Menée en Inde auprès de 1 206 témoins et de 1 158 hommes atteints d'un cancer de la tête et du cou, cette étude analyse l'association entre une utilisation de différents produits tabagiques et le risque de développer la maladie par sous-type

Exclusive use of different types of tobacco products, exposure to second hand tobacco smoke and risk of subtypes of head and neck cancer among Indian males

Gholap, Devyani ; Dikshit, Rajesh ; Chaturvedi, Pankaj ; Chaturvedi, Anil K. ; Manjrekar, Ankita ; Mhatre, Sharayu

Tobacco products are used in vary many forms in India. Although the risk of tobacco uses in developing head and neck cancer (HNC) is known, risk by exclusive use of different tobacco products on HNC and its subtypes is poorly understood. A case-control study was conducted at a tertiary cancer hospital, which receives cases from different geographical regions of India with use of different types of tobacco products. The study included 824 Oral cavity (OC), 149 oropharynx (OPX) 104 hypopharyngeal [...]

Menée au Japon à partir de données portant sur 97 030 participants (durée moyenne de suivi: 16,2 ans), cette étude de cohorte prospective analyse l'association entre le tabagisme et le risque de décès par cancer des voies biliaires, en fonction de la localisation anatomique et du sexe de l'individu (484 décès)

Associations between cigarette smoking and biliary tract cancer by anatomic subsite and sex: a prospective cohort study in Japan

Lin, Yingsong ; Kawai, Sayo ; Sasakabe, Tae ; Kurosawa, Michiko ; Tamakoshi, Akiko ; Kikuchi, Shogo ; The, Jacc Study Group

Purpose : Biliary tract cancer (BTC) has not been considered a tobacco-related cancer, largely because of inconclusive results from epidemiological studies. We herein evaluate the association between cigarette smoking and risk of death from BTC by anatomic subsite and sex using data from a large, prospective cohort study in Japan. Methods : The present study included 97,030 Japanese individuals who were enrolled in 1988–1990 and followed until 31 December 2009. Cox proportional hazards [...]

A partir d'une revue systématique de la littérature publiée entre 1989 et 2020 (33 études), cette méta-analyse évalue l'association entre la consommation de produits laitiers et le risque de cancer de la prostate

The association between dairy products consumption and prostate cancer risk: a systematic review and meta-analysis

Zhao, Zifan ; Wu, Donghong ; Gao, Sirui ; Zhou, Dongda ; Zeng, Xiaoying ; Yao, Yuxuan ; Xu, Yilin ; Zeng, Guohua

In this study, we conducted a meta-analysis to estimate the relationship between the consumption of dairy products and the risk of prostate cancer. We searched PubMed, Embase and Cochrane databases for relevant articles and identified a total of thirty-three cohort studies between 1989 and 2020. The qualities of included studies were assessed using Newcastle–Ottawa scale. Pooled adjusted relative risks (RR) with 95 % CI were calculated. We performed subgroup analyses stratified by dairy type, [...]

Menée à partir des données de 14 études réalisées en Europe et au Canada et portant sur 20 965 témoins et 16 901 patients atteints d'un cancer du poumon, cette étude analyse l'association entre une exposition professionnelle au chrome hexavalent ou au nickel et le risque de développer la maladie, en fonction du statut tabagique

Occupational exposure to nickel and hexavalent chromium and the risk of lung cancer in a pooled analysis of case-control studies (SYNERGY)

Behrens, Thomas ; Ge, Calvin ; Vermeulen, Roel ; Kendzia, Benjamin ; Olsson, Ann ; Schüz, Joachim ; Kromhout, Hans ; Pesch, Beate ; Peters, Susan ; Portengen, Lützen ; Gustavsson, Per ; Mirabelli, Dario ; Guénel, Pascal ; Luce, Danièle ; Consonni, Dario ; Caporaso, Neil E. ; Landi, Maria Teresa ; Field, John K. ; Karrasch, Stefan ; Wichmann, Heinz-Erich ; Siemiatycki, Jack ; Parent, Marie-Élise ; Richiardi, Lorenzo ; Simonato, Lorenzo ; Jöckel, Karl-Heinz ; Ahrens, Wolfgang ; Pohlabeln, Hermann ; Fernández-Tardón, Guillermo ; Zaridze, David ; McLaughlin, John R. ; Demers, Paul A. ; Swiatkowska, Beata ; Lissowska, Jolanta ; Pándics, Tamás ; Fabianova, Eleonora ; Mates, Dana ; Bencko, Vladimir ; Foretova, Lenka ; Janout, Vladimir ; Boffetta, Paolo ; Bueno-de-Mesquita, Bas ; Forastiere, Francesco ; Straif, Kurt ; Brüning, Thomas

There is limited evidence regarding the exposure-effect relationship between lung-cancer risk and hexavalent chromium (Cr(VI)) or nickel. We estimated lung-cancer risks in relation to quantitative indices of occupational exposure to Cr(VI) and nickel and their interaction with smoking habits. We pooled 14 case-control studies from Europe and Canada, including 16,901 lung-cancer cases and 20,965 control subjects. A measurement-based job-exposure-matrix estimated job-year-region specific exposure [...]

Menée à partir des données GLOBOCAN 2022 portant sur 185 pays, cette étude estime la part attribuable à une infection par le papillomavirus humain dans l'incidence du carcinome épidermoïde de l'anus

Global burden of HPV-attributable squamous cell carcinoma of the anus in 2020, according to sex and HIV status: a worldwide analysis

Deshmukh, Ashish A. ; Damgacioglu, Haluk ; Georges, Damien ; Sonawane, Kalyani ; Ferlay, Jacques ; Bray, Freddie ; Clifford, Gary M.

Squamous cell carcinoma of the anus (SCCA) is caused by HPV, and is elevated in persons living with HIV (PLWHIV). We aimed to estimate sex- and HIV-stratified SCCA burden at a country, regional and global level. Using anal cancer incidence estimates from 185 countries available through GLOBOCAN 2020, and region/country-specific proportions of SCCA versus non-SCCA from the Cancer Incidence in Five Continents (CI5) Volume XI database, we estimated country- and sex-specific SCCA incidence. [...]

A partir d'une revue de la littérature (48 articles), cette méta-analyse évalue l'association entre une infection par le virus de l'hépatite B ou C et le risque de cancer des voies biliaires (69 723 cas et 4 047 574 témoins au total)

Hepatitis B and C virus infections and the risk of biliary tract cancers: a meta-analysis of observational studies

Wang, Yizhou ; Yuan, Ye ; Gu, Dongqing

Background : Both hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are important risk factors for hepatocellular carcinoma. However, their effect on other hepatobiliary cancers, such as biliary tract cancers (BTCs), is not well established. We aimed to investigate associations between HBV or HCV infection and BTCs risk by conducting a systematic review and meta-analysis. Methods : We searched PubMed to identify all relevant articles published before June 9, 2021. Meta-analysis was [...]

Menée en Allemagne, en Autriche, en Suisse, en Italie et au Royaume-Uni auprès de 1 866 témoins et 1 214 patients atteints d'un carcinome hépatocellulaire, puis validée auprès de 1 520 personnes consommant de l'alcool avec excès, cette étude d'association sur le génome entier identifie un nouveau locus de susceptibilité à la maladie sur le gène TERT chez des patients atteints d'une cirrhose liée à l'alcool

Genetic variation in TERT modifies the risk of hepatocellular carcinoma in alcohol-related cirrhosis: results from a genome-wide case-control study

Buch, Stephan ; Innes, Hamish ; Lutz, Philipp Ludwig ; Nischalke, Hans Dieter ; Marquardt, Jens U ; Fischer, Janett ; Weiss, Karl Heinz ; Rosendahl, Jonas ; Marot, Astrid ; Krawczyk, Marcin ; Casper, Markus ; Lammert, Frank ; Eyer, Florian ; Vogel, Arndt ; Marhenke, Silke ; von Felden, Johann ; Sharma, Rohini ; Atkinson, Stephen Rahul ; McQuillin, Andrew ; Nattermann, Jacob ; Schafmayer, Clemens ; Franke, Andre ; Strassburg, Christian ; Rietschel, Marcella ; Altmann, Heidi ; Sulk, Stefan ; Thangapandi, Veera Raghavan ; Brosch, Mario ; Lackner, Carolin ; Stauber, Rudolf E ; Canbay, Ali ; Link, Alexander ; Reiberger, Thomas ; Mandorfer, Mattias ; Semmler, Georg ; Scheiner, Bernhard ; Datz, Christian ; Romeo, Stefano ; Ginanni Corradini, Stefano ; Irving, William Lucien ; Morling, Joanne R ; Guha, Indra Neil ; Barnes, Eleanor ; Ansari, M Azim ; Quistrebert, Jocelyn ; Valenti, Luca ; Müller, Sascha A ; Morgan, Marsha Yvonne ; Dufour, Jean-François ; Trebicka, Jonel ; Berg, Thomas ; Deltenre, Pierre ; Mueller, Sebastian ; Hampe, Jochen ; Stickel, Felix

Objective: Hepatocellular carcinoma (HCC) often develops in patients with alcohol-related cirrhosis at an annual risk of up to 2.5%. Some host genetic risk factors have been identified but do not account for the majority of the variance in occurrence. This study aimed to identify novel susceptibility loci for the development of HCC in people with alcohol related cirrhosis. Design: Patients with alcohol-related cirrhosis and HCC (cases: n=1214) and controls without HCC (n=1866), recruited from [...]

Menée à partir des données de registres américains des cancers portant sur 21 141 individus issus de 4 433 familles, cette étude évalue le risque de cancer du pancréas chez des membres de familles ayant des antécédents de cancer du pancréas (167 cas)

Risk of Pancreatic Cancer in the Long-Term Prospective Follow-Up of Familial Pancreatic Cancer Kindreds

Porter, Nancy ; Laheru, Daniel ; Lau, Bryan ; He, Jin ; Zheng, Lei ; Narang, Amol ; Roberts, Nicholas J ; Canto, Marcia I ; Lennon, Anne Marie ; Goggins, Michael G ; Hruban, Ralph H ; Klein, Alison P

Background : A family history of pancreatic cancer is associated with increased pancreatic cancer risk. However, risk estimates for individuals in kindreds with an aggregation of pancreatic cancer (>1 relative) are imprecise due to small samples sizes or potentially impacted by biases inherent in retrospective data. Objective : Determine the age-specific pancreatic cancer risk as a function of family history using prospective data. Methods : We compared pancreatic cancer incidence (n = 167) in [...]

Menée au Japon à l'aide d'une méthode de randomisation mendélienne et de données portant, entre autres, sur 38 042 témoins et 7 936 patients atteints d'un cancer colorectal, cette étude analyse l'association entre les taux sanguins des lipides (cholestérol total, cholestérol des lipoprotéines de haute densité, triglycérides et cholestérol des lipoprotéines de basse densité) et le risque de développer la maladie

Blood lipids and the risk of colorectal cancer: Mendelian randomization analyses in the Japanese Consortium of Genetic Epidemiology studies

Iwagami, Masao ; Goto, Atsushi ; Katagiri, Ryoko ; Sutoh, Yoichi ; Koyanagi, Yuriko N. ; Nakatochi, Masahiro ; Nakano, Shiori ; Hanyuda, Akiko ; Narita, Akira ; Shimizu, Atsushi ; Tanno, Kozo ; Hozawa, Atsushi ; Kinoshita, Kengo ; Oze, Isao ; Ito, Hidemi ; Yamaji, Taiki ; Sawada, Norie ; Nakamura, Yohko ; Nakamura, Sho ; Kuriki, Kiyonori ; Suzuki, Sadao ; Hishida, Asahi ; Kasugai, Yumiko ; Imoto, Issei ; Suzuki, Midori ; Momozawa, Yukihide ; Takeuchi, Kenji ; Yamamoto, Masayuki ; Sasaki, Makoto ; Matsuo, Keitaro ; Tsugane, Shoichiro ; Wakai, Kenji ; Iwasaki, Motoki

The associations between blood lipids, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglycerides, and low-density lipoprotein cholesterol (LDL-C), and colorectal cancer risk are controversial. We evaluated potential causal relationships between blood lipids and colorectal cancer risk. Using the baseline data from the Japanese Consortium of Genetic Epidemiology studies, we estimated the single-nucleotide polymorphism (SNP)–exposure associations (n=34,546 for [...]

A partir d'une revue systématique de la littérature publiée jusqu'en juillet 2022 (10 études incluant un total de 2 205 patients), cette méta-analyse évalue l'association entre le niveau sérique de sélénium et le risque de cancer de la thyroïde

Relationship between Serum Levels of Selenium and Thyroid Cancer: A Systematic Review and Meta-Analysis

Hao, Runhua ; Yu, Ping ; Gui, Lanlan ; Wang, Niannian ; Pan, Da ; Wang, Shaokang

Thyroid cancer is one of the most malignant tumors and a serious threat to human health. Selenium (Se) is an essential trace element that is critical for thyroid function. Since the relationship between Se and thyroid cancer remains unclear, a meta-analysis was performed to clarify the relationship. A total of five databases (PubMed, Web of Science, Scopus, Embase and Cochrane library) were searched for case-control studies and cohort studies on serum levels of Se and thyroid cancer published [...]

Ce rapport américain passe en revue les facteurs environnementaux associés au risque de cancer

Cancer hazard evaluations for contemporary needs: Highlights from new NTP evaluations and methodological advancements

Lunn, Ruth M ; Mehta, Suril S ; Jahnke, Gloria D ; Wang, Amy ; Wolfe, Mary S ; Berridge, Brian R

The National Toxicology Program (NTP) strives to raise awareness of cancer hazards in our environment. Identifying cancer hazards is key to primary prevention, informing public health decision-making, and decreasing the global cancer burden. In December 2021, the U.S. congressionally mandated 15th Report on Carcinogens (RoC) was released, adding eight new substances to the cumulative report. Chronic infection with Helicobacter pylori is listed as ‘known to be a human carcinogen’. Antimony [...]