A partir d'une revue systématique de la littérature (47 articles), cette méta-analyse évalue l'association entre une polypharmacie et/ou une utilisation médicamenteuse inappropriée, des complications post-opératoires, la survenue d'événéments indésirables liés à la chimiothérapie, un déclin physique et fonctionnel, et la mortalité chez des patients âgés atteints d'un cancer

Associations of Polypharmacy and Inappropriate Medications with Adverse Outcomes in Older Adults with Cancer: A Systematic Review and Meta-Analysis

Mohamed, Mostafa R. ; Ramsdale, Erika ; Loh, Kah Poh ; Arastu, Asad ; Xu, Huiwen ; Obrecht, Spencer ; Castillo, Daniel ; Sharma, Manvi ; Holmes, Holly M. ; Nightingale, Ginah ; Juba, Katherine M. ; Mohile, Supriya G.

Background : Polypharmacy (PP) and potentially inappropriate medications (PIM) are highly prevalent in older adults with cancer. This study systematically reviews the associations of PP and/or PIM with outcomes and, through a meta‐analysis, obtains estimates of postoperative outcomes associated with PP in this population. Materials and Methods : We searched PubMed, Embase, Web of Science, and Cochrane Register of Clinical Trials using standardized terms for concepts of PP, PIM, and cancer. [...]

Menée en population asiatique à partir de données portant sur 805 309 participants, cette étude de cohorte analyse l'association entre l'indice de masse corporelle, le tabagisme, une consommation d'alcool et la mortalité par myélome multiple (période de suivi : 10 221 623 personnes-années)

Association of BMI, Smoking, and Alcohol with Multiple Myeloma Mortality in Asians: a Pooled Analysis of More than 800,000 Participants in the Asia Cohort Consortium

Ugai, Tomotaka ; Ito, Hidemi ; Oze, Isao ; Saito, Eiko ; Rahman, Md Shafiur ; Boffetta, Paolo ; Gupta, Prakash C. ; Sawada, Norie ; Tamakoshi, Akiko ; Shu, Xiao Ou ; Koh, Woon-Puay ; Gao, Yu-Tang ; Sadakane, Atsuko ; Tsuji, Ichiro ; Park, Sue K. ; Nagata, Chisato ; You, San-Lin ; Pednekar, Mangesh S. ; Tsugane, Shoichiro ; Cai, Hui ; Yuan, Jian-Min ; Xiang, Yong-Bing ; Ozasa, Kotaro ; Tomata, Yasutake ; Kanemura, Seiki ; Sugawara, Yumi ; Wada, Keiko ; Chen, Chien-Jen ; Yoo, Keun-Young ; Chia, Kee Seng ; Ahsan, Habibul ; Zheng, Wei ; Inoue, Manami ; Kang, Daehee ; Potter, John ; Matsuo, Keitaro

Background: To date, few epidemiologic studies have been conducted to elucidate lifestyle-related risk factors for multiple myeloma in Asia. We investigated the association of body mass index (BMI), smoking, and alcohol intake with the risk of multiple myeloma mortality through a pooled analysis of more than 800,000 participants in the Asia Cohort Consortium. Methods: The analysis included 805,309 participants contributing 10,221,623 person-years of accumulated follow-up across Asia Cohort [...]

Menée en Suède à partir de données portant sur 3 834 patients atteints d'un cancer du poumon non à petites cellules de stade avancé et sur 15 332 témoins, cette étude analyse le taux d'incidence de comorbidités associées au cancer, un an après le diagnostic

Comorbidities and relevant outcomes, commonly associated with cancer, of patients newly diagnosed with advanced non-small-cell lung cancer in Sweden

Linden, Stephan ; Redig, Josefine ; Banos Hernaez, Ana ; Nilsson, Jonas ; Bartels, Dorthee B. ; Justo, Nahila

Objective : The objective was to describe the prevalence of baseline comorbidities in patients with advanced NSCLC and the incidence rate of relevant outcomes commonly associated with NSCLC, and its treatments, in the year after diagnosis. Methods : A non‐interventional cohort study compared adult patients newly diagnosed with advanced NSCLC during 2006–2013 with the general population. The prevalence of comorbidities one year before and incidence of relevant outcomes one year after NSCLC [...]

Menée aux Etats-Unis à partir de données portant sur 562 patients atteints d'un cancer hématologique à cellules B entre 2009 et 2016, cette étude analyse l'incidence et la sévérité d'une hypertension et d'événements cardiovasculaires indésirables en lien avec un traitement par ibrutinib

Hypertension and Incident Cardiovascular Events Following Ibrutinib Initiation

Dickerson, Tyler ; Wiczer, Tracy ; Waller, Allyson ; Philippon, Jennifer ; Porter, Kyle ; Haddad, Devin ; Guha, Avirup ; Rogers, Kerry A. ; Bhatt, Seema ; Byrd, John C. ; Woyach, Jennifer A. ; Awan, Farrukh ; Addison, Daniel

Among lymphoid malignancy patients treated with ibrutinib, the incidence of subsequent new hypertension is nearly 72%.The development of new or worsened hypertension following ibrutinib initiation associates with a >2-fold increased risk of other cardiac events. Ibrutinib is associated with dramatic efficacy against B-cell malignancies. Yet, ibrutinib is linked with potentially-limiting cardiotoxicity, including emerging reports of profound hypertension. However, the long-term incidence, [...]

Cette étude de l'"American Cancer Society" présente les données d'incidence du cancer du sein, de survie et de mortalité spécifique pour la période 2012-2016

Breast cancer statistics, 2019

DeSantis, Carol E. ; Ma, Jiemin ; Gaudet, Mia M. ; Newman, Lisa A. ; Miller, Kimberly D. ; Goding Sauer, Ann ; Jemal, Ahmedin ; Siegel, Rebecca L.

This article is the American Cancer Society's biennial update on female breast cancer statistics in the United States, including data on incidence, mortality, survival, and screening. Over the most recent 5‐year period (2012‐2016), the breast cancer incidence rate increased slightly by 0.3% per year, largely because of rising rates of local stage and hormone receptor‐positive disease. In contrast, the breast cancer death rate continues to decline, dropping 40% from 1989 to 2017 and translating [...]

Menée aux Etats-Unis à partir de données portant sur 10 873 hommes atteints d'un cancer du sein diagnostiqué entre 2004 et 2014 (âge médian : 64 ans), cette étude analyse l'évolution des statégies thérapeutiques, identifie des facteurs pronostiques et analyse la survie

Male breast cancer in the United States: Treatment patterns and prognostic factors in the 21st century

Yadav, Siddhartha ; Karam, Dhauna ; Bin Riaz, Irbaz ; Xie, Hao ; Durani, Urshila ; Duma, Narjust ; Giridhar, Karthik V. ; Hieken, Tina J. ; Boughey, Judy C. ; Mutter, Robert W. ; Hawse, John R. ; Jimenez, Rafael E. ; Couch, Fergus J. ; Leon-Ferre, Roberto A. ; Ruddy, Kathryn J.

Background : Male breast cancer (MBC) is a rare disease for which there is limited understanding of treatment patterns and prognostic factors. Methods : Men with TNM stage I to stage III breast cancer diagnosed between 2004 and 2014 in the National Cancer Data Base were included. Trends in treatment modalities were described using the average annual percentage change (AAPC) and estimated using Joinpoint software for the analysis of trends. Kaplan-Meier curves and the multivariate Cox [...]

Menée aux Pays-Bas à partir de données portant sur 242 patients atteints d'un cancer de la tête et du cou et sur 180 patients atteints d'une autre tumeur solide, cette étude compare, chez ces deux populations, les caractéristiques associées à une fragilité

Patients with head and neck cancer: Are they frailer than patients with other solid malignancies?

Bras, Linda ; Driessen, Daphne A. J. J. ; de Vries, Julius ; Festen, Suzanne ; van der Laan, Bernard F. A. M. ; van Leeuwen, Barbara L. ; de Bock, Geertruida H. ; Halmos, Gyorgy B.

Objective : We aimed to compare frailty status between patients with head and neck cancer (HNC) and other solid malignancies. Methods : Data collection was prospective, and the following were compared between cohorts at baseline: patient and tumour characteristics, Charlson Comorbidity Index (CCI), Groningen Frailty Indicator (GFI), Mini Mental State Examination (MMSE), Activities of Daily Living (ADLs), Instrumental ADLs (IADLs), Timed Up and Go (TUG) and Quality of Life (QoL). Univariate and [...]

Menée aux Etats-Unis à partir de donnnées portant sur 1 512 patients atteints d'un cancer de la tête et du cou traité par radiothérapie définitive entre 2000 et 2010 (âge médian : 55 ans), cette étude analyse les facteurs associés au risque de second cancer primitif et analyse la survie globale à 5 ans

Risk of second primary malignancies in head and neck cancer patients treated with definitive radiotherapy

Ng, Sweet Ping ; Pollard, Courtney ; Kamal, Mona ; Ayoub, Zeina ; Garden, Adam S. ; Bahig, Houda ; Gunn, G. Brandon ; Frank, Steven J. ; Skinner, Heath D. ; Phan, Jack ; Berends, Joel ; Morrison, William H. ; Johnson, Jason M. ; Ferrarotto, Renata ; Sturgis, Erich M. ; Mohamed, Abdallah S. R. ; Lai, Stephen Y. ; Fuller, Clifton D. ; Rosenthal, David I.

Second primary malignancy (SPM) may occur after index head and neck cancer (HNC) treatment. This study evaluated the prevalence and outcome of SPM in patients with HNC treated with definitive radiotherapy. Eligible patients include those with index mucosal HNC treated with definitive radiotherapy between 2000 and 2010. SPM was defined as an invasive cancer at a noncontiguous site diagnosed at least 6 months after completion of radiotherapy. Clinical data were collected, and the Kaplan–Meier [...]

A partir d'une revue systématique de la littérature (7 articles), cette étude évalue l'efficacité des interventions cognitives informatisées dédiées aux patients ayant survécu à un cancer et souffrant de troubles cognitifs

Computerized programs for cancer survivors with cognitive problems: a systematic review

Kim, Yoonjung ; Kang, Sook Jung

Purpose : This study aimed to review and identify characteristics and lessons learned from studies on computerized cognitive interventions for cancer survivors (CSs) with cognitive dysfunction, exploring the content and results of interventions. Methods : Studies were collected from the CINAHL, Web of Science, PubMed, and PsycINFO databases. Results : Seven articles that met the inclusion criteria were included. Reviewed studies measured objective cognitive function, subjective cognitive [...]

Menée en Allemagne auprès de 270 patients atteints d'un cancer, cette étude analyse les facteurs liés à leur utilisation de soins psychologiques, notamment leurs comportements et attitudes pour chercher de l'aide

Cancer patient utilisation of psychological care in Germany: The role of attitudes towards seeking help

Leppin, Nico ; Nagelschmidt, Katharina ; Koch, Martin ; Riera-Knorrenschild, Jorge ; Seifart, Carola ; Rief, Winfried ; Barke, Antonia ; von Blanckenburg, Pia

Objective : Even if significantly distressed, many patients with cancer do not seek psychological help. There is growing evidence that attitudes are central barriers for help-seeking, and instruments to assess cancer patients’ attitudes towards help-seeking are urgently needed. This study aimed to evaluate the German Attitudes towards Seeking Help after Cancer Scale (ASHCa-G) and investigated the relationship between patients’ attitudes and psychological care utilisation. Methods : The ASHCa-G [...]

Menée en Allemagne auprès de 50 patientes ayant survécu à un cancer du sein, cette étude multicentrique évalue l'efficacité d'une intervention de nature psycho-pédagogique dispensée en groupe pour réduire la peur de la récidive et les symptômes de dépression, améliorer leur sentiment d'auto-efficacité et leur qualité de vie

Psychoeducational group intervention for breast cancer survivors: a non-randomized multi-center pilot study

Weis, Joachim B. ; Gschwendtner, Kathrin ; Giesler, Jürgen M. ; Adams, Leonie ; Wirtz, Markus A.

Purpose : The aim of the study was to evaluate an outpatient psychoeducational group program for breast cancer patients aimed to improve various psychosocial parameters, enhancing the patients’ competence and reducing fear of recurrence. Methods : The study is based on a multi-center, non-randomized control group design with three measurement time points (T1 baseline, T2 end of the intervention, T3 6-week follow-up). Breast cancer patients were assessed with various standardized questionnaires [...]

Menée aux Etats-Unis par enquête auprès de 2 632 patients atteints d'un cancer de la thyroïde diagnostiqué entre 2014 et 2015, cette étude analyse l'association entre le niveau de surveillance médicale souhaité par les patients (surveillance minimale, modérée, maximale) et l'utilisation des soins et des examens (visites médicales, scanner et IRM) ainsi que les coûts associés

Role of Patient Maximizing-Minimizing Preferences in Thyroid Cancer Surveillance

Joshua M. Evron ; David Reyes-Gastelum ; Mousumi Banerjee ; Laura D. Scherer ; Lauren P. Wallner ; Ann S. Hamilton ; Kevin C. Ward ; Sarah T. Hawley ; Brian J. Zikmund-Fisher ; Megan R. Haymart

PURPOSE : To understand the effect of patient preferences on thyroid cancer surveillance intensity. PATIENTS AND METHODS : Eligible patients diagnosed with thyroid cancer between January 1, 2014, and December 31, 2015, from the Georgia and Los Angeles County SEER registries were surveyed between February 2017 and October 2018 (N = 2,632; response rate, 63%). Patient reports on health care utilization in the past year and responses to the validated Medical Maximizer-Minimizer Scale were linked [...]

Menée aux Etats-Unis par enquête auprès de 217 patients atteints d'un cancer, cette étude analyse l'impact de séances de délibération démocratique sur leurs opinions concernant l'utilisation d'informations de santé anonymisées

Effect of Public Deliberation on Patient Attitudes Regarding Consent and Data Use in a Learning Health Care System for Oncology

Reshma Jagsi ; Kent A. Griffith ; Rochelle D. Jones ; Chris Krenz ; Michele Gornick ; Rebecca Spence ; Raymond De Vries ; Sarah T. Hawley ; Robin Zon ; Sage Bolte ; Navid Sadeghi ; Richard L. Schilsky ; Angela R. Bradbury

PURPOSE : We sought to generate informed and considered opinions regarding acceptable secondary uses of deidentified health information and consent models for oncology learning health care systems. METHODS : Day-long democratic deliberation sessions included 217 patients with cancer at four geographically and sociodemographically diverse sites. Patients completed three surveys (at baseline, immediately after deliberation, and 1-month follow-up). RESULTS : Participants were 67.3% female, 21.7% [...]

Menée aux Etats-Unis par entretiens auprès de 334 patients atteints d'un cancer de stade avancé recevant une chimiothérapie ou une radiothérapie palliatives, cette étude analyse leur compréhension de la finalité du traitement (curative ou palliative) et celle du pronostic de la maladie

Palliative Chemotherapy or Radiation and Prognostic Understanding among Advanced Cancer Patients: The Role of Perceived Treatment Intent

Login S. George, ; Holly G. Prigerson, ; Andrew S. Epstein, ; Kristy L. Richards, ; Megan J. Shen, ; Heather M. Derry, ; Valerie F. Reyna, ; Manish A. Shah, ; Paul K. Maciejewski

Background: As patients' accurate understanding of their prognosis is essential for informed end-of-life planning, identifying associated factors is important. Objective: We examine if receiving palliative chemotherapy or radiation, and the perception of those treatments as curative or noncurative, is associated with prognostic understanding. Design: Cross-sectional analyses from a multisite, observational study. Setting/Subjects: Patients with advanced cancers refractory to at least one [...]