Ce dossier présente les guides de bonne pratique de la "Multinational Association of Supportive Care in Cancer" et de l'"International Society of Oral Oncology" concernant la prise en charge des complications buccales chez les patients atteints d'un cancer

MASCC/ISOO Clinical Practice Statement: Clinical assessment of salivary gland hypofunction and xerostomia in cancer patients

Hong, Catherine ; Epstein, Joel B. ; Jensen, Siri Beier ; Gueiros, Luiz Alcino ; van Leeuwen, Stephanie J. M. ; Kandwal, Abhishek ; Vissink, Arjan ; Elad, Sharon

Purpose: A MASCC/ISOO Clinical Practice Statement (CPS) is aimed at generating a concise tool for clinicians that concentrates practical information needed for the management of oral complications of cancer patients. This CPS is focused on the clinical assessment of salivary gland hypofunction and xerostomia in cancer patients. Methods: This CPS was developed based on a critical evaluation of the literature followed by a structured discussion of a group of leading experts, members of the Oral [...]

Ce dossier présente les guides de bonne pratique de la "Multinational Association of Supportive Care in Cancer" et de l'"International Society of Oral Oncology" concernant la prise en charge des complications buccales chez les patients atteints d'un cancer

MASCC/ISOO Clinical Practice Statement: Management of salivary gland hypofunction and xerostomia in cancer patients

Hong, Catherine ; Jensen, Siri Beier ; Vissink, Arjan ; Bonomo, Pierluigi ; Santos-Silva, Alan Roger ; Gueiros, Luiz Alcino ; Epstein, Joel B. ; Elad, Sharon

Purpose: A MASCC/ISOO Clinical Practice Statement (CPS) is aimed at generating a concise tool for clinicians that concentrates practical information needed for the management of oral complications of cancer patients. This CPS is focused on the management of salivary gland hypofunction and xerostomia in cancer patients. Methods: This CPS was developed based on critical evaluation of the literature followed by a structured discussion of a group of leading experts, members of the Oral Care Study [...]

Ce dossier présente les guides de bonne pratique de la "Multinational Association of Supportive Care in Cancer" et de l'"International Society of Oral Oncology" concernant la prise en charge des complications buccales chez les patients atteints d'un cancer

MASCC/ISOO clinical practice statement: Current understanding on controversies in basic oral care in hemato-oncology and hematopoietic cell transplantation

Raber-Durlacher, Judith E. ; Zadik, Yehuda ; Treister, Nathaniel S. ; Stempler, Noa ; Bruno, Julia S. ; Epstein, Joel B. ; Elad, Sharon

Purpose: A MASCC/ISOO Clinical Practice Statement (CPS) is aimed at generating a concise tool for clinicians, which concentrates on practical information needed for the management of oral complications of cancer patients. This CPS is focused on the current understanding of controversies that may arise while providing basic oral care in hemato-oncology patients and hematopoietic cell transplantation recipients (HCT). The CPS will summarize and elucidate controversies that have appeared in the [...]

Ce dossier présente les guides de bonne pratique de la "Multinational Association of Supportive Care in Cancer" et de l'"International Society of Oral Oncology" concernant la prise en charge des complications buccales chez les patients atteints d'un cancer

MASCC/ISOO Clinical Practice Statement: Management of oral complications of targeted therapy

Villa, Alessandro ; Epstein, Joel B. ; Yarom, Noam ; Hong, Catherine ; Fulop, Caroline ; Bossi, Paolo ; Elad, Sharon

Purpose: A MASCC/ISOO Clinical Practice Statement (CPS) is aimed at generating a concise tool for clinicians that concentrates practical information needed for the management of oral complications of cancer patients. This CPS is focused on the management of oral complications of targeted therapy. Methods: This CPS was developed based on critical evaluation of the literature followed by a structured discussion of a group of leading experts, members of the Oral Care Study Group of MASCC/ISOO. [...]

Mené sur 125 patients atteints d'un cancer de stade avancé (pancréas ou autre tumeur localisée au niveau du tronc coeliaque ; âge médian : 65,5 ans), cet essai multicentrique de phase II évalue l'intérêt d'une radiochirurgie du plexus coeliaque pour soulager la douleur

Celiac plexus radiosurgery for pain management in advanced cancer: a multicentre, single-arm, phase 2 trial

Lawrence, Yaacov R. ; Miszczyk, Marcin ; Dawson, Laura A. ; Diaz Pardo, Dayssy Alexandra ; Aguiar, Artur ; Limon, Dror ; Pfeffer, Raphael M. ; Buckstein, Michael ; Barry, Aisling S. ; Meron, Tikva ; Dicker, Adam P. ; Wydmański, Jerzy ; Zimmermann, Camilla ; Margalit, Ofer ; Hausner, David ; Morag, Ofir ; Golan, Talia ; Jacobson, Galia ; Dubinski, Sergey ; Stanescu, Teo ; Fluss, Ronen ; Freedman, Laurence S. ; Ben-Ayun, Maoz ; Symon, Zvi

Background: Refractory upper abdominal pain or lower back pain (retroperitoneal pain syndrome) related to celiac plexus involvement characterises pancreatic and other upper gastrointestinal malignancies and is an unmet need. We hypothesised that ablative radiation delivered to the celiac plexus would decrease pain. Methods: This multicentre, single-arm, phase 2 study was done at eight hospitals in five countries (Israel, Poland, Canada, the USA, and Portugal). Eligible patients aged 18 years or [...]

Mené sur 125 patients atteints d'un cancer de stade avancé (pancréas ou autre tumeur localisée au niveau du tronc coeliaque ; âge médian : 65,5 ans), cet essai multicentrique de phase II évalue l'intérêt d'une radiochirurgie du plexus coeliaque pour soulager la douleur

Alleviating retroperitoneal pain with celiac plexus radiosurgery

Moore-Palhares, Daniel ; Ng, Sylvia S. W. ; Louie, Alexander V.

The celiac plexus is a network of nerves surrounding the celiac artery that transmits pain signals from the upper abdominal organs. Abdominal malignancies, notably pancreatic cancer, often cause debilitating pain by disrupting local anatomy and infiltrating the celiac plexus. Initial pain management involve opioids and adjunct medications, but as pain becomes refractory, additional strategies are required. Although celiac plexus neurolysis is commonly employed, randomised controlled trials [...]

Mené sur 53 patients atteints d'un cancer de la prostate (âge médian : 61 ans), cet essai de phase I détermine la faisabilité et l'effet, sur la prolifération des cellules cancéreuses, de différentes intensités d'exercices physiques avant un traitement chirurgical

Neoadjuvant Exercise Therapy in Prostate Cancer: A Phase 1, Decentralized Nonrandomized ControlledTrial

Jones, Lee W. ; Moskowitz, Chaya S. ; Lee, Catherine P. ; Fickera, Gina A. ; Chun, Su S. ; Michalski, Meghan G. ; Stoeckel, Kurtis ; Underwood, Whitney P. ; Lavery, Jessica A. ; Bhanot, Umeshkumar ; Linkov, Irina ; Dang, Chau T. ; Ehdaie, Behfar ; Laudone, Vincent P. ; Eastham, James A. ; Collins, Anne ; Sheerin, Patricia T. ; Liu, Lydia Y. ; Eng, Stefan E. ; Boutros, Paul C.

Importance : Observational data have shown that postdiagnosis exercise is associated with reduced risk of prostate cancer death. The feasibility and tumor biological activity of exercise therapy is not known. Objective : To identify recommended phase 2 dose of exercise therapy for patients with prostate cancer. Design, Setting, and Participants : This single-center, phase 1a dose-finding trial was conducted at a tertiary cancer center using a patientcentric, decentralized platform and included [...]

Mené sur 53 patients atteints d'un cancer de la prostate (âge médian : 61 ans), cet essai de phase I détermine la faisabilité et l'effet, sur la prolifération des cellules cancéreuses, de différentes intensités d'exercices physiques avant un traitement chirurgical

Exercise for Prostate Cancer—Worthy Goals but Suboptimal Trial Designs

Neuhouser, Marian L. ; Schenk, Jeannette M. ; Wright, Jonathan L.

Physical activity is increasingly recognized as a modifiable factor that may influence cancer outcomes. In 2022, an American Society of Clinical Oncology Expert Panel issued a clinical practice guideline on exercise during cancer treatment. Based on a rigorous systematic review process, the panel concluded that exercise interventions during cancer treatment reduced fatigue, enhanced quality of life, and improved physical function. However, evidence was insufficient in the American Society of [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

Cancer nurses’ experience during the COVID-19 pandemic: Multicenter mixed-methods study on coping and resilience strategies

Cadorin, Lucia ; Mazzega-Fabbro, Cristina ; Cedrone, Sonja

In early 2020, the COVID-19 pandemic created severe difficulties in clinical and organizational fields. Healthcare workers needed to protect their health and avoid infecting their family members, but also limit the virus’s spread among vulnerable oncology patients undergoing hospital treatment.

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

The evaluation of risk factors for prolonged viral shedding during anti-SARS-CoV-2 monoclonal antibodies and long-term administration of antivirals in COVID-19 patients with B-cell lymphoma treated by anti-CD20 antibody

Maruyama, Shuhei ; Wada, Daiki ; Kanayama, Shuji ; Shimazu, Haruka ; Miyano, Yumiko ; Inoue, Akira ; Kashihara, Masami ; Okuda, Kazuyuki ; Saito, Fukuki ; Nakamori, Yasushi ; Ishii, Kazuyoshi ; Kuwagata, Yasuyuki

The global impact of the coronavirus disease 2019 (COVID-19) pandemic has resulted in significant morbidity and mortality. Immunocompromised patients, particularly those treated for B-cell lymphoma, have shown an increased risk of persistent infection with SARS-CoV-2 and severe outcomes and mortality. Multi-mutational SARS-CoV-2 variants can arise during the course of such persistent cases of COVID-19. No optimal, decisive strategy is currently available for patients with persistent infection [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

Surgery for pancreatic neuroendocrine tumors during the COVID-19 pandemic: a retrospective cohort from a high-volume center

Paiella, Salvatore ; Landoni, Luca ; De Pastena, Matteo ; Elio, Giovanni ; Casciani, Fabio ; Cingarlini, Sara ; D’Onofrio, Mirko ; Maistri, Giulia ; Ciatti, Ivan ; Tuveri, Massimiliano ; Davì, Maria Vittoria ; Luchini, Claudio ; Donadello, Katia ; Manzini, Gessica ; Malleo, Giuseppe ; Salvia, Roberto

During the COVID-19 pandemic, pancreatic surgery for pancreatic neuroendocrine tumors (PNETs) with surgical indications was postponed or canceled. Patients with PNET patients who underwent pancreatic surgery during the COVID-19 restriction period (3 years) were compared with a similar cohort of patients who underwent surgery in the previous 3 years. Data on patients’ characteristics, waiting time, and surgical and pathology outcomes were evaluated. During the study period, 370 patients received [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

Exposure to obinutuzumab does not affect outcomes of SARS-CoV-2 infection in vaccinated patients with newly diagnosed advanced-stage follicular lymphoma

Pinto, A. ; Caltagirone, M. ; Battista, M. ; Gazzoli, G. C. ; Patti, C. ; Pennese, E. ; De Lorenzo, S. ; Pavone, V. ; Merli, M. ; Chiarenza, A. ; Gorgone, A. G. ; Piazza, F. ; Puccini, B. ; Noto, A. ; Arcaini, L. ; De Filippi, R. ; Zinzani, P. L. ; Ferreri, A. J. M. ; Ladetto, M. ; Ferrari, S. ; Gritti, G.

URBAN is a multicentric, ambispective study evaluating the effectiveness and safety of obinutuzumab-based immuno-chemotherapy and maintenance in patients with untreated advanced follicular lymphoma (FL). The study began before the COVID-19 emergency declaration in Italy. It is currently ongoing for follow-up, and the enrolment timeline encompassed different stages of the pandemic, various vaccination roll-out phases and prevalence of SARS-CoV-2 variants. Outcomes of interest of the present [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée à la COVID-19

Improved outcome of COVID-19 over time in patients treated with CAR T-cell therapy: Update of the European COVID-19 multicenter study on behalf of the European Society for Blood and Marrow Transplantation (EBMT) Infectious Diseases Working Party (IDWP) and the European Hematology Association (EHA) Lymphoma Group

Spanjaart, Anne Mea ; Ljungman, Per ; Tridello, Gloria ; Schwartz, Juana ; Martinez-Cibrián, Nuria ; Barba, Pere ; Kwon, Mi ; López-Corral, Lucía ; Martínez-López, Joaquin ; Ferrà, Christelle ; Di Blasi, Roberta ; Ghesquieres, Herve ; Mutsaers, Pim ; Calkoen, Friso ; Jak, Margot ; Van Doesum, Jaap ; Vermaat, Joost S. P. ; van der Poel, Marjolein ; Maertens, Johan ; Gambella, Massimiliano ; Metafuni, Elisabetta ; Ciceri, Fabio ; Saccardi, Riccardo ; Nicholson, Emma ; Tholouli, Eleni ; Matthew, Collin ; Potter, Victoria ; Bloor, Adrian ; Besley, Caroline ; Roddie, Claire ; Wilson, Keith ; Nagler, Arnon ; Campos, Antonio ; Petersen, Soeren Lykke ; Folber, Frantisek ; Bader, Peter ; Finke, Jürgen ; Kröger, Nicolaus ; Knelange, Nina ; de La Camara, Rafael ; Kersten, Marie Jose ; Mielke, Stephan

COVID-19 has been associated with high mortality in patients treated with Chimeric Antigen Receptor (CAR) T-cell therapy for hematologic malignancies. Here, we investigated whether the outcome has improved over time with the primary objective of assessing COVID-19-attributable mortality in the Omicron period of 2022 compared to previous years. Data for this multicenter study were collected using the MED-A and COVID-19 report forms developed by the EBMT. One-hundred-eighty patients were included [...]