A partir des données de 15 études cas-témoins portant sur l'association entre le tabagisme et le risque de cancer du poumon sur la période 1985-2009, cette étude évalue la pertinence d'un modèle de calcul permettant de mesurer séparément les effets de deux indicateurs, durée et intensité de l'exposition au tabagisme, pour ré-évaluer leur association avec le risque de cancer

Effect Modification of the Association of Cumulative Exposure and Cancer Risk by Intensity of Exposure and Time Since Exposure Cessation: A Flexible Method Applied to Cigarette Smoking and Lung Cancer in the SYNERGY Study

Vlaanderen, Jelle ; Portengen, Lützen ; Schüz, Joachim ; Olsson, Ann ; Pesch, Beate ; Kendzia, Benjamin ; Stücker, Isabelle ; Guida, Florence ; Brüske, Irene ; Wichmann, Heinz-Erich ; Consonni, Dario ; Landi, Maria Teresa ; Caporaso, Neil ; Siemiatycki, Jack ; Merletti, Franco ; Mirabelli, Dario ; Richiardi, Lorenzo ; Gustavsson, Per ; Plato, Nils ; Jöckel, Karl-Heinz ; Ahrens, Wolfgang ; Pohlabeln, Hermann ; Tardon, Adonina ; Zaridze, David ; Field, John K. ; 't Mannetje, Andrea ; Pearce, Neil ; McLaughlin, John ; Demers, Paul ; Szeszenia-Dabrowska, Neonila ; Lissowska, Jolanta ; Rudnai, Peter ; Fabianova, Eleonora ; Stanescu Dumitru, Rodica ; Bencko, Vladimir ; Foretova, Lenka ; Janout, Vladimir ; Boffetta, Paolo ; Forastiere, Francesco ; Bueno-de-Mesquita, Bas ; Peters, Susan ; Brüning, Thomas ; Kromhout, Hans ; Straif, Kurt ; Vermeulen, Roel

The indiscriminate use of the cumulative exposure metric (the product of intensity and duration of exposure) might bias reported associations between exposure to hazardous agents and cancer risk. To assess the independent effects of duration and intensity of exposure on cancer risk, we explored effect modification of the association of cumulative exposure and cancer risk by intensity of exposure. We applied a flexible excess odds ratio model that is linear in cumulative exposure but potentially [...]

A partir des données de la cohorte européenne EPIC incluant 308 036 femmes et couplée à une étude portant sur 609 cas et sur 1 218 témoins, cette étude évalue l'association entre le tabagisme et le risque de néoplasie intraépithéliale de grade 3, de carcinome in situ ou de cancer invasif du col de l'utérus

Smoking as a major risk factor for cervical cancer and pre-cancer: Results from the EPIC cohort

Roura, Esther ; Castellsagué, Xavier ; Pawlita, Michael ; Travier, Noemie ; Waterboer, Tim ; Margall, Núria ; Bosch, F. Xavier ; de Sanjose, Silvia ; Dillner, Joakim ; Gram, Inger T. ; Tjønneland, Anne ; Munk, Christian ; Pala, Valeria ; Palli, Domenico ; Khaw, Kay-Tee ; Barnabas, Ruanne V. ; Overvad, Kim ; Clavel-Chapelon, Françoise ; Boutron-Ruault, Marie-Christine ; Fagherazzi, Guy ; Kaaks, Rudolf ; Lukanova, Annekatrin ; Steffen, Annika ; Trichopoulou, Antonia ; Trichopoulos, Dimitrios ; Klinaki, Eleni ; Tumino, Rosario ; Sacerdote, Carlotta ; Panico, Salvatore ; Bueno-de-Mesquita, H. Bas ; Peeters, Petra H. ; Lund, Eiliv ; Weiderpass, Elisabete ; Redondo, M. Luisa ; Sánchez, María-José ; Tormo, Maria-José ; Barricarte, Aurelio ; Larranaga, Nerea ; Ekström, Johanna ; Hortlund, Maria ; Lindquist, David ; Wareham, Nick ; Travis, Ruth C. ; Rinaldi, Sabina ; Tommasino, Massimo ; Franceschi, Silvia ; Riboli, Elio

A total of 308,036 women were selected from the European Prospective Investigation into Cancer and Nutrition (EPIC) study to evaluate the association between tobacco smoking and the risk of cervical intraepithelial neoplasia of grade 3 (CIN3)/carcinoma in situ (CIS) and invasive cervical cancer (ICC). At baseline, participants completed a questionnaire and provided blood samples. During a mean follow-up time of 9 years, 261 ICC cases and 804 CIN3/CIS cases were reported. In a nested [...]

A partir des données de 9 études cas-témoins menées aux Etats-Unis et en Amérique latine incluant 2 277 cas et 7 639 témoins, cette étude évalue l'association entre une consommation de marijuana et le risque de cancer de l'oropharynx et de cancer de la langue

Association of Marijuana Smoking with Oropharyngeal and Oral Tongue Cancers: Pooled Analysis from the INHANCE Consortium

Marks, Morgan A. ; Chaturvedi, Anil K. ; Kelsey, Karl ; Straif, Kurt ; Berthiller, Julien ; Schwartz, Stephen M. ; Smith, Elaine ; Wyss, Annah ; Brennan, Paul ; Olshan, Andrew F. ; Wei, Qingyi ; Sturgis, Erich M. ; Zhang, Zuo-Feng ; Morgenstern, Hal ; Muscat, Joshua ; Lazarus, Philip ; McClean, Michael ; Chen, Chu ; Vaughan, Thomas L. ; Wünsch-Filho, Victor ; Curado, Maria Paula ; Koifman, Sergio ; Matos, Elena ; Menezes, Ana ; Daudt, Alexander W. ; Fernandez, Leticia ; Posner, Marshall ; Boffetta, Paolo ; Lee, Yuan-Chin Amy ; Hashibe, Mia ; D'Souza, Gypsyamber

Background: The incidence of oropharyngeal and oral tongue cancers has increased over the last 20 years which parallels increased use of marijuana among individuals born after 1950. Methods: A pooled analysis was conducted comprising individual-level data from nine case–control studies from the United States and Latin America in the INHANCE consortium. Self-reported information on marijuana smoking, demographic, and behavioral factors was obtained from 1,921 oropharyngeal cases, 356 oral tongue [...]

Menée au Japon auprès de 73 501 participants suivis de 1995 à 2008, cette étude prospective évalue l'association entre une consommation de riz, de pain, de nouilles, de produits céréaliers et le risque de cancer colorectal

Rice, bread, noodle and cereal intake and colorectal cancer in Japanese men and women: the Japan Public Health Center-based prospective Study (JPHC Study)

Abe, S. K. ; Inoue, M. ; Sawada, N. ; Iwasaki, M. ; Ishihara, J. ; Sasazuki, S. ; Shimazu, T. ; Yamaji, T. ; Shibuya, K. ; Tsugane, S.

Background: Colorectal cancer (CRC) incidence rate increased rapidly in Japan between the 1950s and 1990s. We examined the association between rice intake and CRC risk in comparison with bread, noodles and cereal among Japanese adults enrolled in the Japan Public Health Center-based prospective Study. Methods: A total of 73 501 Japanese men and women were followed-up from 1995 to 1999 until the end of 2008 for an average of 11 years. During 801 937 person-years of follow-up, we identified 1276 [...]

Menée auprès de 60 cas de leucémie myéloïde aiguë, de 241 témoins et de 80 cas de leucémie lymphoïde chronique et de 345 témoins, cette étude évalue l'association entre une exposition professionnelle à de hautes doses de benzène chez des salariés de l'industrie pétrolière et le risque de leucémie

Acute myeloid and chronic lymphoid leukaemias and exposure to low-level benzene among petroleum workers

Rushton, L. ; Schnatter, A. R. ; Tang, G. ; Glass, D. C.

Background: High benzene exposure causes acute myeloid leukaemia (AML). Three petroleum case–control studies identified 60 cases (241 matched controls) for AML and 80 cases (345 matched controls) for chronic lymphoid leukaemia (CLL). Methods: Cases were classified and scored regarding uncertainty by two haematologists using available diagnostic information. Blinded quantitative benzene exposure assessment used work histories and exposure measurements adjusted for era-specific circumstances. [...]

Menée dans l'Etat de New York auprès de 1 875 salariés travaillant dans une usine de fabrication de produits en caoutchouc, cette étude évalue l'association entre une exposition professionnelle à des composés chimiques, o-toluidine, aniline, nitrobenzène, et le risque de cancer de la vessie

Bladder cancer incidence among workers exposed to o-toluidine, aniline and nitrobenzene at a rubber chemical manufacturing plant

Carreon, Tania ; Hein, Misty J ; Hanley, Kevin W ; Viet, Susan M ; Ruder, Avima M

Background : An earlier investigation found increased bladder cancer incidence among workers at a rubber chemical manufacturing plant that used o-toluidine, aniline and nitrobenzene. The cohort was expanded to include additional workers (n=1875) and updated through 2007 to assess bladder cancer with improved exposure characterisation. Methods : Work histories were updated and exposure categories and ranks were developed for o-toluidine, aniline and nitrobenzene combined. Incident cancers were [...]

Cette étude américaine analyse l'association entre des dérèglements du cycle circadien liés à l'utilisation nocturne de la lumière électrique et le risque de cancer du sein

Breast cancer and circadian disruption from electric lighting in the modern world

Stevens, Richard G. ; Brainard, George C. ; Blask, David E. ; Lockley, Steven W. ; Motta, Mario E.

Breast cancer is the leading cause of cancer death among women worldwide, and there is only a limited explanation of why. Risk is highest in the most industrialized countries but also is rising rapidly in the developing world. Known risk factors account for only a portion of the incidence in the high-risk populations, and there has been considerable speculation and many false leads on other possibly major determinants of risk, such as dietary fat. A hallmark of industrialization is the [...]

Menée en population américaine auprès de 478 cas et de 208 105 témoins, cette étude évalue l'association entre des caractéristiques périnatales (infection intra-utérine, accouchement prématuré) et le risque de lymphome chez l'enfant de moins de 5 ans

Birth characteristics and risk of lymphoma in young children

Marcotte, Erin L. ; Ritz, Beate ; Cockburn, Myles ; Clarke, Christina A. ; Heck, Julia E.

Background : Lymphoma is the third most common childhood malignancy and comprises two types, Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL). The etiology of pediatric lymphomas is largely unknown, but has been suggested to have prenatal origins. Methods : In this population-based study, California birth certificates were identified for 478 lymphoma cases diagnosed in children 0–5 years of age between 1988 and 2007; 208,015 controls frequency-matched by birth year were randomly selected [...]

Menée en Australie auprès de 11 297 femmes sans antécédent de cancer et âgées de 47 à 52 ans à l'inclusion, cette étude de cohorte en population évalue l'association entre des symptômes et troubles vasomoteurs de la ménopause et le risque de cancer du sein (durée moyenne de suivi : 13,7 ans)

Vasomotor menopausal symptoms are not associated with incidence of breast cancer in a population-based cohort of mid-aged women

Johanneke van den Berg, M. ; Mishra, Gita D. ; van der Schouw, Yvonne T. ; Herber-Gast, Gerrie-Cor M.

Recently, two case-control studies showed that vasomotor menopausal symptoms (VMS), i.e. hot flushes (HF) and night sweats (NS), are associated with a decreased risk of breast cancer. Until now, however, no prior studies have prospectively examined the association between VMS and breast cancer incidence. We investigated this in a population-based cohort of mid-aged women in Australia. We included 11,297 women without a history of breast cancer aged 47–52years from the Australian Longitudinal [...]

A partir des données de la cohorte "Shanghai Breast Cancer Study" incluant 3 269 cas et 3 341 témoins, cette étude évalue l'association entre divers indicateurs temporels liés à la reproduction et le risque de cancer du sein

Associations of reproductive time events and intervals with breast cancer risk: A report from the Shanghai Breast Cancer Study

Huang, Zhezhou ; Beeghly-Fadiel, Alicia ; Gao, Yu-Tang ; Zheng, Ying ; Dai, Qi ; Lu, Wei ; Zheng, Wei ; Shu, Xiao-Ou

While there is clear evidence for an association between later age at first live birth and increased breast cancer risk, associations with the timing of other reproductive events are less clear. As breast tissues undergo major structural and cellular changes during pregnancy, we examined associations between reproductive time events and intervals with breast cancer risk among parous women from the population-based Shanghai Breast Cancer Study (SBCS). Unconditional logistic regression was used [...]

Menée auprès de 33 057 femmes ménopausées ne prenant pas de traitement hormonal substitutif de la ménopause, cette étude américaine évalue l'association entre le poids au début de l'âge adulte, la prise de poids durant la vie adulte et le risque de cancer de l'endomètre

Body weight in early adulthood, adult weight gain, and risk of endometrial cancer in women not using postmenopausal hormones

Stevens, VictoriaL ; Jacobs, EricJ ; Patel, AlpaV ; Sun, Juzhong ; Gapstur, SusanM ; McCullough, MarjorieL

Purpose : High body mass index (BMI) measured in middle age or later is an established risk factor for endometrial cancer. However, whether BMI measured in early adulthood and adult weight change are associated with endometrial cancer risk is less clear, particularly among nonusers of postmenopausal hormones (PMH). Methods : These associations were investigated among women in the Cancer Prevention Study II Nutrition Cohort. Women taking PMH (n = 11,624, 12 % of all women) were excluded, and the [...]