Menée à l'aide de données danoises portant sur 28 720 femmes âgées de 50 à 65 ans (durée médiane de suivi : 16,5 ans), cette étude analyse l'association entre la trajectoire de consommation d'alcool à l'âge adulte et le risque de cancer du sein (1 591 cas) en fonction du statut ménopausique

Alcohol consumption trajectories and risk of breast cancer among postmenopausal women: a Danish cohort study

Antoniussen, Christian S. ; Proust-Lima, Cecile ; Ibsen, Daniel B. ; Olsen, Anja ; Overvad, Kim ; Tjønneland, Anne ; Ferrari, Pietro ; Dahm, Christina C.

Alcohol consumption is a risk factor for breast cancer (BC), yet little is known about longitudinal alcohol consumption patterns and risk of BC. This study aimed to investigate whether trajectory profiles of alcohol consumption across adulthood were associated with risk of first primary malignant BC in postmenopausal women. At baseline, 28,720 pre-and postmenopausal women aged 50–65 years from the Danish Diet, Cancer and Health Cohort reported their average alcohol intake over the past 12 [...]

A partir d'une revue systématique de la littérature publiée entre 1983 et 2023 (11 études), cette méta-analyse évalue l'association entre la proximité résidentielle d'une centrale nucléaire et le risque de cancer de la thyroïde

The risk of thyroid cancer in relation to residential proximity to nuclear power plants: a systematic review and meta-analysis

Cottagiri, Susanna Abraham ; King, Will ; Rodriguez-Villamizar, Laura ; Villeneuve, Paul J.

Introduction: Ionizing radiation is a human carcinogen, and there is a public concern but limited evidence that it increases the incidence of cancer among those who live near nuclear power plants (NPPs). Previous analyses of thyroid cancer in these populations have been inconsistent, and the last synthesis was published nearly a decade ago. To address these gaps, we undertook a systematic review and meta-analysis. Methods: A search strategy was developed and applied to PubMed, Scopus, and Web [...]

Menée à partir de données portant sur 24 486 femmes présentant un risque familial modéré ou fort de cancer de sein et/ou du côlon-rectum, cette étude analyse les associations entre l'utilisation d'un traitement hormonal substitutif de la ménopause et le risque de développer ces maladies (1 648 cas)

Menopausal hormone therapy: assessing associations with breast and colorectal cancers by familial risk

MacInnis, Robert J ; Jenkins, Mark A ; Milne, Roger L ; John, Esther M ; Daly, Mary B ; Andrulis, Irene L ; Colonna, Sarah V ; Phillips, , Kelly A ; kConFab Investigators ; Le Marchand, Loic ; Newcomb, Polly A ; Phipps, Amanda ; Schmit, Stephanie ; Macrae, Finlay ; Buchanan, Daniel ; Gallinger, steven ; Pai, Rish K ; Samadder, Niloy J ; Giles, Graham G ; Southey, Melissa C ; Hopper, John L ; Terry, Mary Beth

Menopausal hormone therapy (MHT) users are at increased breast cancer (BC) risk and decreased colorectal cancer (CRC) risk compared with never users, but these opposing associations might differ by familial risk of BC and CRC. We harmonized data from three cohorts and generated separate BC and CRC familial risk scores (FRS) based on cancer family history. We defined moderate/strong family history as FRS ≥ 0.4, where 0.4 was equivalent to a 50-year-old woman with one parent diagnosed with either [...]

Menée auprès de 8 295 femmes porteuses d'une mutation BRCA, cette étude analyse le risque de cancer du pancréas après l'âge de 40 ans (34 cas) en fonction du type de mutation

The incidence of pancreatic cancer in women with a BRCA1 or BRCA2 mutation

Katona, Bryson W. ; Lubinski, Jan ; Pal, Tuya ; Huzarski, Tomasz ; Foulkes, William D. ; Moller, Pal ; Eisen, Andrea ; Randall Armel, Susan ; Neuhausen, Susan L. ; Raj, Rebecca ; Aeilts, Amber ; Singer, Christian F. ; Bordeleau, Louise ; Karlan, Beth ; Olopade, Olufunmilayo ; Tung, Nadine ; Zakalik, Dana ; Kotsopoulos, Joanne ; Fruscio, Robert ; Eng, Charis ; Sun, Ping ; Narod, Steven A. ; the Hereditary Breast Cancer Clinical Study Group

Background: The lifetime risk of pancreatic cancer in women with a germline mutation in BRCA1 and BRCA2 is not well established. In an international prospective cohort of female carriers of BRCA1 and BRCA2 mutations, the cumulative incidence of pancreatic cancer from age 40 until 80 years was estimated. Methods: A total of 8295 women with a BRCA1 or BRCA2 mutation were followed for new cases of pancreatic cancer. Subjects were followed from the date of baseline questionnaire or age 40 years [...]

Menée à l'aide de données de séquençage du génome entier de 3 020 témoins et 2 984 patients atteints de cancer du poumon non à petites cellules, cette étude analyse l'association entre 1 818 variants rares des régions promotrices de 172 gènes de réparation des mésappariements de l'ADN et le risque de développer la maladie

Systematic identification of pathogenic variants of non-small cell lung cancer in the promoters of DNA-damage repair genes

An, Mingxing ; Chen, Congcong ; Xiang, Jun ; Li, Yang ; Qiu, Pinyu ; Tang, Yiru ; Liu, Xinyue ; Gu, Yayun ; Qin, Na ; He, Yuanlin ; Zhu, Meng ; Jiang, Yue ; Dai, Juncheng ; Jin, Guangfu ; Ma, Hongxia ; Wang, Cheng ; Hu, Zhibin ; Shen, Hongbing

Background: Deficiency in DNA-damage repair (DDR) genes, often due to disruptive coding variants, is linked to higher cancer risk. Our previous study has revealed the association between rare loss-of-function variants in DDR genes and the risk of lung cancer. However, it is still challenging to study the predisposing role of rare regulatory variants of these genes. Methods: Based on whole-genome sequencing data from 2984 patients with non-small cell lung cancer (NSCLC) and 3020 controls, we [...]

Menée à partir de données de la "UK Biobank" portant sur 74 763 femmes présentant un indice de masse corporelle normal, cette méta-analyse évalue l'association entre le pourcentage de graisse corporelle et le risque de cancer du sein en fonction du statut ménopausique

Normal weight obesity, circulating biomarkers and risk of breast cancer: a prospective cohort study and meta-analysis

Wang, Wenjie ; Wang, Xiaoyan ; Jiang, Ying ; Guo, Yingying ; Fu, Peifen ; He, Wei ; Fu, Xiaohua

Background: Individuals with normal weight obesity (NWO) often escape the attention of healthcare providers who may assume that a normal body mass index (BMI) correlates with low health risks. However, it remains unknown whether NWO increases the risk of breast cancer. Methods: This study included 22,257 and 52,506 pre- and postmenopausal females with normal BMI in the UK Biobank. NWO was defined as participants with a normal BMI (18.5–24.9 kg/m2) and an excess percent body fat (PBF > 33.3%). [...]