A partir d'une revue de la littérature, cette étude analyse les interventions nutritionnelles et à base d'activité physique destinées à prendre en charge une malnutrition ou une perte non intentionnelle de muscle ou de poids chez les patients atteints d'un cancer

A rapid review of nutrition and exercise approaches to managing unintentional weight loss, muscle loss, and malnutrition in cancer

Baguley, Brenton J ; Edbrooke, Lara ; Denehy, Linda ; Prado, Carla M ; Kiss, Nicole

This narrative review summarizes the evidence for nutrition, exercise, and multimodal interventions to maintain weight and muscle mass and prevent malnutrition from meta-analysis, systematic reviews, and randomized controlled trials published within the last 5 years, and in comparison to future research priority areas identified by international guidelines.Dietary counseling with oral nutrition support (ONS), escalated to enteral nutrition if weight loss continues, is the gold standard [...]

A partir d'une revue de la littérature (7 études, 294 patients, 271 aidants, 99 professionnels de santé), cette étude analyse les interventions de soins de support destinées à la fois aux adultes ayant survécu à un cancer et à leurs aidants familiaux

Posttreatment health interventions for adult cancer survivors and their families: an integrated review

Coyne, Elisabeth ; Dieperink, Karin B. ; Voltelen, Barbara ; da Silva Barreto, Mayckel ; Garcia-Vivar, Cristina

Purpose: This review aimed to synthesize the literature regarding health interventions delivered to adult cancer survivors and their families during posttreatment phase. Methods: An integrative literature review was conducted that included quantitative and qualitative studies. The search was carried out in four databases using the same terms or MeSH terms and included data from January 2012 to February 2024. After quality assessment, data were extracted and synthesized. The protocol was [...]

Menée à partir de données portant sur 92 patients atteints d'un cancer, cette étude prospective multicentrique évalue l'intérêt de l'ajout de faibles doses de méthadone à d'autres opioïdes pour soulager la douleur liée à la maladie

Low-dose methadone added to another opioid for cancer pain: a multicentre prospective study

Treillet, Erwan ; Perceau-Chambard, Elise ; Economos, Guillaume ; Chevalier, Luc ; Picard, Stéphane ; Frasca, Matthieu ; Pouget, Julie ; Calvel, Laurent ; Tremellat-Faliere, Flora ; Majerus, Maxime ; Quesnel, Paul Antoine ; Chiquet, Romain ; Evin, Adrien ; Seveque, Marie-Anne ; Lebel, Audrey ; Hardouin, Ines ; Burnod, Alexis ; Renard, Olivier ; Bessodes, Pauline ; Giet, Olivier ; Serresse, Laure

Context: The use of methadone for cancer pain management is gaining wider acceptance. However, switching to methadone treatment can still pose challenges. Consequently, there is ongoing development of its use in low doses in combination with other opioids, despite a lack of clinical evidence regarding its efficacy and safety. Objectives: This study aimed to evaluate the efficacy and tolerability of low-dose methadone in combination with another opioid in patients with moderate-to-severe [...]

Menée à partir de données portant sur 240 patients atteints d'un cancer du poumon, cette étude identifie 5 types de symptômes liés à l'utilisation d'une immunothérapie

Symptom clusters and symptom network analysis during immunotherapy in lung cancer patients

Yang, Xuying ; Bai, Jingcui ; Liu, Ruili ; Wang, Xiaoping ; Zhang, Gongyu ; Zhu, Xuehua

Objective: This study analyzes symptoms in lung cancer patients undergoing immunotherapy to identify core symptom clusters through network analysis and lay a foundation for effective symptom management programs. Methods: The sample comprised 240 lung cancer patients receiving immunotherapy. Participants were assessed using the Memorial Symptom Assessment Scale. Exploratory factor analysis was used to extract symptom clusters, and network analysis using JASP 0.17.3 was performed to explore the [...]

Menée par questionnaire auprès de 132 patients atteints d'un cancer du côlon, cette étude analyse l'association entre la qualité de l'alimentation et la sévérité d'une neuropathie périphérique induite par une chimiothérapie à base d'oxaliplatine

Dietary quality and chemotherapy-induced peripheral neuropathy in colon cancer

Compton, Stephanie L. E. ; Yang, Shengping ; Madere, Joseph ; Weltzien, Erin K. ; Caan, Bette J. ; Meyerhardt, Jeffrey A. ; Schmitz, Kathryn H. ; Brown, Justin C.

Background : Chemotherapy-induced peripheral neuropathy (CIPN) is a common and dose-limiting chemotoxicity caused by oxaliplatin. This study investigated the relationship between dietary quality and the development of moderate and/or severe CIPN in colon cancer survivors using data from the Focus on Reducing Dose-Limiting Toxicities in Colon Cancer with Resistance Exercise trial (ClinicalTrials.gov identifier NCT03291951). Methods: Diet quality was collected using a 127-item food-frequency [...]

A partir d'une revue systématique de la littérature (9 essais, 1 512 patientes), cette méta-analyse évalue l'effet, sur la fatigue des patientes atteintes d'un cancer traité par chimiothérapie, d'interventions à base d'exercices physiques de résistance avec ou sans exercices physiques d'endurance

Impact of resistance training on fatigue among breast cancer patients undergoing chemotherapy: a systematic review and meta-analysis

Lange, Jasmin ; Klassen, Oliver ; Beinert, Konstantin

Purpose: The effects of aerobic exercise interventions for reducing fatigue after cancer treatment are well-established, and the effect of resistance training remains uncertain. Therefore, this systematic review and meta-analysis aim to analyze the effect of resistance training and combined resistance and endurance training on cancer-related fatigue (CRF) in breast cancer patients. Methods : A systematic search for randomized controlled trials (RCTs) was conducted on the PubMed, SPORTDiscus, [...]

Menée à partir des données de 3 cohortes prospectives incluant 10 541 patients atteints d'un cancer, cette étude analyse l'effet, sur la mortalité, de la pratique d'une activité physique avant et après le diagnostic de la maladie

Physical activity before and after cancer diagnosis and mortality risk in three large prospective cohorts

Christopher, Cami N. ; Chandler, Paulette D. ; Zhang, Xuehong ; Tobias, Deirdre K. ; Hazra, Aditi ; Gaziano, J. Michael ; Buring, Julie E. ; Lee, I. Min ; Sesso, Howard D.

Purpose: Physical activity (PA) can improve cancer survival; however, whether the timing of PA differentially affects mortality risk is unclear. We evaluated the association between PA levels pre- and post-diagnosis and mortality risk in the Women’s Health Study (WHS), Physicians’ Health Study (PHS)-I, and PHS-II prospective cohorts. Methods: We categorized PA pre- and post-diagnosis as active (WHS:   [...]

Menée à partir de données des registres américains des cancers, cette étude estime, pour l'année 2020, le nombre de personnes ayant survécu à un cancer diagnostiqué à l'adolescence ou au début de l'âge adulte (âge au diagnostic : 15-39 ans)

Prevalence of cancer survivors diagnosed during adolescence and young adulthood in the United States

Page, Lindsey L ; Devasia, Theresa P ; Mariotto, Angela ; Gallicchio, Lisa ; Mollica, Michelle A ; Tonorezos, Emily

BACKGROUND: Adolescent and young adult (AYA) cancer incidence rates are rising, and survivors are at risk for numerous cancer- and treatment-related consequences. Despite growing attention to this population, prevalence estimates are lacking. PURPOSE: To estimate the number of individuals living in the United States with a history of cancer diagnosed during the AYA period. METHODS: Prevalence of cancer survivors diagnosed between the ages of 15 and 39 years was estimated using data from the [...]

Menée à partir de données portant sur 10 147 patients ayant survécu à un cancer localisé de la prostate diagnostiqué entre 2005 et 2010 (durée de suivi : supérieure à 8 ans), cette étude analyse l'association entre l'intensité d'une surveillance après traitement (prostatectomie radicale ou radiothérapie), définie par le nombre de tests de PSA réalisés au cours de la première année, et la survie globale

Post-Treatment surveillance intensity and overall survival in prostate cancer survivors (AFT-30)

Chen, Ronald C ; Basak, Ramsankar ; Dusetzina, Stacie ; Usinger, Deborah S ; Mohammed, Zahed ; Falchook, Aaron D ; Schumacher, Jessica R ; Francescatti, Amanda B ; Cuddy, Amanda ; Chang, George J ; Kozower, Benjamin D ; Greenberg, Caprice C ; McCarthy, Anne ; Katz, Aaron J

Post-treatment surveillance affects millions of cancer survivors, but empiric data to guide clinical practice is lacking. This study assessed whether the intensity of surveillance testing after radical prostatectomy (RP) or radiation therapy (RT) for localized prostate cancer is associated with overall survival.Men diagnosed with localized prostate cancer between 2005 and 2010 who underwent RP or RT at a Commission on Cancer-accredited facility were randomly sampled. Primary data collected of [...]

Menée au Royaume-Uni, cette étude analyse le rapport coût-efficacité du vaccin nonavalent contre le papillomavirus (Gardasil) chez des patientes ayant reçu un traitement pour une néoplasie cervicale intraépithéliale de haut grade

Cost-Effectiveness of 9-Valent HPV Vaccination for Patients Treated for High-Grade Cervical Intraepithelial Neoplasia in the UK

Cherif, Alhaji ; Ovcinnikova, Olga ; Palmer, Cody ; Engelbrecht, Kayla ; Reuschenbach, Miriam ; Daniels, Vincent

Patients who have been treated for high-grade cervical intraepithelial neoplasia (CIN grade ≥2) are at a high risk for subsequent CIN and other cancers and diseases related to human papillomavirus (HPV). HPV vaccination can reduce the risk of subsequent disease in patients surgically treated for grade 2 or greater CIN; however, there is no formal recommendation for prophylactic HPV vaccination in this high-risk population, and the cost-effectiveness is unknown.To assess the incremental lifetime [...]

Menée par enquête auprès de 626 patients ayant survécu à un cancer, cette étude analyse le rôle des technologies de l'information en santé pour améliorer leurs connaissances concernant les essais cliniques et l'intérêt d'y participer

Clinical trial knowledge among cancer survivors in the United States: the role of health information technology

Akhiwu, Ted O. ; Adewunmi, Comfort ; Bilalaga, Mariah ; Atarere, Joseph O. ; Gaddipati, Greeshma ; Chido-Amajuoyi, Onyema G. ; Eziuche, Diamond K. ; Onyeaka, Henry ; Amonoo, Hermioni L.

Purpose: Clinical trials are essential to the advancement of cancer care. However, clinical trial knowledge and participation remain critically low among adult patients with cancer. Health information technology (HIT) could play an important role in improving clinical trial knowledge and engagement among cancer survivors. Methods: We used data from 3,794 adults who completed the 2020 Health Information National Trends Survey, 626 (16.2%) of whom were cancer survivors. We examined the prevalence [...]

Menée aux Pays-Bas à partir de données portant sur 1 071 patients atteints d'un cancer et ayant reçu une prescription pour des médicaments anticancéreux oraux, cette étude évalue l'intérêt d'une intervention visant à réduire l'empreinte environnementale en minimisant les déchets par la redistribution des médicaments inutilisés

Environmental Outcomes of Reducing Medication Waste by Redispensing Unused Oral Anticancer Drugs

Smale, Elisabeth M. ; Ottenbros, Anne B. ; van den Bemt, Bart J. F. ; Heerdink, Eibert R. ; Verploegen, Jelle ; van Zelm, Rosalie ; Egberts, Toine C. G. ; Bekker, Charlotte L.

Importance : Medications are associated with substantial environmental outcomes, yet frequently end up being unused by patients. Waste-minimizing interventions, such as redispensing of quality-approved oral anticancer drugs remaining unused by patients at home, could reduce the environmental footprint of cancer treatment. Objectives : To assess the environmental outcomes of redispensing quality-assured oral anticancer drugs and to explore how redispensing could be environmentally optimized. [...]

A partir d'une revue de la littérature publiée de 2017 à 2023 (44 articles), cette étude identifie les symptômes liés à une utilisation d'immunothérapies à base de lymphocytes CAR-T chez les patients atteints d'un cancer hématologique et présente un outil permettant aux patients de déclarer ces symptômes

Development of a conceptual framework for an electronic patient-reported outcome (ePRO) system measuring symptoms and impacts of CAR T-cell therapies in patients with haematological malignancies

Khatsuria, Foram ; McMullan, Christel ; Aiyegbusi, Olalekan Lee ; Shaw, Karen L. ; Iqbal, Roshina ; Kinsella, Francesca ; Wilson, Keith ; Pyatt, Lester ; Lewis, Marlene ; Wheldon, Sophie M. R. ; Burns, David ; Chakraverty, Ronjon ; Calvert, Melanie ; Hughes, Sarah E.

Chimeric antigen receptor (CAR) T-cell therapy is associated with potentially severe toxicities that create a substantial burden for patients. Patient-reported outcomes (PROs) offer valuable insights into symptoms, functioning, and other complex constructs of interest. In this Review, we aimed to identify symptom and impact concepts important to patients receiving CAR T-cell therapy, construct a conceptual framework for an electronic patient-reported outcome (ePRO) system, and identify [...]