Menée au Mexique par questionnaire auprès de 1 074 témoins et 1 000 patientes atteintes d'un cancer du sein (âge : 35-69 ans), cette étude analyse l'association entre la consommation de boissons édulcorées et le risque de développer la maladie, en fonction du statut ménopausique

Sugar-sweetened beverage consumption and breast cancer in pre- and post-menopausal women

Garduño-Alanis, Adriana ; Angeles-Llerenas, Angelica ; Sánchez-Zamorano, Luisa Maria ; Flores-Luna, Lourdes ; Flores-Aldana, Mario ; Torres-Mejía, Gabriela

Background: The consumption of sugar-sweetened beverages (SSBs), of which Mexico is a large consumer, has been associated with the risk of breast cancer. We assessed the association between SSBs consumption and breast cancer risk in pre- and postmenopausal women. Methods: We performed a multicenter population-based case-control study in Mexico City, Monterrey, and Veracruz. We recruited 1,000 cases and 1,074 controls; all participants were pre- or postmenopausal women between 35 and 69 years of [...]

Menée à l'aide de données du "California Air Resources Board", cette étude analyse, sur la période 1996-2014, la part des cancers attribuable à une exposition aux polluants atmosphériques associés à l'utilisation d'essence et fait ainsi le point sur l'effet des politiques réglementaires concernant la formulation de l'essence et les émissions des véhicules en Californie

Analysis of gasoline-related pollutant exposures and risks in California between 1996 and 2014

Sultana, Daniel ; Hoover, Sara

Background: Gasoline-powered vehicles and equipment are an important source of air pollution in California. Many gasoline-related pollutants pose significant health concerns. The California Air Resources Board strictly regulates the state’s gasoline formulation and vehicle emissions. Objective: To investigate exposure trends for gasoline-related air pollutants between 1996 and 2014, capturing the period before and after the removal of methyl t-butyl ether (MTBE). Methods: We identified [...]

A partir d'une revue systématique de la littérature publiée jusqu'en janvier 2022 (24 articles), cette étude identifie des facteurs non héréditaires associés au risque de survenue précoce d'un adénocarcinome canalaire du pancréas

Risk factors for early-onset pancreatic ductal adenocarcinoma: a systematic literature review

Chandana, Sreenivasa R. ; Woods, Laura ; Maxwell, Fiona ; Gandolfo, Ruth ; Bekaii-Saab, Tanios

Background: Emerging cancer trends suggest an increase in pancreatic cancer incidence in individuals younger than its typical age of onset, potentially reflecting changes in population exposures and lifestyles. Patients and methods: We conducted a PRISMA-standard systematic literature review to identify non-heritable risk factors for early-onset pancreatic ductal adenocarcinoma (PDAC) (PROSPERO number: CRD42022299397). Systematic searches of MEDLINE and Embase bibliographic databases were [...]

Menée à partir de données 2005-2018 du "Breast Cancer Surveillance Consortium" portant sur 904 615 femmes ayant réalisé une mammographie de dépistage annuelle ou bisannuelle (âge médian : 57 ans), cette étude identifie des facteurs cliniques associés au risque de cancer du sein de stade avancé, en fonction du statut ménopausique et des origines ethniques

Population Attributable Risk of Advanced-Stage Breast Cancer by Race and Ethnicity

Kerlikowske, Karla ; Chen, Shuai ; Bissell, Michael C. S. ; Lee, Christoph I. ; Tice, Jeffrey A. ; Sprague, Brian L. ; Miglioretti, Diana L.

Advanced-stage breast cancer rates vary by race and ethnicity, with Black women having a 2-fold higher rate than White women among regular screeners. Clinical risk factors that explain a large proportion of advanced breast cancers by race and ethnicity are unknown.To evaluate the population attributable risk proportions (PARPs) for advanced-stage breast cancer (prognostic pathologic stage IIA or higher) associated with clinical risk factors among routinely screened premenopausal and [...]

Menée en Finlande à l'aide d'échantillons sanguins collectés auprès de femmes enceintes sur la période 1986-2010, cette étude analyse l'association entre le taux sérique maternel de 19 substances per- et polyfluoroalkyles (PFAS) et le risque de leucémie chez l'enfant (400 cas)

Maternal serum concentrations of per- and polyfluoroalkyl substances and childhood acute lymphoblastic leukemia

Jones, Rena R ; Madrigal, Jessica M ; Troisi, Rebecca ; Surcel, Helja-Marja ; Öhman, Hanna ; Kivelä, Juha ; Kiviranta, Hannu ; Rantakokko, Panu ; Koponen, Jani ; Medgyesi, Danielle N ; McGlynn, Katherine A ; Sampson, Joshua ; Albert, Paul S ; Ward, Mary H

Per- and polyfluoroalkyl substances (PFAS) are widespread and environmentally persistent chemicals with immunotoxic properties. Children are prenatally exposed through maternal transfer of PFAS to cord blood, but no studies have investigated the relationship with childhood leukemia.We measured maternal serum levels of 19 PFAS in first-trimester samples collected in 1986-2010 and evaluated associations with acute lymphoblastic leukemia (ALL) in full-term offspring (<15 years) for 400 cases [...]

Menée en France entre 2021 et 2023 par la recherche systématique de mutations du gène MBD4 chez 289 patients atteints d'un mélanome de l'uvée et 3 240 femmes présentant des antécédents familiaux de cancer du sein, cette étude analyse l'association entre une mutation mono-allélique du gène MBD4 et le risque de développer un mélanome de l'uvée ou d'autres tumeurs

Familial uveal melanoma and other tumours in 25 families with monoallelic germline MBD4 variants

Villy, Marie-Charlotte ; Le Ven, Anaïs ; Le Mentec, Marine ; Masliah-Planchon, Julien ; Houy, Alexandre ; Bièche, Ivan ; Vacher, Sophie ; Vincent-Salomon, Anne ; d’Enghien, Catherine Dubois ; Schwartz, Mathias ; Piperno-Neumann, Sophie ; Matet, Alexandre ; Malaise, Denis ; Bubien, Virginie ; Lortholary, Alain ; Ait Omar, Amal ; Cavaillé, Mathias ; Stoppa-Lyonnet, Dominique ; Cassoux, Nathalie ; Stern, Marc-Henri ; Rodrigues, Manuel ; Golmard, Lisa ; Colas, Chrystelle

Monoallelic germline MBD4 pathogenic variants (PVs) were recently reported to cause a predisposition to uveal melanoma (UM), associated with a specific tumour mutational signature and good response to immunotherapy. Monoallelic tumour PVs have also been described in brain tumours, breast cancers and myxofibrosarcomas, whereas biallelic germline MBD4 PVs have been involved in a recessive hereditary adenomatous polyposis and a specific type of acute myeloid leukaemia.We analysed MBD4 for all [...]

Menée à l'aide des données 2011-2016 d'une étude canadienne portant sur 902 témoins et 497 patientes atteintes d'un cancer de l'ovaire, cette étude analyse l'association entre l'adiposité pendant l'enfance et le risque de développer la maladie

Childhood body fatness and the risk of epithelial ovarian cancer: A population-based case-control study in Montreal, Canada

L'Espérance, Kevin ; Abrahamowicz, Michal ; O'Loughlin, Jennifer ; Koushik, Anita

Objective: To assess the association between childhood body fatness and epithelial ovarian cancer (EOC), and whether this association differs by type of EOC. Methods: Using data from a population-based case-control study (497 cases and 902 controls) in Montreal, Canada conducted 2011–2016, we examined the association between childhood body fatness and EOC, overall and separately for invasive vs. borderline EOCs. A figure rating scale was used to measure body fatness at ages 5 and 10. [...]

Menée au Japon en 2005 auprès de 4,6 millions de personnes (durée moyenne de suivi : 40,7 mois), cette étude analyse l'association entre un syndrome métabolique et le risque de cancer du pancréas (87 857 cas)

Metabolic syndrome is linked to the incidence of pancreatic cancer

Miyashita, Yohei ; Hitsumoto, Tatsuro ; Fukuda, Hiroki ; Kim, Jiyoong ; Ito, Shin ; Kimoto, Naoki ; Asakura, Koko ; Yata, Yutaka ; Yabumoto, Masami ; Washio, Takashi ; Kitakaze, Masafumi

Background: Although previous studies have showed that metabolic syndrome is one of the contributors of pancreatic cancer, there is no clear consensus that early stages of metabolic syndrome are linked to increased incidence of pancreatic cancer. Therefore, we confirmed the linkage between metabolic syndrome and pancreatic cancer, and shown that even early stage of metabolic syndrome is linked to pancreatic cancer in the retrospective observational study. Methods: We recruited approximately 4.6 [...]

Menée aux Etats-Unis auprès de 27 393 femmes ménopausées (durée médiane de suivi : 17,2 ans), cette étude analyse l'association entre la charge allostatique, évaluée par la concentration sérique de 8 biomarqueurs, et le risque de cancer du sein (1 722 cas)

Allostatic load and risk of invasive breast cancer among postmenopausal women in the U.S

Wang, Fengge ; Skiba, Meghan B. ; Follis, Shawna ; Liu, Nianjun ; Bidulescu, Aurelian ; Mitra, Anirban K. ; Mouton, Charles P. ; Qi, Lihong ; Luo, Juhua

Objective: Allostatic load can reflect the body's response to chronic stress. However, little is known about the association between allostatic load and risk of breast cancer in postmenopausal women. This study used a large prospective cohort in the United States to examine the relationship between allostatic load and invasive breast cancer risk, and to evaluate the relationship by racial and ethnic identity and breast cancer subtypes. Methods: Among 161,808 postmenopausal participants in [...]