Mené sur 56 patients atteints d'un cancer du pancréas (durée de suivi : 12 mois), cet essai randomisé évalue l'intérêt, du point de vue de la qualité de vie, d'une intervention de physiothérapie intensive après une résection

Effects of intensive physiotherapy on Quality of Life (QoL) after pancreatic cancer resection: a randomized controlled trial

Weyhe, Dirk ; Obonyo, Dennis ; Uslar, Verena ; Tabriz, Navid

Background : Patients have significantly lower QoL scores after pancreatic resection due to cancer in the physical and psychological domains compared to healthy controls or other cancer patients. Intensified physiotherapy or physical training can increase QoL by reducing fatigue levels and improving physical functioning. However, data on the long-term effects of intensive or supervised physiotherapy is lacking. The aim of this exploratory study is the assessment of QoL in the intervention [...]

Menée au Japon auprès de 525 patientes atteintes d'un cancer de l'ovaire, du col de l'utérus ou de l'endomètre, cette étude transversale analyse la fréquence et la sévérité des symptômes climatériques, en fonction du type de cancer et du temps écoulé depuis le traitement chirurgical

Climacteric symptoms in postoperative patients among endometrial cancer, cervical cancer, and ovarian cancer: a cross-sectional study

Horiba, Yuko ; Yoshino, Tetsuhiro ; Yokota, Megumi ; Iwata, Takashi ; Watanabe, Kenji ; Mimura, Masaru ; Aoki, Daisuke

Purpose : To date, no studies have assessed climacteric symptoms after hystero-adnexectomy for endometrial, cervical, or ovarian cancer. Thus, this study aimed to compare climacteric symptoms among patients who underwent surgery for these three cancer types. Methods : In this cross-sectional study, we interviewed patients who were registered at a menopausal outpatient clinic between January 1999 and July 2016 after undergoing total hysterectomy, intrapelvic only or intrapelvic plus para-aortic [...]

Menée aux Etats-Unis dans un contexte de vie réelle, cette étude analyse les nouvelles hospitalisations et les visites dans les services d'urgences hospitalières dans les 12 mois suivant l'administration d'une immunothérapie à base de lymphocytes CAR-T chez des patients atteints d'un cancer et bénéficiant d'une assurance médicale privée

Assessment of Hospitalizations and Emergency Department Visits After Chimeric Antigen Receptor T-Cell Therapy Among Commercially Insured Patients

Kenzik, Kelly M. ; Johnson, P. Connor ; Bhatia, Ravi ; Bhatia, Smita

Chimeric antigen receptor T (CAR) T-cell therapy has transformed the treatment of relapsed and refractory hematologic malignancies. However, this treatment carries notable toxicity risks, including cytokine release syndrome, neurologic complications, and infections, and potentially greater intensive health care use. Real-world data on health care use after hospital discharge from CAR T-cell infusion are lacking but are needed for risk-stratified disease management strategies. We examined [...]

Cet article analyse la nature du syndrome de cachexie lié au cancer et les implications thérapeutiques

Cancer cachexia: a nutritional or a systemic inflammatory syndrome?

McGovern, Josh ; Dolan, Ross D. ; Skipworth, Richard J. ; Laird, Barry J. ; McMillan, Donald C.

Cancer cachexia has long been perceived as a nutritional syndrome. However, nutritional interventions have continued to be ineffective. With the recent recognition of the importance of systemic inflammation in the definition of this syndrome and treatment, has the time come to consider whether this syndrome is primarily a manifestation of systemic inflammation with the consequent implications for future treatment?

A partir d'une revue de la littérature publiée jusqu'en mars 2021, cette étude identifie les facteurs associés au risque de thromboembolie veineuse chez les patientes atteintes d'un cancer du sein

Risk factors associated with venous thromboembolism in breast cancer: a narrative review

Razouki, Zayd Adnan ; Ali, Nadeen T. ; Nguyen, Vinh Q. ; Escalante, Carmen P.

Purpose : To date, there is no universally acceptable risk assessment tool in clinical practice that accurately estimates the risk of venous thromboembolism (VTE) in patients with breast cancer, despite the large number of published studies. Thus, the aim of this narrative review was to summarize the most relevant risk factors for VTE in these patients. Methods : We searched Ovid Embase and Ovid MEDLINE, from inception to March 26, 2021, to identify all articles that focused on breast cancer [...]

Menée aux Etats-Unis à partir de données portant sur des patients décédés d'un cancer du cerveau entre 2003 et 2016, cette étude analyse les disparités concernant le lieu de décès

Disparities in place of death for patients with primary brain tumors and brain metastases in the USA

Shenker, Rachel F. ; Elizabeth McLaughlin, Mary ; Chino, Fumiko ; Chino, Junzo

Purpose : Patients with primary or metastatic brain tumors often require intensive end-of-life care, for which place of death may serve as a quality metric. Death at home or hospice is considered a more “ideal” location. Comprehensive information on place of death of people with brain tumors is lacking. Methods : Using CDC Wonder Database data, those who died in the USA from a solid cancer from 2003 to 2016 were included and place of death for those with primary brain, brain metastases, and [...]

Menée à partir des données des registres américains des cancers portant sur 208 587 patientes atteintes d'un cancer de l'endomètre diagnostiqué entre 2000 et 2017, cette étude de cohorte analyse les disparités ethniques dans la mortalité spécifique, en fonction du stade de la maladie et du sous-type histologique, et en tenant compte d'antécédents d'hystérectomie

Racial and Ethnic Differences in Hysterectomy-Corrected Uterine Corpus Cancer Mortality by Stage and Histologic Subtype

Clarke, Megan A. ; Devesa, Susan S. ; Hammer, Anne ; Wentzensen, Nicolas

Importance : Uterine cancer incidence has been increasing, particularly rates of aggressive, nonendometrioid subtypes, which are disproportionately higher among non-Hispanic Black women. The association of subtype-specific trends with uterine cancer mortality and with the role of tumor subtype and stage at diagnosis with racial disparities in uterine cancer deaths at the population-based level are not known. Objective : To estimate histologic subtype- and stage-specific uterine cancer mortality [...]

Menée en Slovaquie auprès de 696 patients ayant survécu à un cancer, cette étude analyse l'association entre la croissance post-traumatique, la capacité de résilience, des stratégies pour faire face aux épreuves et le sentiment de statisfaction à l'égard de la vie

Relationships between satisfaction with life, posttraumatic growth, coping strategies, and resilience in cancer survivors: A network analysis approach

Adamkovič, Matúš ; Fedáková, Denisa ; Kentoš, Michal ; Bozogáňová, Miroslava ; Havrillová, Dominika ; Baník, Gabriel ; Dědová, Mária ; Piterová, Ivana

Objective : Cancer survivors’ satisfaction with life should be seen through the psychological factors related to a person’s capabilities to face and handle the situation. This study aimed to (1) examine the relationships of satisfaction with life, posttraumatic growth, resilience and coping strategies in a global network model, (2) find the bridge indicators between satisfaction with life and the other constructs, and (3) test for the invariance of the network structures across several [...]

Menée dans un contexte japonais, cette étude analyse le rapport coût-efficacité d'une prophylaxie par pegfilgrastim chez des patients atteints d'un cancer du poumon non à petites cellules traité par ramucirumab et docétaxel

Cost-effectiveness analysis of pegfilgrastim in patients with non-small cell lung cancer receiving ramucirumab plus docetaxel in Japan

Kondo, Yu ; Tachi, Tomoya ; Sakakibara, Takayoshi ; Kato, Jun ; Kato, Aki ; Mizuno, Takahito ; Miyake, Yoshio ; Teramachi, Hitomi

Purpose : The dose-limiting factor of ramucirumab plus docetaxel (RAM + DTX) in patients with non-small cell lung cancer (NSCLC) is febrile neutropenia (FN), which has a high incidence in Asians. This study aimed to evaluate the cost-effectiveness of pegfilgrastim (Peg-G) in patients with NSCLC receiving RAM + DTX in Japan. Methods : We simulated model patients treated with RAM + DTX in Japan and developed a decision-analytical model for patients receiving Peg-G prophylaxis or no primary [...]

Menée en Allemagne à partir de données portant sur 363 patientes ayant survécu à un cancer du sein, cette étude prospective multicentrique analyse l'évolution de leurs difficultés financières (avant, pendant et 5 ans après les traitements) en fonction d'un passé migratoire

Financial difficulties in breast cancer survivors with and without migration background in Germany—results from the prospective multicentre cohort study BRENDA II

Riccetti, N. ; Felberbaum, R. ; Flock, F. ; Kühn, T. ; Leinert, E. ; Schwentner, L. ; Singer, S. ; Taylor, K. ; Wöckel, A. ; Janni, W.

Purpose : We aimed to explore the trajectory of financial difficulties among breast cancer survivors in the German health system and its association with migration background. Methods : In a multicentre prospective study, breast cancer survivors were approached four times (before surgery, before and after adjuvant therapy, five years after surgery) and asked about their migration history and financial difficulties. Migrants were defined as born/resided outside Germany or having [...]

Cet article présente les recommandations de l'"International Late Effects of Childhood Cancer Guideline Harmonization Group" concernant le suivi des résultats en matière d'éducation ou d'emploi chez les jeunes adultes, les adolescents ou enfants ayant survécu à un cancer

Recommendations for the surveillance of education and employment outcomes in survivors of childhood, adolescent, and young adult cancer: A report from the International Late Effects of Childhood Cancer Guideline Harmonization Group

Devine, Katie A. ; Christen, Salome ; Mulder, Renée L. ; Brown, Morven C. ; Ingerski, Lisa M. ; Mader, Luzius ; Potter, Emma J. ; Sleurs, Charlotte ; Viola, Adrienne S. ; Waern, Susanna ; Constine, Louis S. ; Hudson, Melissa M. ; Kremer, Leontien C. M. ; Skinner, Roderick ; Michel, Gisela ; Gilleland Marchak, Jordan ; Schulte, Fiona S. M. ; for the International Guidelines Harmonization Group Psychological Late Effects, Group

Educational achievement and employment outcomes are critical indicators of quality of life in survivors of childhood, adolescent, and young adult (CAYA) cancer. This review is aimed at providing an evidence-based clinical practice guideline (CPG) with internationally harmonized recommendations for the surveillance of education and employment outcomes in survivors of CAYA cancer diagnosed before the age of 30 years. The CPG was developed by a multidisciplinary panel under the umbrella of the [...]