Menée à partir des données de 38 études portant sur 11 519 femmes ménopausées atteintes d'un cancer colorectal et 16 967 témoins, cette étude sur le génome entier analyse l'effet de certains polymorphismes à simple nucléotide sur l'association entre un traitement hormonal substitutif et le risque de développer la maladie

Genome-Wide Interaction Analysis of Genetic Variants with Menopausal Hormone Therapy for Colorectal Cancer Risk

Tian, Yu ; Kim, Andre E ; Bien, Stephanie A ; Lin, Yi ; Qu, Conghui ; Harrison, Tabitha ; Carreras-Torres, Robert ; Díez-Obrero, Virginia ; Dimou, Niki ; Drew, David A ; Hidaka, Akihisa ; Huyghe, Jeroen R ; Jordahl, Kristina M ; Morrison, John ; Murphy, Neil ; Obón-Santacana, Mireia ; Ulrich, Cornelia M ; Ose, Jennifer ; Peoples, Anita R ; Ruiz-Narvaez, Edward A ; Shcherbina, Anna ; Stern, Mariana ; Su, Yu-Ru ; van Duijnhoven, Franzel J B ; Arndt, Volker ; Baurley, James ; Berndt, Sonja I ; Bishop, D Timothy ; Brenner, Hermann ; Buchanan, Daniel D ; Chan, Andrew T ; Figueiredo, Jane C ; Gallinger, steven ; Gruber, Stephen B ; Harlid, Sophia ; Hoffmeister, Michael ; Jenkins, Mark A ; Joshi, Amit D ; Keku, Temitope O ; Larsson, Susanna C ; Le Marchand, Loic ; Li, Li ; Giles, Graham G ; Milne, Roger L ; Nan, Hongmei ; Nassir, Rami ; Ogino, Shuji ; Budiarto, Arif ; Platz, Elizabeth A ; Potter, John D ; Prentice, Ross L ; Rennert, Gad ; Sakoda, Lori C ; Schoen, Robert E ; Slattery, Martha L ; Thibodeau, Stephen N ; Van Guelpen, Bethany ; Visvanathan, Kala ; White, Emily ; Wolk, Alicja ; Woods, Michael O ; Wu, Anna H ; Campbell, Peter T ; Casey, Graham ; Conti, David V ; Gunter, Marc J ; Kundaje, Anshul ; Lewinger, Juan Pablo ; Moreno, Víctor ; Newcomb, Polly A ; Pardamean, Bens ; Thomas, Duncan C ; Tsilidis, Konstantinos K ; Peters, Ulrike ; Gauderman, W James ; Hsu, Li ; Chang-Claude, Jenny

The use of menopausal hormone therapy (MHT) may interact with genetic variants to influence colorectal cancer (CRC) risk.We conducted a genome-wide gene-environment interaction between single nucleotide polymorphisms and the use of any MHT, estrogen-only, and combined estrogen-progestogen therapy with CRC risk, among 28,486 postmenopausal women (11,519 cases and 16,967 controls) from 38 studies, using logistic regression, two-step method, and 2- or 3-degree-of-freedom (d.f.) joint test. A [...]

Cette étude passe en revue les données concernant l'association entre une infection par l'agent de la tuberculose et le risque de cancer du poumon

The relationship between previous pulmonary tuberculosis and risk of lung cancer in the future

Qin, Yongwei ; Chen, Yujie ; Chen, Jinliang ; Xu, Kuang ; Xu, Feifan ; Shi, Jiahai

Various investigations have expanded the views that tuberculosis is an important risk factor for lung cancer occurrence. Lung cancer originates from chronic inflammation and infection. It is becoming clearer that Mycobacterium tuberculosis (M.tb) in tuberculosis patients meticulously schemes multiple mechanisms to induce tumor formation and is indispensable to participate in the occurrence of lung cancer. In addition, some additional factors such as age, sex and smoking, accelerate the [...]

Menée en Suède auprès de 430 472 hommes, cette étude analyse l'association entre la pression artérielle et le risque de cancer de la prostate (32 720 cas) ainsi que la mortalité spécifique (6 718 décès)

Association of blood pressure with prostate cancer risk by disease severity, and prostate cancer death: a pooled cohort study

Jochems, Sylvia H.J. ; Häggström, Christel ; Stattin, Pär ; Järvholm, Bengt ; Stocks, Tanja

Background: The association of blood pressure (BP) with prostate cancer risk after accounting for asymptomatic prostate-specific antigen (PSA) testing, and with prostate cancer death, is unclear. Methods: We investigated BP, measured at a mean age of 38 years amongst 430,472 men from five Swedish cohorts, in association with incident prostate cancer (n=32,720) and prostate cancer death (n=6718). Hazard ratios (HRs) were calculated from multivariable Cox regression models. Results: Increasing [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données de la "UK Biobank" portant sur 253 813 femmes (durée médiane de suivi : 6,7 ans), cette étude analyse l'association entre la densité minérale osseuse et le risque de cancer du sein

Bone mineral density and risk of breast cancer: A cohort study and Mendelian randomization analysis

Zhang, Yanyu ; Mao, Xinhe ; Yu, Xingxing ; Huang, Xiaoxi ; He, Wei ; Yang, Haomin

BACKGROUND: Estrogen is involved in both bone metabolism and breast cancer proliferation. However, evidence about the risk of breast cancer according to women's bone mineral density (BMD) is scarce, and little is known about their causal associations. METHODS: Women participating in the UK Biobank cohort were used to investigate the association between BMD and the risk of breast cancer using Cox regression models. Instrumental variants associated with estimated BMD (eBMD) were extracted from [...]