A partir des données du registre de Colombie britannique portant sur 902 survivants et 9 020 témoins, cette étude de cohorte rétrospective analyse le risque de morbidités tardives entraînant une hospitalisation de survivants à cinq ans d'un cancer survenu pendant l'enfance, l'adolescence ou le début de l'âge adulte

Late morbidity leading to hospitalization among 5-year survivors of young adult cancer: A report of the childhood, adolescent and young adult cancer survivors research program

Zhang, Yang ; Lorenzi, Maria F. ; Goddard, Karen ; Spinelli, John J. ; Gotay, Carolyn ; McBride, Mary L.

To estimate the risk of late morbidity leading to hospitalization among young adult cancer 5-year survivors compared to the general population and to examine the long-term effects of demographic and disease-related factors on late morbidity, a retrospective cohort of 902 five-year survivors of young adult cancer diagnosed between 1981 and 1999 was identified from British Columbia (BC) Cancer Registry. A matched comparison group (N = 9020) was randomly selected from the provincial health [...]

Menée dans douze pays européens auprès de 1 241 personnels infirmiers, cette étude analyse, selon les pays, la prise en charge des accès douloureux paroxystiques des patients atteints de cancer, ainsi que les besoins de formation sur cette problématique

The management of breakthrough cancer pain – educational needs a European nursing survey

Wengström, Y. ; Rundström, C. ; Geerling, J. ; Pappa, T. ; Weisse, I. ; Williams, S. C. ; Zavratnik, B. ; Rustøen, T.

Poorly managed cancer pain is well known to profoundly impact the patient's daily life and interfere with quality of life. Nurses who cared for patients with cancer from 12 European countries participated in a survey of breakthrough cancer pain practice. The purpose was to investigate how nurses assess breakthrough cancer pain, use of standardised tools, confidence in supporting patients and awareness of medications. Responses from 1241 participants showed country variations. The majority of [...]

A partir d'une revue systématique de la littérature (17 études), cette étude fait le point sur l'efficacité et l'utilisation de l'acupuncture dans le traitement de divers symptômes associés au cancer

What is the evidence for the use of acupuncture as an intervention for symptom management in cancer supportive and palliative care: an integrative overview of reviews

Towler, P. ; Molassiotis, A. ; Brearley, S. G.

Purpose : This study aims to systematically appraise the evidence for the use of acupuncture for symptom management in cancer and supportive care and to identify recommendations for clinical practice and future research. Methods : A systematic search was carried out to identify reviews of the use of acupuncture in cancer supportive and palliative care, using MEDLINE, EMBASE, CINAHL, Web of Science, Cochrane Library, British Nursing Index, Index to Theses, Dissertations and Theses (via Proquest) [...]

Cette étude rétrospective américaine analyse l'utilisation de bisphosphonates intraveineux pour prévenir l'ostéoporose des patients présentant des métastases osseuses d'un cancer du sein, du poumon ou de la prostate

Utilization of intravenous bisphosphonates in patients with bone metastases secondary to breast, lung, or prostate cancer

Hagiwara, May ; Delea, ThomasE ; Cong, Ze ; Chung, Karen

Purpose : Cancer patients with bone metastases (BMets) are predisposed to skeletal complications. Bone-targeted therapies such as denosumab or intravenous bisphosphonates (IVBs) reduce the risk of these complications. This study characterized patterns of IVB use in these patients in the USA. Methods : This was a retrospective, observational study using the Truven Health MarketScan® Commercial and Medicare databases (2002–2011). Subjects with ≥1 claims of diagnosis of breast, lung, or prostate [...]

Menée à Hong Kong par enquête téléphonique auprès de 614 cas et de 208 témoins, cette étude analyse la qualité de vie et la détresse psychologique de jeunes survivants adultes d'un cancer pédiatrique

Health-related quality-of-life and psychological distress of young adult survivors of childhood cancer in Hong Kong

Chan, Carmen W. H. ; Choi, Kai Chow ; Chien, Wai Tong ; Cheng, Karis K. F. ; Goggins, William ; So, Winnie K. W. ; Li, Chi Kong ; Yuen, Hui Leung ; Li, Chi Keung

Background and purpose : Previous literatures on young adult survivors of childhood cancer show inconsistent findings with regards to their psychological distress and health-related quality of life (HRQOL). Much of the available data focus on negative patient outcomes following cancer treatments prescribed from 1970 to 1990. In the present study, HRQOL and psychological distress of young adult survivors in Hong Kong was examined. It focused on subjects who had received cancer treatments [...]

Menée auprès de 103 patientes présentant un lymphœdème associé à un cancer du sein, cet essai randomisé évalue, du point de vue du taux de réduction du volume du bras, l'efficacité d'une thérapie lymphatique décongestive

Randomized Trial of Decongestive Lymphatic Therapy for the Treatment of Lymphedema in Women With Breast Cancer

Dayes, Ian S. ; Whelan, Tim J. ; Julian, Jim A. ; Parpia, Sameer ; Pritchard, Kathleen I. ; D'Souza, David Paul ; Kligman, Lyn ; Reise, Donna ; LeBlanc, Linda ; McNeely, Margaret L. ; Manchul, Lee ; Wiernikowski, Jennifer ; Levine, Mark N.

Purpose : Because of its morbidity and chronicity, arm lymphedema remains a concerning complication of breast cancer treatment. Although massage-based decongestive therapy is often recommended, randomized trials have not consistently demonstrated benefit over more conservative measures. Patients and Methods : Women previously treated for breast cancer with lymphedema were enrolled from six institutions. Volumes were calculated from circumference measurements. Patients with a minimum of 10% [...]

Menée auprès de 437 patientes atteintes d'un cancer du sein, cette étude de cohorte rétrospective évalue l'association entre des douleurs articulaires auto-déclarées et l'arrêt prématuré d'un traitement par inhibiteurs de l'aromatase

Joint pain severity predicts premature discontinuation of aromatase inhibitors in breast cancer survivors

Chim, Kannie ; Xie, Sharon ; Stricker, Carrie ; Li, Qing ; Gross, Robert ; Farrar, John ; DeMichele, Angela ; Mao, Jun

BACKGROUND:Premature discontinuation of aromatase inhibitors (AIs) in breast cancer survivors compromises treatment outcomes. We aimed to evaluate whether patient-reported joint pain predicts premature discontinuation of AIs. METHODS:We conducted a retrospective cohort study of postmenopausal women with breast cancer on AIs who had completed a survey about their symptom experience on AIs with specific measurements of joint pain. The primary outcome was premature discontinuation of AIs, defined [...]

Menée par questionnaire auprès de 141 survivantes d'un cancer du sein et atteintes d'un lymphœdème, cette étude américaine analyse leur adhésion à un programme (durée : 1 an) comportant diverses modalités thérapeutiques (exercice physique, auto-drainage lymphatique, etc.)

Prescription and adherence to lymphedema self-care modalities among women with breast cancer-related lymphedema

Brown, JustinC ; Cheville, AndreaL ; Tchou, JuliaC ; Harris, SusanR ; Schmitz, KathrynH

Purpose : To profile the prescription for and adherence to breast cancer-related lymphedema (BCRL) self-care modalities among breast cancer (BrCa) survivors with BCRL in a 12-month randomized weightlifting trial. Methods : We developed a questionnaire that assessed prescription for and adherence to 10 BCRL self-care modalities that included physical therapy exercise, pneumatic compression pump, medication, lymphedema bandaging, arm elevation, self-administered lymphatic drainage, [...]

Mené auprès de 60 participants, cet essai américain randomisé analyse l'efficacité d'une solution de rinçage buccal sursaturée en ions phosphate et calcium pour atténuer la sévérité d'une mucite aiguë liée aux traitements d'un cancer de la tête et du cou

The effect of a supersaturated calcium phosphate mouth rinse on the development of oral mucositis in head and neck cancer patients treated with (chemo)radiation

Lambrecht, Maarten ; Mercier, Carole ; Geussens, Yasmyne ; Nuyts, Sandra

Objectives : Mucosal damage is an important and debilitating side effect when treating head and neck cancer patients with (chemo-)radiation. The aim of this randomized clinical trial was to investigate whether the addition of a neutral, supersaturated, calcium phosphate (CP) mouth rinse benefits the severity and duration of acute mucositis in head and neck cancer patients treated with (chemo)radiation. Materials and methods : A total of 60 patients with malignant neoplasms of the head and neck [...]

A partir des données du registre australien des cancers pédiatriques portant sur 196 enfants indigènes et 6 376 enfants non-indigènes entre 1997 et 2007, cette étude analyse les disparités de survie en fonction de l'origine ethnique des patients pédiatriques

Cancer survival in Indigenous and non-Indigenous Australian children: what is the difference?

Valery, PatriciaC ; Youlden, DannyR ; Baade, PeterD ; Ward, LeisaJ ; Green, AdeleC ; Aitken, JoanneF

Purpose : This study assessed variation in childhood cancer survival by Indigenous status in Australia, and explored the effect of place of residence and socio-economic disadvantage on survival. Methods : All children diagnosed with cancer during 1997–2007 were identified through the Australian Pediatric Cancer Registry. Cox regression analysis was used to assess the adjusted differences in survival. Results : Overall, 5-years survival was 75.0 % for Indigenous children (n = 196) and 82.3 % for [...]

Menée auprès de 3 124 patientes atteintes d'un cancer du sein et âgées de plus de 75 ans, cette étude de cohorte rétrospective évalue l'association entre un diabète, la période sans récidive de cancer du sein et la mortalité toutes causes confondues

Diabetes in relation to breast cancer relapse and all-cause mortality in elderly breast cancer patients: a FOCUS study analysis

Kiderlen, M. ; de Glas, N. A. ; Bastiaannet, E. ; Engels, C. C. ; van de Water, W. ; de Craen, A. J. M. ; Portielje, J. E. A. ; van de Velde, C. J. H. ; Liefers, G. J.

Background : In developed countries, 40% of breast cancer patients are >65 years of age at diagnosis, of whom 16% additionally suffer from diabetes. The aim of this study was to assess the impact of diabetes on relapse-free period (RFP) and overall mortality in elderly breast cancer patients. Patients and Methods : Patients were selected from the retrospective FOCUS cohort, which contains detailed information of elderly breast cancer patients. RFP was calculated using Fine and Gray competing [...]

A partir de la base de données danoise des cancers gynécologiques portant sur 1 961 cas de cancer du col de l'utérus diagnostiqués entre 2005 et 2010, cette étude analyse l'association entre des facteurs socioéconomiques et la survie des patientes, en prenant en compte le stade du cancer au diagnostic, des comorbidités, des facteurs liés au mode de vie et les traitements reçus

'Socioeconomic position and survival after cervical cancer: influence of cancer stage, comorbidity and smoking among Danish women diagnosed between 2005 and 2010

Ibfelt, E. H. ; Kjar, S. K. ; Hogdall, C. ; Steding-Jessen, M. ; Kjar, T. K. ; Osler, M. ; Johansen, C. ; Frederiksen, K. ; Dalton, S. O.

Background: In an attempt to decrease social disparities in cancer survival, it is important to consider the mechanisms by which socioeconomic position influences cancer prognosis. We aimed to investigate whether any associations between socioeconomic factors and survival after cervical cancer could be explained by socioeconomic differences in cancer stage, comorbidity, lifestyle factors or treatment. Methods: We identified 1961 cases of cervical cancer diagnosed between 2005 and 2010 in the [...]

A partir des données des registres américains des cancers, cette étude analyse l'évolution des disparités ethniques dans l'incidence du carcinome du rhinopharynx ainsi que dans la mortalité, sur la période 1973-2009

Racial differences in nasopharyngeal carcinoma in the United States

Wang, Yu ; Zhang, Yawei ; Ma, Shuangge

Abstract : Background: Nasopharyngeal carcinoma (NPC) is a malignant neoplasm arising from the mucosal epithelium of the nasopharynx. Different races can have different etiology, presentation, and progression patterns. Methods: Data were analyzed on NPC patients in the United States reported to the SEER (Surveillance, Epidemiology, and End Results) database between 1973 and 2009. Racial groups studied included non-Hispanic whites, Hispanic whites, blacks, Asians, and others. Patient [...]

Menée en Suède par questionnaire auprès de 537 oncologues, cette étude analyse leurs perceptions sur leurs capacités à aborder des sujets de nature psychosociale avec leurs patients

Barriers Against Psychosocial Communication: Oncologists’ Perceptions

Fagerlind, Hanna ; Kettis, Åsa ; Glimelius, Bengt ; Ring, Lena

Purpose : To explore oncologists’ psychosocial attitudes and beliefs and their perceptions regarding barriers against psychosocial communication. Methods : A questionnaire was distributed to oncologists in Sweden (n = 537). Questions covered demography, the Physician Psychosocial Beliefs Scale (PPBS), and barriers against psychosocial communication. Stepwise multiple regression was used to determine what factors contribute the most to the PPBS score and the total number of barriers and barriers [...]

A partir d'une revue de la littérature publiée entre 1990 et 2013, cette étude analyse les facteurs associés à l'adhésion des patients atteints de cancer à leurs traitements par voie orale

Adherence to oral antineoplastic agents by cancer patients: definition and literature review

Bassan, F. ; Peter, F. ; Houbre, B. ; Brennstuhl, M. J. ; Costantini, M. ; Speyer, E. ; Tarquinio, C.

Since the 1990s, oral chemotherapy has been gaining ground as cancer treatment. This therapy seems to have few toxic effects and offers patients good quality of life. However, in addition to the fears the therapy might generate in patients, oral treatment raises a new issue, which, until now, has been marginal in this field: therapeutic observance or adherence. We investigated the research into adherence to oral chemotherapy among cancer patients published between 1990 and July 2013. Studies [...]

Menée par questionnaire auprès de 158 couples, cette étude longitudinale américaine analyse la qualité de vie et la détresse psychologique des couples dont l'un des époux est atteint d'un cancer du poumon

Longitudinal associations between caregiver burden and patient and spouse distress in couples coping with lung cancer

Milbury, Kathrin ; Badr, Hoda ; Fossella, Frank ; Pisters, KatherineM ; Carmack, CindyL

Purpose : While spouses play a vital role in the care of cancer patients, caregiving exerts a physical and psychological toll. Caregiving burden may not only compromise spouses’ quality of life but also the quality of care and support they are able to provide. Consequently, spousal caregiving burden may also negatively impact patients’ psychological adjustment. However, the effect of caregiving burden on patients’ psychological distress is unknown. Thus, this 6-month longitudinal study examined [...]

A partir de données de deux études prospectives et d'une étude transversale (incluant respectivement 740, 189 et 463 participants), cette étude australienne évalue l'efficacité d'un outil permettant de détecter et de mesurer la détresse psychologique chez des patients atteints d'un cancer de la prostate

The validity of the distress thermometer in prostate cancer populations

Chambers, Suzanne K. ; Zajdlewicz, Leah ; Youlden, Danny R. ; Holland, Jimmie C. ; Dunn, Jeff

Background : The Distress Thermometer (DT) is widely recommended for screening for distress after cancer. However, the validity of the DT in men with prostate cancer and over differing time points from diagnosis has not been well examined. Method : Receiver operating characteristics analyses were used to evaluate the diagnostic accuracy of the DT compared with three commonly used standardised scales in two prospective and one cross-sectional survey of men with prostate cancer (n = 740, 189 and [...]

Menée par entretiens auprès de 15 participantes, cette étude qualitative canadienne analyse les expériences de femmes cherchant à établir une relation amoureuse avec un nouveau partenaire après un cancer du sein

Wearing my heart on my chest: dating, new relationships, and the reconfiguration of self-esteem after breast cancer

Kurowecki, Darya ; Fergus, Karen D.

Objective : This study investigated women's experiences of establishing an intimate relationship with a new partner after breast cancer diagnosis and treatment. Methods : Fifteen breast cancer survivors, who were either actively dating or in a new intimate relationship that began post-diagnosis, participated in semi-structured interviews. Interview transcripts were analyzed using the grounded theory method. Results : The analysis yielded Wearing My Heart on My Chest as the core category with [...]

Menée auprès de 493 femmes salariées, cette étude américaine analyse l'impact d'un diagnostic de cancer du sein et des traitements sur l'état psychologique et physique des patientes, en fonction du type d'emploi occupé

Job attributes, job satisfaction and the return to health after breast cancer diagnosis and treatment

Barnes, Andrew J. ; Robert, Nicholas ; Bradley, Cathy J.

Background : As detection and treatment of cancer has advanced, the number of working age women with breast cancer has increased. This study provides new information on the intersection of breast cancer treatment and job tasks and how, together, they impact employed and newly diagnosed women. Methods : The sample comprised 493 employed women within 2 months of initiating treatment. Job satisfaction and demands were assessed by a pre-diagnosis recall along with measures of mental and physical [...]

Menée par questionnaire téléphonique auprès de 68 femmes originaires d'Amérique latine, cette étude américaine analyse les facteurs de risque de dépression chez des survivantes à 5 ans d'un cancer du sein

Risk factors associated with increased depressive symptoms among Latinas diagnosed with breast cancer within 5 years of survivorship

Aguado Loi, Claudia X. ; Baldwin, Julie A. ; McDermott, Robert J. ; McMillan, Susan ; Martinez Tyson, Dinorah ; Yampolskaya, Svetlana ; VandeWeerd, Carla

Background : Co-occurring depression in women with cancer can complicate cancer treatment, lead to poor treatment adherence for both conditions, and decrease survival if left untreated. The purpose of this study was to explore risk factors for depression among Latina breast cancer survivors. Methods : A closed-ended questionnaire was administered by telephone to 68 Latinas diagnosed with breast cancer within the past 5 years. Depression symptoms were measured using the Patient Health [...]

A partir de données portant sur 4 960 survivants de cancer et 64 431 témoins âgés de plus de 18 ans, cette étude évalue les montants des dépenses médicales et les coûts associés à la perte de productivité chez les survivants sur la période 2008-2010 aux Etats-Unis

Economic Burden of Cancer Survivorship Among Adults in the United States

Guy, Gery P. ; Ekwueme, Donatus U. ; Yabroff, K. Robin ; Dowling, Emily C. ; Li, Chunyu ; Rodriguez, Juan L. ; de Moor, Janet S. ; Virgo, Katherine S.

Purpose: To present nationally representative estimates of the impact of cancer survivorship on medical expenditures and lost productivity among adults in the United States. Methods : Using the 2008 to 2010 Medical Expenditure Panel Survey, we identified 4,960 cancer survivors and 64,431 individuals without a history of cancer age ≥ 18 years. Direct medical costs were measured using annual health care expenditures and examined by source of payment and service type. Indirect morbidity costs were [...]

Menée auprès de 6 588 patientes originaires de 12 pays et atteintes d'un cancer du sein, cette étude internationale analyse et compare, selon les pays, les délais entre le diagnostic de la maladie et le début des traitements

Delays in diagnosis and treatment of breast cancer: a multinational analysis

Jassem, Jacek ; Ozmen, Vahit ; Bacanu, Florin ; Drobniene, Monika ; Eglitis, Janis ; Lakshmaiah, Kuntegowdanahalli C. ; Kahan, Zsuzsanna ; Mardiak, Jozef ; Pienkowski, Tadeusz ; Semiglazova, Tatiana ; Stamatovic, Ljiljana ; Timcheva, Constanta ; Vasovic, Suzana ; Vrbanec, Damir ; Zaborek, Piotr

Background: Reducing treatment delay improves outcomes in breast cancer. The aim of this study was to determine factors influencing patient- and system-related delays in commencing breast cancer treatment in different countries. Methods: A total of 6 588 female breast cancer patients from 12 countries were surveyed. Total delay time was determined as the sum of the patient-related delay time (time between onset of the first symptoms and the first medical visit) and system-related delay time [...]

Menée auprès de 1 521 patientes atteintes d'un cancer du sein et traitées en milieu hospitalier, cette étude américaine analyse leur satisfaction vis-à-vis de la qualité des soins reçus et l'association entre le degré de satisfaction et la survie

Patient satisfaction with service quality as a predictor of survival outcomes in breast cancer

Gupta, Digant ; Rodeghier, Mark ; Lis, ChristopherG

Purpose : Despite the recognized relevance of symptom burden in breast cancer, there has been limited exploration of whether an individual patient's assessment of the overall quality of care received might influence outcome. We therefore evaluated the relationship between patient-reported satisfaction with service quality and survival in breast cancer. Methods : A random sample of 1,521 breast cancer patients treated at Cancer Treatment Centers of America. A questionnaire which covered several [...]