A partir d'une revue systématique de la littérature publiée jusqu'en mai 2018 (16 études), cette méta-analyse évalue l'association entre une consommation d'alcool et le risque de développer un cancer de la vessie

Impact of alcohol consumption on the risk of developing bladder cancer: a systematic review and meta-analysis

Vartolomei, Mihai Dorin ; Iwata, Takehiro ; Roth, Beat ; Kimura, Shoji ; Mathieu, Romain ; Ferro, Matteo ; Shariat, Shahrokh F. ; Seitz, Christian

Background : Epidemiologic studies that investigated alcohol consumption in relation to the risk of bladder cancer (BCa) have demonstrated inconsistent results. We conducted a systematic review and meta-analysis of the literature to investigate the association of alcohol including different types of alcoholic beverages consumption with the risk of BCa. Materials and methods : A systematic search of Web of Science, Medline/PubMed and Cochrane library was performed in May 2018. Studies were [...]

Menée au Japon auprès de 87 628 participants (durée moyenne de suivi : 15,3 ans), cette étude analyse l'association entre une consommation d'acrylamide dans l'alimentation et le cancer de l'œsophage, de l'estomac et du cancer colorectal (5 079 cas)

Dietary Acrylamide Intake and Risk of Esophageal, Gastric, and Colorectal Cancer: The Japan Public Health Center-based Prospective Study

Liu, Rong ; Sobue, Tomotaka ; Kitamura, Tetsuhisa ; Kitamura, Yuri ; Ishihara, Junko ; Kotemori, Ayaka ; Zha, Ling ; Ikeda, Sayaka ; Sawada, Norie ; Iwasaki, Motoki ; Tsugane, Shoichiro

Background : Acrylamide has been classified as a probable human carcinogen based chiefly on laboratory evidence. However, the influence of dietary acrylamide intake on risk of esophageal, gastric, and colorectal cancer has not been extensively studied. We aimed to evaluate the association between dietary acrylamide intake and esophageal, gastric, and colorectal cancer using data from the Japan Public Health Center-based Prospective Study. Methods : Our study included 87,628 participants who [...]

Menée en 1999 auprès de 109 030 personnes (âge moyen : 69,2 ans ; durée moyenne de suivi : 10 ans), cette étude analyse l'association entre l'activité physique, d'intensité modérée à intense, le temps passé en position assise et le risque de développer une tumeur myéloïde (409 cas)

Physical activity, sitting time, and risk of myelodysplastic syndromes, acute myeloid leukemia, and other myeloid malignancies

Rees-Punia, Erika ; Patel, Alpa V. ; Fallon, Elizabeth A ; Gapstur, Susan M. ; Teras, Lauren R.

Introduction : There is limited research on associations of moderate-to-vigorous physical activity (MVPA) and sitting with risk of myeloid neoplasms (MN) or MN subtypes. We examined these associations in the Cancer Prevention Study-II Nutrition Cohort. Methods : Among 109,030 cancer-free participants (mean age 69.2, SD 6.1 years) in 1999, 409 were identified as having been diagnosed with a MN (n=155 acute myeloid leukemia [AML], n=154 myelodysplastic syndromes [MDS], n=100 other ML) through [...]

A partir de données des cohortes "the Nurses’ Health Study" et "the Health Professionals Follow-Up Study" impliquant 53 553 femmes et 27 916 hommes (durée de suivi : 1,2 millions personnes-années), cette étude analyse l'association entre les variations de consommation de viande rouge et la mortalité toutes causes confondues (14 019 décès) ou par cancer (4 892 décès)

Association of changes in red meat consumption with total and cause specific mortality among US women and men: two prospective cohort studies

Zheng, Yan ; Li, Yanping ; Satija, Ambika ; Pan, An ; Sotos-Prieto, Mercedes ; Rimm, Eric ; Willett, Walter C ; Hu, Frank B

Objective : To evaluate the association of changes in red meat consumption with total and cause specific mortality in women and men. Design : Two prospective cohort studies with repeated measures of diet and lifestyle factors. Setting : Nurses’ Health Study and the Health Professionals Follow-up Study, United States. Participants : 53 553 women and 27 916 men without cardiovascular disease or cancer at baseline. Main outcome measure : Death confirmed by state vital statistics records, the [...]

A partir d'une revue systématique de la littérature publiée jusqu'en janvier 2019 (9 études incluant 290 911 personnes), cette méta-analyse évalue l'association entre l'indice ou la charge glycémique des aliments et le risque de cancer de la prostate

Dietary Glycemic Index and Glycemic Load and the Risk of Prostate Cancer: An Updated Systematic Review and Dose–Response Meta-Analysis

Sadeghi, Alireza ; Sadeghi, Omid ; Khodadost, Mahmoud ; Pirouzi, Aliyar ; Hosseini, Banafsheh ; Saedisomeolia, Ahmad

A meta-analysis in 2015 revealed no significant association between glycemic index (GI), glycemic load (GL), and prostate cancer. Moreover, until now, no study has examined the dose-response association of GI, GL, and prostate cancer yet. The online databases were searched by two independent researchers for relevant publications up to Jan. 2019, using relevant keywords. Nine studies including five prospective and four case?control studies were included in the current systematic review and [...]

Menée en Chine entre 2004 et 2008 auprès de 496 732 personnes (âge moyen : 51,5 ans ; 59% de femmes ; durée de suivi : 4,4 millions personnes-années), cette étude analyse l'association entre une infection chronique par le virus de l'hépatite B et un risque plus élevé de tout type de cancer

Associations Between Hepatitis B Virus Infection and Risk of All Cancer Types

Song, Ci ; Lv, Jun ; Liu, Yao ; Chen, Jian Guo ; Ge, Zijun ; Zhu, Jian ; Dai, Juncheng ; Du, Ling-Bin ; Yu, Canqing ; Guo, Yu ; Bian, Zheng ; Yang, Ling ; Chen, Yiping ; Chen, Zhengming ; Liu, Jibin ; Jiang, Jie ; Zhu, Liguo ; Zhai, Xiangjun ; Jiang, Yue ; Ma, Hongxia ; Jin, Guangfu ; Shen, Hongbing ; Li, Liming ; Hu, Zhibin ; for the China Kadoorie Biobank Collaborative Group

Hepatitis B virus (HBV) has been identified as a major risk factor for hepatocellular carcinoma. However, the associations between HBV infection and other cancer types are not well understood.To assess the associations between chronic HBV infection and risk of all cancer types.This population-based study involved 3 cohorts in China. The China Kadoorie Biobank (CKB) prospective cohort study, conducted between June 2004 and July 2008, used a dipstick assay for detection of serum hepatitis B [...]

Menée au Royaume-Uni auprès de 54 261 patientes, cette étude analyse l'association entre une ovariectomie et le risque de cancer du foie (767 cas)

Oophorectomy and risk of non-alcoholic fatty liver disease and primary liver cancer in the Clinical Practice Research Datalink

Florio, Andrea A. ; Graubard, Barry I. ; Yang, Baiyu ; Thistle, Jake E. ; Bradley, Marie C. ; McGlynn, Katherine A. ; Petrick, Jessica L.

Incidence of non-alcoholic fatty liver disease (NAFLD) and liver cancer are 2–3 times higher in males than females. Hormonal mechanisms are hypothesized, with studies suggesting that oophorectomy may increase risk, but population-based evidence is limited. Thus, we conducted a study within the Clinical Practice Research Datalink, with controls matched to cases of NAFLD (n = 10,082 cases/40,344 controls) and liver cancer (n = 767 cases/3068 controls). Odds ratios (OR) and 95% confidence [...]

A partir d'une revue systématique de la littérature publiée jusqu'en janvier 2019 (7 études ; 42 602 patients), cette méta-analyse évalue l'association entre l'anorexie mentale et le risque de développer un cancer ou d'en mourir

Association of Anorexia Nervosa With Risk of Cancer: A Systematic Review and Meta-analysis

Catalá-López, Ferrán ; Forés-Martos, Jaume ; Driver, Jane A. ; Page, Matthew J. ; Hutton, Brian ; Ridao, Manuel ; Alonso-Arroyo, Adolfo ; Macías Saint-Gerons, Diego ; Genova-Maleras, Ricard ; Valderas, Jose M. ; Vieta, Eduard ; Valencia, Alfonso ; Tabarés-Seisdedos, Rafael

Anorexia nervosa is recognized as an important cause of morbidity in young people. However, the risk of cancer in people with anorexia nervosa remains uncertain.To evaluate the association of anorexia nervosa with the risk of developing or dying of cancer.MEDLINE, Scopus, Embase, and Web of Science from database inception to January 9, 2019.Published observational studies in humans examining the risk of cancer in people with anorexia nervosa compared with the general population or those without [...]

Menée aux Pays-Bas auprès de 283 personnes porteuses de la mutation p16-Leiden, cette étude analyse l'association entre le variant génétique rs36115365-C, situé sur chr5p15.33 et agissant sur les activités de TERT, et le risque de cancer du pancréas ou de mélanome

Assessing a single SNP located at TERT/CLPTM1L multi-cancer risk region as a genetic modifier for risk of pancreatic cancer and melanoma in Dutch CDKN2A mutation carriers

Christodoulou, E. ; Visser, M. ; Potjer, T. P. ; van der Stoep, N. ; Rodríguez-Girondo, M. ; van Doorn, R. ; Gruis, N.

Carriers of pathogenic variants in CDKN2A have a 70% life-time risk of developing melanoma and 15–20% risk of developing pancreatic cancer (PC). In the Netherlands, a 19-bp deletion in exon 2 of CDKN2A (p16-Leiden mutation) accounts for most hereditary melanoma cases. Clinical experience suggests variability in occurrence of melanoma and PC in p16-Leiden families. Thereby, the risk of developing cancer could be modified by both environmental and genetic contributors, suggesting that [...]

Menée au Royaume-Uni par questionnaires auprès de 548 741 femmes nées entre 1935 et 1950 (durée de suivi : 9,8 millions personnes-années), cette étude analyse l'association entre l'allaitement maternel et le risque, pour l'enfant, de développer un cancer à l'âge adulte (8 localisations ; 57 998 cas)

Adult cancer risk in women who were breastfed as infants: large UK prospective study

Yang, TienYu Owen ; Cairns, Benjamin J. ; Green, Jane ; Reeves, Gillian K. ; Floud, Sarah ; Bradbury, Kathryn E. ; Beral, Valerie ; Abbiss, Hayley ; Abbott, Simon ; Alison, Rupert ; Armstrong, Miranda ; Baker, Krys ; Balkwill, Angela ; Barnes, Isobel ; Black, Judith ; Blanks, Roger ; Bradbury, Kathryn ; Brown, Anna ; Cairns, Benjamin ; Chadwick, Andrew ; Ewart, Dave ; Gaitskell, Kezia ; Gathani, Toral ; Gerrard, Laura ; Goodill, Adrian ; Guiver, Lynden ; Heath, Alicia ; Hogg, Darren ; Lingard, Isobel ; Kan, Sau Wan ; Langston, Nicky ; Pirie, Kirstin ; Price, Alison ; Reeves, Gillian ; Shaw, Keith ; Sherman, Emma ; Simpson, Rachel ; Strange, Helena ; Sweetland, Sian ; Travis, Ruth ; Trickett, Lyndsey ; Webster, Anthony ; Wotton, Clare ; Wright, Lucy ; Yang, Owen ; Young, Heather ; Banks, Emily ; Carpenter, Lucy ; Dezateux, Carol ; Patnick, Julietta ; Peto, Richard ; Sudlow, Cathie ; for the Million Women Study Collaborators

There are known short-term benefits in breastfed infants versus bottle-fed infants in terms of lower risks of infection and obesity in infancy and childhood, but the long-term effect on the risk of adult cancers is unclear. In a cohort of 1 in 4 UK women born in 1935–1950 we report the incidence of adult cancers in relation to having been breastfed in infancy. In median year 2001 (interquartile range 2000–2003) 548,741 women without prior cancer reported whether they had been breastfed. There [...]

Menée aux Etats-Unis à partir de l'étude d'association sur le génome entier "PanC4" portant sur 3 568 personnes atteintes d'un cancer du pancréas et sur 3 363 témoins, cette étude analyse les facteurs génétiques et héréditaires de la maladie

Analysis of Heritability and Genetic Architecture of Pancreatic Cancer: A PanC4 Study

Chen, Fei ; Childs, Erica J. ; Mocci, Evelina ; Bracci, Paige ; Gallinger, steven ; Li, Donghui ; Neale, Rachel E. ; Olson, Sara H. ; Scelo, Ghislaine ; Bamlet, William R. ; Blackford, Amanda L. ; Borges, Michael ; Brennan, Paul ; Chaffee, Kari G. ; Duggal, Priya ; Hassan, Manal J. ; Holly, Elizabeth A. ; Hung, Rayjean J. ; Goggins, Michael G. ; Kurtz, Robert C. ; Oberg, Ann L. ; Orlow, Irene ; Yu, Herbert ; Petersen, Gloria M. ; Risch, Harvey A. ; Klein, Alison P.

Background : Pancreatic cancer is the fourth-leading cause of cancer death in both men and women in the United States. The currently identified common susceptibility loci account for a small fraction of estimated heritability. We sought to estimate overall heritability of pancreatic cancer and partition the heritability by variant frequencies and functional annotations. Methods : Analysis using the genome-based restricted maximum likelihood method (GREML) was conducted on Pancreatic Cancer [...]

Menée principalement à partir de données suédoises portant sur plus de 400 000 patients, cette étude analyse les caractéristiques de l'association entre les maladies auto-immunes et les cancers hématologiques

Autoimmune diseases and hematological malignancies: exploring the underlying mechanisms from epidemiological evidence

Hemminki, Kari ; Huang, Wuqing ; Sundquist, Jan ; Sundquist, Kristina ; Ji, Jianguang

Autoimmune diseases are characterized by the irregular functioning of the immune system that leads to the loss of tolerance to self-antigens. The underlying nature of autoimmune diseases has led to speculation that the risk of malignancy might be higher or lower in patients with such diseases. However, the rarity and heterogeneity of both autoimmune diseases and malignancies is the main challenge for systematic exploration of associations between autoimmune diseases and cancer. The nationwide [...]

A partir d'une revue systématique de la littérature publiée jusqu'en décembre 2018 (23 études), cette méta-analyse évalue les associations entre l’apport en fer, le statut en fer de l'organisme et le risque de cancer du sein

Iron intake, body iron status, and risk of breast cancer: a systematic review and meta-analysis

Chang, Vicky C. ; Cotterchio, Michelle ; Khoo, Edwin

Background : Iron has been shown to promote breast carcinogenesis in animal models through generation of oxidative stress and interaction with estrogen. Heme iron, which is found exclusively in animal-sourced foods, is suggested to have a more detrimental effect. Epidemiological evidence of the association between iron and breast cancer risk remains inconclusive and has not been comprehensively summarized. This systematic review and meta-analysis evaluated associations between both iron intake [...]

Cette étude présente, à partir des études d'association sur le génome entier existantes, les avancées récentes et les perspectives concernant la génétique du cancer de l'endomètre

Genome-Wide Association Studies of Endometrial Cancer: Latest Developments and Future Directions

O'Mara, Tracy A. ; Glubb, Dylan M. ; Kho, Pik Fang ; Thompson, Deborah J. ; Spurdle, Amanda B.

Endometrial cancer, the most commonly diagnosed cancer of the female reproductive tract in developed countries, has a heritable component. To date, 16 genetic risk regions have been robustly discovered by genome-wide association studies (GWAS) of endometrial cancer. Post-GWAS analyses including expression quantitative trait loci analysis and laboratory-based functional studies have been successful in identifying genes and pathways involved in endometrial carcinogenesis. Mendelian randomization [...]

Menée aux Pays-Bas auprès de 39 femmes (âge médian au diagnostic : 68 ans), cette étude analyse l'association entre l'indice de masse corporelle, le volume de graisse viscérale et sous-cutanée et les taux sériques de stéroïdes sexuels et de lipides chez les patients atteints d'un cancer de l'endomètre

Impact of body mass index and fat distribution on sex steroid levels in endometrial carcinoma: a retrospective study

van Weelden, Willem Jan ; Fasmer, Kristine Eldevik ; Tangen, Ingvild L. ; IntHout, Joanna ; Abbink, Karin ; van Herwaarden, Antionius E. ; Krakstad, Camilla ; Massuger, Leon F. A. G. ; Haldorsen, Ingfrid S. ; Pijnenborg, Johanna M. A.

Background : Obesity is an important cause of multiple cancer types, amongst which endometrial cancer (EC). The relation between obesity and cancer is complicated and involves alterations in insulin metabolism, response to inflammation and alterations in estradiol metabolism. Visceral obesity is assumed to play the most important role in the first two mechanisms, but its role in estradiol metabolism is unclear. Therefore, this retrospective study explores the relationship of body mass index [...]

Cette étude présente une méthode alternative d'estimation du risque de cancer colorectal chez une famille atteinte du syndrome de Lynch

An alternative approach to establishing unbiased colorectal cancer risk estimation in Lynch syndrome

Suerink, Manon ; Rodríguez-Girondo, Mar ; van der Klift, Heleen M. ; Colas, Chrystelle ; Brugières, Laurence ; Lavoine, Noémie ; Jongmans, Marjolijn ; Munar, Gabriel Capellá ; Evans, D. Gareth ; Farrell, Michael P. ; Genuardi, Maurizio ; Goldberg, Yael ; Gomez-Garcia, Encarna ; Heinimann, Karl ; Hoell, Jessica I. ; Aretz, Stefan ; Jasperson, Kory W. ; Kedar, Inbal ; Modi, Mitul B. ; Nikolaev, Sergey ; van Os, Theo A. M. ; Ripperger, Tim ; Rueda, Daniel ; Senter, Leigha ; Sjursen, Wenche ; Sunde, Lone ; Therkildsen, Christina ; Tibiletti, Maria G. ; Trainer, Alison H. ; Vos, Yvonne J. ; Wagner, Anja ; Winship, Ingrid ; Wimmer, Katharina ; Zimmermann, Stefanie Y. ; Vasen, Hans F. ; van Asperen, Christi J. ; Houwing-Duistermaat, Jeanine J. ; ten Broeke, Sanne W. ; Nielsen, Maartje

Purpose : Biallelic pathogenic variants in the mismatch repair (MMR) genes cause a recessive childhood cancer predisposition syndrome known as constitutional mismatch repair deficiency (CMMRD). Family members with a heterozygous MMR variant have Lynch syndrome. We aimed at estimating cancer risk in these heterozygous carriers as a novel approach to avoid complicated statistical methods to correct for ascertainment bias. Methods : Cumulative colorectal cancer incidence was estimated in a cohort [...]