A partir d'une revue systématique de la littérature (30 études), cette méta-analyse évalue l'association entre une exposition professionnelle aux gaz d'échappement de moteurs diesel et le risque de leucémie

Occupational-related exposure to diesel exhaust and risk of leukemia: systematic review and meta-analysis of cohort studies

Shah, Darshi ; DeStefano, Vincent ; Collatuzzo, Giulia ; Teglia, Federica ; Boffetta, Paolo

Purpose: Diesel exhaust (DE) is an established lung carcinogen. The association with leukemia is not well established. We conducted a systematic review and meta-analysis of cohort studies to determine the association between occupational DE exposure and risk of leukemia. Methods: A systematic literature review was performed to identify all cohort studies on occupational exposure to DE and associated risk of leukemia. STROBE guidelines and PECOS criteria were followed. Meta-analyses with fixed [...]

A partir d'une revue systématique de la littérature publiée jusqu'en novembre 2021 (32 études), cette méta-analyse évalue l'association entre une exposition professionnelle au soleil et le risque de carcinome basocellulaire

Occupational solar exposure and basal cell carcinoma. A review of the epidemiologic literature with meta-analysis focusing on particular methodological aspects

Wendt, Andrea ; Möhner, Matthias

Background: Numerous epidemiologic studies and a few systematic reviews have investigated the association between occupational solar exposure and basal cell carcinoma (BCC). However, previous reviews have several deficits with regard to included and excluded studies/risk estimates and the assessment of risk of selection bias (RoSB). Our aim was to review epidemiologic studies with a focus on these deficits and to use meta-(regression) analyses to summarize risk estimates. Methods: We [...]

Menée en Norvège auprès de 2 035 témoins et 399 patients atteints d'un cancer du poumon et inclus dans une cohorte d'employés de l'industrie pétrolière offshore sur la période 1965-1998, cette étude analyse l'association entre une exposition professionnelle au benzène et le risque de développer la maladie

Benzene exposure and risk of lung cancer in the Norwegian Offshore Petroleum Worker cohort: a prospective case-cohort study

Ronnie Babigumira ; Marit B Veierød ; H Dean Hosgood ; Sven Ove Samuelsen ; Magne Bråtveit ; Jorunn Kirkeleit ; Nathaniel Rothman ; Qing Lan ; Debra T Silverman ; Melissa C Friesen ; Nita Kaupang Shala ; Tom K Grimsrud ; Jo Steinson Stenehjem

Objective: The objective of our study was to examine whether occupational exposure to benzene is associated with lung cancer among males in the Norwegian Offshore Petroleum Workers cohort. Methods: Among 25 347 male offshore workers employed during 1965–1998, we conducted a case-cohort study with 399 lung cancer cases diagnosed between 1999 and 2021, and 2035 non-cases sampled randomly by 5-year birth cohorts. Individual work histories were coupled to study-specific job-exposure matrices for [...]

Menée aux Etats-Unis à l'aide de données portant sur 409 876 personnes, cette étude analyse l'association entre une exposition aux particules fines (PM2,5) et le risque de cancer

Air quality and cancer risk in the All of Us Research Program

Craver, Andrew ; Luo, Jiajun ; Kibriya, Muhammad G. ; Randorf, Nina ; Bahl, Kendall ; Connellan, Elizabeth ; Powell, Johnny ; Zakin, Paul ; Jones, Rena R. ; Argos, Maria ; Ho, Joyce ; Kim, Karen ; Daviglus, Martha L. ; Greenland, Philip ; Ahsan, Habibul ; Aschebrook-Kilfoy, Briseis

Introduction: The NIH All of Us Research Program has enrolled over 544,000 participants across the US with unprecedented racial/ethnic diversity, offering opportunities to investigate myriad exposures and diseases. This paper aims to investigate the association between PM2.5 exposure and cancer risks. Materials and methods: This work was performed on data from 409,876 All of Us Research Program participants using the All of Us Researcher Workbench. Cancer case ascertainment was performed using [...]

Menée à l'aide de données internationales portant sur 7 102 témoins et 2 084 patients atteints d'un cancer de l'estomac, cette étude analyse l'association entre les principaux facteurs de reproduction, l'utilisation d'un traitement hormonal de la ménopause et le risque de développer la maladie chez les femmes

Reproductive factors, hormonal interventions, and gastric cancer risk in the Stomach cancer Pooling (StoP) Project

Song, Minkyo ; Jayasekara, Harindra ; Pelucchi, Claudio ; Rabkin, Charles S. ; Johnson, Kenneth C. ; Hu, Jinfu ; Palli, Domenico ; Ferraroni, Monica ; Liao, Linda M. ; Bonzi, Rossella ; Zaridze, David ; Maximovitch, Dmitry ; Aragonés, Nuria ; Martin, Vicente ; Castaño-Vinyals, Gemma ; Guevara, Marcela ; Tsugane, Shoichiro ; Hamada, Gerson Shigueaki ; Hidaka, Akihisa ; Negri, Eva ; Ward, Mary H. ; Sinha, Rashmi ; Lagiou, Areti ; Lagiou, Pagona ; Boffetta, Paolo ; Curado, Maria Paula ; Lunet, Nuno ; Vioque, Jesús ; Zhang, Zuo-Feng ; La Vecchia, Carlo ; Camargo, M. Constanza

Background: Gastric cancer incidence is higher in men, and a protective hormone-related effect in women is postulated. We aimed to investigate and quantify the relationship in the Stomach cancer Pooling (StoP) Project consortium. Methods: A total of 2,084 cases and 7,102 controls from 11 studies in seven countries were included. Summary odds ratios (ORs) and 95% confidence intervals (CIs) assessing associations of key reproductive factors and menopausal hormone therapy (MHT) with gastric cancer [...]

Menée à l'aide d'échantillons sanguins collectés auprès de 2 000 témoins et 2 500 patients atteints d'un ulcère ou d'un cancer de l'oesophage, de l'estomac ou du duodénum, cette étude analyse l'association entre 19 agents pathogènes et le risque de développer ces maladies

Infectious pathogens and risk of esophageal, gastric and duodenal cancers and ulcers in China: A case-cohort study

Kartsonaki, Christiana ; Yao, Pang ; Butt, Julia ; Jeske, Rima ; de Martel, Catherine ; Plummer, Martyn ; Sun, Dianjianyi ; Clark, Sarah ; Walters, Robin G. ; Chen, Yiping ; Lv, Jun ; Yu, Canqing ; Hill, Michael ; Peto, Richard ; Li, Liming ; Waterboer, Tim ; Chen, Zhengming ; Millwood, Iona Y. ; Yang, Ling

Infection by certain pathogens is associated with cancer development. We conducted a case-cohort study of ~2500 incident cases of esophageal, gastric and duodenal cancer, and gastric and duodenal ulcer and a randomly selected subcohort of ~2000 individuals within the China Kadoorie Biobank study of >0.5 million adults. We used a bead-based multiplex serology assay to measure antibodies against 19 pathogens (total 43 antigens) in baseline plasma samples. Associations between pathogens and [...]

A partir d'une revue systématique de la littérature publiée jusqu'en septembre 2023 (39 études), cette méta-analyse estime la part des lymphomes non hodgkiniens attribuables à une infection par le VIH dans le monde

Estimates of the global burden of non-Hodgkin lymphoma attributable to HIV: a population attributable modeling study

Chen, Yan ; Zhao, Jianhui ; Sun, Ping ; Cheng, Mengli ; Xiong, Yiquan ; Sun, Zhaochen ; Zhang, Yixuan ; Li, Kangning ; Ye, Yunli ; Shuai, Ping ; Huang, Hairong ; Li, Xue ; Liu, Yuping ; Wan, Zhengwei

Background: Human immunodeficiency virus (HIV) significantly increases the risk of non-Hodgkin lymphoma (NHL) development, yet the population-level impact on NHL burden is unquantified. We aim to quantify this association and estimate the global burden of HIV-associated NHL. Methods: In this meta-analysis, we searched five databases (PubMed, EMBASE, Cochrane Library, Web of Science, Scopus) from database inception up to September 13, 2023, identifying cohort, case–control, or cross-sectional [...]

Menée aux Etats-Unis à l'aide de données multicentriques 2003-2020 portant sur 23 201 témoins et 8 286 patients souffrant d'un abcès hépatique pyogène (AHP) (96,5 % d'hommes ; âge moyen : 66 ans ; durée de suivi : jusqu'à 10 ans), cette étude analyse l'association entre un AHP et le risque de cancer colorectal

Incidence of Colorectal Cancer in Patients Diagnosed With Pyogenic Liver Abscess

Suzuki, Hiroyuki ; Kidder, Ian ; Tanaka, Tomohiro ; Goto, Michihiko

Colorectal cancer (CRC) can compromise the mucosal barrier and subsequently allow a route for bacterial invasion into the portal system or systemic circulation. Despite preliminary data suggesting that patients who experienced pyogenic liver abscess (PLA) have higher CRC incidence rates, data from outside the Southeast Asian population are sparse.To investigate whether there is an association between PLA and the subsequent incidence of diagnosed CRC using the Veterans Health Administration [...]

Menée par questionnaire auprès de 3 145 familles d'un enfant atteint d'un cancer, cette étude analyse l'association entre la consommation maternelle de tabac, d'alcool et/ou de drogues illicites pendant la grossesse et le risque, pour l'enfant, de développer la maladie

Maternal prenatal use of alcohol, tobacco, and illicit drugs and associations with childhood cancer subtypes

Wimberly, Courtney Elise. ; Gulrajani, Natalie B. ; Russ, Jeffrey B. ; Landi, Daniel ; Wiemels, Joseph L. ; Towry, Lisa ; Wiencke, John K. ; Walsh, Kyle M.

Background: The association between childhood cancer risk and maternal prenatal substance use/abuse remains uncertain due to modest sample sizes and heterogeneous study designs. Methods: We surveyed parents of children with cancer regarding maternal gestational use of tobacco, alcohol, and illicit drugs, using a Likert-type scale, and demographic, perinatal, and clinical variables. Multivariable log-Poisson regression assessed differences in frequency of prenatal substance use across fifteen [...]

Menée aux Etats-Unis auprès de 13 463 personnes (durée moyenne de suivi : 19 ans), cette étude analyse l'association entre la durée d'exposition à un indice de masse corporelle supérieur ou égal à 25kg/m2 et le risque de cancer (3 876 cas)

Overweight-years and cancer risk: A prospective study of the association and comparison of predictive performance with body mass index (Atherosclerosis Risk in Communities Study)

Hawwash, Nadin K. ; Sperrin, Matthew ; Martin, Glen P. ; Joshu, Corinne E. ; Florido, Roberta ; Platz, Elizabeth A. ; Renehan, Andrew G.

Excess body mass index (BMI) is associated with a higher risk of at least 13 cancers, but it is usually measured at a single time point. We tested whether the overweight-years metric, which incorporates exposure time to BMI ≥25 kg/m2, is associated with cancer risk and compared this with a single BMI measure. We used adulthood BMI readings in the Atherosclerosis Risk in Communities (ARIC) study to derive the overweight-years metric. We calculated associations between the metric and BMI and the [...]

Menée auprès de 141 621 femmes ménopausées (âge : 50-79 ans ; durée moyenne de suivi : 17,2 ans), cette étude analyse l'association entre une hystérectomie et/ou une ovariectomie et le risque de lymphome non hodgkinien (1 719 cas), en fonction de l'utilisation d'un traitement hormonal substitutif

Hysterectomy, oophorectomy and risk of non-Hodgkin's lymphoma

Luo, Juhua ; Hendryx, Michael ; Rohan, Thomas E. ; Saquib, Nazmus ; Shadyab, Aladdin H. ; Su, Le ; Hosgood, Dean ; Schnatz, Peter F. ; Qi, Lihong ; Anderson, Garnet L.

Hysterectomy is associated with an increased risk for adverse health outcomes. However, its connection to the risk of non-Hodgkin's lymphoma (NHL) remains unclear. The aims of our study were to investigate the associations between hysterectomy, oophorectomy and risk of NHL and its major subtypes (eg, diffuse large B-cell lymphoma [DLBCL]), and whether these associations were modified by exogenous hormone use. Postmenopausal women (n = 141,621) aged 50–79 years at enrollment (1993–1998) from the [...]

Menée à partir de données portant sur 244 personnes, cette étude analyse l'association entre des facteurs liés au microbiome salivaire et le risque de dysplasie de haut grade ou de cancer de l'oesophage

The Salivary Microbiome and Predicted Metabolite Production are Associated with Barrett’s Esophagus and High Grade Dysplasia or Adenocarcinoma

Solfisburg, Quinn S. ; Baldini, Federico ; Baldwin-Hunter, Brittany ; Austin, George I. ; Lee, Harry H. ; Park, Heekuk ; Freedberg, Daniel E. ; Lightdale, Charles J. ; Korem, Tal ; Abrams, Julian A.

Background: Esophageal adenocarcinoma (EAC) is rising in incidence, and established risk factors do not explain this trend. Esophageal microbiome alterations have been associated with Barrett’s esophagus (BE) and dysplasia and EAC. The oral microbiome is tightly linked to the esophageal microbiome; this study aimed to identify salivary microbiome-related factors associated with BE, dysplasia, and EAC. Methods: Clinical data and oral health history were collected from patients with and without [...]

Menée en Chine auprès de 623 témoins et 610 patients atteints d'un cancer du pancréas (âge moyen : 52 ans ; 61 % de femmes), cette étude analyse le rôle de 92 biomarqueurs protéiques dans l'association entre un diabète de type 2 et le risque de cancer du pancréas

Associations of diabetes, circulating protein biomarkers, and risk of pancreatic cancer

Pang, Yuanjie ; Lv, Jun ; Wu, Ting ; Yu, Canqing ; Guo, Yu ; Chen, Yiping ; Yang, Ling ; Millwood, Iona Y. ; Walters, Robin G. ; Yang, Xiaoming ; Stevens, Rebecca ; Clarke, Robert ; Chen, Junshi ; Li, Liming ; Chen, Zhengming ; Kartsonaki, Christiana

Background: Type 2 diabetes (T2D) is associated with higher risk of pancreatic cancer (PC), but the underlying mechanisms are not fully understood. Methods: We conducted a case-subcohort study involving 610 PC cases and 623 subcohort participants with 92 protein biomarkers measured in baseline plasma samples. Genetically-instrumented T2D was derived using 86 single-nucleotide polymorphisms (SNPs), including insulin resistance (IR) SNPs. Results: In observational analyses of 623 subcohort [...]

Menée à partir de données des pays nordiques, cette étude analyse l'association entre des facteurs liés à la grossesse et le risque de sarcome utérin, de tumeur müllerienne ou de carcinome endométrial de type I

Associations between pregnancy-related factors and birth characteristics with risk of rare uterine cancer subtypes: a Nordic population-based case–control study

Abril, Jazmine ; Trabert, Britton ; Troisi, Rebecca ; Grotmol, Tom ; Ekbom, Anders ; Engeland, Anders ; Gissler, Mika ; Glimelius, Ingrid ; Madanat-Harjuoja, Laura ; Gulbech Ording, Anne ; Sørensen, Henrik Toft ; Tretli, Steinar ; Bjørge, Tone

Purpose: Uterine sarcomas are a rare group of uterine malignancies. Due to the low incidence and changes in uterine sarcoma classification, risk factors are not well characterized. Our objective was to evaluate risk factors for uterine sarcoma and compare risk factors between uterine sarcoma, malignant mixed Mullerian tumors (MMMTs), and type I endometrial carcinomas. Methods: This nested case–control study utilized linked data from population-based medical birth and cancer registries in [...]