Menée aux Etats-Unis par entretiens téléphoniques auprès de 24 patients atteints d’un cancer (âge médian : 57 ans), cette étude qualitative analyse leurs expériences liées à une utilisation de cannabis thérapeutique

Cancer patients’ experiences with medicinal cannabis–related care

Ilana M. Braun, Manan M. Nayak, Anna Revette (et al.)

Background : Little is known about medical cannabis (MC)–related care for patients with cancer using MC. Methods : Semistructured telephone interviews were conducted in a convenience sample of individuals (n = 24) with physician?confirmed oncologic diagnoses and state/district authorization to use MC (Arizona, California, Florida, Illinois, Massachusetts, Oregon, New York, and Washington, DC) from April 2017 to March 2019. Standard qualitative techniques were used to assess the degree of [...]

Mené sur 91 patients atteints d’un cancer, cet essai randomisé évalue l’efficacité du polaprézinc pour prévenir une mucite buccale induite par une chimiothérapie suivie d'une greffe de cellules souches hématopoïétiques

Polaprezinc for prevention of oral mucositis in patients receiving chemotherapy followed by hematopoietic stem cell transplantation: a multi-institutional randomized controlled trial

Junichi Kitagawa, Ryo Kobayashi, Yasuyuki Nagata (et al.)

Oral mucositis is a common and distressing complication in patients receiving high?dose chemotherapy followed by hematopoietic stem cell transplantation (HSCT). We reported previously in a single?center retrospective analysis that zinc?L?carnosine (polaprezinc, PZ) reduced the incidence of oral mucositis associated with HSCT. To verify the accuracy of the prophylactic effect of PZ against oral mucositis, we carried out a multi?institutional prospective randomized controlled study. Patients were [...]

Cette étude présente les recommandations de l'"European Society for Medical Oncology" concernant les stratégies de préservation de la fertilité chez des patients atteints d'un cancer après la puberté

Fertility preservation and post-treatment pregnancies in post-pubertal cancer patients: ESMO Clinical Practice Guidelines

Lambertini, M. ; Peccatori, F. A. ; Demeestere, I. ; Amant, F. ; Wyns, C. ; Stukenborg, J. B. ; Paluch-Shimon, S. ; Halaska, M. J. ; Uzan, C. ; Meissner, J. ; von Wolff, M. ; Anderson, R. A. ; Jordan, K.

Cancer remains a public health problem worldwide that also includes young adults.1 Given the ongoing improvements in survival for most malignancies, a significant proportion of people affected by cancer face the consequences of treatment-related late effects, making survivorship an area of crucial importance. At the time of diagnosis, a significant proportion of young patients are concerned about the possible impact of anticancer treatments on their fertility and future chances of [...]

Mené au Royaume-Uni par questionnaire auprès de 46 patients ayant survécu à un lymphome, cet essai randomisé compare l’efficacité, du point de vue de l’amélioration de la qualité de vie, d’une intervention à base de relaxation et d’une intervention à base d’exercices physiques après une chimiothérapie

Relaxation versus exercise for improved quality of life in lymphoma survivors—a randomised controlled trial

Suchita Hathiramani, R. Pettengell, H. Moir, A. Younis

Purpose : Lymphoma survivors experience persisting needs as a consequence of disease and treatment, which have an impact on quality of life (QoL). There is evidence supporting the use of relaxation and exercise to improve QoL, but there is no agreement on which is more beneficial. This study aims to compare a relaxation intervention versus an exercise intervention to determine which has a greater impact on QoL post-chemotherapy. Methods : Eligible participants (n?=?46) were randomised to a [...]

Mené aux Etats-Unis sur 55 patients atteints d’un cancer du poumon non à petites cellules, cet essai de phase II compare l’efficacité de la plinabuline et du pegfilgrastim pour prévenir une neutropénie induite par une chimiothérapie à base de docétaxel

Efficacy of Plinabulin vs Pegfilgrastim for Prevention of Chemotherapy-Induced Neutropenia in Adults With Non–Small Cell Lung Cancer :A Phase 2 Randomized Clinical Trial

Douglas W. Blayney, Qingyuan Zhang, Jifeng Feng (et al.)

Importance : Plinabulin is a novel, non–granulocyte colony-stimulating factor (GCSF) small molecule with both anticancer and neutropenia-prevention effects. Objective : To assess the efficacy and safety of plinabulin compared with pegfilgrastim for the prevention of chemotherapy-induced neutropenia following docetaxel chemotherapy in patients with non–small lung cancer. Design, Setting, and Participants : This was a randomized, open-label, phase 2 clinical trial of 4 treatment arms that was [...]

Menée en Australie par questionnaire auprès de 558 puis 387 patients atteints d’un cancer de la prostate, cette étude de cohorte prospective analyse leurs besoins en soins de support pour leur sexualité après une prostatectomie radicale ou d’autres traitements anticancéreux non hormonaux

Men’s sexual help-seeking and care needs after radical prostatectomy or other non-hormonal, active prostate cancer treatments

Melissa K. Hyde, Melissa Opozda, Kirstyn Laurie, Andrew D. Vincent (et al.)

Objective : To examine prostate cancer (PCa) survivors’ sexual help-seeking intentions, behaviours, and unmet needs. Methods : In this prospective cohort study, men who underwent active, non-hormonal treatment completed baseline (N = 558) and 6-month follow-up (N = 387) questionnaires. Theory of planned behaviour (TPB) constructs (sexual help-seeking intention, perceived behavioural control (PBC), subjective norm, attitude), masculine values (e.g., sexual importance/priority, emotional [...]

Menée au Danemark par questionnaire auprès de 2 234 patients ayant survécu à un cancer du testicule, cette étude de cohorte analyse la neurotoxicité des traitements anticancéreux et l’effet de cette toxicité sur la qualité de vie (durée médiane de suivi : 18,4 ans)

Long-term neurotoxicity and quality of life in testicular cancer survivors—a nationwide cohort study

Jakob Lauritsen, Mikkel Bandak, Michael Kreiberg (et al.)

Purpose : To evaluate neurotoxicity in testicular cancer survivors (TCSs) years after treatment and secondly the influence of neurotoxicity on quality-of-life (QoL). Methods : We identified 2234 TCSs who completed the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity questionnaire. QoL was evaluated with the European Organization for Research and Treatment of Cancer QLQ-C30. Patients were grouped according to treatment strategy: surveillance (N?=?1113), [...]

Menée aux Etats-Unis sur la période 2007-2011, cette étude analyse, au niveau du comté, l'association entre la pauvreté et le taux de mortalité par cancer

Persistent Poverty and Cancer Mortality Rates: An Analysis of County-Level Poverty Designations

Moss, Jennifer L. ; Pinto, Casey N. ; Srinivasan, Shobha ; Cronin, Kathleen A. ; Croyle, Robert T.

Background: Cancer mortality is higher in counties with high levels of (current) poverty, but less is known about associations with persistent poverty. Persistent poverty counties (with ≥20% of residents in poverty since 1980) face social, structural, and behavioral challenges that may make their residents more vulnerable to cancer. Methods: We calculated 2007 to 2011 county-level, age-adjusted, and overall and type-specific cancer mortality rates (deaths/100,000 people/year) by persistent [...]

Menée aux Etats-Unis à partir de données portant sur 2 139 adultes ayant survécu à un cancer pédiatrique et sur 282 témoins, cette étude analyse l’association entre l’accélération du vieillissement induit par des processus épigénétiques, l’exposition aux traitements anticancéreux, des comportements de santé et des comorbidités

Epigenetic Age Acceleration and Chronic Health Conditions among Adult Survivors of Childhood Cancer

Na Qin, MD, Zhenghong Li, Nan Song (et al.)

Background : Mounting evidence supports the occurrence of accelerating aging among long-term survivors of childhood cancer. We aimed to investigate epigenetic age acceleration (EAA) in survivors and evaluate associations between EAA, treatment exposures, health behaviors, and chronic health conditions (CHCs). Methods : Genome-wide methylation data were generated with Infinium EPIC BeadChip on blood-derived DNA from 2139 survivors and 282 frequency matched controls from the St. Jude Lifetime [...]

Menée en France à partir des données de 11 registres des cancers portant sur 287 patients atteints d’un cancer localisé de la prostate diagnostiqué en 2001 et sur des témoins, cette étude analyse l’évolution, 10 ans après les traitements anticancéreux, de leurs conditions de vie familiales, sociales et professionnelles et leur qualité de vie

Evaluation of long-term living conditions in patients treated for localised prostate cancer

Dingyu Xiao, Anne?Valérie Guizard, Laetitia Daubisse?Marliac (et al.)

Purpose : To evaluate the evolution of living conditions (LC) in long?term survivors of localised prostate cancer 10 years after treatment compared with those of a same?age control group from the general population. Methods : Two hundred and eighty?seven patients diagnosed with prostate cancer in 2001 were selected in 11 French cancer registries. They were matched with controls randomly selected for age and residency. Both patients and controls completed a self?administered LC questionnaire [...]

Menée à partir des données des registres américains des cancers, cette étude présente une estimation du taux de récidive de la maladie chez des patients atteints d'un cancer colorectal diagnostiqué sur la période 1975-1984 et diagnostiqué sur la période 1994-2003

Estimating population-based recurrence rates of colorectal cancer over time in the United States

Kunst, Natalia ; Alarid-Escudero, Fernando ; Aas, Eline ; Coupé, Veerle M.H. ; Schrag, Deborah ; Kuntz, Karen M.

Background: Population-based metastatic recurrence rates for patients diagnosed with non-metastatic colorectal cancer (CRC) cannot be estimated directly from population-based cancer registries because recurrence information is not reported. We derived population-based CRC recurrence rates using disease-specific survival data based on our understanding of the CRC recurrence-death process. Methods: We used a statistical continuous-time multistate survival model to derive population-based annual [...]

Menée à partir des données de la base GLOBOCAN, cette étude analyse, pour l'année 2018 et au niveau mondial, l'incidence du cancer de la vessie, la mortalité spécifique selon le sexe, et examine leur association avec une utilisation de produits tabagiques et le produit intérieur brut par habitant

Global Trends of Bladder Cancer Incidence and Mortality, and Their Associations with Tobacco Use and Gross Domestic Product Per Capita

Teoh, Jeremy Yuen-Chun ; Huang, Junjie ; Ko, Wendy Yuet-Kiu ; Lok, Veeleah ; Choi, Peter ; Ng, Chi-Fai ; Sengupta, Shomik ; Mostafid, Hugh ; Kamat, Ashish M. ; Black, Peter C. ; Shariat, Shahrokh ; Babjuk, Marek ; Wong, Martin Chi-Sang

Background : Bladder cancer is a major urological disease, with approximately 550 000 new cases diagnosed in 2018. Objective : We examined gender-specific incidence and mortality patterns, and trends of bladder cancer from a global perspective. We further investigated their associations with tobacco use and gross domestic product (GDP) per capita. Design, setting, and participants : We retrieved data on the incidence and mortality of bladder cancer from the GLOBOCAN database, Cancer Incidence [...]

Mené aux Etats-Unis sur 103 patients atteints d’un cancer de stade avancé (âge médian : 67 ans) et sur 39 aidants (âge médian : 66 ans), cet essai randomisé évalue l’efficacité d’une intervention basée sur le concept de la pleine conscience et dispensée via téléphone portable pour améliorer leur qualité de vie et diminuer leur détresse psychologique

Pilot pragmatic randomized trial of mHealth mindfulness-based intervention for advanced cancer patients and their informal caregivers

Ai Kubo, Elaine Kurtovich, MegAnn McGinnis, Sara Aghaee (et al.)

Objective : Assess the feasibility of conducting a cluster randomized trial (RCT) comparing technology?delivered mindfulness?based intervention (MBI) programs against a waitlist control arm targeting advanced cancer patients and their informal caregivers. Methods : Two?arm cluster RCT within Kaiser Permanente Northern California (KPNC). We recruited patients with metastatic solid malignancies or hematological cancers and their informal caregivers. Intervention?group participants chose to use [...]

Mené sur 167 patients atteints d'un cancer traité par chimiothérapie (âge médian : 51 ans), cet essai de phase III évalue l'intérêt d'un programme de réadaptation cognitive assistée par ordinateur pour prendre en charge leurs déficiences cognitives et leurs symptômes de dépression et d'anxiété

Cognitive rehabilitation program to improve cognition of cancer patients treated with chemotherapy: A 3-arm randomized trial

Dos Santos, Mélanie ; Hardy-Léger, Isabelle ; Rigal, Olivier ; Licaj, Idlir ; Dauchy, Sarah ; Levy, Christelle ; Noal, Sabine ; Segura, Carine ; Delcambre, Corinne ; Allouache, Djelila ; Parzy, Aurélie ; Barriere, Jérôme ; Petit, Thierry ; Lange, Marie ; Capel, Aurélie ; Clarisse, Bénédicte ; Grellard, Jean Michel ; Lefel, Johan ; Joly, Florence

Background : There is no treatment for cancer‐related cognitive impairment, an important adverse effect that negatively impacts quality of life (QOL). We conducted a 3‐arm randomized controlled trial to evaluate the impact of computer‐assisted cognitive rehabilitation (CR) on cognition, QOL, anxiety, and depression among cancer patients treated with chemotherapy. Methods : Patients who reported cognitive complaints during or after completing chemotherapy were randomly assigned to 1 of 3 12‐week [...]

Menée en Norvège par enquête auprès de 936 jeunes adultes ayant survécu 5 ans à un cancer (âge lors du diagnostic : 19-39 ans), cette étude de cohorte analyse les facteurs associés à la peur de la récidive

Fear of cancer recurrence among young adult cancer survivors—exploring long-term contributing factors in a large, population-based cohort

Kathrine F. Vandraas, Kristin V. Reinertsen, Cecilie E. Kiserud (et al.)

Purpose : Fear of cancer recurrence (FCR) may be debilitating, yet knowledge of FCR among the growing population of long-term young adult cancer survivors (YACS) is scarce. We explored risk of FCR and associated factors in a nation-wide, population-based cohort of YACS. Methods : All 5-year survivors diagnosed at the ages of 19–39 years with breast cancer (BC), malignant melanoma (MM), colorectal cancer (CRC), leukemia (LEU), or non-Hodgkin lymphoma (NHL) between 1985 and 2009 in Norway were [...]

Menée dans un contexte américain, cette étude compare le rapport coût-efficacité d'un test génétique suivi d'un traitement de première ligne personnalisé et d'un traitement par imatinib chez des patients atteints d'une tumeur stromale gastrointestinale de stade métastatique récemment diagnostiquée

Cost-effectiveness Analysis of Genetic Testing and Tailored First-Line Therapy for Patients With Metastatic Gastrointestinal Stromal Tumors

Banerjee, Sudeep ; Kumar, Abhishek ; Lopez, Nicole ; Zhao, Beiqun ; Tang, Chih-Min ; Yebra, Mayra ; Yoon, Hyunho ; Murphy, James D. ; Sicklick, Jason K.

Importance : Gastrointestinal stromal tumor (GIST) is frequently driven by oncogenic KIT variations. Imatinib targeting of KIT marked a new era in GIST treatment and ushered in precision oncological treatment for all solid malignant neoplasms. However, studies on the molecular biological traits of GIST have found that tumors respond differentially to imatinib dosage based on the KIT exon with variation. Despite this knowledge, few patients undergo genetic testing at diagnosis, and empirical [...]

Menée en Italie à partir de données portant sur 160 patients atteints d’un cancer, cette étude rétrospective estime les coûts associés à la radiothérapie dispensée dans leur dernier mois de vie

The challenge of sustainability in healthcare systems: cost of radiotherapy in the last month of life in an Italian cancer center

Romina Rossi, Valentina Danesi, Ilaria Massa, William Balzi (et al.)

Purpose : Cost evaluation is becoming mandatory to support healthcare sustainability and optimize the decision-making process. This topic is a challenge, especially for complex and rapidly evolving treatment modalities such as radiotherapy (RT). The aim of the present study was to investigate the cost of RT in the last month of life of patients in an Italian cancer center. Methods : This was a retrospective study on a cancer population (N=?160) who underwent RT or only an RT planning simulation [...]

Menée dans un contexte américain, cette étude compare le rapport coût-efficacité d'un traitement par pembrolizumab-axitinib et d'un traitement par sunitinib en première ligne chez des patients atteints d'un carcinome à cellules rénales

Cost-Effectiveness of Pembrolizumab plus Axitinib Versus Sunitinib as First-Line Therapy in Advanced Renal Cell Carcinoma in the U.S

Ding, Dong ; Hu, Huabin ; Shi, Yin ; She, Longjiang ; Yao, Linli ; Zhu, Youwen ; Zeng, Shan ; Shen, Liangfang ; Huang, Jin

Background : The data from the phase III clinical trial KEYNOTE-426 indicated that pembrolizumab plus axitinib compared with sunitinib could generate clinical benefits in patients with previously untreated advanced renal cell carcinoma (RCC). Given the incremental clinical benefits, we examined the potential cost-effectiveness of pembrolizumab plus axitinib versus sunitinib in the first-line setting for patients with advanced RCC from the U.S. payers’ perspective. Materials and Methods : Cost [...]

A partir d'une revue de la littérature (40 articles), cette étude analyse, dans les pays à faibles ou moyens revenus, les facteurs facilitant ou entravant la communication entre les soignants, les enfants atteints d'un cancer et leurs aidants familiaux

Pediatric cancer communication in low- and middle-income countries: A scoping review

Graetz, Dylan E. ; Garza, Marcela ; Rodriguez-Galindo, Carlos ; Mack, Jennifer W.

The burden of global childhood cancer lies in low- and middle-income countries (LMICs). Communication is essential to pediatric cancer care, and the National Cancer Institute (NCI) has defined 6 functions of communication between patients, family members, and providers, including 1) fostering healing relationships, 2) responding to emotions, 3) exchanging information, 4) making decisions, 5) managing uncertainty, and 6) enabling self-management. Nevertheless, communication needs and practices [...]