Menée à partir de données portant sur 467 patients recevant différents types de greffes de cellules souches hématopoïétiques, cette étude rétrospective analyse le risque de mucite buccale sévère

The incidence of severe oral mucositis in patients undergoing different conditioning regimens in haematopoietic stem cell transplantation

Nakagaki, Midori ; Kennedy, Glen A. ; Gavin, Nicole C. ; Clavarino, Alexandra ; Whitfield, Karen

Purpose : Oral mucositis is a common complication during haematopoietic stem cell transplantation (HSCT). This study aimed to assess the incidence of severe mucositis in patients undergoing different HSCT regimens. Methods : This single-centre retrospective study reviewed daily oral assessment for 467 consecutive patients who underwent different transplant regimens for matched unrelated or related allogeneic HSCT with post-transplant methotrexate, haploidentical or mismatched HSCT with [...]

Menée à partir de données portant sur 219 patients atteints d'un cancer et inclus dans un essai de phase I, cette étude compare la sévérité des symptômes déclarés par le médecin et celle déclarée par les patients

Evaluation of the patient experience of symptomatic adverse events on Phase I clinical trials using PRO-CTCAE

Watson, Geoffrey A. ; Veitch, Zachary W. ; Shepshelovich, Daniel ; Liu, Zhihui Amy ; Spreafico, Anna ; Abdul Razak, Albiruni R. ; Bedard, Philippe L. ; Siu, Lillian L. ; Minasian, Lori ; Hansen, Aaron R.

Background : Adverse event (AE) reporting in early-phase clinical trials is essential in determining the tolerability of experimental anticancer therapies. The patient-reported outcome version of the CTCAE (PRO-CTCAE) evaluates AE components such as severity and interference in daily life. The aim of this study was to correlate the grade of clinician-reported AEs with patients’ reported experience of these toxicities using PRO-CTCAE. Methods : Patients with advanced solid tumours enrolled on [...]

Menée en France auprès de 609 patients atteints d'un cancer, cette étude rétrospective analyse l'association entre la présence d'un diabète (119 cas) et la survenue d'événements indésirables sévères pendant la chimiothérapie

Diabetes Is Associated with High Risk of Severe Adverse Events during Chemotherapy for Cancer Patients: a Single-Center Study

Mailliez, Aurélie ; Ternynck, Camille ; Duhamel, Alain ; Mailliez, Audrey ; Ploquin, Anne ; Desauw, Christophe ; Lemaitre, Madleen ; Bertrand, Nicolas ; Vambergue, Anne ; Turpin, Anthony

Diabetes mellitus (DM) is a common comorbidity among cancer patients, but its impact on chemotherapy tolerance has not been widely studied. We aimed to compare the occurrence of severe grade 3/4 adverse events (G3/4 AEs) within 90 days of starting chemotherapy between patients with and without diabetes. We conducted a retrospective single-center study in Lille University Hospital Oncology Department, France. Patients who received the first cycle of chemotherapy for gastrointestinal, [...]

Menée au Texas à partir de données portant sur 8 402 adolescentes et jeunes adultes atteintes d'un cancer (âge : 15-39 ans), cette étude analyse les facteurs associés à la mortalité foetale (11 628 naissances d'enfants vivants et 68 enfants morts-nés)

Stillbirth after adolescent and young adult cancer: a population-based study

Murphy, Caitlin C ; Betts, Andrea C ; Allicock, Marlyn A ; Shay, L Aubree ; Preston, Sharice M ; Cohn, Barbara A ; Lupo, Philip J ; Pruitt, Sandi L

Background : Gonadotoxic effects of cancer treatment may increase risk of adverse birth outcomes in adolescent and young adult (AYA, age 15-39 years) women diagnosed with cancer. We estimated risk of stillbirth (fetal death of gestational age ≥20 weeks or weighing ≥350 grams) in a population-based sample of AYA women. Methods : AYA women diagnosed with cancer between January 1, 1995 and December 31, 2015 were identified using the Texas Cancer Registry and linked to live birth and fetal death [...]

Menée à partir de données portant sur 856 patients ayant survécu au moins 5 ans à une leucémie myéloide aiguë diagnostiquée entre 1970 et 1999 (âge médian au diagnostic : 7,1 ans ; âge médian lors du dernier suivi : 29,4 ans), cette étude analyse leur état de santé et la mortalité tardive (mortalité à 20 ans) selon les traitements anticancéreux reçus

Chronic Conditions, Late Mortality and Health Status After Childhood AML: A Childhood Cancer Survivor Study Report

Turcotte, Lucie M ; Whitton, Jillian A ; Leisenring, Wendy M ; Howell, Rebecca ; Neglia, Joseph P ; Phelan, Rachel ; Oeffinger, Kevin C ; Ness, Kirsten K ; Woods, William Guard ; Kolb, E. Anders ; Robison, Leslie L ; Armstrong, Gregory T ; Chow, Eric J

Five-year survival following childhood acute myeloid leukemia (AML) has increased due to improvements in treatment and supportive care. The impact of these changes on long-term health outcomes is unknown. To address this, cumulative incidence of late mortality and grades 3-5 chronic health conditions (CHCs) standardized mortality ratios (SMR) were estimated among five-year AML survivors from the Childhood Cancer Survivor Study diagnosed 1970-1999. Survivors were compared by treatment group [...]

Menée à partir des données des registres américains des cancers sur la période 2000-2018, cette étude analyse l'évolution de l'incidence du lymphome cutané à cellules T, en fonction du sous-type de la tumeur et du sexe, de l'âge, de l'origine ethnique et du statut socioéconomique du patient

Incidence Trends of Primary Cutaneous T-Cell Lymphoma in the US From 2000 to 2018: A SEER Population Data Analysis

Cai, Zhuo Ran ; Chen, Michael L. ; Weinstock, Martin A. ; Kim, Youn H. ; Novoa, Roberto A. ; Linos, Eleni

Recent incidence patterns of cutaneous T-cell lymphoma (CTCL) in the US are not well described. We sought to describe recent incidence trends by tumor subtype, sex, age, race and ethnicity, socioeconomic status (SES), and geography.

Menée en Suède à partir de données portant sur 1 275 patientes atteintes d'un cancer du sein (âge moyen au diagnostic : 32,9 ans), cette étude de cohorte prospective évalue l'association entre une procédure de préservation de la fertilité impliquant une stimulation hormonale et le risque de récidive ainsi que la mortalité spécifique

Relapse Rates and Disease-Specific Mortality Following Procedures for Fertility Preservation at Time of Breast Cancer Diagnosis

Marklund, Anna ; Lekberg, Tobias ; Hedayati, Elham ; Liljegren, Annelie ; Bergh, Jonas ; Lundberg, Frida E. ; Rodriguez-Wallberg, Kenny A.

Importance : Breast cancer (BC) is the most common indication for fertility preservation (FP) in women of reproductive age. Procedures for FP often include hormonal stimulation, but current data are scarce regarding whether using hormonal stimulation for FP is associated with any deterioration in BC prognosis. Objective : To investigate the risk of disease-specific mortality and relapse in women who underwent FP with or without hormonal stimulation compared with women who did not at time of BC [...]

A partir d'une revue systématique de la littérature publiée jusqu'en décembre 2020 (10 essais randomisés), cette étude analyse l'effet, sur la qualité de vie, la dépression, le stress, l'estime de soi, la douleur, la fatigue, l'adhésion au traitement, des intervention psychosociales chez des enfants et adolescents atteints d'un cancer (âge : inférieur ou égal à 18 ans)

Effectiveness of psychosocial interventions on health outcomes of children with cancer: A systematic review of randomised controlled trials

Melesse, Tenaw Gualu ; Chau, Janita Pak Chun ; Nan, M. A.

Introduction : Nowadays, there is promising evidence that psychosocial interventions could be helpful in paediatric oncology. Thus, this review aimed to describe the impact of psychosocial interventions on cancer-related health outcomes in children. Methods : Fifteen English electronic databases were searched from October to December 2020. Only randomised controlled trials that (1) included children ≤18 years old diagnosed with cancer, (2) evaluated the effects of psychosocial interventions, [...]

Menée au Danemark par enquête auprès de 1 538 patients ayant survécu à un cancer, cette étude transversale analyse les facteurs associés à leur peur de la récidive de la maladie, 2 ans et demi après le diagnostic

Fear of cancer recurrence at 2.5 years after a cancer diagnosis: a cross-sectional study in Denmark

Rasmussen, Linda Aagaard ; Jensen, Henry ; Pedersen, Anette Fischer ; Vedsted, Peter

Purpose : The aim was to investigate the characteristics of cancer survivors with high levels of fear of cancer recurrence, and how such fear is associated with their needs for care. Methods : This cross-sectional study was based on survey data from Danish cancer survivors at 2.5 years after a cancer diagnosis. These data were linked to nationwide register data. We used the 7-item Fear of Cancer Recurrence Inventory (FCR7) to measure fear of cancer recurrence, focussing on emotional, cognitive [...]

Menée aux Pays-Bas par questionnaire auprès de 336 patients atteints d'un cancer colorectal de stade I à IV récemment diagnostiqué, cette étude analyse l'association entre le concept de pleine conscience, la sévérité d'une neuropathie périphérique chronique et des troubles auto-déclarés (anxiété, troubles du sommeil, symptômes de dépression, fatigue), jusqu'à 2 ans après le diagnostic

Mindfulness is associated with severity of peripheral neuropathy and related patient-reported outcomes among colorectal cancer patients

Bonhof, Cynthia S. ; van de Poll-Franse, Lonneke V. ; de Hingh, Ignace H. ; Vreugdenhil, Gerard ; Mols, Floortje

Purpose : Despite the detrimental impact of chronic (chemotherapy-induced) peripheral neuropathy PN on patients’ lives, treatment options remain limited. We examined the association between mindfulness and chronic PN symptom severity and impairments in related patient-reported outcomes (PROs) among colorectal cancer (CRC) patients up to 2 years after diagnosis. Methods : Newly diagnosed stage I–IV CRC patients from four Dutch hospitals were eligible for participation. Patients (N = 336) [...]

A partir d'une revue de la littérature (222 essais menés dans 19 pays), cette étude analyse les caractéristiques des essais cliniques évaluant l'intérêt de l'acupuncture chez des patients atteints d'un cancer

The characteristics of registered acupuncture clinical trials enrolling cancer patients

Jin, Ming ; Xie, Lulu ; Mao, Ni ; Wei, Jianzi ; Chen, Junchao ; Chen, Xuefen ; Mao, Huijuan

Purpose : This study sought to explore and summarize the global state of acupuncture clinical trials enrolling cancer patients included in international registries to date. Methods : All relevant trials evaluating acupuncture-related interventions for the treatment of cancer that were registered in 16 trial registries from January 1, 2001, through December 31, 2020, were identified. Subsequent publications related to these trials were additionally retrieved from the PubMed, Cochrane Library, [...]