Menée à partir des données de 9 études portant au total sur 9 115 témoins et 5 653 patients atteints d'un lymphome non hodgkinien, cette étude analyse l'association entre une activité physique d'intensité modérée à vigoureuse et le risque de développer la maladie

Physical activity and the risk of non-Hodgkin lymphoma subtypes: a pooled analysis

Boyle, Terry ; Kleinstern, Geffen ; Bracci, Paige M. ; Cerhan, James R. ; Benavente, Yolanda ; Casabonne, Delphine ; Chiu, Brian C.-H. ; Habermann, Thomas M. ; Holly, Elizabeth A. ; Liebow, Mark ; Norman, Aaron ; Paltiel, Ora ; Robinson, Dennis ; Rothman, Nathaniel ; Seir, Rania Abu ; Slager, Susan L. ; Villeneuve, Paul J. ; Wang, Sophia S ; Weisenburger, Dennis D. ; Spinelli, John J.

Non-Hodgkin lymphoma (NHL) is composed of a heterogeneous collection of subtypes with considerable differences in genetics, biology and aetiology. Studies to date on physical activity and NHL risk have not had sufficient sample size to evaluate whether associations differ by subtype. We pooled data from nine case-control studies to examine the association between moderate-to-vigorous intensity physical activity (MVPA) and risk of NHL overall and by subtype (diffuse large B-cell lymphoma, [...]

Menée au Japon par questionnaire auprès de 14 517 hommes et 21 583 femmes (durée médiane de suivi : 17,9 ans), cette étude analyse l'association entre l'apport alimentaire en manganèse et le risque de cancer du foie (239 cas)

Dietary Manganese Intake and Risk of Liver Cancer in Japanese Men and Women: The JACC Study

Kasai, Fumiko ; Eshak, Ehab S. ; Tamakoshi, Akiko ; Iso, Hiroyasu

We explored the association between dietary manganese intake and the risk of liver cancer in 14,517 men and 21,583 women who participated in the Japan Collaborative Cohort Study for Cancer Risk Assessment. We assessed dietary manganese intake using a food frequency questionnaire and incident liver cancer by reviewing cancer registries. According to manganese intake, we estimated the liver cancer risk by Cox regression analyses. During the 513,657 person-year follow-ups within a median of [...]

Menée à l'aide de 5 modèles murins de cancer du sein ER-, cette étude analyse l'efficacité de l'évérolimus, un inhibiteur de mTOR, pour prévenir la croissance des tumeurs mammaires

Targeting the mTOR Pathway for the Prevention of ER-negative Breast Cancer

Mazumdar, Abhijit ; Tahaney, William M. ; Hill, Jamal L. ; Zhang, Yun ; Ramachandran, Sumankalai ; Kawedia, Jitesh ; Qian, Jing ; Contreras, Alejandro ; Savage, Michelle I. ; Vornik, Lana A. ; Sei, Shizuko ; Mohammed, Altaf ; Brown, Powel H.

Prevention of estrogen receptor (ER)-positive breast cancer is now possible using anti-estrogen drugs; however, this treatment is ineffective against ER-negative breast cancers. In this study we hypothesized that inhibition of mTOR will suppress the growth of ER-negative and triple-negative breast cancers. To test the hypothesis, we used five ER-negative breast cancer models: MMTV-erbB2, C3(1)/SV40TAg, p53-null mammary gland-transplant, p53-mutant mammary gland-transplant, and BRCA1co/co; [...]

Menée aux Etats-Unis à partir de données d'enquêtes réalisées entre 2010 et 2019, cette étude analyse l'effet d'une campagne nationale, lancée en 2015, pour améliorer la promotion, auprès des médecins, du vaccin contre le papillomavirus humain chez les garçons âgés de 13 à 17 ans pour prévenir le cancer

Impact assessment of a provider-targeted national vaccine messaging campaign on human papillomavirus vaccination rates among US adolescent males

Agana-Norman, Denny Fe ; Berenson, Abbey B. ; Chang, Mihyun

Initial uptake of the cancer-preventative human papillomavirus (HPV) vaccine in the US was slow, especially among adolescent males. To address this, the US Centers for Disease Control and Prevention (CDC) partnered with the Hager Sharp communications development company to launch a national campaign in 2015 to improve physician counseling and rebrand the vaccine as cancer prevention. In this study, we compared HPV vaccination rates among 13–17-year-old males before (2010–2014) and after [...]