Menée à partir de données de la cohorte américaine "the Health Professionals Follow-Up Study" portant sur 10 269 hommes (durée de suivi : 26 ans), cette étude analyse l'influence d'un régime alimentaire sain sur l'association entre des prédispositions génétiques, mesurées par un score de risque polygénique, et le risque de cancer fatal de la prostate (253 cas)

Healthy dietary patterns and risk of prostate cancer in men at high genetic risk

Zhang, Yiwen ; Stopsack, Konrad H. ; Song, Mingyang ; Mucci, Lorelei A. ; Liu, Binkai ; Penney, Kathryn L. ; Tabung, Fred K. ; Giovannucci, Edward ; Plym, Anna

Prostate cancer has high heritability. Healthy lifestyle has been associated with lower lethal prostate cancer risk among men at increased genetic susceptibility, but the role of healthy dietary patterns remains unknown. We prospectively followed 10,269 genotyped men in the Health Professionals Follow-up Study (1993–2019). Genetic risk was quantified using an established polygenic risk score (PRS). Five dietary patterns were investigated: healthy eating index, Mediterranean, diabetes [...]

Menée à l'aide des données d'une étude multicentrique italienne portant sur 4 154 témoins et 1 953 patients atteints d'un cancer colorectal, cette étude analyse l'association entre l'adhésion à un régime de réduction du risque de diabète et le risque de cancer colorectal

Diabetes risk reduction diet and colorectal cancer risk

Natale, Arianna ; Turati, Federica ; Taborelli, Martina ; Giacosa, Attilio ; Augustin, Livia S. A. ; Crispo, Anna ; Negri, Eva ; Rossi, Marta ; La Vecchia, Carlo

Background: Diabetes has been associated with colorectal cancer (CRC). We aimed at evaluating whether adherence to a diabetes risk reduction diet (DRRD) could favorably influence the risk of CRC. Methods: Data came from a multicentric Italian case-control study including 1,953 histologically confirmed CRC cases and 4,154 hospital controls admitted for acute non-neoplastic diseases. Diet was assessed through a validated and reproducible food frequency questionnaire. The DRRD score was computed [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données d'études pangénomiques portant sur 205 771 personnes (âge médian : 63 ans), cette étude analyse l'association entre les apports alimentaires, l'utilisation de médicaments et le risque de cancer de la vessie (1 701 cas)

An Atlas of Dietary Intakes and Medication Uses on Risk of Bladder Cancer: A Wide-Angle Mendelian Randomization Analysis

Chen, Ya-Ting ; Tang, Qiu-Yi ; Zhang, Yan-Xi ; Wang, Shi-Zhi ; Wesselius, Anke ; Li, Wen-Chao ; Zeegers, Maurice P. ; Yu, Evan Yi-Wen

Observational studies suggests that diets and medications affect bladder cancer (BC) development, which are subject to confounding and difficult to make causal inference. Here we aimed to investigate whether those observational associations are causal and determining the potential directions and pathways. We used 2-sample Mendelian randomization (MR) analysis to assess associations of dietary intakes, medication uses and molecules with BC risk. Genetic summary data were derived from [...]

Menée en Chine par enquête auprès de 1 438 étudiantes, cette étude analyse l'association entre les connaissances ou la perception du risque liées au vaccin et l'attitude à l'égard de la vaccination contre le papillomavirus humain

Risk perception and trust in the relationship between knowledge and HPV vaccine hesitancy among female university students in China: a cross-sectional study

Chen, Xing ; Wang, Lei ; Huang, Yan ; Zhang, Luying

Background: Cervical cancer poses a heavy health burden in China, with the second highest incidence and mortality rate among female tumors, yet human papillomavirus (HPV) vaccination rate among female university students remain remains low. This study conducted a cross-sectional survey to assess the degree of HPV vaccine hesitancy among female university students and to explore the potential association between knowledge, risk perception, trust, and HPV vaccine hesitancy. Methods: A total of [...]

A partir d'une revue systématique de la littérature publiée jusqu'en novembre 2022, cette étude analyse les caractéristiques et les résultats de campagnes de communication pour la prévention du tabagisme passif (73 campagnes, 50 pays)

A systematic review of second-hand smoking mass media campaigns (2002–2022)

Lim, Carmen C. W. ; Rutherford, Brienna ; Gartner, Coral ; McClure-Thomas, Caitlin ; Foo, Shaun ; Su, Fang-Yi ; Scheurer, Roman ; Sebayang, Susy ; Chan, Gary ; Stjepanović, Daniel ; Fausiah, Fitri ; Farassania, Ghea ; Leung, Janni

Background: Second-hand smoking (SHS) increases the risk of chronic disease in adults and poses a serious health threat to children. Mass media campaigns are instrumental in raising awareness and reducing SHS exposure. There is a need to identify recent SHS mass media campaigns and assess their sustainability in terms of knowledge, attitudes, and behavioural changes. This systematic review summarises the characteristics and outcomes of mass media campaigns on SHS prevention. Methods: PubMed, [...]