Menée à partir de données chinoises portant sur 8 019 témoins et 2 969 patients atteints d'un cancer de l'oesophage, cette étude analyse l'association entre une exposition à la fumée de tabac ambiante et le risque de développer la maladie, en fonction du sexe et du statut tabagique

Environmental tobacco smoking (ETS) and esophageal cancer: A population-based case-control study in Jiangsu Province, China

Jin, Zi-Yi ; Liu, Kuangyu ; Wallar, Gina ; Zhou, Jin-Yi ; Mu, Li-Na ; Liu, Xing ; Li, Li-Ming ; He, Na ; Wu, Ming ; Zhao, Jin-Kou ; Zhang, Zuo-Feng

Esophageal cancer continues to pose a significant public health issue in areas with increased incidence rates such as China. Although involuntary smoking was defined as a group 1 carcinogen for lung cancer, few studies have explored the impact of environmental tobacco smoking (ETS) on esophageal cancer. In this paper, we examined the association between ETS and esophageal cancer in high-risk groups in Jiangsu Province, China. Epidemiologic data were collected for 2969 newly diagnosed cases and [...]

Menée à l'aide de données finlandaises portant sur 240 724 personnes ayant vécu sur la période 1971-2016 dans des bâtiments équipés de postes de transformation intérieurs, cette étude analyse l'association entre une exposition résidentielle aux champs magnétiques extrêmement basses fréquences et le risque de cancer chez l'adulte (15 901 cas)

Magnetic fields from indoor transformer stations and risk of cancer in adults: a cohort study

Juutilainen, Jukka ; Khan, Muhammad Waseem ; Naarala, Jonne ; Roivainen, Päivi

Objectives: Studies assessing the association of adult cancers with extremely low frequency (ELF) magnetic fields (MF) have provided inconclusive results, probably affected by limitations such as low exposure levels, confounding and various forms of bias. This study investigated the association between residential ELF MF exposure and adult cancer using a design that avoids the main limitations of previous studies. Methods: Persons who have lived in buildings with indoor transformer stations [...]

Menée à partir de données d'un registre danois sur l'infertilité portant sur 146 110 femmes (âge : 20-45 ans ; durée médiane de suivi : 10,3 ans), cette étude analyse l'association entre un traitement pour la fertilité et le risque de cancer de l'ovaire (114 cas)

Fertility treatment and risk of ovarian cancer in a large nationwide cohort of infertile Danish women

Jensen, Allan ; Guleria, Sonia ; Albieri, Vanna ; Nøhr, Bugge ; Frederiksen, Kirsten ; Kjær, Susanne K.

Whether fertility treatment increases the risk of ovarian cancer has been a concern for many decades, but previous research has yielded conflicting findings. We therefore investigated this association within a large population-based cohort study of infertile women aged 20–45 years and living in Denmark between 1995 and 2017, as identified in the Danish Infertility Cohort (n = 146,110). The study cohort was linked to nationwide registers to obtain information on fertility drug use, cancer [...]

A partir d'une revue systématique de la littérature, cette étude analyse l'association entre les oestrogènes et le risque de cancer du sein

Estrogens and breast cancer

Kim, J. ; Munster, P. N.

Estrogens have been associated with an increase in breast cancer risk. Yet emerging clinical and experimental evidence points to progestogens (endogenous progesterone or synthetic progesterone [progestin]) as the primary hormonal driver underlying seemingly estrogen-associated breast cancer risk. Estrogens may contribute to breast cancer risk indirectly by induction of the progesterone receptor (PR) and thus amplifying progesterone signaling. Large studies of hormonal contraceptives suggest [...]

Menée à partir de données 1992-2020 des registres américains des cancers portant sur 550 007 femmes ayant survécu à un cancer du sein (durée moyenne de suivi : 9,7 ans), cette étude analyse l'association entre un traitement par radiothérapie et le risque de cancer primitif du poumon (8 014 cas)

Associations of radiotherapy receipt with lung cancer risk by histological subtype among breast cancer survivors in the United States

Jiang, Chenxi ; Freedman, Rachel A. ; Punglia, Rinaa S. ; Jemal, Ahmedin ; Sung, Hyuna

Radiotherapy for breast cancer has been associated with an increased risk of secondary malignancies, including primary lung cancer. Whether this association varies by histological subtype of lung cancer remains unknown. Based on the data from 12 Surveillance, Epidemiology, and End Results registries, we examined the association between radiotherapy receipt and the risk of subtype-specific subsequent primary lung cancer (SPLC) among female first primary breast cancer cases diagnosed between ages [...]

Menée au Royaume-Uni à partir de données portant sur 5 169 témoins et 2 721 femmes, cette étude analyse l'association entre une infection ou une maladie déclarée chez la mère pendant la grossesse et le risque de cancer chez l'enfant (0-14 ans)

Maternal illnesses during pregnancy and the risk of childhood cancer: A medical-record based analysis (UKCCS)

Bonaventure, Audrey ; Simpson, Jill ; Kane, Eleanor ; Roman, Eve

Often relying on mother's recollections of past events, the possible relationship between maternal illness in pregnancy and risk of malignancy in their offspring has long been a focus of research. Free from recall bias, this study of childhood cancer (0–14 years) examined these associations using data abstracted from mothers' primary-care (1623 cases, 2521 controls) and obstetric (2721 cases, 5169 controls) records. Maternal infections and other illnesses in pregnancy were examined for any [...]

Menée à partir de données du consortium "ABACus 2" portant sur 312 132 hommes et 408 078 femmes (durée médiane de suivi : 9,9-10,8 ans), cette méta-analyse évalue l'association entre le degré de l'obésité à l'âge adulte, sa durée et le risque de cancer (49 468 cas)

Excess weight by degree and duration and cancer risk (ABACus2 consortium): a cohort study and individual participant data meta-analysis

Hawwash, Nadin K. ; Sperrin, Matthew ; Martin, Glen P. ; Sinha, Rashmi ; Matthews, Charles E. ; Ricceri, Fulvio ; Tjønneland, Anne ; Heath, Alicia K. ; Neuhouser, Marian L. ; Joshu, Corinne E. ; Platz, Elizabeth A. ; Freisling, Heinz ; Gunter, Marc J. ; Renehan, Andrew G.

Background: Elevated body mass index (BMI) ≥25 kg/m2 is a major preventable cause of cancer. A single BMI measure does not capture the degree and duration of exposure to excess BMI. We investigate associations between adulthood overweight-years, incorporating exposure time to BMI ≥25 kg/m2, and cancer incidence, and compare this with single BMI. Methods: In this cohort study and individual participant data meta-analysis, we obtained data from the ABACus 2 Consortium, consisting of four US [...]

Menée auprès de 20 593 femmes ménopausées (durée médiane de suivi : 21 ans), cette étude analyse l'association entre le phénotype métabolique, la présence d'un dysfonctionnement métabolique, l'indice de masse corporelle et le risque de cancer lié à l'obésité

Metabolic phenotype and risk of obesity-related cancers in the Women's Health Initiative

Karra, Prasoona ; Hardikar, Sheetal ; Winn, Maci ; Anderson, Garnet L. ; Haaland, Benjamin ; Shadyab, Aladdin H. ; Neuhouser, Marian L. ; Seguin-Fowler, Rebecca A. ; Thomson, Cynthia A. ; Coday, Mace ; Wactawski-Wende, Jean ; Stefanick, Marcia L. ; Zhang, Xiaochen ; Cheng, Ting-Yuan David. ; Karanth, Shama ; Sun, Yangbo ; Saquib, Nazmus ; Pichardo, Margaret S. ; Jung, Su Yon ; Tabung, Fred K. ; Summers, Scott A. ; Holland, William L. ; Jalili, Thunder ; Gunter, Marc J. ; Playdon, Mary C.

Body mass index (BMI) may misclassify obesity-related cancer (ORC) risk, as metabolic dysfunction can occur across BMI levels. We hypothesized that metabolic dysfunction at any BMI increases ORC risk compared to normal BMI without metabolic dysfunction. Postmenopausal women (n=20,593) in the Women’s Health Initiative with baseline metabolic dysfunction biomarkers (blood pressure, fasting triglycerides, high-density lipoprotein-cholesterol, fasting glucose, Homeostatic Model Assessment for [...]

A partir d'une revue systématique de la littérature publiée jusqu'en juillet 2024 (15 études, 62 121 personnes), cette méta-analyse évalue la prévalence globale du cancer chez les personnes atteintes du syndrome de Down

The prevalence of solid tumors and hematologic malignancies among patients with Down Syndrome: A systematic review and meta-analysis

Rozalem, Nayara Moretti ; Nardelli, Ana Beatriz da Silva ; Guimarães, GuimaraesLetícia Vieira ; de Paula Bezerra, Ian ; Taumaturgo, João Arthur Cerqueira ; Alves, Natália Gabrielli Silva ; Kelly, Francinny Alves ; Moraes, Francisco Cezar Aquino de

Background: Patients with Down syndrome (DS) have a unique genetic and clinical profile that may increase the risk of cancer. Methods: A literature search on PubMed, Scopus, Web of Science, and the Cochrane databases was conducted, focusing on studies to investigate the prevalence of solid and hematologic tumors in DS. Results: Fifteen studies were included, encompassing 62,121 individuals with Down syndrome (DS). The overall prevalence of cancer in DS was 2.02% (95% CI: 1.63% to 2.50%). The [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données de séquençage de l'ARN issues du projet "The Cancer Genome Atlas", cette étude analyse l'association entre 190 phénotypes de cellules B et le risque de cancer de l'oesophage

Association of B cells and the risk of Esophageal cancer: a bidirectional two-sample mendelian randomization study

Guo, Jinzhou ; Si, Gao ; Song, Xuejie ; Si, Fuchun

Background and objectives: Currently, research on the role of B cells in esophageal cancer (EC) is limited, and existing studies on their impact are controversial. Therefore, this study was conducted to elucidate the complex causal relationship between B cells and EC, expand the understanding of esophageal cancer immunology. Methods: Bidirectional two-sample Mendelian randomization (MR) was performed to assess the causal relationships between 190 B cell phenotypes and EC. To complement the MR [...]

Menée à partir de données 1992-2016 portant sur 702 525 Suédois (âge : 20-79 ans ; durée de suivi : 15 ans), cette étude analyse le risque de cancer du pancréas après une maladie bénigne de la vésicule biliaire

Pancreatic cancer risk after benign gallbladder disease: A Swedish population-based cohort study

Radkiewicz, Cecilia ; Ludvigsson, Jonas F. ; Sparrelid, Ernesto ; Emilsson, Louise

Aim: The purpose of this nationwide registry-based cohort study was to outline pancreatic cancer risk after benign gallbladder disease (GBD). Anatomically adjacent cancers were investigated to address incidental findings. Methods: We included all Swedes aged 20-79 years with histologically confirmed GBD (cholecystitis and/or cholecystectomy) in 1992-2016 and five matched non-exposed population comparators. Follow-up started one month after GBD and incidence rates (IR) and hazard ratios (HR) [...]

Menée à l'aide de données portant sur 25 000 témoins et 16 184 patientes atteintes d'un carcinome canalaire in situ (CCIS), cette étude analyse la fréquence de variants constitutionnels associés au risque de CCIS dans des gènes prédisposant au cancer du sein (ATM, BARD1, BRCA1, BRCA2, CDH1, CHEK2, PALB2, RAD51C et RAD51D)

Pathogenic variants in cancer susceptibility genes predispose to Ductal Carcinoma In situ of the breast

Huang, Huaizhi ; Couch, Ronan E. ; Karam, Rachid ; Hu, Chunling ; Boddicker, Nicholas ; Polley, Eric C. ; Na, Jie ; Ambrosone, Christine B. ; Yao, Song ; Trentham-Dietz, Amy ; Eliassen, A. Heather ; Penney, Kathryn ; Brantley, Kristen ; Bodelon, Clara ; Teras, Lauren R. ; Hodge, James ; Patel, Alpa ; Haiman, Christopher A. ; John, Esther M. ; Neuhausen, Susan L. ; Martinez, Elena ; Lacey, James V. ; O'Brien, Katie M. ; Sandler, Dale P. ; Weinberg, Clarice R. ; Palmer, Julie R. ; Bertrand, Kimberly A. ; Vachon, Celine M. ; Olson, Janet E. ; Ruddy, Kathryn E. ; Anton-Culver, Hoda ; Ziogas, Argyrios ; Goldgar, David E. ; Nathanson, Katherine L. ; Domchek, Susan M. ; Weitzel, Jeffrey N. ; Kraft, Peter ; Dolinsky, Jill S. ; Pesaran, Tina ; Richardson, Marcy E. ; Yadav, Siddhartha ; Couch, Fergus J.

Purpose: To determine the relationship between germline pathogenic variants (PVs) in cancer predisposition genes and the risk of ductal carcinoma in situ (DCIS). Methods: Germline PV frequencies in breast cancer predisposition genes (ATM, BARD1, BRCA1, BRCA2, CDH1, CHEK2, PALB2, RAD51C, and RAD51D) were compared between DCIS cases and unaffected controls, and between DCIS and infiltrating ductal carcinoma (IDC) cases from a clinical-testing cohort (n=9,887), a population-based cohort (n=3,876) [...]