Menée aux Pays-Bas par questionnaires auprès de 700 et 46 patientes atteintes d'un cancer du sein, cette étude analyse les facteurs sociodémographiques, cliniques et psychiques associés à leurs besoins en soins après les traitements anticancéreux

Risk factors of unmet needs among women with breast cancer in the post-treatment phase

Lo-Fo-Wong, Deborah N.N. ; de Haes, Hanneke C.J.M. ; Aaronson, Neil K. ; van Abbema, Doris L. ; den Boer, Mathilda D. ; van Hezewijk, Marjan ; Immink, Marcelle ; Kaptein, Ad A. ; Menke-Pluijmers, Marian B.E. ; Reyners, Anna K.L. ; Russell, Nicola S. ; Schriek, Manon ; Sijtsema, Sieta ; van Tienhoven, Geertjan ; Verdam, Mathilde G.E. ; Sprangers, Mirjam A.G.

Objective : Unmet health care needs require additional care resources to achieve optimal patient well‐being. In this nationwide study we examined associations between a number of risk factors and unmet needs after treatment among women with breast cancer, while taking into account their health care practices. We expected that more care use would be associated with lower levels of unmet needs. Methods : A multicenter, prospective, observational design was employed. Women with primary breast [...]

Menée aux Etats-Unis à partir des données de 3 cohortes prospectives incluant 168 153 femmes et 49 602 hommes sans antécédent de cancer lors de l'inclusion, cette étude analyse l'association entre une consommation de produits laitiers et la mortalité par cancer (durée de suivi : 32 ans, 51 438 décès dont 15 120 décès par cancer)

Associations of dairy intake with risk of mortality in women and men: three prospective cohort studies

Ding, Ming ; Li, Jun ; Qi, Lu ; Ellervik, Christina ; Zhang, Xuehong ; Manson, JoAnn E ; Stampfer, Meir ; Chavarro, Jorge E ; Rexrode, Kathryn M ; Kraft, Peter ; Chasman, Daniel ; Willett, Walter C ; Hu, Frank B

Objective :To examine the association of consumption of dairy foods with risk of total and cause specific mortality in women and men. Design :Three prospective cohort studies with repeated measures of diet and lifestyle factors. Setting :Nurses’ Health Study, Nurses’ Health Study II, and the Health Professionals Follow-up Study, in the United States. Participants :168 153 women and 49 602 men without cardiovascular disease or cancer at baseline. Main outcome measure :Death confirmed by state [...]

Menée à partir de données portant sur 2 448 patients atteints d'une leucémie lymphoblastique aiguë (âge : 1 - 45 ans), cette étude prospective analyse, en fonction de l'âge, les facteurs associés au risque de pancréatite liée à l'asparaginase

Asparaginase-Associated Pancreatitis in Acute Lymphoblastic Leukemia: Results From the NOPHO ALL2008 Treatment of Patients 1-45 Years of Age

Cecilie U. Rank ; Benjamin O. Wolthers ; Kathrine Grell ; Birgitte K. Albertsen ; Thomas L. Frandsen ; Ulrik M. Overgaard ; Nina Toft ; Ove J. Nielsen ; Peder S. Wehner ; Arja Harila-Saari ; Mats M. Heyman ; Johan Malmros ; Jonas Abrahamsson ; Ulrika Norén-Nyström ; Beata Tomaszewska-Toporska ; Bendik Lund ; Kirsten B. Jarvis ; Petter Quist-Paulsen ; Goda E. Vaitkevičienė ; Laimonas Griškevičius ; Mervi Taskinen ; Ulla Wartiovaara-Kautto ; Kristi Lepik ; Mari Punab ; Ólafur G. Jónsson ; Kjeld Schmiegelow

PURPOSE : Asparaginase-associated pancreatitis (AAP) is common in patients with acute lymphoblastic leukemia (ALL), but risk differences across age groups both in relation to first-time AAP and after asparaginase re-exposure have not been explored. PATIENTS AND METHODS : We prospectively registered AAP (n = 168) during treatment of 2,448 consecutive ALL patients aged 1.0-45.9 years diagnosed from July 2008 to October 2018 and treated according to the Nordic Society of Pediatric Hematology and [...]

Menée à partir des données des registres américains des cancers sur la période 2001-2015, cette étude analyse l'évolution de l'incidence de la leucémie-lymphome à cellules T chez l'adulte et les facteurs associés à la survie (2 148 cas)

Epidemiology and survival trend of adult T-cell leukemia/lymphoma in the United States

Shah, Urvi A. ; Shah, Nishi ; Qiao, Baozhen ; Acuna-Villaorduna, Ana ; Pradhan, Kith ; Adrianzen Herrera, Diego ; Sica, R. Alejandro ; Shastri, Aditi ; Mantzaris, Ioannis ; Derman, Olga ; Kornblum, Noah ; Braunschweig, Ira ; Ye, B. Hilda ; Verma, Amit ; Janakiram, Murali

Background : Globally, 5 million to 10 million people are infected with human T‐cell leukemia virus type 1, which causes adult T‐cell leukemia/lymphoma (ATLL) in 2% to 5% of the carriers. ATLL is a rare but extremely aggressive malignancy that can be challenging to diagnose. Very little data exist on the incidence patterns of ATLL in the United States. Methods : ATLL cases reported to the National Program of Cancer Registries, the Surveillance, Epidemiology, and End Results (SEER) program, and [...]

Menée en Irlande à partir de données portant sur 130 patients atteints d'un adénocarcinome de l'œsophage entre 2004 et 2012, cette étude de cohorte analyse l'association entre une consommation d'alcool, le tabagisme et la survie

Alcohol intake, tobacco smoking, and esophageal adenocarcinoma survival: a molecular pathology epidemiology cohort study

McCain, R. Stephen ; McManus, Damian T. ; McQuaid, Stephen ; James, Jacqueline A. ; Salto-Tellez, Manuel ; Reid, Nathan B. ; Craig, Stephanie ; Chisambo, Chintapuza ; Bingham, Victoria ; McCarron, Eamon ; Parkes, Eileen ; Turkington, Richard C. ; Coleman, Helen G.

Purpose : To investigate the association between cigarette smoking, alcohol consumption, and esophageal adenocarcinoma survival, including stratified analysis by selected prognostic biomarkers. Methods : A population-representative sample of 130 esophageal adenocarcinoma patients (n = 130) treated at the Northern Ireland Cancer Centre between 2004 and 2012. Cox proportional hazards models were applied to evaluate associations between smoking status, alcohol intake, and survival. Secondary [...]

Menée au Japon à partir de données portant sur 191 patients atteints d'un carcinome thymique de stade avancé, cette étude rétrospective analyse les facteurs associés à la survie globale après une chimiothérapie de seconde ligne

Clinical Outcomes of Second-Line Chemotherapy in Patients with Previously Treated Advanced Thymic Carcinoma: A Retrospective Analysis of 191 Patients from the NEJ023 Study

Tateishi, Kazunari ; Ko, Ryo ; Shukuya, Takehito ; Okuma, Yusuke ; Watanabe, Satoshi ; Kuyama, Shoichi ; Murase, Kyoko ; Tsukita, Yoko ; Ashinuma, Hironori ; Nakagawa, Taku ; Uematsu, Kazutsugu ; Nakao, Mika ; Mori, Yoshiaki ; Kaira, Kyoichi ; Mouri, Atsuto ; Miyabayashi, Takao ; Sakashita, Hiroyuki ; Matsumoto, Yoko ; Tanigawa, Tomoyuki ; Koizumi, Tomonobu ; Morita, Satoshi ; Kobayashi, Kunihiko ; Nukiwa, Toshihiro ; Takahashi, Kazuhisa ; North East Japan Study Group

Background : Owing to the rarity of this tumor, there is limited information about second-line chemotherapy for patients with previously treated advanced thymic carcinoma. Material and Methods : We performed a multi‐institutional, retrospective study named NEJ023 for patients with advanced thymic carcinoma. Patients without indications for curative treatment were treated with chemotherapy from 1995 to 2014 at 40 institutions in the North East Japan Study Group. Demographic and clinicopathologic [...]

Menée à partir des données des registres américains des cancers portant sur 9 017 patientes atteintes d'un cancer épithélial de l'ovaire diagnostiqué entre l'âge de 15 et de 44 ans, cette étude analyse les facteurs associés au recours à un traitement chirurgical préservant la fertilité (salpingo-ovariectomie unilatérale et conservation utérine), puis analyse l'association entre ce traitement et la survie globale, en fonction des caractéristiques de la tumeur (stade, grade, histologie)

Fertility-sparing surgery and survival among reproductive-age women with epithelial ovarian cancer in 2 cancer registries

Crafton, Sarah M. ; Cohn, David E. ; Llamocca, Elyse N. ; Louden, Elaine ; Rhoades, Jennifer ; Felix, Ashley S.

Background : This study examined predictors of fertility‐sparing surgery (FSS) among reproductive‐age women diagnosed with epithelial ovarian cancer (EOC). In addition, relationships between FSS and survival were assessed in models stratified by tumor characteristics. Methods : The Surveillance, Epidemiology, and End Results (SEER) program and the National Cancer Database (NCDB) were queried for women 44 years old or younger with a primary EOC. FSS included unilateral salpingo‐oophorectomy and [...]

Menée auprès de 2 631 patients atteints d'un cancer du poumon diagnostiqué entre 2012 et 2015 (âge : 40 ans ou plus), cette étude analyse pour 10 pays les délais entre la survenue des symptômes, le diagnostic de la maladie et l'accès au traitement

Time intervals and routes to diagnosis for lung cancer in 10 jurisdictions: cross-sectional study findings from the International Cancer Benchmarking Partnership (ICBP)

Menon, Usha ; Vedsted, Peter ; Zalounina Falborg, Alina ; Jensen, Henry ; Harrison, Samantha ; Reguilon, Irene ; Barisic, Andriana ; Bergin, Rebecca J. ; Brewster, David H. ; Butler, John ; Brustugun, Odd Terje ; Bucher, Oliver ; Cairnduff, Victoria ; Gavin, Anna ; Grunfeld, Eva ; Harland, Elizabeth ; Kalsi, Jatinderpal ; Knudsen, Anne Kari ; Lambe, Mats ; Law, Rebecca-Jane ; Lin, Yulan ; Malmberg, Martin ; Turner, Donna ; Neal, Richard D. ; White, Victoria ; Weller, David

Objective: Differences in time intervals to diagnosis and treatment between jurisdictions may contribute to previously reported differences in stage at diagnosis and survival. The International Cancer Benchmarking Partnership Module 4 reports the first international comparison of routes to diagnosis and time intervals from symptom onset until treatment start for patients with lung cancer. Design : Newly diagnosed patients with lung cancer, their primary care physicians (PCPs) and cancer [...]

Menée à partir des données du "Centre international de recherche sur le cancer" et des registres de 28 pays européens, cette étude présente des projections d'incidence du cancer du testicule, pour la période 2010-2035

Testicular cancer incidence predictions in Europe 2010-2035: a rising burden despite population ageing

Znaor, A. ; Skakkebaek, N.E. ; Rajpert-De Meyts, E. ; Laversanne, M. ; Kuliš, T. ; Gurney, J. ; Sarfati, D. ; McGlynn, K.A. ; Bray, F.

Testicular cancer is the most common cancer among young men of European ancestry, with about one-third of all cases occurring in Europe. With the historically increasing trends in some high-incidence populations reported to have stabilised in recent years, we aimed to assess recent trends and predict the future testicular cancer incidence burden across Europe. We extracted testicular cancer (ICD-10 C62) incidence data from Cancer Incidence in Five Continents Volumes VII-XI and complemented this [...]

Menée au Canada à partir de données portant sur 94 patients atteints d'une tumeur desmoïde (âge moyen : 40 ans), cette étude identife les facteurs associés à la persistence d'une détresse émotionnelle

High Prevalence of Persistent Emotional Distress in Desmoid Tumor

Ingley, K.M. ; Klein, R. ; Theobalds, N. ; Burtenshaw, S. ; Abdul Razak, A.R. ; Chen, B. ; Xu, W. ; Gladdy, R. ; Li, M. ; Gupta, A.A.

Abstract : Clinical experience suggests a high prevalence of emotional distress in patients with desmoid tumor (DT). We examine longitudinal Distress Assessment and Response Tool (DART) scores to estimate prevalence and persistence of distress, and compare cross sectional data between DT and malignant sarcoma cohorts, to identify predictors of distress. Methods : Patients with DT completed DART at: T1‐ diagnosis, T2‐ during, T3‐ <6 months and T4‐ ≥6 months, post‐treatment. DART includes [...]

Menée dans 10 pays d'Europe centrale et d'Europe de l'est, cette étude analyse l'accès aux nouveaux traitements anticancéreux pour les patients atteints d'un cancer du poumon non à petites cellules, les coûts et les politiques de remboursement associés

Access to Novel Drugs for Non-Small Cell Lung Cancer in Central and Southeastern Europe: A Central European Cooperative Oncology Group Analysis

Cufer, Tanja ; Ciuleanu, Tudor E. ; Berzinec, Peter ; Galffy, Gabriela ; Jakopovic, Marko ; Jassem, Jacek ; Jovanovic, Dragana ; Mihaylova, Zhasmina ; Ostoros, Gyula ; Thallinger, Christiane ; Zemanova, Milada ; Zielinski, Christoph

Background : Treatment of non‐small cell lung cancer (NSCLC) improved substantially in the last decades. Novel targeted and immune‐oncologic drugs were introduced into routine treatment. Despite accelerated development and subsequent drug registrations by the European Medicinal Agency (EMA), novel drugs for NSCLC are poorly accessible in Central and Eastern European (CEE) countries. Material and Methods : The Central European Cooperative Oncology Group conducted a survey among experts from 10 [...]

Mené au Canada par enquête auprès de 1 118 patients ayant survécu à un cancer, cette étude analyse leurs connaissances concernant les méfaits de la poursuite du tabagisme après le diagnostic

Awareness of the Harms of Continued Smoking Among Cancer Survivors

Eng, Lawson ; Alton, Devon ; Song, Yuyao ; Su, Jie ; Zhang, Qihuang ; Che, Jiahua ; Farzanfar, Delaram ; Mohan, Rahul ; Krys, Olivia ; Mattina, Katie ; Harper, Christopher ; Liu, Sophia ; Yoannidis, Tom ; Milne, Robin ; Abdelmutti, Nazek ; Brown, M. Catherine ; Vennettilli, Ashlee ; Hope, Andrew J. ; Howell, Doris ; Jones, Jennifer M. ; Selby, Peter ; Evans, William K. ; Xu, Wei ; Goldstein, David Paul ; Giuliani, Meredith Elana ; Liu, Geoffrey

Background : Smoking cessation is an integral part of cancer survivorship. To help improve survivorship education, clinicians need an understanding of patient awareness of the harms of continued smoking. Methods : Cancer survivors from Princess Margaret Cancer Centre (Toronto, ON) were surveyed on their awareness of the harms of continued smoking on cancer-related outcomes. Multivariable logistic regression models assessed factors associated with awareness and whether awareness was associated [...]

Menée en Australie auprès de 26 oncologues de 179 patients atteints d'un cancer de stade avancé, cette étude compare, chez les médecins et chez les patients, leurs estimations du temps de survie

Estimating survival in advanced cancer: a comparison of estimates made by oncologists and patients

Smith-Uffen, M. E. S. ; Johnson, S. B. ; Martin, A. J. ; Tattersall, M. H. N. ; Stockler, M. R. ; Bell, M. L. ; Detering, K. ; Clayton, J. M. ; Silvester, W. ; Clarke, S. ; Vaccaro, L. ; Beale, P. ; Kiely, B. E.

Purpose : To compare estimates of expected survival time (EST) made by patients with advanced cancer and their oncologists. Methods : At enrolment patients recorded their “understanding of how long you may have to live” in best-case, most-likely, and worst-case scenarios. Oncologists estimated survival time for each of their patients as the “median survival of a group of identical patients”. We hypothesized that oncologists’ estimates of EST would be unbiased (~ 50% longer or shorter than the [...]

Mené sur 31 oncologues et sur 194 patients atteints d'un cancer, cet essai randomisé à 4 bras évalue l'efficacité d'une formation pédagogique destinée à l'oncologue pour la prise de décision partagée sur le traitement palliatif et d'un support de communication destiné au patient

Effect of a Skills Training for Oncologists and a Patient Communication Aid on Shared Decision Making About Palliative Systemic Treatment: A Randomized Clinical Trial

Henselmans, Inge ; van Laarhoven, Hanneke W.M. ; van Maarschalkerweerd, Pomme ; de Haes, Hanneke C.J.M. ; Dijkgraaf, Marcel G.W. ; Sommeijer, Dirkje W. ; Ottevanger, Petronella B. ; Fiebrich, Helle‐Brit ; Dohmen, Serge ; Creemers, Geert‐Jan ; de Vos, Filip Y.F.L. ; Smets, Ellen M.A.

Background : Palliative systematic treatment offers uncertain and often limited benefits, and the burden can be high. Hence, treatment decisions require shared decision making (SDM). This trial examined the independent and combined effect of an oncologist training and a patient communication aid on SDM. Methods : In this multicenter randomized controlled trial with four parallel arms (2016–2018), oncologists (n = 31) were randomized to receive SDM communication skills training or not. The [...]

Menée en Corée à partir de données portant sur 301 patients atteints d'un cancer (âge : 70-93 ans, âge médian : 75 ans) et recevant une chimiothérapie palliative de première ligne, cette étude prospective analyse l'association entre une polypharmacie, une utilisation médicamenteuse potentiellement inappropriée et des interactions médicamenteuses, puis analyse l'effet de cette polypharmacie sur le taux d'hospitalisation, sur le recours aux services d'urgence et sur la survie

Polypharmacy, Inappropriate Medication Use, and Drug Interactions in Older Korean Patients with Cancer Receiving First-Line Palliative Chemotherapy

Hong, Soojung ; Lee, Ju Hyun ; Chun, Eun Kyeong ; Kim, Kwang‐Il ; Kim, Jin Won ; Kim, Se Hyun ; Lee, Yun‐Gyoo ; Hwang, In Gyu ; Kim, Jin Young ; Koh, Su‐Jin ; Ko, Yoon Ho ; Shin, Seong Hoon ; Woo, In Sook ; Kim, Tae‐Yong ; Baek, Ji Yeon ; Kim, Hyun Jung ; Kim, Hyo Jung ; Lee, Myung Ah ; Kwon, Jung Hye ; Hong, Yong Sang ; Ryoo, Hun‐Mo ; Kim, Jee Hyun

Background : Polypharmacy is an important issue in the care of older patients with cancer, as it increases the risk of unfavorable outcomes. We estimated the prevalence of polypharmacy, potentially inappropriate medication (PIM) use, and drug–drug interactions (DDIs) in older patients with cancer in Korea and their associations with clinical outcomes. Subjects, Materials, and Methods : This was a secondary analysis of a prospective observational study of geriatric patients with cancer [...]

A partir d'une revue de la littérature (111 articles), cette étude compare les effets de soins manuels, notamment le shiatsu, issus des médecines complémentaires (médecine anthroposophique, médecine traditionnelle chinoise, médecine ayurvédique) pour améliorer le bien-être des patients atteints d'un cancer

The power of touch: external applications from whole medical systems in the care of cancer patients (literature review)

Mühlenpfordt, Inga ; Stritter, Wiebke ; Bertram, Mathias ; Ben-Arye, Eran ; Seifert, Georg

Purpose : In the context of whole medical systems (WMSs), external applications are manual treatments that stem from complementary medicine and are performed by practitioners, nurses and caregivers through the application of interpersonal touch. These applications work via physiological, psychological and social processes and are intended for holistic healing. In integrative oncology, these applications are used to improve patients’ wellbeing. The purpose of the review is to collect and compare [...]