 2003, cette étude de cohorte rétrospective analyse l'évolution du taux d'admissions en hôpital psychiatrique ou en milieu hospitalier pour des troubles sévères et la durée du séjour chez des survivants à 5 ans d'un cancer

Subsequent hospitalisation experience of 5-year survivors of childhood, adolescent, and young adult cancer in Scotland: a population based, retrospective cohort study

Brewster, D. H. ; Clark, D. ; Hopkins, L. ; Bauer, J. ; Wild, S. H. ; Edgar, A. B. ; Wallace, W. H.

Background: Survivors of childhood, adolescent, and young adult cancer are known to be at risk of late effects of their disease and its treatment. Most population-based studies of cancer survivors have reported on second primary cancers and mortality. The aim of this study was to research acute and psychiatric hospital admission rates and length of stay in 5-year survivors of cancer diagnosed before the age of 25 years. Methods: This was a population-based retrospective cohort study using [...]

Cette étude américaine passe en revue les facteurs associés aux disparités ethniques dans l'incidence de la leucémie lymphoblastique pédiatrique ainsi que dans les traitements

Genomics of racial and ethnic disparities in childhood acute lymphoblastic leukemia

Lim, Joshua Yew-Suang ; Bhatia, Smita ; Robison, Leslie L. ; Yang, Jun J.

Although the cure rates of childhood acute lymphoblastic leukemia (ALL) have improved dramatically in the past 40 years, not all children have benefited equally from this impressive progress. Racial and ethnic disparities in the incidence and treatment outcome of childhood ALL persist, with Hispanic children having an elevated risk of developing ALL and one of the lowest survival rates after ALL therapy. A critical barrier to progress is the lack of an understanding of the causes of ALL [...]

Menée à Hong Kong auprès de 81 patients atteints d'un lymphome diffus à grandes cellules B, cette étude rétrospective analyse l'impact d'une infection par le virus de l'hépatite B sur leur survie

The impact of hepatitis B virus (HBV) infection on clinical outcomes of patients with diffuse large B-cell lymphoma

Law, M. F. ; Lai, H. K. ; Chan, H. N. ; Ha, C. Y. ; Ng, C. ; Yeung, Y. M. ; Yip, S. F.

We performed a retrospective study to analyse the characteristics and clinical outcomes of diffuse large B-cell lymphoma (DLBCL) patients with hepatitis B virus (HBV) infection and compare with those without HBV infection. The occurrence of hepatitis after withdrawal of prophylactic antiviral treatment on completion of chemotherapy was also assessed. The HBsAg-positive patients were given prophylactic antiviral treatment until 6 months after finishing chemotherapy. A total of 81 patients were [...]

A partir des données de la base Medicare incluant 56 642 071 bénéficiaires, cette étude américaine analyse l'évolution des morbidités et de la mortalité chez les patients atteints d'un cancer du pancréas, ainsi que l'évolution des soins et traitements, sur la période 2000-2010

National trends in pancreatic cancer outcomes and pattern of care among Medicare beneficiaries, 2000 through 2010

Wang, Yun ; Schrag, Deborah ; Brooks, Gabriel A. ; Dominici, Francesca

BACKGROUND Pancreatic cancer is a major cause of morbidity and mortality in the Medicare population. Whether the health care burden of pancreatic cancer has changed over the last decade is unknown. METHODS The authors used Medicare data from 2000 to 2010 to identify beneficiaries aged ≥ 65 years who were hospitalized for the management of pancreatic cancer. Annual trends were estimated for the age-sex-race–adjusted initial hospitalization rate, the age-sex-race-comorbidity–adjusted 1-year [...]

A partir des données du registre national irlandais des cancers, cette étude analyse l'évolution de l'incidence du mésothéliome pleural malin ainsi que la survie, sur la période 1994-2009

Malignant pleural mesothelioma incidence and survival in the Republic of Ireland 1994–2009

Jennings, Cormac J. ; Walsh, Paul M. ; Deady, Sandra ; Harvey, Brian J. ; Thomas, Warren

Objective : Malignant pleural mesothelioma (MPM) is a rare malignancy associated with exposure to asbestos. The protracted latent period of MPM means that its incidence has continued to rise across Europe after the introduction of restrictions on asbestos use. In order to obtain a clearer indication of trends in the Republic of Ireland (ROI), incidence and survival were assessed based on all MPM cases reported since the establishment of the National Cancer Registry of Ireland (NCR). Methods : [...]

Menée au Royaume-Uni auprès de 11 920 patients atteints d'un cancer de la prostate, cette étude de cohorte évalue l'association entre un diabète et le risque de mortalité, par cancer et toutes causes confondues

Type 2 diabetes and the risk of mortality among patients with prostate cancer

Bensimon, Leah ; Yin, Hui ; Suissa, Samy ; Pollak, MichaelN ; Azoulay, Laurent

Purpose : The aim of this study was to determine whether type 2 diabetes is associated with the incidence of prostate cancer mortality and all-cause mortality. Methods : This study was conducted by linking four databases from the United Kingdom: the National Cancer Data Repository, the Clinical Practice Research Datalink, the Hospital Episodes Statistics database, and the Office for National Statistics database. The cohort consisted of men newly diagnosed with non-metastatic prostate cancer [...]

A partir des données du registre néerlandais des cancers incluant 5 144 patients (âge moyen : 74 ans), cette étude en population analyse l'évolution de l'incidence des syndromes myélodysplasiques et des traitements reçus ainsi que la survie, sur la période 2001-2010

Trends in incidence, initial treatment and survival of myelodysplastic syndromes: A population-based study of 5144 patients diagnosed in the Netherlands from 2001 to 2010

Dinmohamed, Avinash G. ; Visser, Otto ; van Norden, Yvette ; Huijgens, Peter C. ; Sonneveld, Pieter ; van de Loosdrecht, Arjan A. ; Jongen-Lavrencic, Mojca

Studies with long-term follow-up of patients with myelodysplastic syndromes (MDS) based on data from nationwide population-based cancer registries are lacking. We conducted a nationwide population-based study to assess trends in incidence, initial treatment and survival in MDS patients diagnosed in the Netherlands from 2001 to 2010. We identified 5144 MDS patients (median age, 74years) from the Netherlands Cancer Registry (NCR). The NCR only includes MDS cases that were confirmed by bone marrow [...]

A partir des données des registres danois, finlandais, islandais et norvégien des cancers portant sur 1 111 survivantes d'un cancer du sein, cette étude analyse les facteurs sociodémographiques, les comorbidités et les symptômes chroniques (douleur, fatigue, anxiété, dépression) associés à une retraite anticipée ou au non-emploi après les traitements

Early retirement and non-employment after breast cancer

Lindbohm, M. L. ; Kuosma, E. ; Taskila, T. ; Hietanen, P. ; Carlsen, K. ; Gudbergsson, S. ; Gunnarsdottir, H.

Objective : This study examined whether workplace support, sociodemographic factors and co-morbidity are associated with early retirement or non-employment due to other reasons among breast cancer survivors. We also compared quality of life and chronic symptoms (pain, fatigue, anxiety and depression) among employed, retired and other non-employed breast cancer survivors. Methods : We identified breast cancer survivors diagnosed between 1997 and 2002 from either a hospital or a cancer registry [...]

Menée aux Etats-Unis auprès de 1 521 patientes atteintes d'un cancer du sein, cette étude analyse l'association entre leur satisfaction vis-à-vis de la qualité des soins et leur survie

Patient satisfaction with service quality as a predictor of survival outcomes in breast cancer

Gupta, Digant ; Rodeghier, Mark ; Lis, ChristopherG

Purpose : Despite the recognized relevance of symptom burden in breast cancer, there has been limited exploration of whether an individual patient's assessment of the overall quality of care received might influence outcome. We therefore evaluated the relationship between patient-reported satisfaction with service quality and survival in breast cancer. Methods : A random sample of 1,521 breast cancer patients treated at Cancer Treatment Centers of America. A questionnaire which covered several [...]

A partir d'échantillons tumoraux inclus en paraffine prélevés entre 1940 et 2007 dans 11 pays d'Amérique centrale et du Sud, d'Asie et d'Europe, cette étude analyse l'évolution de la distribution des sous-types de papillomavirus humains dans les cas de cancer invasif du col de l'utérus

Time trends of human papillomavirus types in invasive cervical cancer, from 1940 to 2007

Alemany, Laia ; de Sanjose, Silvia ; Tous, Sara ; Quint, Wim ; Vallejos, Carlos ; Shin, Hai-Rim ; Bravo, Luis E. ; Alonso, Patricia ; Lima, Marcus A. ; Guimerà, Núria ; Klaustermeier, JoEllen ; Llombart-Bosch, Antonio ; Kasamatsu, Elena ; Tatti, Silvio A. ; Felix, Ana ; Molina, Carla ; Velasco, Julio ; Lloveras, Belen ; Clavero, Omar ; Lerma, Enrique ; Laco, Jan ; Bravo, Ignacio G. ; Guarch, Rosa ; Pelayo, Adela ; Ordi, Jaume ; Andújar, Miguel ; Sanchez, Gloria I. ; Castellsagué, Xavier ; Muñoz, Nubia ; Bosch, F. Xavier ; on Behalf of the, R. I. S. H. P. V. T. T. Study Group

Contribution over time of human papillomavirus (HPV) types in human cancers has been poorly documented. Such data is fundamental to measure current HPV vaccines impact in the years to come. We estimated the HPV type-specific distribution in a large international series of invasive cervical cancer (ICC) over 70 years prior to vaccination. Paraffin embedded ICC cases diagnosed between 1940 and 2007 were retrieved from eleven countries in Central-South America, Asia and Europe. Included countries [...]

Menée aux Pays-Bas auprès de 598 patients atteints d'un cancer invasif de la vessie, cette étude prospective cas-témoins analyse leur état de santé et leur qualité de vie avant une cystectomie et un an après

Patient-reported outcomes for patients undergoing radical cystectomy: a prospective case–control study

Goossens - Laan, CatharinaA ; Kil, PaulJ M. ; Bosch, J. L. H. Ruud ; Vries, Jolanda

Purpose : The purpose of this study was to measure patient-reported outcomes (PROs) for patients with muscle-invasive bladder cancer (BC) before the diagnosis of BC was known, thus before cystectomy, and until 1 year postcystectomy. The differences in outcomes between a health status (HS) and quality of life (QoL) questionnaires were examined. Methods : From July 2007 to July 2010, 598 patients with primary hematuria were enrolled in this prospective, multi-centre case–control (CC) study. [...]

Menée en Corée auprès de 990 dyades composées du patient et de membres de sa famille, cette étude analyse la prévalence de leurs sentiments de culpabilité et la dissimulation de leurs pratiques tabagiques un mois après le diagnostic de cancer

Guilt, censure, and concealment of active smoking status among cancer patients and family members after diagnosis: a nationwide study

Shin, Dong Wook ; Park, Jong Hyock ; Kim, So Young ; Park, Eal Whan ; Yang, Hyung Kook ; Ahn, Eunmi ; Park, Seon Mee ; Lee, Young Joon ; Lim, Myong Cheol ; Seo, Hong Gwan

Objectives : We aimed to identify the prevalence of feelings of guilt, censure, and concealment of smoking status among cancer patients and their family members who continued to smoke after the patient's diagnosis. Methods : Among 990 patient–family member dyads, 45 patients and 173 family members who continued to smoke for at least 1 month after the patients' diagnoses were administered questions examining feelings of guilt, censure, and smoking concealment. Results : Most patients who [...]

Menée à Londres par entretiens auprès de 54 femmes d'origines ethniques diverses, cette étude qualitative analyse les facteurs facilitant ou retardant la détection précoce de symptômes liés à un cancer du sein ou à un cancer du col de l'utérus

Facilitators and barriers to help-seeking for breast and cervical cancer symptoms: a qualitative study with an ethnically diverse sample in London

Marlow, Laura A. V. ; McGregor, Lesley M. ; Nazroo, James Y. ; Wardle, Jane

Objective : Earlier diagnosis of cancer has become a policy priority. There is evidence that minority ethnic groups are more likely to delay help-seeking for cancer symptoms, but few studies have explored reasons for delay in these groups. The present study explored facilitators and barriers to help-seeking for breast and cervical cancer in an ethnically diverse sample of women. Methods : Semi-structured interviews were carried out with 54 healthy women from a range of ethnic backgrounds; [...]

Menée par entretiens auprès de 15 patients atteints de cancer, cette étude qualitative australiennne analyse leurs besoins en aide spirituelle et le rôle du médecin dans ce genre de support

Spiritual support of cancer patients and the role of the doctor

Best, Megan ; Butow, Phyllis ; Olver, Ian

Purpose : Spiritual care is reported as important for cancer patients, but the role of the doctor in its provision is unclear. We undertook to understand the nature of spiritual support for Australian cancer patients and their preferences regarding spiritual care from doctors. Methods : Using grounded theory, semistructured interviews were conducted with 15 cancer patients with advanced disease in a variety of care settings. Patients were asked about the source of their spiritual support and [...]

A partir d'une revue systématique de la littérature en population américaine (33 études), cette étude fait le point sur la façon de faire face à un diagnostic de cancer du sein chez des femmes issues de minorités ethniques

Breast cancer and coping among women of color: a systematic review of the literature

Yoo, GraceJ ; Levine, EllenG ; Pasick, Rena

Breast cancer is the most commonly diagnosed form of cancer for women regardless of race/ethnicity. Women of color are diagnosed at later stages and experience greater mortality than their White counterparts. However, there has been comparatively little research on coping with breast among racial/ethnic minorities at time of diagnosis, during treatment, or in the course of survivorship. This is despite the fact that research has repeatedly shown that distress can impact disease progression and [...]

Menée par enquête en ligne auprès de 1 830 femmes (âge moyen : 54 ans), cette étude qualitative australienne analyse leurs expériences et leur ressenti relatifs à l'infertilité après un diagnostic de cancer du sein

Loss, uncertainty, or acceptance: subjective experience of changes to fertility after breast cancer

Perz, J. ; Ussher, J. ; Gilbert, E.

This qualitative study examines the subjective experience of infertility in a large sample of Australian women with breast cancer. Participants were 1830 women, average age 54, who responded to an email invitation to complete an online survey on sexual well-being and fertility concerns after breast cancer. 24.6% (n = 452) reported that cancer had affected their fertility; 21.3% (n = 391) did not know their fertility status. In thematic analysis of open-ended responses provided by 381 women [...]

A partir des données de la base Medicare, cette étude américaine analyse les effets de complications survenant à la suite de six types de résection d'un cancer (colectomie, résection rectale, lobectomie pulmonaire, pneumonectomie, œsophagectomie, résection pancréatique) sur les coûts des soins

The influence of complications on the costs of complex cancer surgery

Short, Marah N. ; Aloia, Thomas A. ; Ho, Vivian

BACKGROUND It is widely known that outcomes after cancer surgery vary widely, depending on interactions between patient, tumor, neoadjuvant therapy, and provider factors. Within this complex milieu, the influence of complications on the cost of surgical oncology care remains unknown. The authors examined rates of Patient Safety Indicator (PSI) occurrence for 6 cancer operations and their association with costs of care. METHODS The Agency for Healthcare Research and Quality (AHRQ) PSI [...]

A partir de données portant sur 1 541 patients atteints de leucémie myéloïde chronique et âgés de 18 à 64 ans, cette étude analyse l'évolution des coûts, des dépenses et de l'observance associés à un traitement par imatinib sur la période 2002-2011 aux Etats-Unis

Cost Sharing and Adherence to Tyrosine Kinase Inhibitors for Patients With Chronic Myeloid Leukemia

Dusetzina, Stacie B. ; Winn, Aaron N. ; Abel, Gregory A. ; Huskamp, Haiden A. ; Keating, Nancy L.

Purpose : The introduction of imatinib, a tyrosine kinase inhibitor (TKI), has greatly increased survival for patients with chronic myeloid leukemia (CML). Conversely, nonadherence to imatinib and other TKIs undoubtedly results in disease progression and treatment resistance. We examined trends in imatinib expenditures from 2002 to 2011 and assessed the association between copayment requirements for imatinib and TKI adherence. Patients and Methods : We used MarketScan health plan claims from [...]

Menée aux Pays-Bas auprès de 206 patients atteints d'un cancer du côlon de stade III traité en 2005 et 2006, cette étude observationnelle analyse le rapport coût-efficacité des traitements adjuvants et les coûts associés aux hospitalisations

Real-world resource use and costs of adjuvant treatment for stage III colon cancer

van Gils, C. W. M. ; de Groot, S. ; Tan, S. S. ; Redekop, W. K. ; Koopman, M. ; Punt, C. J. A. ; Uyl-de Groot, C. A.

Since the generalisability of trial-based economic evaluations may be limited, there is an increasing focus on real-world cost-effectiveness. Real-world studies involve evaluating the effects and costs of treatments in daily clinical practice. This study reports on the real-world resource use and costs of adjuvant treatments of stage III colon cancer in a population-based observational study. Analyses were based on a detailed retrospective medical chart review which was conducted for 206 [...]

Menée par entretiens auprès de 25 survivantes d'un cancer du sein, cette étude qualitative américaine analyse les facteurs associés à leur décision de participer à un essai clinique à base d'acupuncture pour traiter leurs symptômes

Breast cancer survivors willingness to participate in an acupuncture clinical trial: a qualitative study

Schapira, MarilynM ; Mackenzie, ElizabethR ; Lam, Regina ; Casarett, David ; Seluzicki, ChristinaM ; Barg, FrancesK ; Mao, JunJ

Purpose : Acupuncture is a complementary and alternative medicine (CAM) modality that shows promise as a component of supportive breast cancer care. Lack of robust recruitment for clinical trial entry has limited the evidence base for acupuncture as a treatment modality among breast cancer survivors. The objective of this study is to identify key decision-making factors among breast cancer survivors considering entry into an acupuncture clinical trial for treatment of symptoms. Methods : [...]

Mené auprès de 47 patientes atteintes d'un cancer du sein, cet essai randomisé en double aveugle analyse l'efficacité de l'acupuncture pour réduire les symptômes musculo-squelettiques de patientes recevant un traitement adjuvant par inhibiteurs de l'aromatase

Patient-reported outcomes in women with breast cancer enrolled in a dual-center, double-blind, randomized controlled trial assessing the effect of acupuncture in reducing aromatase inhibitor-induced musculoskeletal symptoms

Bao, Ting ; Cai, Ling ; Snyder, Claire ; Betts, Kelly ; Tarpinian, Karineh ; Gould, Jeff ; Jeter, Stacie ; Medeiros, Michelle ; Chumsri, Saranya ; Bardia, Aditya ; Tan, Ming ; Singh, Harvinder ; Tkaczuk, Katherin H. R. ; Stearns, Vered

BACKGROUND Aromatase inhibitors (AIs) have been associated with decrements in patient-reported outcomes (PROs). The objective of this study was to assess whether real acupuncture (RA), compared with sham acupuncture (SA), improves PROs in patients with breast cancer who are receiving an adjuvant AI. METHODS Postmenopausal women with a stage 0 through III breast cancer who received an AI and had treatment-associated musculoskeletal symptoms were randomized to receive 8 weekly RA versus SA in a [...]

Menée auprès des registres des cancers en Europe, cette étude analyse leurs pratiques pour assurer l'exhaustivité et l'actualisation du recueil des données et plaide pour une amélioration de leurs performances

Completeness and timeliness: Cancer registries could/should improve their performance

Zanetti, R. ; Schmidtmann, I. ; Sacchetto, L. ; Binder-Foucard, F. ; Bordoni, A. ; Coza, D. ; Ferretti, S. ; Galceran, J. ; Gavin, A. ; Larranaga, N. ; Robinson, D. ; Tryggvadottir, L. ; Van Eycken, E. ; Zadnik, V. ; Coebergh, J. W. W. ; Rosso, S.

Cancer registries must provide complete and reliable incidence information with the shortest possible delay for use in studies such as comparability, clustering, cancer in the elderly and adequacy of cancer surveillance. Methods of varying complexity are available to registries for monitoring completeness and timeliness. We wished to know which methods are currently in use among cancer registries, and to compare the results of our findings to those of a survey carried out in 2006. In the [...]

A partir des données du registre de Genève des cancers portant sur 10 534 femmes atteintes d'un cancer du sein diagnostiqué entre 1970 et 2009, cette étude analyse la pertinence d'une révision de la cause du décès et son impact sur l'estimation de la survie

Accuracy of cause of death data routinely recorded in a population-based cancer registry: impact on cause-specific survival and validation using the Geneva cancer registry

Schaffar, Robin ; Rapiti, Elisabetta ; Rachet, Bernard ; Woods, Laura

BACKGROUND:Information on the underlying cause of death of cancer patients is of interest because it can be used to estimate net survival. The population-based Geneva Cancer Registry is unique because registrars are able to review the official cause of death. This study aims to describe the difference between the official and revised cause-of-death variables and the impact on cancer survival estimates. METHODS:The recording process for each cause of death variable is summarised. We describe the [...]

Cette étude australienne analyse l'impact de la participation des radiologues dans une équipe pluridisciplinaire dédiée au cancer du sein sur la prise de décision et l'amélioration des soins

Radiologist participation in multi-disciplinary teams in breast cancer improves reflective practice, decision making and isolation

Alcantara, S. B. ; Reed, W. ; Willis, K. ; Lee, W. ; Brennan, P. ; Lewis, S.

This study aims to explore Australian radiologists' experiences of participating in breast cancer multi-disciplinary team (MDT) meetings to identify enablers and barriers to participation as well their perception of confidence and patient care. Qualitative methods incorporating observation and interviews were used. Twenty-one breast cancer MDT meetings were observed across Sydney to study the dynamics of the meetings, the level of participation by radiologists and their most important [...]