Menée à partir de données des cohortes américaines "the Nurses’ Health Studies" et "the Health Professionals Follow-Up Study" portant sur 227 916 personnes, cette étude analyse la corrélation entre la consommation d'alcool et l'incidence du cancer colorectal (825 cas) en fonction de signatures mutationnelles tumorales associées à une déficience du système de réparation des mésappariements de l'ADN

Alcohol and colorectal cancer risk subclassified by mutational signatures of DNA mismatch repair deficiency

Fang, Aiping ; Ugai, Tomotaka ; Gurjao, Carino ; Zhong, Rong ; Liu, Zhenhua ; Zhang, Xinyuan ; Wang, Peilu ; Nowak, Jonathan ; Wang, Molin ; Giannakis, Marios ; Ogino, Shuji ; Zhang, Xuehong ; Giovannucci, Edward

We examined whether the association between alcohol consumption and CRC incidence was stronger for tumors with higher contributions of defective MMR (dMMR)-related tumor mutational signatures (TMSs).We used data from 227,916 men and women who participated in the Nurses’ Health Study (1980-2016), the Nurses’ Health Study II (1991-2017), and the Health Professionals Follow-up Study (1986-2016). Dietary data was collected every 4 years through validated food frequency questionnaires. Relative [...]

Menée à partir des données météorologiques 2006-2016 de 484 villes chinoises, cette étude analyse l'association entre la température ambiante, l'humidité relative ou absolue et l'incidence du carcinome rhinopharyngé

Effects of ambient temperature, relative humidity and absolute humidity on risk of nasopharyngeal carcinoma in China

Di, Wenyi ; Yu, Jiamin ; Zong, Dan ; Ge, Yizhi ; Zhang, Yujie ; Chen, Xin ; He, Xia

Nasopharyngeal carcinoma (NPC) has a unique geographic distribution. It is unknown whether meteorological factors are related to the incidence of NPC. To investigate the effect of ambient temperature, relative humidity (RH), and absolute humidity (AH) on the incidence of NPC, we collected the incidence rate of NPC in 2016 and meteorological data from 2006 to 2016 from 484 cities and counties across 31 provinces in China. Generalized additive models with quasi-Poisson regression and generalized [...]

Menée à l'aide de données 2007-2021 des registres des cancers au Danemark, en Norvège et en Suède (durée moyenne de suivi : 3,9 ans), cette étude analyse l'association entre une utilisation d'agonistes des récepteurs du peptide 1 de type glucagon (GLP1) et le risque de cancer de la thyroïde

Glucagon-like peptide 1 receptor agonist use and risk of thyroid cancer: Scandinavian cohort study

Björn Pasternak ; Viktor Wintzell ; Anders Hviid ; Björn Eliasson ; Soffia Gudbjörnsdottir ; Christian Jonasson ; Kristian Hveem ; Henrik Svanström ; Mads Melbye ; Peter Ueda

Objective: To investigate whether use of glucagon-like peptide 1 (GLP1) receptor agonists is associated with increased risk of thyroid cancer. Design: Scandinavian cohort study. Setting: Denmark, Norway, and Sweden, 2007-21. Participants: Patients who started GLP1 receptor agonist treatment were compared with patients who started dipeptidyl peptidase 4 (DPP4) inhibitor treatment, and in an additional analysis, patients who started sodium-glucose cotransporter 2 (SGLT2) inhibitor treatment. Main [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données portant sur 211 microbiotes intestinaux, 17 159 témoins et 4 112 patients atteints d'un cancer de l'oesophage, cette étude analyse l'association entre le microbiote intestinal et le risque de développer la maladie par sous-type puis identifie des facteurs de risque ou de protection

Investigating the causal role of the gut microbiota in esophageal cancer and its subtypes: a two-sample Mendelian randomization study

Li, Jia ; Gao, Xuedi ; Sun, Xiaoming ; Li, Hao ; Wei, Jiaheng ; Lv, Lin ; Zhu, Liangming

Background: Through research on the gut microbiota (GM), increasing evidence has indicated that the GM is associated with esophageal cancer (ESCA). However, the specific cause-and-effect relationship remains unclear. In this study, Mendelian randomization (MR) analysis was applied to investigate the causal relationship between the GM and ESCA, including its subtypes. Methods: We collected information on 211 GMs and acquired data on ESCA and its subtypes through genome-wide association studies [...]

Cette étude passe en revue les facteurs de risque modifiables et non modifiables d'adénocarcinome canalaire du pancréas

Genetic and other risk factors for pancreatic ductal adenocarcinoma (PDAC)

Jacobs, Michelle F. ; Stoffel, Elena M.

Pancreatic ductal adenocarcinoma (PDAC) is often diagnosed at an advanced stage, resulting in poor prognosis and low 5-year survival rates. While early evidence suggests increased long-term survival in those with screen-detected resectable cancers, surveillance imaging is currently only recommended for individuals with a lifetime risk of PDAC ≥ 5%. Identification of risk factors for PDAC provides opportunities for early detection, risk reducing interventions, and targeted therapies, thus [...]

Menée en Corée auprès de 125 188 femmes âgées de 20 à 54 ans (durée moyenne de suivi : 6,7 ans), cette étude analyse l'association entre des paramètres de composition corporelle (IMC, tour de taille, masse musculaire, masse grasse) et le risque de cancer du sein avant la ménopause (1 110 cas)

Adiposity, Body Composition Measures, and Breast Cancer Risk in Korean Premenopausal Women

Tran, Thi Xuan Mai ; Chang, Yoosoo ; Choi, Hye Rin ; Kwon, Ria ; Lim, Ga-Young ; Kim, Eun Young ; Ryu, Seungho ; Park, Boyoung

To investigate the association between body composition parameters and breast cancer (BC) risk in premenopausal women.Prospective cohort study using data from the Kangbuk Samsung Cohort Study. Participants were women aged 20 to 54 years who were enrolled from 2011 to 2019 and followed up for BC development until December 31, 2020. Data were analyzed from June to August 2023.Trained nurses conducted anthropometric measurements and assessed body composition using segmental bioelectric impedance [...]