Menée aux Etats-Unis auprès des participantes de la "California Teachers Study" (âge médian : 53 ans), cette étude analyse l'association entre une consommation de riz, source potentielle d'arsenic, et le risque de cancer du sein (7 351 cas), du poumon (1 100 cas), du pancréas (411 cas), de la vessie (344 cas) et du rein (238 cas)

Association between rice consumption and risk of cancer incidence in the California Teachers Study

Sanchez, Tiffany R. ; Klu, Yaa Asantewaa Kafui ; Genkinger, Jeanine M. ; Lacey, James V. ; Chung, Nadia T. ; Navas-Acien, Ana

Purpose: We evaluated the contribution of rice intake, a source of dietary arsenic, to cancer risk in a population of women with likely low arsenic exposure from drinking water and variable rice intake who participated in the California Teachers Study. Methods: Rice consumption was categorized into quartiles (< 9.6, 9.7–15.6, 15.7–42.7, and ≥ 42.8 g/day). Multivariable-adjusted hazard ratios and 95% confidence intervals (95% CI) for incident cancer were estimated comparing rice consumption [...]

A partir d'une revue systématique de la littérature publiée jusqu'en mars 2019 (55 articles), cette étude évalue l'association entre les niveaux sériques de la protéine C-réactive et la présence de maladies chroniques (maladies cardiovasculaires, maladies auto-immunes, cancers, ...)

Global assessment of C-reactive protein and health-related outcomes: an umbrella review of evidence from observational studies and Mendelian randomization studies

Markozannes, Georgios ; Koutsioumpa, Charalampia ; Cividini, Sofia ; Monori, Grace ; Tsilidis, Konstantinos K. ; Kretsavos, Nikolaos ; Theodoratou, Evropi ; Gill, Dipender ; Ioannidis, John P. A. ; Tzoulaki, Ioanna

C-reactive protein (CRP) has been studied extensively for association with a large number of non-infectious diseases and outcomes. We aimed to evaluate the breadth and validity of associations between CRP and non-infectious, chronic health outcomes and biomarkers. We conducted an umbrella review of systematic reviews and meta-analyses and a systematic review of Mendelian randomization (MR) studies. PubMed, Scopus, and Cochrane Database of Systematic Reviews were systematically searched from [...]

A partir d'une revue systématique de la littérature publiée jusqu'en décembre 2019 (66 études), cette méta-analyse évalue l'association entre 20 facteurs de reproduction et le risque de cancer du poumon

Reproductive factors and lung cancer risk: a comprehensive systematic review and meta-analysis

Yin, Xin ; Zhu, Zhiying ; Hosgood, H. Dean ; Lan, Qing ; Seow, Wei Jie

Background: A number of studies have investigated the association between reproductive factors and lung cancer risk, however findings are inconsistent. This meta-analysis aimed to evaluate the association between female reproductive factors and lung cancer risk. Methods: We conducted a comprehensive systematic search to identify relevant and eligible studies published before 18th December 2019. Inter-study heterogeneity was assessed using the Q test and I2 statistic. Based on the heterogeneity [...]

Menée à partir de données génétiques portant sur 473 patients atteints d'un cancer colorectal avec prédisposition familiale et à l'aide des résultats de 5 études portant sur 6 200 patients supplémentaires, cette étude analyse l'association entre des variants pathogènes du gène TP53 et le risque de développer un cancer colorectal chez des patients ne présentant pas les caractéristiques d'un syndrome de Li-Fraumeni

TP53, a gene for colorectal cancer predisposition in the absence of Li-Fraumeni-associated phenotypes

Terradas, Mariona ; Mur, Pilar ; Belhadj, Sami ; Woodward, Emma R ; Burghel, George J ; Munoz-Torres, Pau M ; Quintana, Isabel ; Navarro, Matilde ; Brunet, Joan ; Lázaro, Conxi ; Pineda, Marta ; Moreno, Víctor ; Capella, Gabriel ; Evans, D Gareth R ; Valle, Laura

Objective: Germline TP53 pathogenic (P) variants cause Li-Fraumeni syndrome (LFS), an aggressive multitumor-predisposing condition. Due to the implementation of multigene panel testing, TP53 variants have been detected in individuals without LFS suspicion, for example, patients with colorectal cancer (CRC). We aimed to decipher whether these findings are the result of detecting the background population prevalence or the aetiological basis of CRC. Design: We analysed TP53 in 473 [...]

Menée à partir des données d'un registre américain portant sur 124 témoins et sur 62 femmes ayant un risque familial de cancer du sein (âge moyen : 48,8 ans), cette étude analyse l'association entre le métabolome stéroïdien (androgènes surrénaliens et glucocorticoïdes) et le risque de développer la maladie

The steroid metabolome and breast cancer risk in women with a family history of breast cancer: the novel role of adrenal androgens and glucocorticoids

Houghton, Lauren C ; Howland, Renata E. ; Wei, Ying ; Ma, Xinran ; Kehm, Rebecca D ; Chung, Wendy K. ; Genkinger, Jeanine M ; Santella, Regina M ; Hartmann, Michaela F. ; Wudy, Stefan A. ; Terry, Mary Beth

Background: No study has comprehensively examined how the steroid metabolome is associated with breast cancer (BC) risk in women with familial risk. Methods: We examined 36 steroid metabolites across the spectrum of familial risk (5-year risk ranged from 0.14 to 23.8%) in pre- and post-menopausal women participating in the NY site of the Breast Cancer Family Registry (BCFR). We conducted a nested case-control study with 62 cases/124 controls individually matched on menopausal status, age and [...]

Menée à partir de données portant sur 2 011 patients atteints d'un cancer de la vessie et sur 2 259 témoins, cette étude analyse l'association entre la longueur des télomères leucocytaires et le risque de développer la maladie

Leukocyte telomere length and bladder cancer risk: a large case control study and Mendelian randomization analysis

Chen, Meng ; Xu, Yifan ; Xu, Junfeng ; Chancoco, Haidee ; Gu, Jian

Background: Leukocyte telomere length (LTL) has been associated with risk of several cancers. The association between LTL and bladder cancer is still inconsistent. Methods: In this large case control study consisting of 2,011 bladder cancer patients and 2,259 healthy controls of European ancestry, we investigated the associations of real-time quantitative PCR (qPCR) measured LTL (a retrospective case control study) and genetically predicted LTL (a Mendelian randomization [MR] study) with [...]